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dc.contributor.authorChen W
dc.contributor.authorHayward C
dc.contributor.authorWright AF
dc.contributor.authorHicks AA
dc.contributor.authorVitart V
dc.contributor.authorKnott S
dc.contributor.authorWild SH
dc.contributor.authorPramstaller PP
dc.contributor.authorWilson JF
dc.contributor.authorRudan I
dc.contributor.authorPorteous DJ
dc.date.accessioned2018-10-30T10:59:00Z
dc.date.available2018-10-30T10:59:00Z
dc.date.issued2011
dc.identifier.issn1932-6203
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0023087
dc.identifier.urihttp://hdl.handle.net/10863/6758
dc.description.abstractGenome analysis provides a powerful approach to test for evidence of genetic variation within and between geographical regions and local populations. Copy number variants which comprise insertions, deletions and duplications of genomic sequence provide one such convenient and informative source. Here, we investigate copy number variants from genome wide scans of single nucleotide polymorphisms in three European population isolates, the island of Vis in Croatia, the islands of Orkney in Scotland and the South Tyrol in Italy. We show that whereas the overall copy number variant frequencies are similar between populations, their distribution is highly specific to the population of origin, a finding which is supported by evidence for increased kinship correlation for specific copy number variants within populations.en_US
dc.language.isoenen_US
dc.rights
dc.titleCopy number variation across European populationsen_US
dc.typeArticleen_US
dc.date.updated2018-10-30T10:29:37Z
dc.language.isiEN-GB
dc.journal.titlePLoS ONE
dc.description.fulltextopenen_US


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