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dc.contributor.authorGlobal Lipids Genetics Consortium
dc.contributor.authorWiller CJ
dc.contributor.authorSchmidt EM
dc.contributor.authorSengupta S
dc.contributor.authorPeloso GM
dc.contributor.authorGustafsson S
dc.contributor.authorKanoni S
dc.contributor.authorGanna A
dc.contributor.authorChen J
dc.contributor.authorBuchkovich ML
dc.contributor.authorMora S
dc.contributor.authorBeckmann JS
dc.contributor.authorBragg-Gresham JL
dc.contributor.authorChang HY
dc.contributor.authorDemirkan A
dc.contributor.authorDen Hertog HM
dc.contributor.authorDo R
dc.contributor.authorDonnelly LA
dc.contributor.authorEhret GB
dc.contributor.authorEsko T
dc.contributor.authorFeitosa MF
dc.contributor.authorFerreira T
dc.contributor.authorFischer K
dc.contributor.authorFontanillas P
dc.contributor.authorFraser RM
dc.contributor.authorFreitag DF
dc.contributor.authorGurdasani D
dc.contributor.authorHeikkilä K
dc.contributor.authorHyppönen E
dc.contributor.authorIsaacs A
dc.contributor.authorJackson AU
dc.contributor.authorJohansson A
dc.contributor.authorJohnson T
dc.contributor.authorKaakinen M
dc.contributor.authorKettunen J
dc.contributor.authorKleber ME
dc.contributor.authorLi X
dc.contributor.authorLuan J
dc.contributor.authorLyytikäinen LP
dc.contributor.authorMagnusson PK
dc.contributor.authorMangino M
dc.contributor.authorMihailov E
dc.contributor.authorMontasser ME
dc.contributor.authorMüller-Nurasyid M
dc.contributor.authorNolte IM
dc.contributor.authorO'Connell JR
dc.contributor.authorPalmer CD
dc.contributor.authorPerola M
dc.contributor.authorPetersen AK
dc.contributor.authorSanna S
dc.contributor.authorSaxena R
dc.contributor.authorService SK
dc.contributor.authorShah S
dc.contributor.authorShungin D
dc.contributor.authorSidore C
dc.contributor.authorSong C
dc.contributor.authorStrawbridge RJ
dc.contributor.authorSurakka I
dc.contributor.authorTanaka T
dc.contributor.authorTeslovich TM
dc.contributor.authorThorleifsson G
dc.contributor.authorVan den Herik EG
dc.contributor.authorVoight BF
dc.contributor.authorVolcik KA
dc.contributor.authorWaite LL
dc.contributor.authorWong A
dc.contributor.authorWu Y
dc.contributor.authorZhang W
dc.contributor.authorAbsher D
dc.contributor.authorAsiki G
dc.contributor.authorBarroso I
dc.contributor.authorBeen LF
dc.contributor.authorBolton JL
dc.contributor.authorBonnycastle LL
dc.contributor.authorBrambilla P
dc.contributor.authorBurnett MS
dc.contributor.authorCesana G
dc.contributor.authorDimitriou M
dc.contributor.authorDoney AS
dc.contributor.authorDöring A
dc.contributor.authorElliott P
dc.contributor.authorEpstein SE
dc.contributor.authorEyjolfsson GI
dc.contributor.authorGigante B
dc.contributor.authorGoodarzi MO
dc.contributor.authorGrallert H
dc.contributor.authorGravito ML
dc.contributor.authorGroves CJ
dc.contributor.authorHallmans G
dc.contributor.authorHartikainen AL
dc.contributor.authorHayward C
dc.contributor.authorHernandez D
dc.contributor.authorHicks AA
dc.contributor.authorHolm H
dc.contributor.authorHung YJ
dc.contributor.authorIllig T
dc.contributor.authorJones MR
dc.contributor.authorKaleebu P
dc.contributor.authorKastelein JJ
dc.contributor.authorKhaw KT
dc.contributor.authorKim E
dc.contributor.authorKlopp N
dc.contributor.authorKomulainen P
dc.contributor.authorKumari M
dc.contributor.authorLangenberg C
dc.contributor.authorLehtimäki T
dc.contributor.authorLin SY
dc.contributor.authorLindström J
dc.contributor.authorLoos RJ
dc.contributor.authorMach F
dc.contributor.authorMcArdle WL
dc.contributor.authorMeisinger C
dc.contributor.authorMitchell BD
dc.contributor.authorMüller G
dc.contributor.authorNagaraja R
dc.contributor.authorNarisu N
dc.contributor.authorNieminen TV
dc.contributor.authorNsubuga RN
dc.contributor.authorOlafsson I
dc.contributor.authorOng KK
dc.contributor.authorPalotie A
dc.contributor.authorPapamarkou T
dc.contributor.authorPomilla C
dc.contributor.authorPouta A
dc.contributor.authorRader DJ
dc.contributor.authorReilly MP
dc.contributor.authorRidker PM
dc.contributor.authorRivadeneira F
dc.contributor.authorRudan I
dc.contributor.authorRuokonen A
dc.contributor.authorSamani N
dc.contributor.authorScharnagl H
dc.contributor.authorSeeley J
dc.contributor.authorSilander K
dc.contributor.authorStancáková A
dc.contributor.authorStirrups K
dc.contributor.authorSwift AJ
dc.contributor.authorTiret L
dc.contributor.authorUitterlinden AG
