Show simple item record

dc.contributor.authorScott RA
dc.contributor.authorLagou V
dc.contributor.authorWelch RP
dc.contributor.authorWheeler E
dc.contributor.authorMontasser ME
dc.contributor.authorLuan J
dc.contributor.authorMägi R
dc.contributor.authorStrawbridge RJ
dc.contributor.authorRehnberg E
dc.contributor.authorGustafsson S
dc.contributor.authorKanoni S
dc.contributor.authorRasmussen-Torvik LJ
dc.contributor.authorYengo L
dc.contributor.authorLecoeur C
dc.contributor.authorShungin D
dc.contributor.authorSanna S
dc.contributor.authorSidore C
dc.contributor.authorJohnson PC
dc.contributor.authorJukema JW
dc.contributor.authorJohnson T
dc.contributor.authorMahajan A
dc.contributor.authorVerweij N
dc.contributor.authorThorleifsson G
dc.contributor.authorHottenga JJ
dc.contributor.authorShah S
dc.contributor.authorSmith AV
dc.contributor.authorSennblad B
dc.contributor.authorGieger C
dc.contributor.authorSalo P
dc.contributor.authorPerola M
dc.contributor.authorTimpson NJ
dc.contributor.authorEvans DM
dc.contributor.authorPourcain BS
dc.contributor.authorWu Y
dc.contributor.authorAndrews JS
dc.contributor.authorHui J
dc.contributor.authorBielak LF
dc.contributor.authorZhao W
dc.contributor.authorHorikoshi M
dc.contributor.authorNavarro P
dc.contributor.authorIsaacs A
dc.contributor.authorO'Connell JR
dc.contributor.authorStirrups K
dc.contributor.authorVitart V
dc.contributor.authorHayward C
dc.contributor.authorEsko T
dc.contributor.authorMihailov E
dc.contributor.authorFraser RM
dc.contributor.authorFall T
dc.contributor.authorVoight BF
dc.contributor.authorRaychaudhuri S
dc.contributor.authorChen H
dc.contributor.authorLindgren CM
dc.contributor.authorMorris AP
dc.contributor.authorRayner NW
dc.contributor.authorRobertson N
dc.contributor.authorRybin D
dc.contributor.authorLiu CT
dc.contributor.authorBeckmann JS
dc.contributor.authorWillems SM
dc.contributor.authorChines PS
dc.contributor.authorJackson AU
dc.contributor.authorKang HM
dc.contributor.authorStringham HM
dc.contributor.authorSong K
dc.contributor.authorTanaka T
dc.contributor.authorPeden JF
dc.contributor.authorGoel A
dc.contributor.authorHicks AA
dc.contributor.authorAn P
dc.contributor.authorMüller-Nurasyid M
dc.contributor.authorFranco-Cereceda A
dc.contributor.authorFolkersen L
dc.contributor.authorMarullo L
dc.contributor.authorJansen H
dc.contributor.authorOldehinkel AJ
dc.contributor.authorBruinenberg M
dc.contributor.authorPankow JS
dc.contributor.authorNorth KE
dc.contributor.authorForouhi NG
dc.contributor.authorLoos RJ
dc.contributor.authorEdkins S
dc.contributor.authorVarga TV
dc.contributor.authorHallmans G
dc.contributor.authorOksa H
dc.contributor.authorAntonella M
dc.contributor.authorNagaraja R
dc.contributor.authorTrompet S
dc.contributor.authorFord I
dc.contributor.authorBakker SJ
dc.contributor.authorKong A
dc.contributor.authorKumari M
dc.contributor.authorGigante B
dc.contributor.authorHerder C
dc.contributor.authorMunroe PB
dc.contributor.authorCaulfield M
dc.contributor.authorAntti J
dc.contributor.authorMangino M
dc.contributor.authorSmall K
dc.contributor.authorMiljkovic I
dc.contributor.authorLiu Y
dc.contributor.authorAtalay M
dc.contributor.authorKiess W
dc.contributor.authorJames AL
dc.contributor.authorRivadeneira F
dc.contributor.authorUitterlinden AG
dc.contributor.authorPalmer CN
dc.contributor.authorDoney AS
dc.contributor.authorWillemsen G
dc.contributor.authorSmit JH
dc.contributor.authorCampbell S
dc.contributor.authorPolasek O
dc.contributor.authorBonnycastle LL
dc.contributor.authorHercberg S
dc.contributor.authorDimitriou M
dc.contributor.authorBolton JL
dc.contributor.authorFowkes GR
dc.contributor.authorKovacs P
dc.contributor.authorLindström J
