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dc.contributor.authorHedrich K
dc.contributor.authorWinkler S
dc.contributor.authorHagenah J
dc.contributor.authorKabakci K
dc.contributor.authorKasten M
dc.contributor.authorSchwinger E
dc.contributor.authorVolkmann J
dc.contributor.authorPramstaller PP
dc.contributor.authorKostic V
dc.contributor.authorVieregge P
dc.contributor.authorKlein C
dc.date.accessioned2018-10-08T13:08:57Z
dc.date.available2018-10-08T13:08:57Z
dc.date.issued2006
dc.identifier.issn0885-3185
dc.identifier.urihttp://dx.doi.org/10.1002/mds.20990
dc.identifier.urihttp://hdl.handle.net/10863/6431
dc.description.abstractMutations in LRRK2 (leucine-rich repeat kinase 2) have been associated with autosomal dominant Parkinson's disease (PD) and cluster in several 3' exons of the gene. The majority of mutations have been detected in late-onset cases (age at onset >50 years). We screened 5 of the 51 exons of LRRK2 that previously have been reported to harbor mutations in 98 early-onset and 42 late-onset PD patients. We identified two mutations (c.4321C>T, c.6055G>A) in three early-onset patients. Screening of an additional 220 early-onset PD patients for these mutations revealed another mutation carrier. In conclusion, LRRK2 mutations need to be considered also in early-onset PD.en_US
dc.language.isoenen_US
dc.rights
dc.titleRecurrent LRRK2 (Park8) mutations in early-onset Parkinson's diseaseen_US
dc.typeArticleen_US
dc.date.updated2018-10-08T11:54:21Z
dc.language.isiEN-GB
dc.journal.titleMovement Disorders
dc.description.fulltextnoneen_US


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