dc.contributor.authorvan Pelt LJ
dc.contributor.authorVedantam S
dc.contributor.authorWainwright N
dc.contributor.authorWijmenga C
dc.contributor.authorWild SH
dc.contributor.authorWillemsen G
dc.contributor.authorWilsgaard T
dc.contributor.authorWilson JF
dc.contributor.authorYoung EH
dc.contributor.authorZhao JH
dc.contributor.authorAdair LS
dc.contributor.authorArveiler D
dc.contributor.authorAssimes TL
dc.contributor.authorBandinelli S
dc.contributor.authorBennett F
dc.contributor.authorBochud M
dc.contributor.authorBoehm BO
dc.contributor.authorBoomsma DI
dc.contributor.authorBorecki IB
dc.contributor.authorBornstein SR
dc.contributor.authorBovet P
dc.contributor.authorBurnier M
dc.contributor.authorCampbell H
dc.contributor.authorChakravarti A
dc.contributor.authorChambers JC
dc.contributor.authorChen YD
dc.contributor.authorCollins FS
dc.contributor.authorCooper RS
dc.contributor.authorDanesh J
dc.contributor.authorDedoussis G
dc.contributor.authorde Faire U
dc.contributor.authorFeranil AB
dc.contributor.authorFerrières J
dc.contributor.authorFerrucci L
dc.contributor.authorFreimer NB
dc.contributor.authorGieger C
dc.contributor.authorGroop LC
dc.contributor.authorGudnason V
dc.contributor.authorGyllensten U
dc.contributor.authorHamsten A
dc.contributor.authorHarris TB
dc.contributor.authorHingorani A
dc.contributor.authorHirschhorn JN
dc.contributor.authorHofman A
dc.contributor.authorHovingh GK
dc.contributor.authorHsiung CA
dc.contributor.authorHumphries SE
dc.contributor.authorHunt SC
dc.contributor.authorHveem K
dc.contributor.authorIribarren C
dc.contributor.authorJärvelin MR
dc.contributor.authorJula A
dc.contributor.authorKähönen M
dc.contributor.authorKaprio J
dc.contributor.authorKesäniemi A
dc.contributor.authorKivimaki M
dc.contributor.authorKooner JS
dc.contributor.authorKoudstaal PJ
dc.contributor.authorKrauss RM
dc.contributor.authorKuh D
dc.contributor.authorKuusisto J
dc.contributor.authorKyvik KO
dc.contributor.authorLaakso M
dc.contributor.authorLakka TA
dc.contributor.authorLind L
dc.contributor.authorLindgren CM
dc.contributor.authorMartin NG
dc.contributor.authorMärz W
dc.contributor.authorMcCarthy MI
dc.contributor.authorMcKenzie CA
dc.contributor.authorMeneton P
dc.contributor.authorMetspalu A
dc.contributor.authorMoilanen L
dc.contributor.authorMorris AD
dc.contributor.authorMunroe PB
dc.contributor.authorNjølstad I
dc.contributor.authorPedersen NL
dc.contributor.authorPower C
dc.contributor.authorPramstaller PP
dc.contributor.authorPrice JF
dc.contributor.authorPsaty BM
dc.contributor.authorQuertermous T
dc.contributor.authorRauramaa R
dc.contributor.authorSaleheen D
dc.contributor.authorSalomaa V
dc.contributor.authorSanghera DK
dc.contributor.authorSaramies J
dc.contributor.authorSchwarz PE
dc.contributor.authorSheu WH
dc.contributor.authorShuldiner AR
dc.contributor.authorSiegbahn A
dc.contributor.authorSpector TD
dc.contributor.authorStefansson K
dc.contributor.authorStrachan DP
dc.contributor.authorTayo BO
dc.contributor.authorTremoli E
dc.contributor.authorTuomilehto J
dc.contributor.authorUusitupa M
dc.contributor.authorvan Duijn CM
dc.contributor.authorVollenweider P
dc.contributor.authorWallentin L
dc.contributor.authorWareham NJ
dc.contributor.authorWhitfield JB
dc.contributor.authorWolffenbuttel BH
dc.contributor.authorOrdovas JM
dc.contributor.authorBoerwinkle E
dc.contributor.authorPalmer CN
dc.contributor.authorThorsteinsdottir U
dc.contributor.authorChasman DI
dc.contributor.authorRotter JI
dc.contributor.authorFranks PW
dc.contributor.authorRipatti S
dc.contributor.authorCupples LA
dc.contributor.authorSandhu MS
dc.contributor.authorRich SS
dc.contributor.authorBoehnke M
dc.contributor.authorDeloukas P
dc.contributor.authorKathiresan S
dc.contributor.authorMohlke KL
dc.contributor.authorIngelsson E
dc.contributor.authorAbecasis GR
dc.date.accessioned2018-10-01T14:26:39Z
dc.date.available2018-10-01T14:26:39Z
dc.date.issued2013
dc.identifier.issn1061-4036
dc.identifier.urihttp://dx.doi.org/10.1038/ng.2797
dc.identifier.urihttp://hdl.handle.net/10863/6275
dc.description.abstractLevels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.en_US
dc.language.isoenen_US
dc.rights
dc.titleDiscovery and refinement of loci associated with lipid levelsen_US
dc.typeArticleen_US
dc.date.updated2018-10-01T14:04:53Z
dc.language.isiEN-GB
dc.journal.titleNature genetics
dc.description.fulltextnoneen_US


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