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dc.contributor.authorDestro-Bisol G
dc.contributor.authorDonati F
dc.contributor.authorCoia V
dc.contributor.authorBoschi I
dc.contributor.authorVerginelli F
dc.contributor.authorCaglià A
dc.contributor.authorTofanelli S
dc.contributor.authorSpedini G
dc.contributor.authorCapelli C
dc.date.accessioned2018-10-30T15:00:46Z
dc.date.available2018-10-30T15:00:46Z
dc.date.issued2004
dc.identifier.issn0737-4038
dc.identifier.urihttp://dx.doi.org/10.1093/molbev/msh186
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-4143062395&doi=10.1093/molbev/msh186∂nerID=40&md5=0c9bc4ac0d3f1b208a236ab12aa61054
dc.identifier.urihttp://hdl.handle.net/10863/6785
dc.description.abstractIn this paper, we present a study of genetic variation in sub-Saharan Africa, which is based on published and unpublished data on fast-evolving (hypervariable region 1 of mitochondrial DNA and six microsatellites of Y chromosome) and slow-evolving (haplogroup frequencies) polymorphisms of mtDNA and Y chromosome. Our study reveals a striking difference in the genetic structure of food-producer (Bantu and Sudanic speakers) and hunter-gatherer populations (Pygmies,!Kung, and Hadza). In fact, the ratio of mtDNA to Y-chromosome Nu is substantially higher in food producers than in hunter-gatherers as determined by fast-evolving polymorphisms (1.76 versus 0.11). This finding indicates that the two population groups differ substantially in female and male migration rate and/or effective size. The difference also persists when linguistically homogeneous populations are used and outlier populations are eliminated (1.78 vs 0.19) or when the jacknife procedure is applied to a paired population data set (1.32 to 7.84 versus 0.14 to 0.66). The higher ratio of mtDNA to Y-chromosome Nv in food producers than in hunter-gatherers is further confirmed by the use of slow-evolving polymorphisms (1.59 to 7.91 versus 0.12 to 0.35). To explain these results, we propose a model that integrates demographic and genetic aspects and incorporates ethnographic knowledge. In such a model, the asymmetric gene flow, polyginy, and patrilocality play an important role in differentiating the genetic structure of sub-Saharan populations. The existence of an asymmetric gene flow is supported by the phylogeographic features of mtDNA and Y-chromosome haplogroups found in the two population groups. The role of polyginy and patrilocality is sustained by the evidence of a differential pressure of genetic drift and gene flow on maternal and paternal lineages of food producers and hunter-gatherers that is revealed through the analysis of mitochondrial and Y-chromosomal intrapopulational variation.en_US
dc.language.isoenen_US
dc.rights
dc.titleVariation of female and male lineages in sub-Saharan populations: The importance of sociocultural factorsen_US
dc.typeArticleen_US
dc.date.updated2018-10-30T14:31:48Z
dc.language.isiEN-GB
dc.journal.titleMolecular Biology and Evolution
dc.description.fulltextnoneen_US


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