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dc.contributor.authorPankratz N
dc.contributor.authorBeecham GW
dc.contributor.authorDeStefano AL
dc.contributor.authorDawson TM
dc.contributor.authorDoheny KF
dc.contributor.authorFactor SA
dc.contributor.authorHamza TH
dc.contributor.authorHung AY
dc.contributor.authorHyman BT
dc.contributor.authorIvinson AJ
dc.contributor.authorKrainc D
dc.contributor.authorLatourelle JC
dc.contributor.authorClark LN
dc.contributor.authorMarder K
dc.contributor.authorMartin ER
dc.contributor.authorMayeux R
dc.contributor.authorRoss OA
dc.contributor.authorScherzer CR
dc.contributor.authorSimon DK
dc.contributor.authorTanner C
dc.contributor.authorVance JM
dc.contributor.authorWszolek ZK
dc.contributor.authorZabetian CP
dc.contributor.authorMyers RH
dc.contributor.authorPayami H
dc.contributor.authorScott WK
dc.contributor.authorForoud T
dc.contributor.authorPD GWAS Consortium
dc.description.abstractOBJECTIVE: Genome-wide association (GWAS) methods have identified genes contributing to Parkinson's disease (PD); we sought to identify additional genes associated with PD susceptibility. METHODS: A 2-stage design was used. First, individual level genotypic data from 5 recent PD GWAS (Discovery Sample: 4,238 PD cases and 4,239 controls) were combined. Following imputation, a logistic regression model was employed in each dataset to test for association with PD susceptibility and results from each dataset were meta-analyzed. Second, 768 single-nucleotide polymorphisms (SNPs) were genotyped in an independent Replication Sample (3,738 cases and 2,111 controls). RESULTS: Genome-wide significance was reached for SNPs in SNCA (rs356165; G: odds ratio [OR]=1.37; p=9.3×10(-21)), MAPT (rs242559; C: OR=0.78; p=1.5×10(-10)), GAK/DGKQ (rs11248051; T: OR=1.35; p=8.2×10(-9)/rs11248060; T: OR=1.35; p=2.0×10(-9)), and the human leukocyte antigen (HLA) region (rs3129882; A: OR=0.83; p=1.2×10(-8)), which were previously reported. The Replication Sample confirmed the associations with SNCA, MAPT, and the HLA region and also with GBA (E326K; OR=1.71; p=5×10(-8) Combined Sample) (N370; OR=3.08; p=7×10(-5) Replication sample). A novel PD susceptibility locus, RIT2, on chromosome 18 (rs12456492; p=5×10(-5) Discovery Sample; p=1.52×10(-7) Replication sample; p=2×10(-10) Combined Sample) was replicated. Conditional analyses within each of the replicated regions identified distinct SNP associations within GBA and SNCA, suggesting that there may be multiple risk alleles within these genes. INTERPRETATION: We identified a novel PD susceptibility locus, RIT2, replicated several previously identified loci, and identified more than 1 risk allele within SNCA and GBA.en_US
dc.titleMeta-analysis of Parkinson's disease: identification of a novel locus, RIT2en_US
dc.journal.titleAnnals of Neurology

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