Show simple item record

dc.contributor.authorGrazio D
dc.contributor.authorPichler I
dc.contributor.authorFuchsberger C
dc.contributor.authorZolezzi F
dc.contributor.authorGuarnieri P
dc.contributor.authorHeidegger H
dc.contributor.authorScherer A
dc.contributor.authorEngl B
dc.contributor.authorMessini S
dc.contributor.authorEgarter-Vigl E
dc.contributor.authorPramstaller PP
dc.date.accessioned2018-10-08T09:32:32Z
dc.date.available2018-10-08T09:32:32Z
dc.date.issued2008
dc.identifier.issn0392-2936
dc.identifier.urihttp://hdl.handle.net/10863/6383
dc.description.abstractGene expression products represent candidate biomarkers with the potential for early screening and therapy of patients with ovarian serous carcinoma. The present study, using patients that originate from the population isolate of South Tyrol, Italy, substantiates the feasibility of differential gene expression analysis in a genetically isolated population for the identification of potential markers of ovarian cancer. Gene expression profiles of fresh-frozen ovarian serous papillary carcinoma samples were analyzed and compared to normal ovarian control tissues using oligonucleotide microarrays complementary to 14,500 human genes. Supervised analysis of gene expression profiling data identified 225 genes that are down-regulated and 635 that are up-regulated in malignant compared to normal ovarian tissues. Class-prediction analysis identified 40 differentially expressed genes for further investigation as potential classifiers for ovarian cancer, including 20 novel candidates. Our findings provide a glimpse into the potential of population isolate genomics in oncological research.en_US
dc.language.isoenen_US
dc.rights
dc.titleDifferential gene expression analysis of ovarian cancer in a population isolateen_US
dc.typeArticleen_US
dc.date.updated2018-10-08T08:54:13Z
dc.language.isiEN-GB
dc.journal.titleEuropean Journal of Gynaecological Oncology
dc.description.fulltextnoneen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record