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dc.contributor.authorRied JS
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dc.contributor.authorRudan I
dc.contributor.authorSalomaa V
dc.contributor.authorSchwarz PE
dc.contributor.authorShudiner AR
dc.contributor.authorSmit JH
dc.contributor.authorSørensen TI
dc.contributor.authorSpector TD
dc.contributor.authorStefansson K
dc.contributor.authorStumvoll M
dc.contributor.authorTremblay A
dc.contributor.authorTuomilehto J
dc.contributor.authorUitterlinden AG
dc.contributor.authorUusitupa M
dc.contributor.authorVölker U
dc.contributor.authorVollenweider P
dc.contributor.authorWareham NJ
dc.contributor.authorWatkins H
dc.contributor.authorWilson JF
dc.contributor.authorZeggini E
dc.contributor.authorAbecasis GR
dc.contributor.authorBoehnke M
dc.contributor.authorBorecki IB
dc.contributor.authorDeloukas P
dc.contributor.authorvan Duijn CM
dc.contributor.authorFox C
dc.contributor.authorGroop LC
dc.contributor.authorHeid IM
dc.contributor.authorHunter DJ
dc.contributor.authorKaplan RC
dc.contributor.authorMcCarthy MI
dc.contributor.authorNorth KE
dc.contributor.authorO'Connell JR
dc.contributor.authorSchlessinger D
dc.contributor.authorThorsteinsdottir U
dc.contributor.authorStrachan DP
dc.contributor.authorFrayling T
dc.contributor.authorHirschhorn JN
dc.contributor.authorMüller-Nurasyid M
dc.contributor.authorLoos RJ
dc.date.accessioned2018-10-08T14:28:09Z
dc.date.available2018-10-08T14:28:09Z
dc.date.issued2016
dc.identifier.issn2041-1723
dc.identifier.urihttp://dx.doi.org/10.1038/ncomms13357
dc.identifier.urihttp://hdl.handle.net/10863/6440
dc.description.abstractLarge consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.en_US
dc.language.isoenen_US
dc.rights
dc.titleA principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shapeen_US
dc.typeArticleen_US
dc.date.updated2018-10-08T14:25:59Z
dc.language.isiEN-GB
dc.journal.titleNature Communications
dc.description.fulltextopenen_US


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