Acceleration of the loss of the first-phase insulin response during the progression to type 1 diabetes in diabetes prevention trial-type 1 participants
Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups
MetadataShow full item record
We studied the change in the first-phase insulin response (FPIR) during the progression to type 1 diabetes (T1D). Seventy-four oral insulin trial progressors to T1D from the Diabetes Prevention Trial-Type 1 with at least one FPIR measurement after baseline and before diagnosis were studied. The FPIR was examined longitudinally in 26 progressors who had FPIR measurements during each of the 3 years before diagnosis. The association between the change from the baseline FPIR to the last FPIR and time to diagnosis was studied in the remainder (n = 48). The 74 progressors had lower baseline FPIR values than nonprogressors (n = 270), with adjustments made for age and BMI. In the longitudinal analysis of the 26 progressors, there was a greater decline in the FPIR from 1.5 to 0.5 years before diagnosis than from 2.5 to 1.5 years before diagnosis. This accelerated decline was also evident in a regression analysis of the 48 remaining progressors in whom the rate of decline became more marked with the approaching diagnosis. The patterns of decline were similar between the longitudinal and regression analyses. There is an acceleration of decline in the FPIR during the progression to T1D, which becomes especially marked between 1.5 and 0.5 years before diagnosis.
Showing items related by title, author, creator and subject.
Analysing the effect of stand density and site conditions on structure and growth of oak species using Nelder trials along an environmental gradient: experimental design, evaluation methods, and results Uhl, E; Biber, P; Ulbricht, M; Heym, M; Horváth, T; Lakatos, F; Gál, J; Steinacker, L; Tonon, G; Ventura, M; Pretzsch, H (2015)Most current approaches in forest science and practice require information about structure and growth of individual trees rather than - or in addition to - sum and mean values of growth and yield at forest stand level as ...
Emission of Volatile Compounds from Apple Plants Infested with Pandemis heparana Larvae, Antennal Response of Conspecific Adults, and Preliminary Field Trial Giacomuzzi V; Cappellin L; Khomenko I; Biasioli F; Schuetz S; Tasin M; Knight AL; Angeli S (2016)This study investigated the volatile emission from apple (Malus x domestica Borkh., cv. Golden Delicious) foliage that were either intact, mechanically-injured, or exposed to larval feeding by Pandemis heparana (Denis and ...