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dc.contributor.authorPattaro C
dc.contributor.authorKöttgen A
dc.contributor.authorTeumer A
dc.contributor.authorGarnaas M
dc.contributor.authorBöger CA
dc.contributor.authorFuchsberger C
dc.contributor.authorOlden M
dc.contributor.authorChen MH
dc.contributor.authorTin A
dc.contributor.authorTaliun D
dc.contributor.authorLi M
dc.contributor.authorGao X
dc.contributor.authorGorski M
dc.contributor.authorYang Q
dc.contributor.authorHundertmark C
dc.contributor.authorFoster MC
dc.contributor.authorO'Seaghdha CM
dc.contributor.authorGlazer N
dc.contributor.authorIsaacs A
dc.contributor.authorLiu CT
dc.contributor.authorSmith AV
dc.contributor.authorO'Connell JR
dc.contributor.authorStruchalin M
dc.contributor.authorTanaka T
dc.contributor.authorLi G
dc.contributor.authorJohnson AD
dc.contributor.authorGierman HJ
dc.contributor.authorFeitosa M
dc.contributor.authorHwang SJ
dc.contributor.authorAtkinson EJ
dc.contributor.authorLohman K
dc.contributor.authorCornelis MC
dc.contributor.authorJohansson Å
dc.contributor.authorTönjes A
dc.contributor.authorDehghan A
dc.contributor.authorChouraki V
dc.contributor.authorHolliday EG
dc.contributor.authorSorice R
dc.contributor.authorKutalik Z
dc.contributor.authorLehtimäki T
dc.contributor.authorEsko T
dc.contributor.authorDeshmukh H
dc.contributor.authorUlivi S
dc.contributor.authorChu AY
dc.contributor.authorMurgia F
dc.contributor.authorTrompet S
dc.contributor.authorImboden M
dc.contributor.authorKollerits B
dc.contributor.authorPistis G
dc.contributor.authorCARDIoGRAM Consortium
dc.contributor.authorICBP Consortium
dc.contributor.authorCARe Consortium
dc.contributor.authorWellcome Trust Case Control Consortium 2
dc.contributor.authorHarris TB
dc.contributor.authorLauner LJ
dc.contributor.authorAspelund T
dc.contributor.authorEiriksdottir G
dc.contributor.authorMitchell BD
dc.contributor.authorBoerwinkle E
dc.contributor.authorSchmidt H
dc.contributor.authorCavalieri M
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dc.contributor.authorHu FB
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dc.contributor.authorTurner ST
dc.contributor.authorDing J
dc.contributor.authorAndrews JS
dc.contributor.authorFreedman BI
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dc.contributor.authorIllig T
dc.contributor.authorDöring A
dc.contributor.authorWichmann HE
dc.contributor.authorKolcic I
dc.contributor.authorZemunik T
dc.contributor.authorBoban M
dc.contributor.authorMinelli C
dc.contributor.authorWheeler HE
dc.contributor.authorIgl W
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dc.contributor.authorWild SH
dc.contributor.authorWright AF
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dc.contributor.authorEllinghaus D
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dc.contributor.authorMägi R
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dc.contributor.authorUitterlinden AG
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dc.contributor.authorAulchenko YS
dc.contributor.authorPolasek O
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dc.contributor.authorVitart V
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dc.contributor.authorViikari J
dc.contributor.authorNikopensius T
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dc.contributor.authorDoney A
dc.contributor.authorRobino A
dc.contributor.authorGiulianini F
dc.contributor.authorKrämer BK
dc.contributor.authorPortas L
dc.contributor.authorFord I
dc.contributor.authorBuckley BM
dc.contributor.authorAdam M
dc.contributor.authorThun GA
dc.contributor.authorPaulweber B
dc.contributor.authorHaun M
dc.contributor.authorSala C
dc.contributor.authorMetzger M
dc.contributor.authorMitchell P
dc.contributor.authorCiullo M
dc.contributor.authorKim SK
dc.contributor.authorVollenweider P
dc.contributor.authorRaitakari O
dc.contributor.authorMetspalu A
dc.contributor.authorPalmer C
dc.contributor.authorGasparini P
dc.contributor.authorPirastu M
dc.contributor.authorJukema JW
dc.contributor.authorProbst-Hensch NM
dc.contributor.authorKronenberg F
dc.contributor.authorToniolo D
dc.contributor.authorGudnason V
dc.contributor.authorShuldiner AR
dc.contributor.authorCoresh J
dc.contributor.authorSchmidt R
dc.contributor.authorFerrucci L
dc.contributor.authorSiscovick DS
dc.contributor.authorvan Duijn CM
dc.contributor.authorBorecki I
dc.contributor.authorKardia SL
dc.contributor.authorLiu Y
dc.contributor.authorCurhan GC
dc.contributor.authorRudan I
dc.contributor.authorGyllensten U
dc.contributor.authorWilson JF
dc.contributor.authorFranke A
dc.contributor.authorPramstaller PP
dc.contributor.authorRettig R
dc.contributor.authorProkopenko I
dc.contributor.authorWitteman JC
dc.contributor.authorHayward C
dc.contributor.authorRidker P
dc.contributor.authorParsa A
dc.contributor.authorBochud M
dc.contributor.authorHeid IM
dc.contributor.authorGoessling W
dc.contributor.authorChasman DI
dc.contributor.authorKao WH
dc.contributor.authorFox CS
dc.date.accessioned2018-10-30T09:39:44Z
dc.date.available2018-10-30T09:39:44Z
dc.date.issued2012
dc.identifier.issn1553-7390
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pgen.1002584
dc.identifier.urihttp://hdl.handle.net/10863/6725
dc.description.abstractChronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD.en_US
dc.language.isoenen_US
dc.rights
dc.titleGenome-wide association and functional follow-up reveals new loci for kidney functionen_US
dc.typeArticleen_US
dc.date.updated2018-10-30T08:41:27Z
dc.language.isiEN-GB
dc.journal.titlePLoS genetics
dc.description.fulltextopenen_US


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