Now showing items 1-15 of 15

    • 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function 

      Gorski M; van der Most PJ; Teumer A; Chu AY; Li M; Mijatovic V; Nolte IM; Cocca M; Taliun D; Gomez F; Li Y; Tayo B; Tin A; Feitosa MF; Aspelund T; Attia J; Biffar R; Bochud M; Boerwinkle E; Borecki I; Bottinger EP; Chen MH; Chouraki V; Ciullo M; Coresh J; Cornelis MC; Curhan GC; D'Adamo AP; Dehghan A; Dengler L; Ding J; Eiriksdottir G; Endlich K; Enroth S; Esko T; Franco OH; Gasparini P; Gieger C; Girotto G; Gottesman O; Gudnason V; Gyllensten U; Hancock SJ; Harris TB; Helmer C; Höllerer S; Hofer E; Hofman A; Holliday EG; Homuth G; Hu FB; Huth C; Hutri-Kähönen N; Hwang SJ; Imboden M; Johansson Å; Kähönen M; König W; Kramer H; Krämer BK; Kumar A; Kutalik Z; Lambert JC; Launer LJ; Lehtimäki T; de Borst M; Navis G; Swertz M; Liu Y; Lohman K; Loos RJF; Lu Y; Lyytikäinen LP; McEvoy MA; Meisinger C; Meitinger T; Metspalu A; Metzger M; Mihailov E; Mitchell P; Nauck M; Oldehinkel AJ; Olden M; Wjh Penninx B; Pistis G; Pramstaller PP; Probst-Hensch N; Raitakari OT; Rettig R; Ridker PM; Rivadeneira F; Robino A; Rosas SE; Ruderfer D; Ruggiero D; Saba Y; Sala C; Schmidt H; Schmidt R; Scott RJ; Sedaghat S; Smith AV; Sorice R; Stengel B; Stracke S; Strauch K; Toniolo D; Uitterlinden AG; Ulivi S; Viikari JS; Völker U; Vollenweider P; Völzke H; Vuckovic D; Waldenberger M; Jin Wang J; Yang Q; Chasman DI; Tromp G; Snieder H; Heid IM; Fox CS; Köttgen A; Pattaro C; Böger CA; Fuchsberger C (2017)
      HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, ...
    • A catalog of genetic loci associated with kidney function from analyses of a million individuals 

      Wuttke M; Li Y; Li M; Sieber KB; Feitosa MF; Gorski M; Tin A; Wang L; Chu AY; Hoppmann A; Kirsten H; Giri A; Chai JF; Sveinbjornsson G; Tayo BO; Nutile T; Fuchsberger C; Marten J; Cocca M; Ghasemi S; Xu Y; Horn K; Noce D; van der Most PJ; Sedaghat S; Yu Z; Akiyama M; Afaq S; Ahluwalia TS; Almgren P; Amin N; Ärnlöv J; Bakker SJL; Bansal N; Baptista D; Bergmann S; Biggs ML; Biino G; Boehnke M; Boerwinkle E; Boissel M; Bottinger EP; Boutin TS; Brenner H; Brumat M; Burkhardt R; Butterworth AS; Campana E; Campbell A; Campbell H; Canouil M; Carroll RJ; Catamo E; Chambers JC; Chee ML; Chen X; Cheng CY; Cheng Y; Christensen K; Cifkova R; Ciullo M; Concas MP; Cook JP; Coresh J; Corre T; Sala CF; Cusi D; Danesh J; Daw EW; de Borst MH; De Grandi A; de Mutsert R; de Vries APJ; Degenhardt F; Delgado G; Demirkan A; Di Angelantonio E; Dittrich K; Divers J; Dorajoo R; Eckardt KU; Ehret G; Elliott P; Endlich K; Evans MK; Felix JF; Foo VHX; Franco OH; Franke A; Freedman BI; Freitag-Wolf S; Friedlander Y; Froguel P; Gansevoort RT; Gao H; Gasparini P; Gaziano JM; Giedraitis V; Gieger C; Girotto G; Giulianini F; Gögele M; Gordon SD; Gudbjartsson DF; Gudnason V; Haller T; Hamet P; Harris TB; Hartman CA; Hayward C; Hellwege JN; Heng CK; Hicks AA; Hofer E; Huang W; Hutri-Kähönen N; Hwang SJ; Ikram MA; Indridason OS; Ingelsson E; Ising M; Jaddoe VWV; Jakobsdottir J; Jonas JB; Joshi PK; Josyula NS; Jung B; Kähönen M; Kamatani Y; Kammerer CM; Kanai M; Kastarinen M; Kerr SM; Khor CC; Kiess W; Kleber ME; Koenig W; Kooner JS; Körner A; Kovacs P; Kraja AT; Krajcoviechova A; Kramer H; Krämer BK; Kronenberg F; Kubo M; Kühnel B; Kuokkanen M; Kuusisto J; La Bianca M; Laakso M; Lange LA; Langefeld CD; Lee JJ; Lehne B; Lehtimäki T; Lieb W; Lim SC; Lind L; Lindgren CM; Liu J; Loeffler M; Loos RJF; Lucae S; Lukas MA; Lyytikäinen LP; Mägi R; Magnusson PKE; Mahajan A; Martin NG; Martins J; März W; Mascalzoni D; Matsuda K; Meisinger C; Meitinger T; Melander O; Metspalu A; Mikaelsdottir EK; Milaneschi Y; Miliku K; Mishra PP; Mohlke KL; Mononen N; Montgomery GW; Mook-Kanamori DO; Mychaleckyj JC; Nadkarni GN; Nalls MA; Nauck M; Nikus K; Ning B; Nolte IM; Noordam R; O'Connell J; O'Donoghue ML; Olafsson I; Oldehinkel AJ; Orho-Melander M; Ouwehand WH; Padmanabhan S; Palmer ND; Palsson R; Penninx BWJH; Perls T; Perola M; Pirastu M; Pirastu N; Pistis G; Podgornaia AI; Polasek O; Ponte B; Porteous DJ; Poulain T; Pramstaller PP; Preuss MH; Prins BP; Province MA; Rabelink TJ; Raffield LM; Raitakari OT; Reilly DF; Rettig R; Rheinberger M; Rice KM; Ridker PM; Rivadeneira F; Rizzi F; Roberts DJ; Robino A; Rossing P; Rudan I; Rueedi R; Ruggiero D; Ryan KA; Saba Y; Sabanayagam C; Salomaa V; Salvi E; Saum KU; Schmidt H; Schmidt R; Schöttker B; Schulz CA; Schupf N; Shaffer CM; Shi Y; Smith AV; Smith BH; Soranzo N; Spracklen CN; Strauch K; Stringham HM; Stumvoll M; Svensson PO; Szymczak S; Tai ES; Tajuddin SM; Tan NYQ; Taylor KD; Teren A; Tham YC; Thiery J; Thio CHL; Thomsen H; Thorleifsson G; Toniolo D; Tönjes A; Tremblay J; Tzoulaki I; Uitterlinden AG; Vaccargiu S; van Dam RM; van der Harst P; van Duijn CM; Velez Edward DR; Verweij N; Vogelezang S; Völker U; Vollenweider P; Waeber G; Waldenberger M; Wallentin L; Wang YX; Wang C; Waterworth DM; Bin Wei W; White H; Whitfield JB; Wild SH; Wilson JF; Wojczynski MK; Wong C; Wong TY; Xu L; Yang Q; Yasuda M; Yerges-Armstrong LM; Zhang W; Zonderman AB; Rotter JI; Bochud M; Psaty BM; Vitart V; Wilson JG; Dehghan A; Parsa A; Chasman DI; Ho K; Morris AP; Devuyst O; Akilesh S; Pendergrass SA; Sim X; Böger CA; Okada Y; Edwards TL; Snieder H; Stefansson K; Hung AM; Heid IM; Scholz M; Teumer A; Köttgen A; Pattaro C (2019)
      Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate ...
    • Common variants in Mendelian kidney disease genes and their association with renal function 