dc.contributor.authorZemunik T
dc.contributor.authorBandinelli S
dc.contributor.authorWild SH
dc.contributor.authorBasart HV
dc.contributor.authorRathmann W
dc.contributor.authorGrallert H
dc.contributor.authorDIAGRAM Consortium
dc.contributor.authorMaerz W
dc.contributor.authorKleber ME
dc.contributor.authorBoehm BO
dc.contributor.authorPeters A
dc.contributor.authorPramstaller PP
dc.contributor.authorProvince MA
dc.contributor.authorBorecki IB
dc.contributor.authorHastie ND
dc.contributor.authorRudan I
dc.contributor.authorCampbell H
dc.contributor.authorWatkins H
dc.contributor.authorFarrall M
dc.contributor.authorStumvoll M
dc.contributor.authorFerrucci L
dc.contributor.authorWaterworth DM
dc.contributor.authorBergman RN
dc.contributor.authorCollins FS
dc.contributor.authorTuomilehto J
dc.contributor.authorWatanabe RM
dc.contributor.authorde Geus EJ
dc.contributor.authorPenninx BW
dc.contributor.authorHofman A
dc.contributor.authorOostra BA
dc.contributor.authorPsaty BM
dc.contributor.authorVollenweider P
dc.contributor.authorWilson JF
dc.contributor.authorWright AF
dc.contributor.authorHovingh GK
dc.contributor.authorMetspalu A
dc.contributor.authorUusitupa M
dc.contributor.authorMagnusson PK
dc.contributor.authorKyvik KO
dc.contributor.authorKaprio J
dc.contributor.authorPrice JF
dc.contributor.authorDedoussis GV
dc.contributor.authorDeloukas P
dc.contributor.authorMeneton P
dc.contributor.authorLind L
dc.contributor.authorBoehnke M
dc.contributor.authorShuldiner AR
dc.contributor.authorvan Duijn CM
dc.contributor.authorMorris AD
dc.contributor.authorToenjes A
dc.contributor.authorPeyser PA
dc.contributor.authorBeilby JP
dc.contributor.authorKörner A
dc.contributor.authorKuusisto J
dc.contributor.authorLaakso M
dc.contributor.authorBornstein SR
dc.contributor.authorSchwarz PE
dc.contributor.authorLakka TA
dc.contributor.authorRauramaa R
dc.contributor.authorAdair LS
dc.contributor.authorSmith GD
dc.contributor.authorSpector TD
dc.contributor.authorIllig T
dc.contributor.authorde Faire U
dc.contributor.authorHamsten A
dc.contributor.authorGudnason V
dc.contributor.authorKivimaki M
dc.contributor.authorHingorani A
dc.contributor.authorKeinanen-Kiukaanniemi SM
dc.contributor.authorSaaristo TE
dc.contributor.authorBoomsma DI
dc.contributor.authorStefansson K
dc.contributor.authorvan der Harst P
dc.contributor.authorDupuis J
dc.contributor.authorPedersen NL
dc.contributor.authorSattar N
dc.contributor.authorHarris TB
dc.contributor.authorCucca F
dc.contributor.authorRipatti S
dc.contributor.authorSalomaa V
dc.contributor.authorMohlke KL
dc.contributor.authorBalkau B
dc.contributor.authorFroguel P
dc.contributor.authorPouta A
dc.contributor.authorJarvelin MR
dc.contributor.authorWareham NJ
dc.contributor.authorBouatia-Naji N
dc.contributor.authorMcCarthy MI
dc.contributor.authorFranks PW
dc.contributor.authorMeigs JB
dc.contributor.authorTeslovich TM
dc.contributor.authorFlorez JC
dc.contributor.authorLangenberg C
dc.contributor.authorIngelsson E
dc.contributor.authorProkopenko I
dc.contributor.authorBarroso I
dc.date.accessioned2018-10-30T09:59:50Z
dc.date.available2018-10-30T09:59:50Z
dc.date.issued2012
dc.identifier.issn1061-4036
dc.identifier.urihttp://dx.doi.org/10.1038/ng.2385
dc.identifier.urihttp://hdl.handle.net/10863/6745
dc.description.abstractThrough genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control.en_US
dc.language.isoenen_US
dc.rights
dc.titleLarge-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathwaysen_US
dc.typeArticleen_US
dc.date.updated2018-10-30T08:42:01Z
dc.language.isiEN-GB
dc.journal.titleNature genetics
dc.description.fulltextnoneen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record