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dc.contributor.authorManning AK
dc.contributor.authorHivert MF
dc.contributor.authorScott RA
dc.contributor.authorGrimsby JL
dc.contributor.authorBouatia-Naji N
dc.contributor.authorChen H
dc.contributor.authorRybin D
dc.contributor.authorLiu CT
dc.contributor.authorBielak LF
dc.contributor.authorProkopenko I
dc.contributor.authorAmin N
dc.contributor.authorBarnes D
dc.contributor.authorCadby G
dc.contributor.authorHottenga JJ
dc.contributor.authorIngelsson E
dc.contributor.authorJackson AU
dc.contributor.authorJohnson T
dc.contributor.authorKanoni S
dc.contributor.authorLadenvall C
dc.contributor.authorLagou V
dc.contributor.authorLahti J
dc.contributor.authorLecoeur C
dc.contributor.authorLiu Y
dc.contributor.authorMartinez-Larrad MT
dc.contributor.authorMontasser ME
dc.contributor.authorNavarro P
dc.contributor.authorPerry JR
dc.contributor.authorRasmussen-Torvik LJ
dc.contributor.authorSalo P
dc.contributor.authorSattar N
dc.contributor.authorShungin D
dc.contributor.authorStrawbridge RJ
dc.contributor.authorTanaka T
dc.contributor.authorvan Duijn CM
dc.contributor.authorAn P
dc.contributor.authorde Andrade M
dc.contributor.authorAndrews JS
dc.contributor.authorAspelund T
dc.contributor.authorAtalay M
dc.contributor.authorAulchenko Y
dc.contributor.authorBalkau B
dc.contributor.authorBandinelli S
dc.contributor.authorBeckmann JS
dc.contributor.authorBeilby JP
dc.contributor.authorBellis C
dc.contributor.authorBergman RN
dc.contributor.authorBlangero J
dc.contributor.authorBoban M
dc.contributor.authorBoehnke M
dc.contributor.authorBoerwinkle E
dc.contributor.authorBonnycastle LL
dc.contributor.authorBoomsma DI
dc.contributor.authorBorecki IB
dc.contributor.authorBöttcher Y
dc.contributor.authorBouchard C
dc.contributor.authorBrunner E
dc.contributor.authorBudimir D
dc.contributor.authorCampbell H
dc.contributor.authorCarlson O
dc.contributor.authorChines PS
dc.contributor.authorClarke R
dc.contributor.authorCollins FS
dc.contributor.authorCorbatón-Anchuelo A
dc.contributor.authorCouper D
dc.contributor.authorde Faire U
dc.contributor.authorDedoussis GV
dc.contributor.authorDeloukas P
dc.contributor.authorDimitriou M
dc.contributor.authorEgan JM
dc.contributor.authorEiriksdottir G
dc.contributor.authorErdos MR
dc.contributor.authorEriksson JG
dc.contributor.authorEury E
dc.contributor.authorFerrucci L
dc.contributor.authorFord I
dc.contributor.authorForouhi NG
dc.contributor.authorFox CS
dc.contributor.authorFranzosi MG
dc.contributor.authorFranks PW
dc.contributor.authorFrayling TM
dc.contributor.authorFroguel P
dc.contributor.authorGalan P
dc.contributor.authorde Geus E
dc.contributor.authorGigante B
dc.contributor.authorGlazer NL
dc.contributor.authorGoel A
dc.contributor.authorGroop L
dc.contributor.authorGudnason V
dc.contributor.authorHallmans G
dc.contributor.authorHamsten A
dc.contributor.authorHansson O
dc.contributor.authorHarris TB
dc.contributor.authorHayward C
dc.contributor.authorHeath S
dc.contributor.authorHercberg S
dc.contributor.authorHicks AA
dc.contributor.authorHingorani A
dc.contributor.authorHofman A
dc.contributor.authorHui J
dc.contributor.authorHung J
dc.contributor.authorJarvelin MR
dc.contributor.authorJhun MA
dc.contributor.authorJohnson PC
dc.contributor.authorJukema JW
dc.contributor.authorJula A
dc.contributor.authorKao WH
dc.contributor.authorKaprio J
dc.contributor.authorKardia SL
dc.contributor.authorKeinanen-Kiukaanniemi S
dc.contributor.authorKivimaki M
dc.contributor.authorKolcic I
dc.contributor.authorKovacs P
dc.contributor.authorKumari M
dc.contributor.authorKuusisto J
dc.contributor.authorKyvik KO
dc.contributor.authorLaakso M
dc.contributor.authorLakka T
dc.contributor.authorLannfelt L
dc.contributor.authorLathrop GM
dc.contributor.authorLauner LJ
