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dc.contributor.authorCasula, EP
dc.contributor.authorTarantino, V
dc.contributor.authorBasso, D
dc.contributor.authorArcara, G
dc.contributor.authorMarino, G
dc.contributor.authorToffolo, GM
dc.contributor.authorRothwell, JC
dc.contributor.authorBisiacchi, PS
dc.date.accessioned2015-06-30T15:05:06Z
dc.date.available2015-06-30T15:05:06Z
dc.date.issued2014
dc.identifier.issn1053-8119
dc.identifier.urihttp://dx.doi.org/10.1016/j.neuroimage.2014.04.065
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S1053811914003450
dc.identifier.urihttp://hdl.handle.net/10863/992
dc.description.abstractThe neuromodulatory effects of repetitive transcranial magnetic stimulation (rTMS) have been mostly investigated by peripheral motor-evoked potentials (MEPs). New TMS-compatible EEG systems allow a direct investigation of the stimulation effects through the analysis of TMS-evoked potentials (TEPs). We investigated the effects of 1-Hz rTMS over the primary motor cortex (M1) of 15 healthy volunteers on TEP evoked by single pulse TMS over the same area. A second experiment in which rTMS was delivered over the primary visual cortex (V1) of 15 healthy volunteers was conducted to examine the spatial specificity of the effects. Single-pulse TMS evoked four main components: P30, N45, P60 and N100. M1-rTMS resulted in a significant decrease of MEP amplitude and in a significant increase of P60 and N100 amplitude. There was no effect after V1-rTMS. 1-Hz rTMS appears to increase the amount of inhibition following a TMS pulse, as demonstrated by the higher N100 and P60, which are thought to originate from GABAb-mediated inhibitory post-synaptic potentials. Our results confirm the reliability of the TMS-evoked N100 as a marker of cortical inhibition and provide insight into the neuromodulatory effects of 1-Hz rTMS. The present finding could be of relevance for therapeutic and diagnostic purposes.en_US
dc.publisherElsevieren_US
dc.titleLow-frequency rTMS inhibitory effects in the primary motor cortex: Insights from TMS-evoked potentialsen_US
dc.typeArticleen_US
dc.date.updated2015-06-25T06:50:22Z
dc.journal.titleNeuroImage
dc.description.fulltextnoneen_US


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