Now showing items 1-4 of 4

    • Genetic studies of body mass index yield new insights for obesity biology 

      Locke AE; Kahali B; Berndt SI; Justice AE; Pers TH; Day FR; Powell C; Vedantam S; Buchkovich ML; Yang J; Croteau-Chonka DC; Esko T; Fall T; Ferreira T; Gustafsson S; Kutalik Z; Luan J; Mägi R; Randall JC; Winkler TW; Wood AR; Workalemahu T; Faul JD; Smith JA; Hua Zhao J; Zhao W; Chen J; Fehrmann R; Hedman ÅK; Karjalainen J; Schmidt EM; Absher D; Amin N; Anderson D; Beekman M; Bolton JL; Bragg-Gresham JL; Buyske S; Demirkan A; Deng G; Ehret GB; Feenstra B; Feitosa MF; Fischer K; Goel A; Gong J; Jackson AU; Kanoni S; Kleber ME; Kristiansson K; Lim U; Lotay V; Mangino M; Mateo Leach I; Medina-Gomez C; Medland SE; Nalls MA; Palmer CD; Pasko D; Pechlivanis S; Peters MJ; Prokopenko I; Shungin D; Stančáková A; Strawbridge RJ; Ju Sung Y; Tanaka T; Teumer A; Trompet S; van der Laan SW; van Setten J; van Vliet-Ostaptchouk JV; Wang Z; Yengo L; Zhang W; Isaacs A; Albrecht E; Ärnlöv J; Arscott GM; Attwood AP; Bandinelli S; Barrett A; Bas IN; Bellis C; Bennett AJ; Berne C; Blagieva R; Blüher M; Böhringer S; Bonnycastle LL; Böttcher Y; Boyd HA; Bruinenberg M; Caspersen IH; Ida Chen YD; Clarke R; Daw EW; de Craen AJ; Delgado G; Dimitriou M; Doney AS; Eklund N; Estrada K; Eury E; Folkersen L; Fraser RM; Garcia ME; Geller F; Giedraitis V; Gigante B; Go AS; Golay A; Goodall AH; Gordon SD; Gorski M; Grabe HJ; Grallert H; Grammer TB; Gräßler J; Grönberg H; Groves CJ; Gusto G; Haessler J; Hall P; Haller T; Hallmans G; Hartman CA; Hassinen M; Hayward C; Heard-Costa NL; Helmer Q; Hengstenberg C; Holmen O; Hottenga JJ; James AL; Jeff JM; Johansson Å; Jolley J; Juliusdottir T; Kinnunen L; Koenig W; Koskenvuo M; Kratzer W; Laitinen J; Lamina C; Leander K; Lee NR; Lichtner P; Lind L; Lindström J; Sin Lo K; Lobbens S; Lorbeer R; Lu Y; Mach F; Magnusson PK; Mahajan A; McArdle WL; McLachlan S; Menni C; Merger S; Mihailov E; Milani L; Moayyeri A; Monda KL; Morken MA; Mulas A; Müller G; Müller-Nurasyid M; Musk AW; Nagaraja R; Nöthen MM; Nolte IM; Pilz S; Rayner NW; Renstrom F; Rettig R; Ried JS; Ripke S; Robertson NR; Rose LM; Sanna S; Scharnagl H; Scholtens S; Schumacher FR; Scott WR; Seufferlein T; Shi J; Vernon Smith A; Smolonska J; Stanton AV; Steinthorsdottir V; Stirrups K; Stringham HM; Sundström J; Swertz MA; Swift AJ; Syvänen AC; Tan ST; Tayo BO; Thorand B; Thorleifsson G; Tyrer JP; Uh HW; Vandenput L; Verhulst FC; Vermeulen SH; Verweij N; Vonk JM; Waite LL; Warren HR; Waterworth D; Weedon MN; Wilkens LR; Willenborg C; Wilsgaard T; Wojczynski MK; Wong A; Wright AF; Zhang Q; LifeLines Cohort Study; Brennan EP; Choi M; Dastani Z; Drong AW; Eriksson P; Franco-Cereceda A; Gådin JR; Gharavi AG; Goddard ME; Handsaker RE; Huang J; Karpe F; Kathiresan S; Keildson S; Kiryluk K; Kubo M; Lee JY; Liang L; Lifton RP; Ma B; McCarroll SA; McKnight AJ; Min JL; Moffatt MF; Montgomery GW; Murabito JM; Nicholson G; Nyholt DR; Okada Y; Perry JR; Dorajoo R; Reinmaa E; Salem RM; Sandholm N; Scott RA; Stolk L; Takahashi A; Van't Hooft FM; Vinkhuyzen AA; Westra HJ; Zheng W; Zondervan KT; ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium; Heath AC; Arveiler D; Bakker SJ; Beilby J; Bergman RN; Blangero J; Bovet P; Campbell H; Caulfield MJ; Cesana G; Chakravarti A; Chasman DI; Chines PS; Collins FS; Crawford DC; Cupples LA; Cusi D; Danesh J; de Faire U; den Ruijter HM; Dominiczak AF; Erbel R; Erdmann J; Eriksson JG; Farrall M; Felix SB; Ferrannini E; Ferrières J; Ford I; Forouhi NG; Forrester T; Franco OH; Gansevoort RT; Gejman PV; Gieger C; Gottesman O; Gudnason V; Gyllensten U; Hall AS; Harris TB; Hattersley AT; Hicks AA; Hindorff LA; Hingorani AD; Hofman A; Homuth G; Hovingh GK; Humphries SE; Hunt SC; Hyppönen E; Illig T; Jacobs KB; Jarvelin MR; Jöckel KH; Johansen B; Jousilahti P; Jukema JW; Jula AM; Kaprio J; Kastelein JJ; Keinanen-Kiukaanniemi SM; Kiemeney LA; Knekt P; Kooner JS; Kooperberg C; Kovacs P; Kraja AT; Kumari M; Kuusisto J; Lakka TA; Langenberg C; Le Marchand L; Lehtimäki T; Lyssenko V; Männistö S; Marette A; Matise TC; McKenzie CA; McKnight B; Moll FL; Morris AD; Morris AP; Murray JC; Nelis M; Ohlsson C; Oldehinkel AJ; Ong KK; Madden PA; Pasterkamp G; Peden JF; Peters A; Postma DS; Pramstaller PP; Price JF; Qi L; Raitakari OT; Rankinen T; Rao DC; Rice TK; Ridker PM; Rioux JD; Ritchie MD; Rudan I; Salomaa V; Samani NJ; Saramies J; Sarzynski MA; Schunkert H; Schwarz PE; Sever P; Shuldiner AR; Sinisalo J; Stolk RP; Strauch K; Tönjes A; Trégouët DA; Tremblay A; Tremoli E; Virtamo J; Vohl MC; Völker U; Waeber G; Willemsen G; Witteman JC; Zillikens MC; Adair LS; Amouyel P; Asselbergs FW; Assimes TL; Bochud M; Boehm BO; Boerwinkle E; Bornstein SR; Bottinger EP; Bouchard C; Cauchi S; Chambers JC; Chanock SJ; Cooper RS; de Bakker PI; Dedoussis G; Ferrucci L; Franks PW; Froguel P; Groop LC; Haiman CA; Hamsten A; Hui J; Hunter DJ; Hveem K; Kaplan RC; Kivimaki M; Kuh D; Laakso M; Liu Y; Martin NG; März W; Melbye M; Metspalu A; Moebus S; Munroe PB; Njølstad I; Oostra BA; Palmer CN; Pedersen NL; Perola M; Pérusse L; Peters U; Power C; Quertermous T; Rauramaa R; Rivadeneira F; Saaristo TE; Saleheen D; Sattar N; Schadt EE; Schlessinger D; Slagboom PE; Snieder H; Spector TD; Thorsteinsdottir U; Stumvoll M; Tuomilehto J; Uitterlinden AG; Uusitupa M; van der Harst P; Walker M; Wallaschofski H; Wareham NJ; Watkins H; Weir DR; Wichmann HE; Wilson JF; Zanen P; Borecki IB; Deloukas P; Fox CS; Heid IM; O'Connell JR; Strachan DP; Stefansson K; van Duijn CM; Abecasis GR; Franke L; Frayling TM; McCarthy MI; Visscher PM; Scherag A; Willer CJ; Boehnke M; Mohlke KL; Lindgren CM; Beckmann JS; Barroso I; North KE; Ingelsson E; Hirschhorn JN; Loos RJ; Speliotes EK (2015)
      Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure ...
    • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels 

      Kilpeläinen TO; Carli JF; Skowronski AA; Sun Q; Kriebel J; Feitosa MF; Hedman ÅK; Drong AW; Hayes JE; Zhao J; Pers TH; Schick U; Grarup N; Kutalik Z; Trompet S; Mangino M; Kristiansson K; Beekman M; Lyytikäinen LP; Eriksson J; Henneman P; Lahti J; Tanaka T; Luan J; Del Greco M F; Pasko D; Renström F; Willems SM; Mahajan A; Rose LM; Guo X; Liu Y; Kleber ME; Pérusse L; Gaunt T; Ahluwalia TS; Ju Sung Y; Ramos YF; Amin N; Amuzu A; Barroso I; Bellis C; Blangero J; Buckley BM; Böhringer S; I Chen YD; de Craen AJ; Crosslin DR; Dale CE; Dastani Z; Day FR; Deelen J; Delgado GE; Demirkan A; Finucane FM; Ford I; Garcia ME; Gieger C; Gustafsson S; Hallmans G; Hankinson SE; Havulinna AS; Herder C; Hernandez D; Hicks AA; Hunter DJ; Illig T; Ingelsson E; Ioan-Facsinay A; Jansson JO; Jenny NS; Jørgensen ME; Jørgensen T; Karlsson M; Koenig W; Kraft P; Kwekkeboom J; Laatikainen T; Ladwig KH; LeDuc CA; Lowe G; Lu Y; Marques-Vidal P; Meisinger C; Menni C; Morris AP; Myers RH; Männistö S; Nalls MA; Paternoster L; Peters A; Pradhan AD; Rankinen T; Rasmussen-Torvik LJ; Rathmann W; Rice TK; Brent Richards J; Ridker PM; Sattar N; Savage DB; Söderberg S; Timpson NJ; Vandenput L; van Heemst D; Uh HW; Vohl MC; Walker M; Wichmann HE; Widén E; Wood AR; Yao J; Zeller T; Zhang Y; Meulenbelt I; Kloppenburg M; Astrup A; Sørensen TI; Sarzynski MA; Rao DC; Jousilahti P; Vartiainen E; Hofman A; Rivadeneira F; Uitterlinden AG; Kajantie E; Osmond C; Palotie A; Eriksson JG; Heliövaara M; Knekt PB; Koskinen S; Jula A; Perola M; Huupponen RK; Viikari JS; Kähönen M; Lehtimäki T; Raitakari OT; Mellström D; Lorentzon M; Casas JP; Bandinelli S; März W; Isaacs A; van Dijk KW; van Duijn CM; Harris TB; Bouchard C; Allison MA; Chasman DI; Ohlsson C; Lind L; Scott RA; Langenberg C; Wareham NJ; Ferrucci L; Frayling TM; Pramstaller PP; Borecki IB; Waterworth DM; Bergmann S; Waeber G; Vollenweider P; Vestergaard H; Hansen T; Pedersen O; Hu FB; Eline Slagboom P; Grallert H; Spector TD; Jukema JW; Klein RJ; Schadt EE; Franks PW; Lindgren CM; Leibel RL; Loos RJ (2016)
      Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe ...
    • Genomewide meta-analysis identifies loci associated with IGF-I and IGEBP-3 levels with impact on age-related traits (vol 15, pg 811, 2016) [erratum] 