      Parsa A; Fuchsberger C; Köttgen A; O'Seaghdha CM; Pattaro C; de Andrade M; Chasman DI; Teumer A; Endlich K; Olden M; Chen MH; Tin A; Kim YJ; Taliun D; Li M; Feitosa M; Gorski M; Yang Q; Hundertmark C; Foster MC; Glazer N; Isaacs A; Rao M; Smith AV; O'Connell JR; Struchalin M; Tanaka T; Li G; Hwang SJ; Atkinson EJ; Lohman K; Cornelis MC; Johansson A; Tönjes A; Dehghan A; Couraki V; Holliday EG; Sorice R; Kutalik Z; Lehtimäki T; Esko T; Deshmukh H; Ulivi S; Chu AY; Murgia F; Trompet S; Imboden M; Kollerits B; Pistis G; Harris TB; Launer LJ; Aspelund T; Eiriksdottir G; Mitchell BD; Boerwinkle E; Schmidt H; Hofer E; Hu F; Demirkan A; Oostra BA; Turner ST; Ding J; Andrews JS; Freedman BI; Giulianini F; Koenig W; Illig T; Döring A; Wichmann HE; Zgaga L; Zemunik T; Boban M; Minelli C; Wheeler HE; Igl W; Zaboli G; Wild SH; Wright AF; Campbell H; Ellinghaus D; Nöthlings U; Jacobs G; Biffar R; Ernst F; Homuth G; Kroemer HK; Nauck M; Stracke S; Völker U; Völzke H; Kovacs P; Stumvoll M; Mägi R; Hofman A; Uitterlinden AG; Rivadeneira F; Aulchenko YS; Polasek O; Hastie N; Vitart V; Helmer C; Wang JJ; Stengel B; Ruggiero D; Bergmann S; Kähönen M; Viikari J; Nikopensius T; Province M; Colhoun H; Doney A; Robino A; Krämer BK; Portas L; Ford I; Buckley BM; Adam M; Thun GA; Paulweber B; Haun M; Sala C; Mitchell P; Ciullo M; Vollenweider P; Raitakari O; Metspalu A; Palmer C; Gasparini P; Pirastu M; Jukema JW; Probst-Hensch NM; Kronenberg F; Toniolo D; Gudnason V; Shuldiner AR; Coresh J; Schmidt R; Ferrucci L; van Duijn CM; Borecki I; Kardia SL; Liu Y; Curhan GC; Rudan I; Gyllensten U; Wilson JF; Franke A; Pramstaller PP; Rettig R; Prokopenko I; Witteman J; Hayward C; Ridker PM; Bochud M; Heid IM; Siscovick DS; Fox CS; Kao WL; Böger CA (2013)
      Many common genetic variants identified by genome-wide association studies for complex traits map to genes previously linked to rare inherited Mendelian disorders. A systematic analysis of common single-nucleotide polymorphisms ...
    • CUBN is a gene locus for albuminuria 

      Böger CA; Chen MH; Tin A; Olden M; Köttgen A; de Boer IH; Fuchsberger C; O'Seaghdha CM; Pattaro C; Teumer A; Liu CT; Glazer NL; Li M; O'Connell JR; Tanaka T; Peralta CA; Kutalik Z; Luan J; Zhao JH; Hwang SJ; Akylbekova E; Kramer H; van der Harst P; Smith AV; Lohman K; de Andrade M; Hayward C; Kollerits B; Tönjes A; Aspelund T; Ingelsson E; Eiriksdottir G; Launer LJ; Harris TB; Shuldiner AR; Mitchell BD; Arking DE; Franceschini N; Boerwinkle E; Egan J; Hernandez D; Reilly M; Townsend RR; Lumley T; Siscovick DS; Psaty BM; Kestenbaum B; Haritunians T; Bergmann S; Vollenweider P; Waeber G; Mooser V; Waterworth D; Johnson AD; Florez JC; Meigs JB; Lu X; Turner ST; Atkinson EJ; Leak TS; Aasarød K; Skorpen F; Syvänen AC; Illig T; Baumert J; Koenig W; Krämer BK; Devuyst O; Mychaleckyj JC; Minelli C; Bakker SJ; Kedenko L; Paulweber B; Coassin S; Endlich K; Kroemer HK; Biffar R; Stracke S; Völzke H; Stumvoll M; Mägi R; Campbell H; Vitart V; Hastie ND; Gudnason V; Kardia SL; Liu Y; Polasek O; Curhan G; Kronenberg F; Prokopenko I; Rudan I; Arnlöv J; Hallan S; Navis G; CKDGen Consortium; Parsa A; Ferrucci L; Coresh J; Shlipak MG; Bull SB; Paterson NJ; Wichmann HE; Wareham NJ; Loos RJ; Rotter JI; Pramstaller PP; Cupples LA; Beckmann JS; Yang Q; Heid IM; Rettig R; Dreisbach AW; Bochud M; Fox CS; Kao WH (2011)
      Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants ...
    • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function 

      Pattaro C; Teumer A; Gorski M; Chu AY; Li M; Mijatovic V; Garnaas M; Tin A; Sorice R; Li Y; Taliun D; Olden M; Foster M; Yang Q; Chen MH; Pers TH; Johnson AD; Ko YA; Fuchsberger C; Tayo B; Nalls M; Feitosa MF; Isaacs A; Dehghan A; D'Adamo P; Adeyemo A; Dieffenbach AK; Zonderman AB; ; Nolte IM; van der Most PJ; Wright AF; Shuldiner AR; Morrison AC; Hofman A; Smith AV; Dreisbach AW; Franke A; Uitterlinden AG; Metspalu A; Tonjes A; Lupo A; Robino A; Johansson A; Demirkan A; Kollerits B; Freedman BI; Ponte B; Oostra BA; Paulweber B; Krämer BK (2016)
      Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular ...
    • Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation 

      Teumer A; Chaker L; Groeneweg S; Li Y; Di Munno C; Barbieri C; Schultheiss UT; Traglia M; Ahluwalia TS; Akiyama M; Appel EVR; Arking DE; Arnold A; Astrup A; Beekman M; Beilby JP; Bekaert S; Boerwinkle E; Brown SJ; De Buyzere M; Campbell PJ; Ceresini G; Cerqueira C; Cucca F; Deary IJ; Deelen J; Eckardt KU; Ekici AB; Eriksson JG; Ferrrucci L; Fiers T; Fiorillo E; Ford I; Fox CS; Fuchsberger C; Galesloot TE; Gieger C; Gögele M; De Grandi A; Grarup N; Greiser KH; Haljas K; Hansen T; Harris SE; van Heemst D; den Heijer M; Hicks AA; den Hollander W; Homuth G; Hui J; Ikram MA; Ittermann T; Jensen RA; Jing J; Jukema JW; Kajantie E; Kamatani Y; Kasbohm E; Kaufman JM; Kiemeney LA; Kloppenburg M; Kronenberg F; Kubo M; Lahti J; Lapauw B; Li S; Liewald DCM; Lifelines Cohort Study; Lim EM; Linneberg A; Marina M; Mascalzoni D; Matsuda K; Medenwald D; Meisinger C; Meulenbelt I; De Meyer T; Meyer Zu Schwabedissen HE; Mikolajczyk R; Moed M; Netea-Maier RT; Nolte IM; Okada Y; Pala M; Pattaro C; Pedersen O; Petersmann A; Porcu E; Postmus I; Pramstaller PP; Psaty BM; Ramos YFM; Rawal R; Redmond P; Richards JB; Rietzschel ER; Rivadeneira F; Roef G; Rotter JI; Sala CF; Schlessinger D; Selvin E; Slagboom PE; Soranzo N; Sørensen TIA; Spector TD; Starr JM; Stott DJ; Taes Y; Taliun D; Tanaka T; Thuesen B; Tiller D; Toniolo D; Uitterlinden AG; Visser WE; Walsh JP; Wilson SG; Wolffenbuttel BHR; Yang Q; Zheng HF; Cappola A; Peeters RP; Naitza S; Völzke H; Sanna S; Köttgen A; Visser TJ; Medici M (2018)
      Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only ...
    • Genome-wide association analyses identify 18 new loci associated with serum urate concentrations 

      Köttgen A; Albrecht E; Teumer A; Vitart V; Krumsiek J; Hundertmark C; Pistis G; Ruggiero D; O'Seaghdha CM; Haller T; Yang Q; Tanaka T; Johnson AD; Kutalik Z; Smith AV; Shi J; Struchalin M; Middelberg RP; Brown MJ; Gaffo AL; Pirastu N; Li G; Hayward C; Zemunik T; Huffman J; Yengo L; Zhao JH; Demirkan A; Feitosa MF; Liu X; Malerba G; Lopez LM; van der Harst P; Li X; Kleber ME; Hicks AA; Nolte IM; Johansson A; Murgia F; Wild SH; Bakker SJ; Peden JF; Dehghan A; Steri M; Tenesa A; Lagou V; Salo P; Mangino M; Rose LM; Lehtimäki T; Woodward OM; Okada Y; Tin A; Müller C; Oldmeadow C; Putku M; Czamara D; Kraft P; Frogheri L; Thun GA; Grotevendt A; Gislason GK; Harris TB; Launer LJ; McArdle P; Shuldiner AR; Boerwinkle E; Coresh J; Schmidt H; Schallert M; Martin NG; Montgomery GW; Kubo M; Nakamura Y; Munroe PB; Samani NJ; Jacobs DR; Liu K; D'Adamo P; Ulivi S; Rotter JI; Psaty BM; Vollenweider P; Waeber G; Campbell S; Devuyst O; Navarro P; Kolcic I; Hastie N; Balkau B; Froguel P; Esko T; Salumets A; Khaw KT; Langenberg C; Wareham NJ; Isaacs A; Kraja A; Zhang Q; Wild PS; Scott RJ; Holliday EG; Org E; Viigimaa M; Bandinelli S; Metter JE; Lupo A; Trabetti E; Sorice R; Döring A; Lattka E; Strauch K; Theis F; Waldenberger M; Wichmann HE; Davies G; Gow AJ; Bruinenberg M; LifeLines Cohort Study; Stolk RP; Kooner JS; Zhang W; Winkelmann BR; Boehm BO; Lucae S; Penninx BW; Smit JH; Curhan G; Mudgal P; Plenge RM; Portas L; Persico I; Kirin M; Wilson JF; Mateo Leach I; van Gilst WH; Goel A; Ongen H; Hofman A; Rivadeneira F; Uitterlinden AG; Imboden M; von Eckardstein A; Cucca F; Nagaraja R; Piras MG; Nauck M; Schurmann C; Budde K; Ernst F; Farrington SM; Theodoratou E; Prokopenko I; Stumvoll M; Jula A; Perola M; Salomaa V; Shin SY; Spector TD; Sala C; Ridker PM; Kähönen M; Viikari J; Hengstenberg C; Nelson CP; CARDIoGRAM Consortium; DIAGRAM Consortium; ICBP Consortium; MAGIC Consortium; Meschia JF; Nalls MA; Sharma P; Singleton AB; Kamatani N; Zeller T; Burnier M; Attia J; Laan M; Klopp N; Hillege HL; Kloiber S; Choi H; Pirastu M; Tore S; Probst-Hensch NM; Völzke H; Gudnason V; Parsa A; Schmidt R; Whitfield JB; Fornage M; Gasparini P; Siscovick DS; Polašek O; Campbell H; Rudan I; Bouatia-Naji N; Metspalu A; Loos RJ; van Duijn CM; Borecki IB; Ferrucci L; Gambaro G; Deary IJ; Wolffenbuttel BH; Chambers JC; März W; Pramstaller PP; Snieder H; Gyllensten U; Wright AF; Navis G; Watkins H; Witteman JC; Sanna S; Schipf S; Dunlop MG; Tönjes A; Ripatti S; Soranzo N; Toniolo D; Chasman DI; Raitakari O; Kao WH; Ciullo M; Fox CS; Caulfield M; Bochud M; Gieger C (2013)
      Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we ...
    • Genome-wide association and functional follow-up reveals new loci for kidney function 

