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    • Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease 

      Zanoni P; Khetarpal SA; Larach DB; Hancock-Cerutti WF; Millar JS; Cuchel M; DerOhannessian S; Kontush A; Surendran P; Saleheen D; Trompet S; Jukema JW; De Craen A; Deloukas P; Sattar N; Ford I; Packard C; Majumder Aa; Alam DS; Di Angelantonio E; Abecasis G; Chowdhury R; Erdmann J; Nordestgaard BG; Nielsen SF; Tybjærg-Hansen A; Schmidt RF; Kuulasmaa K; Liu DJ; Perola M; Blankenberg S; Salomaa V; Männistö S; Amouyel P; Arveiler D; Ferrières J; Müller-Nurasyid M; Ferrario M; Kee F; Willer CJ; Samani N; Schunkert H; Butterworth AS; Howson JM; Peloso GM; Stitziel NO; Danesh J; Kathiresan S; Rader DJ; CHD Exome+ Consortium; CARDIoGRAM Exome Consortium; Global Lipids Genetics Consortium (2016)
      Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice ...