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dc.contributor.authorGorski M
dc.contributor.authorvan der Most PJ
dc.contributor.authorTeumer A
dc.contributor.authorChu AY
dc.contributor.authorLi M
dc.contributor.authorMijatovic V
dc.contributor.authorNolte IM
dc.contributor.authorCocca M
dc.contributor.authorTaliun D
dc.contributor.authorGomez F
dc.contributor.authorLi Y
dc.contributor.authorTayo B
dc.contributor.authorTin A
dc.contributor.authorFeitosa MF
dc.contributor.authorAspelund T
dc.contributor.authorAttia J
dc.contributor.authorBiffar R
dc.contributor.authorBochud M
dc.contributor.authorBoerwinkle E
dc.contributor.authorBorecki I
dc.contributor.authorBottinger EP
dc.contributor.authorChen MH
dc.contributor.authorChouraki V
dc.contributor.authorCiullo M
dc.contributor.authorCoresh J
dc.contributor.authorCornelis MC
dc.contributor.authorCurhan GC
dc.contributor.authorD'Adamo AP
dc.contributor.authorDehghan A
dc.contributor.authorDengler L
dc.contributor.authorDing J
dc.contributor.authorEiriksdottir G
dc.contributor.authorEndlich K
dc.contributor.authorEnroth S
dc.contributor.authorEsko T
dc.contributor.authorFranco OH
dc.contributor.authorGasparini P
dc.contributor.authorGieger C
dc.contributor.authorGirotto G
dc.contributor.authorGottesman O
dc.contributor.authorGudnason V
dc.contributor.authorGyllensten U
dc.contributor.authorHancock SJ
dc.contributor.authorHarris TB
dc.contributor.authorHelmer C
dc.contributor.authorHöllerer S
dc.contributor.authorHofer E
dc.contributor.authorHofman A
dc.contributor.authorHolliday EG
dc.contributor.authorHomuth G
dc.contributor.authorHu FB
dc.contributor.authorHuth C
dc.contributor.authorHutri-Kähönen N
dc.contributor.authorHwang SJ
dc.contributor.authorImboden M
dc.contributor.authorJohansson Å
dc.contributor.authorKähönen M
dc.contributor.authorKönig W
dc.contributor.authorKramer H
dc.contributor.authorKrämer BK
dc.contributor.authorKumar A
dc.contributor.authorKutalik Z
dc.contributor.authorLambert JC
dc.contributor.authorLauner LJ
dc.contributor.authorLehtimäki T
dc.contributor.authorde Borst M
dc.contributor.authorNavis G
dc.contributor.authorSwertz M
dc.contributor.authorLiu Y
dc.contributor.authorLohman K
dc.contributor.authorLoos RJF
dc.contributor.authorLu Y
dc.contributor.authorLyytikäinen LP
dc.contributor.authorMcEvoy MA
dc.contributor.authorMeisinger C
dc.contributor.authorMeitinger T
dc.contributor.authorMetspalu A
dc.contributor.authorMetzger M
dc.contributor.authorMihailov E
dc.contributor.authorMitchell P
dc.contributor.authorNauck M
dc.contributor.authorOldehinkel AJ
dc.contributor.authorOlden M
dc.contributor.authorWjh Penninx B
dc.contributor.authorPistis G
dc.contributor.authorPramstaller PP
dc.contributor.authorProbst-Hensch N
dc.contributor.authorRaitakari OT
dc.contributor.authorRettig R
dc.contributor.authorRidker PM
dc.contributor.authorRivadeneira F
dc.contributor.authorRobino A
dc.contributor.authorRosas SE
dc.contributor.authorRuderfer D
dc.contributor.authorRuggiero D
dc.contributor.authorSaba Y
dc.contributor.authorSala C
dc.contributor.authorSchmidt H
dc.contributor.authorSchmidt R
dc.contributor.authorScott RJ
dc.contributor.authorSedaghat S
dc.contributor.authorSmith AV
dc.contributor.authorSorice R
dc.contributor.authorStengel B
dc.contributor.authorStracke S
dc.contributor.authorStrauch K
dc.contributor.authorToniolo D
dc.contributor.authorUitterlinden AG
dc.contributor.authorUlivi S
dc.contributor.authorViikari JS
dc.contributor.authorVölker U
dc.contributor.authorVollenweider P
dc.contributor.authorVölzke H
dc.contributor.authorVuckovic D
dc.contributor.authorWaldenberger M
dc.contributor.authorJin Wang J
dc.contributor.authorYang Q
dc.contributor.authorChasman DI
dc.contributor.authorTromp G
dc.contributor.authorSnieder H
dc.contributor.authorHeid IM
dc.contributor.authorFox CS
dc.contributor.authorKöttgen A
dc.contributor.authorPattaro C
dc.contributor.authorBöger CA
dc.contributor.authorFuchsberger C
dc.date.accessioned2018-10-01T11:29:30Z
dc.date.available2018-10-01T11:29:30Z
dc.date.issued2017
dc.identifier.issn2045-2322
dc.identifier.urihttp://dx.doi.org/10.1038/srep45040
dc.identifier.urihttp://hdl.handle.net/10863/6243
dc.description.abstractHapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The 1000 Genomes project, promise to identify novel loci that have been missed by previous efforts. To investigate the value of such a more complete variant catalog, we conducted a GWAS meta-analysis of kidney function based on the estimated glomerular filtration rate (eGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 × 10-8 previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2, and EPB41L3) are tagged by common SNPs unique to the 1000 Genomes reference panel. Using pathway analysis, we identified 39 significant (FDR < 0.05) genes and 127 significantly (FDR < 0.05) enriched gene sets, which were missed by our previous analyses. Among those, the 10 identified novel genes are part of pathways of kidney development, carbohydrate metabolism, cardiac septum development and glucose metabolism. These results highlight the utility of re-imputing from denser reference panels, until whole-genome sequencing becomes feasible in large samples.en_US
dc.rights
dc.title1000 Genomes-based meta-analysis identifies 10 novel loci for kidney functionen_US
dc.typeArticleen_US
dc.date.updated2018-10-01T11:26:52Z
dc.language.isiEN-GB
dc.journal.titleScientific Reports
dc.description.fulltextopenen_US


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