      Pattaro C; Köttgen A; Teumer A; Garnaas M; Böger CA; Fuchsberger C; Olden M; Chen MH; Tin A; Taliun D; Li M; Gao X; Gorski M; Yang Q; Hundertmark C; Foster MC; O'Seaghdha CM; Glazer N; Isaacs A; Liu CT; Smith AV; O'Connell JR; Struchalin M; Tanaka T; Li G; Johnson AD; Gierman HJ; Feitosa M; Hwang SJ; Atkinson EJ; Lohman K; Cornelis MC; Johansson Å; Tönjes A; Dehghan A; Chouraki V; Holliday EG; Sorice R; Kutalik Z; Lehtimäki T; Esko T; Deshmukh H; Ulivi S; Chu AY; Murgia F; Trompet S; Imboden M; Kollerits B; Pistis G; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium; Wellcome Trust Case Control Consortium 2; Harris TB; Launer LJ; Aspelund T; Eiriksdottir G; Mitchell BD; Boerwinkle E; Schmidt H; Cavalieri M; Rao M; Hu FB; Demirkan A; Oostra BA; de Andrade M; Turner ST; Ding J; Andrews JS; Freedman BI; Koenig W; Illig T; Döring A; Wichmann HE; Kolcic I; Zemunik T; Boban M; Minelli C; Wheeler HE; Igl W; Zaboli G; Wild SH; Wright AF; Campbell H; Ellinghaus D; Nöthlings U; Jacobs G; Biffar R; Endlich K; Ernst F; Homuth G; Kroemer HK; Nauck M; Stracke S; Völker U; Völzke H; Kovacs P; Stumvoll M; Mägi R; Hofman A; Uitterlinden AG; Rivadeneira F; Aulchenko YS; Polasek O; Hastie N; Vitart V; Helmer C; Wang JJ; Ruggiero D; Bergmann S; Kähönen M; Viikari J; Nikopensius T; Province M; Ketkar S; Colhoun H; Doney A; Robino A; Giulianini F; Krämer BK; Portas L; Ford I; Buckley BM; Adam M; Thun GA; Paulweber B; Haun M; Sala C; Metzger M; Mitchell P; Ciullo M; Kim SK; Vollenweider P; Raitakari O; Metspalu A; Palmer C; Gasparini P; Pirastu M; Jukema JW; Probst-Hensch NM; Kronenberg F; Toniolo D; Gudnason V; Shuldiner AR; Coresh J; Schmidt R; Ferrucci L; Siscovick DS; van Duijn CM; Borecki I; Kardia SL; Liu Y; Curhan GC; Rudan I; Gyllensten U; Wilson JF; Franke A; Pramstaller PP; Rettig R; Prokopenko I; Witteman JC; Hayward C; Ridker P; Parsa A; Bochud M; Heid IM; Goessling W; Chasman DI; Kao WH; Fox CS (2012)
      Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD ...
    • Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria 

      Teumer A; Li Y; Ghasemi S; Prins BP; Wuttke M; Hermle T; Giri A; Sieber KB; Qiu C; Kirsten H; Tin A; Chu AY; Bansal N; Feitosa MF; Wang L; Chai JF; Cocca M; Fuchsberger C; Gorski M; Hoppmann A; Horn K; Li M; Marten J; Noce D; Nutile T; Sedaghat S; Sveinbjornsson G; Tayo BO; van der Most PJ; Xu Y; Yu Z; Gerstner L; Ärnlöv J; Bakker SJL; Baptista D; Biggs ML; Boerwinkle E; Brenner H; Burkhardt R; Carroll RJ; Chee ML; Chen M; Cheng CY; Cook JP; Coresh J; Corre T; Danesh J; de Borst MH; De Grandi A; de Mutsert R; de Vries APJ; Degenhardt F; Dittrich K; Divers J; Eckardt KU; Ehret G; Endlich K; Felix JF; Franco OH; Franke A; Freedman BI; Freitag-Wolf S; Gansevoort RT; Giedraitis V; Gögele M; Grundner-Culemann F; Gudbjartsson DF; Gudnason V; Hamet P; Harris TB; Hicks AA; Holm H; Foo VHX; Hwang SJ; Ikram MA; Ingelsson E; Jaddoe VWV; Jakobsdottir J; Josyula NS; Jung B; Kähönen M; Khor CC; Kiess W; Koenig W; Körner A; Kovacs P; Kramer H; Krämer BK; Kronenberg F; Lange LA; Langefeld CD; Lee JJ; Lehtimäki T; Lieb W; Lim SC; Lind L; Lindgren CM; Liu J; Loeffler M; Lyytikäinen LP; Mahajan A; Maranville JC; Mascalzoni D; McMullen B; Meisinger C; Meitinger T; Miliku K; Mook-Kanamori DO; Müller-Nurasyid M; Mychaleckyj JC; Nauck M; Nikus K; Ning B; Noordam R; Connell JO; Olafsson I; Palmer ND; Peters A; Podgornaia AI; Ponte B; Poulain T; Pramstaller PP; Rabelink TJ; Raffield LM; Reilly DF; Rettig R; Rheinberger M; Rice KM; Rivadeneira F; Runz H; Ryan KA; Sabanayagam C; Saum KU; Schöttker B; Shaffer CM; Shi Y; Smith AV; Strauch K; Stumvoll M; Sun BB; Szymczak S; Tai ES; Tan NYQ; Taylor KD; Teren A; Tham YC; Thiery J; Thio CHL; Thomsen H; Thorsteinsdottir U; Tönjes A; Tremblay J; Uitterlinden AG; van der Harst P; Verweij N; Vogelezang S; Völker U; Waldenberger M; Wang C; Wilson OD; Wong C; Wong TY; Yang Q; Yasuda M; Akilesh S; Bochud M; Böger CA; Devuyst O; Edwards TL; Ho K; Morris AP; Parsa A; Pendergrass SA; Psaty BM; Rotter JI; Stefansson K; Wilson JG; Susztak K; Snieder H; Heid IM; Scholz M; Butterworth AS; Hung AM; Pattaro C; Köttgen A (2019)
      Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we ...
    • Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes 

