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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
(2012)Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin ... -
Discovery and fine mapping of serum protein loci through transethnic meta-analysis
(2012)Many disorders are associated with altered serum protein concentrations, including malnutrition, cancer, and cardiovascular, kidney, and inflammatory diseases. Although these protein concentrations are highly heritable, ... -
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
(2012)In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated ... -
Discovery and fine mapping of serum protein loci through transethnic meta-analysis
(2012)Many disorders are associated with altered serum protein concentrations, including malnutrition, cancer, and cardiovascular, kidney, and inflammatory diseases. Although these protein concentrations are highly heritable, ... -
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations
(2012)Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their ... -
Genome-wide association and functional follow-up reveals new loci for kidney function
(2012)Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD ... -
FTO genotype is associated with phenotypic variability of body mass index
(2012)There is evidence across several species for genetic control of phenotypic variation of complex traits, such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important ... -
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
(2012)Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci ... -
Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts
(2012)Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric ... -
Sequencing of high-complexity DNA pools for identification of nucleotide and structural variants in regions associated with complex traits
(2012)We have used targeted genomic sequencing of high-complexity DNA pools based on long-range PCR and deep DNA sequencing by the SOLiD technology. The method was used for sequencing of 286 kb from four chromosomal regions with ...