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dc.contributor.authorBäumer T
dc.contributor.authorPramstaller PP
dc.contributor.authorSiebner HR
dc.contributor.authorSchippling S
dc.contributor.authorHagenah J
dc.contributor.authorPeller M
dc.contributor.authorGerloff C
dc.contributor.authorKlein C
dc.contributor.authorMünchau A
dc.date.accessioned2018-10-08T12:50:51Z
dc.date.available2018-10-08T12:50:51Z
dc.date.issued2007
dc.identifier.issn0028-3878
dc.identifier.urihttp://dx.doi.org/10.1212/01.wnl.0000278109.76607.0a
dc.identifier.urihttp://hdl.handle.net/10863/6410
dc.description.abstractBACKGROUND: In patients with Parkinson disease (PD), transcranial magnetic stimulation (TMS) studies have consistently demonstrated a reduced inhibitory tone in the sensorimotor cortex. It remains unclear whether this is related to motor symptoms or represents adaptive compensatory changes to degeneration of dopaminergic neurons. Here we used short-interval afferent inhibition after digital stimulation (dSAI) and intracortical paired-pulse inhibition and facilitation to probe intracortical sensorimotor excitability in clinically asymptomatic carriers of a single mutant Parkin allele who have a latent nigrostriatal dopaminergic dysfunction. METHODS: Nine heterozygous mutation carriers and nine healthy controls were investigated. For dSAI testing, electrical pulses were applied to the right index finger followed by TMS pulses over the left motor cortex at interstimulus intervals (ISI) of 25, 30, and 40 msec. Intracortical paired-pulse excitability was tested at ISIs of 2 to 15 msec. RESULTS: dSAI was reduced at an ISI of 25 msec in carriers of a single mutant Parkin allele, whereas paired-pulse TMS was normal. CONCLUSION: The relative decrease in sensorimotor inhibition may be a direct consequence of the Parkin mutation or represent adaptive changes at the cortical level in response to a subcortical dysfunction, but is not caused by motor symptoms.en_US
dc.language.isoenen_US
dc.rights
dc.titleSensorimotor integration is abnormal in asymptomatic Parkin mutation carriers: a TMS studyen_US
dc.typeArticleen_US
dc.date.updated2018-10-08T11:53:44Z
dc.language.isiEN-GB
dc.journal.titleNeurology
dc.description.fulltextnoneen_US


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