      Teumer A; Tin A; Sorice R; Gorski M; Yeo NC; Chu AY; Li M; Li Y; Mijatovic V; Ko YA; Taliun D; Luciani A; Chen MH; Yang Q; Foster MC; Olden M; Hiraki LT; Tayo BO; Fuchsberger C; Dieffenbach AK; Shuldiner AR; Smith AV; Zappa AM; Lupo A; Kollerits B; Ponte B; Stengel B; Krämer BK; Paulweber B; Mitchell BD; Hayward C; Helmer C; Meisinger C; Gieger C; Shaffer CM; Müller C; Langenberg C; Ackermann D; Siscovick D; DCCT/EDIC; Boerwinkle E; Kronenberg F; Ehret GB; Homuth G; Waeber G; Navis G; Gambaro G; Malerba G; Eiriksdottir G; Li G; Wichmann HE; Grallert H; Wallaschofski H; Völzke H; Brenner H; Kramer H; Mateo Leach I; Rudan I; Hillege HL; Beckmann JS; Lambert JC; Luan J; Zhao JH; Chalmers J; Coresh J; Denny JC; Butterbach K; Launer LJ; Ferrucci L; Kedenko L; Haun M; Metzger M; Woodward M; Hoffman MJ; Nauck M; Waldenberger M; Pruijm M; Bochud M; Rheinberger M; Verweij N; Wareham NJ; Endlich N; Soranzo N; Polasek O; van der Harst P; Pramstaller PP; Vollenweider P; Wild PS; Gansevoort RT; Rettig R; Biffar R; Carroll RJ; Katz R; Loos RJ; Hwang SJ; Coassin S; Bergmann S; Rosas SE; Stracke S; Harris TB; Corre T; Zeller T; Illig T; Aspelund T; Tanaka T; Lendeckel U; Völker U; Gudnason V; Chouraki V; Koenig W; Kutalik Z; O'Connell JR; Parsa A; Heid IM; Paterson AD; de Boer IH; Devuyst O; Lazar J; Endlich K; Susztak K; Tremblay J; Hamet P; Jacob HJ; Böger CA; Fox CS; Pattaro C; Köttgen A (2016)
      Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic kidney disease and are associated with an increased risk for end-stage renal disease and cardiovascular events. To gain insight into ...
    • Genome-wide association study of kidney function decline in individuals of European descent 

      Gorski M; Tin A; Garnaas M; McMahon GM; Chu AY; Tayo BO; Pattaro C; Teumer A; Chasman DI; Chalmers J; Hamet P; Tremblay J; Woodward M; Aspelund T; Eiriksdottir G; Gudnason V; Harris TB; Launer LJ; Smith AV; Mitchell BD; O'Connell JR; Shuldiner AR; Coresh J; Li M; Freudenberger P; Hofer E; Schmidt H; Schmidt R; Holliday EG; Mitchell P; Wang JJ; de Boer IH; Li G; Siscovick DS; Kutalik Z; Corre T; Vollenweider P; Waeber G; Gupta J; Kanetsky PA; Hwang SJ; Olden M; Yang Q; de Andrade M; Atkinson EJ; Kardia SL; Turner ST; Stafford JM; Ding J; Liu Y; Barlassina C; Cusi D; Salvi E; Staessen JA; Ridker PM; Grallert H; Meisinger C; Müller-Nurasyid M; Krämer BK; Kramer H; Rosas SE; Nolte IM; Penninx BW; Snieder H; Del Greco M F; Franke A; Nöthlings U; Lieb W; Bakker SJ; Gansevoort RT; van der Harst P; Dehghan A; Franco OH; Hofman A; Rivadeneira F; Sedaghat S; Uitterlinden AG; Coassin S; Haun M; Kollerits B; Kronenberg F; Paulweber B; Aumann N; Endlich K; Pietzner M; Völker U; Rettig R; Chouraki V; Helmer C; Lambert JC; Metzger M; Stengel B; Lehtimäki T; Lyytikäinen LP; Raitakari O; Johnson A; Parsa A; Bochud M; Heid IM; Goessling W; Köttgen A; Kao WH; Fox CS; Böger CA (2015)
      Genome-wide association studies (GWASs) have identified multiple loci associated with cross-sectional eGFR, but a systematic genetic analysis of kidney function decline over time is missing. Here we conducted a GWAS ...
    • Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function 