dc.contributor.authorLeander K
dc.contributor.authorLi G
dc.contributor.authorLind L
dc.contributor.authorLindstrom J
dc.contributor.authorLobbens S
dc.contributor.authorLoos RJ
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dc.contributor.authorPalmer LJ
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dc.contributor.authorPankow JS
dc.contributor.authorPeden JF
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dc.contributor.authorPehlic M
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dc.contributor.authorPenninx B
dc.contributor.authorPericic M
dc.contributor.authorPerola M
dc.contributor.authorPerusse L
dc.contributor.authorPeyser PA
dc.contributor.authorPolasek O
dc.contributor.authorPramstaller PP
dc.contributor.authorProvince MA
dc.contributor.authorRäikkönen K
dc.contributor.authorRauramaa R
dc.contributor.authorRehnberg E
dc.contributor.authorRice K
dc.contributor.authorRotter JI
dc.contributor.authorRudan I
dc.contributor.authorRuokonen A
dc.contributor.authorSaaristo T
dc.contributor.authorSabater-Lleal M
dc.contributor.authorSalomaa V
dc.contributor.authorSavage DB
dc.contributor.authorSaxena R
dc.contributor.authorSchwarz P
dc.contributor.authorSeedorf U
dc.contributor.authorSennblad B
dc.contributor.authorSerrano-Ríos M
dc.contributor.authorShuldiner AR
dc.contributor.authorSijbrands EJ
dc.contributor.authorSiscovick DS
dc.contributor.authorSmit JH
dc.contributor.authorSmall KS
dc.contributor.authorSmith NL
dc.contributor.authorSmith AV
dc.contributor.authorStancáková A
dc.contributor.authorStirrups K
dc.contributor.authorStumvoll M
dc.contributor.authorSun YV
dc.contributor.authorSwift AJ
dc.contributor.authorTönjes A
dc.contributor.authorTuomilehto J
dc.contributor.authorTrompet S
dc.contributor.authorUitterlinden AG
dc.contributor.authorUusitupa M
dc.contributor.authorVikström M
dc.contributor.authorVitart V
dc.contributor.authorVohl MC
dc.contributor.authorVoight BF
dc.contributor.authorVollenweider P
dc.contributor.authorWaeber G
dc.contributor.authorWaterworth DM
dc.contributor.authorWatkins H
dc.contributor.authorWheeler E
dc.contributor.authorWiden E
dc.contributor.authorWild SH
dc.contributor.authorWillems SM
dc.contributor.authorWillemsen G
dc.contributor.authorWilson JF
dc.contributor.authorWitteman JC
dc.contributor.authorWright AF
dc.contributor.authorYaghootkar H
dc.contributor.authorZelenika D
dc.contributor.authorZemunik T
dc.contributor.authorZgaga L
dc.contributor.authorDIAGRAM Consortium
dc.contributor.authorMuTHER Consortium
dc.contributor.authorWareham NJ
dc.contributor.authorMcCarthy MI
dc.contributor.authorBarroso I
dc.contributor.authorWatanabe RM
dc.contributor.authorFlorez JC
dc.contributor.authorDupuis J
dc.contributor.authorMeigs JB
dc.contributor.authorLangenberg C
dc.date.accessioned2018-10-01T14:56:57Z
dc.date.available2018-10-01T14:56:57Z
dc.date.issued2012
dc.identifier.issn1061-4036
dc.identifier.urihttp://dx.doi.org/10.1038/ng.2274
dc.identifier.urihttp://hdl.handle.net/10863/6288
dc.description.abstractRecent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P < 5 × 10(-8) in combined discovery and follow-up analyses of 52 studies comprising up to 96,496 non-diabetic individuals. Risk variants were associated with higher triglyceride and lower high-density lipoprotein (HDL) cholesterol levels, suggesting a role for these loci in insulin resistance pathways. The discovery of these loci will aid further characterization of the role of insulin resistance in T2D pathophysiology.en_US
dc.language.isoenen_US
dc.rights
dc.titleA genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistanceen_US
dc.typeArticleen_US
dc.date.updated2018-10-01T14:45:48Z
dc.language.isiEN-GB
dc.journal.titleNature genetics
dc.description.fulltextnoneen_US


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