      Chasman DI; Fuchsberger C; Pattaro C; Teumer A; Böger CA; Endlich K; Olden M; Chen MH; Tin A; Taliun D; Li M; Gao X; Gorski M; Yang Q; Hundertmark C; Foster MC; O'Seaghdha CM; Glazer N; Isaacs A; Liu CT; Smith AV; O'Connell JR; Struchalin M; Tanaka T; Li G; Johnson AD; Gierman HJ; Feitosa MF; Hwang SJ; Atkinson EJ; Lohman K; Cornelis MC; Johansson A; Tönjes A; Dehghan A; Lambert JC; Holliday EG; Sorice R; Kutalik Z; Lehtimäki T; Esko T; Deshmukh H; Ulivi S; Chu AY; Murgia F; Trompet S; Imboden M; Coassin S; Pistis G; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium; WTCCC2; Harris TB; Launer LJ; Aspelund T; Eiriksdottir G; Mitchell BD; Boerwinkle E; Schmidt H; Cavalieri M; Rao M; Hu F; Demirkan A; Oostra BA; de Andrade M; Turner ST; Ding J; Andrews JS; Freedman BI; Giulianini F; Koenig W; Illig T; Meisinger C; Gieger C; Zgaga L; Zemunik T; Boban M; Minelli C; Wheeler HE; Igl W; Zaboli G; Wild SH; Wright AF; Campbell H; Ellinghaus D; Nöthlings U; Jacobs G; Biffar R; Ernst F; Homuth G; Kroemer HK; Nauck M; Stracke S; Völker U; Völzke H; Kovacs P; Stumvoll M; Mägi R; Hofman A; Uitterlinden AG; Rivadeneira F; Aulchenko YS; Polasek O; Hastie N; Vitart V; Helmer C; Wang JJ; Stengel B; Ruggiero D; Bergmann S; Kähönen M; Viikari J; Nikopensius T; Province M; Ketkar S; Colhoun H; Doney A; Robino A; Krämer BK; Portas L; Ford I; Buckley BM; Adam M; Thun GA; Paulweber B; Haun M; Sala C; Mitchell P; Ciullo M; Kim SK; Vollenweider P; Raitakari O; Metspalu A; Palmer C; Gasparini P; Pirastu M; Jukema JW; Probst-Hensch NM; Kronenberg F; Toniolo D; Gudnason V; Shuldiner AR; Coresh J; Schmidt R; Ferrucci L; Siscovick DS; van Duijn CM; Borecki IB; Kardia SL; Liu Y; Curhan GC; Rudan I; Gyllensten U; Wilson JF; Franke A; Pramstaller PP; Rettig R; Prokopenko I; Witteman J; Hayward C; Ridker PM; Parsa A; Bochud M; Heid IM; Kao WH; Fox CS; Köttgen A (2012)
      In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated ...
    • New loci associated with kidney function and chronic kidney disease 

      Köttgen A; Pattaro C; Böger CA; Fuchsberger C; Olden M; Glazer NL; Parsa A; Gao X; Yang Q; Smith AV; O'Connell JR; Li M; Schmidt H; Tanaka T; Isaacs A; Ketkar S; Hwang SJ; Johnson AD; Dehghan A; Teumer A; Paré G; Atkinson EJ; Zeller T; Lohman K; Cornelis MC; Probst-Hensch NM; Kronenberg F; Tönjes A; Hayward C; Aspelund T; Eiriksdottir G; Launer LJ; Harris TB; Rampersaud E; Mitchell BD; Arking DE; Boerwinkle E; Struchalin M; Cavalieri M; Singleton A; Giallauria F; Metter J; de Boer IH; Haritunians T; Lumley T; Siscovick D; Psaty BM; Zillikens MC; Oostra BA; Feitosa M; Province M; de Andrade M; Turner ST; Schillert A; Ziegler A; Wild PS; Schnabel RB; Wilde S; Munzel TF; Leak TS; Illig T; Klopp N; Meisinger C; Wichmann HE; Koenig W; Zgaga L; Zemunik T; Kolcic I; Minelli C; Hu FB; Johansson A; Igl W; Zaboli G; Wild SH; Wright AF; Campbell H; Ellinghaus D; Schreiber S; Aulchenko YS; Felix JF; Rivadeneira F; Uitterlinden AG; Hofman A; Imboden M; Nitsch D; Brandstätter A; Kollerits B; Kedenko L; Mägi R; Stumvoll M; Kovacs P; Boban M; Campbell S; Endlich K; Völzke H; Kroemer HK; Nauck M; Völker U; Polasek O; Vitart V; Badola S; Parker AN; Ridker PM; Kardia SL; Blankenberg S; Liu Y; Curhan GC; Franke A; Rochat T; Paulweber B; Prokopenko I; Wang W; Gudnason V; Shuldiner AR; Coresh J; Schmidt R; Ferrucci L; Shlipak MG; van Duijn CM; Borecki I; Krämer BK; Rudan I; Gyllensten U; Wilson JF; Witteman JC; Pramstaller PP; Rettig R; Hastie N; Chasman DI; Kao WH; Heid IM; Fox CS (2010)
      Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association ...
    • SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function 

      Li M; Li Y; Weeks O; Mijatovic V; Teumer A; Huffman JE; Tromp G; Fuchsberger C; Gorski M; Lyytikäinen LP; Nutile T; Sedaghat S; Sorice R; Tin A; Yang Q; Ahluwalia TS; Arking DE; Bihlmeyer NA; Böger CA; Carroll RJ; Chasman DI; Cornelis MC; Dehghan A; Faul JD; Feitosa MF; Gambaro G; Gasparini P; Giulianini F; Heid I; Huang J; Imboden M; Jackson AU; Jeff J; Jhun MA; Katz R; Kifley A; Kilpeläinen TO; Kumar A; Laakso M; Li-Gao R; Lohman K; Lu Y; Mägi R; Malerba G; Mihailov E; Mohlke KL; Mook-Kanamori DO; Robino A; Ruderfer D; Salvi E; Schick UM; Schulz CA; Smith AV; Smith JA; Traglia M; Yerges-Armstrong LM; Zhao W; Goodarzi MO; Kraja AT; Liu C; Boerwinkle E; Borecki IB; Bork-Jensen J; Bottinger EP; Braga D; Brandslund I; Brody JA; Campbell A; Carey DJ; Christensen C; Coresh J; Crook E; Curhan GC; Cusi D; de Boer IH; de Vries AP; Denny JC; Devuyst O; Dreisbach AW; Endlich K; Esko T; Franco OH; Fulop T; Gerhard GS; Glümer C; Gottesman O; Grarup N; Gudnason V; Hansen T; Harris TB; Hayward C; Hocking L; Hofman A; Hu FB; Husemoen LL; Jackson RD; Jørgensen T; Jørgensen ME; Kähönen M; Kardia SL; König W; Kooperberg C; Kriebel J; Launer LJ; Lauritzen T; Lehtimäki T; Levy D; Linksted P; Linneberg A; Liu Y; Loos RJ; Lupo A; Meisinger C; Melander O; Metspalu A; Mitchell P; Nauck M; Nürnberg P; Orho-Melander M; Parsa A; Pedersen O; Peters A; Peters U; Polasek O; Porteous D; Probst-Hensch NM; Psaty BM; Qi L; Raitakari OT; Reiner AP; Rettig R; Ridker PM; Rivadeneira F; Rossouw JE; Schmidt F; Siscovick D; Soranzo N; Strauch K; Toniolo D; Turner ST; Uitterlinden AG; Ulivi S; Velayutham D; Völker U; Völzke H; Waldenberger M; Wang JJ; Weir DR; Witte D; Kuivaniemi H; Fox CS; Franceschini N; Goessling W; Köttgen A; Chu AY; Wessel J (2017)
      Genome-wide association studies have identified >50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analysis of associations ...
    • Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels 

      Tin A; Marten J; Halperin Kuhns VL; Li Y; Wuttke M; Kirsten H; Sieber KB; Qiu C; Gorski M; Yu Z; Giri A; Sveinbjornsson G; Li M; Chu AY; Hoppmann A; O'Connor LJ; Prins B; Nutile T; Noce D; Akiyama M; Cocca M; Ghasemi S; van der Most PJ; Horn K; Xu Y; Fuchsberger C; Sedaghat S; Afaq S; Amin N; Ärnlöv J; Bakker SJL; Bansal N; Baptista D; Bergmann S; Biggs ML; Biino G; Boerwinkle E; Bottinger EP; Boutin TS; Brumat M; Burkhardt R; Campana E; Campbell A; Campbell H; Carroll RJ; Catamo E; Chambers JC; Ciullo M; Concas MP; Coresh J; Corre T; Cusi D; Felicita SC; de Borst MH; De Grandi A; de Mutsert R; de Vries APJ; Delgado G; Demirkan A; Devuyst O; Dittrich K; Eckardt KU; Ehret G; Endlich K; Evans MK; Gansevoort RT; Gasparini P; Giedraitis V; Gieger C; Girotto G; Gögele M; Gordon SD; Gudbjartsson DF; Gudnason V; Haller T; Hamet P; Harris TB; Hayward C; Hicks AA; Hofer E; Holm H; Huang W; Hutri-Kähönen N; Hwang SJ; Ikram MA; Lewis RM; Ingelsson E; Jakobsdottir J; Jonsdottir I; Jonsson H; Joshi PK; Josyula NS; Jung B; Kähönen M; Kamatani Y; Kanai M; Kerr SM; Kiess W; Kleber ME; Koenig W; Kooner JS; Körner A; Kovacs P; Krämer BK; Kronenberg F; Kubo M; Kühnel B; La Bianca M; Lange LA; Lehne B; Lehtimäki T; Liu J; Loeffler M; Loos RJF; Lyytikäinen LP; Magi R; Mahajan A; Martin NG; März W; Mascalzoni D; Matsuda K; Meisinger C; Meitinger T; Metspalu A; Milaneschi Y; O'Donnell CJ; Wilson OD; Gaziano JM; Mishra PP; Mohlke KL; Mononen N; Montgomery GW; Mook-Kanamori DO; Müller-Nurasyid M; Nadkarni GN; Nalls MA; Nauck M; Nikus K; Ning B; Nolte IM; Noordam R; O'Connell JR; Olafsson I; Padmanabhan S; Penninx BWJH; Perls T; Peters A; Pirastu M; Pirastu N; Pistis G; Polasek O; Ponte B; Porteous DJ; Poulain T; Preuss MH; Rabelink TJ; Raffield LM; Raitakari OT; Rettig R; Rheinberger M; Rice KM; Rizzi F; Robino A; Rudan I; Krajcoviechova A; Cifkova R; Rueedi R; Ruggiero D; Ryan KA; Saba Y; Salvi E; Schmidt H; Schmidt R; Shaffer CM; Smith AV; Smith BH; Spracklen CN; Strauch K; Stumvoll M; Sulem P; Tajuddin SM; Teren A; Thiery J; Thio CHL; Thorsteinsdottir U; Toniolo D; Tönjes A; Tremblay J; Uitterlinden AG; Vaccargiu S; van der Harst P; van Duijn CM; Verweij N; Völker U; Vollenweider P; Waeber G; Waldenberger M; Whitfield JB; Wild SH; Wilson JF; Yang Q; Zhang W; Zonderman AB; Bochud M; Wilson JG; Pendergrass SA; Ho K; Parsa A; Pramstaller PP; Psaty BM; Böger CA; Snieder H; Butterworth AS; Okada Y; Edwards TL; Stefansson K; Susztak K; Scholz M; Heid IM; Hung AM; Teumer A; Pattaro C; Woodward OM; Vitart V; Köttgen A (2019)
      Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, ...