      Teumer A; Qi Q; Nethander M; Aschard H; Bandinelli S; Beekman M; Berndt SI; Bidlingmaier M; Broer L; CHARGE Longevity Working Group; Cappola A; Ceda GP; Chanock S; Chen MH; Chen TC; Chen YD; Chung J; Del Greco M F; Eriksson J; Ferrucci L; Friedrich N; Gnewuch C; Goodarzi MO; Grarup N; Guo T; Hammer E; Hayes RB; Hicks AA; Hofman A; Houwing-Duistermaat JJ; Hu F; Hunter DJ; Husemoen LL; Isaacs A; Jacobs KB; Janssen JA; Jansson JO; Jehmlich N; Johnson S; Juul A; Karlsson M; Kilpelainen TO; Kovacs P; Kraft P; Li C; Linneberg A; Liu Y; Loos RJ; Body Composition Genetics Consortium; Lorentzon M; Lu Y; Maggio M; Magi R; Meigs J; Mellström D; Nauck M; Newman AB; Pollak MN; Pramstaller PP; Prokopenko I; Psaty BM; Reincke M; Rimm EB; Rotter JI; Saint-Pierre A; Schurmann C; Seshadri S; Sjögren K; Slagboom P; Strickler HD; Stumvoll M; Suh Y; Sun Q; Zhang C; Svensson J; Tanaka T; Tare A; Tönjes A; Uh HW; van Duijn CM; van Heemst D; Vandenput L; Vasan RS; Völker U; Willems SM; Ohlsson C; Wallaschofski H; Kaplan RC (2017)
      The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in ...
    • Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits 

      Teumer A; Qi Q; Nethander M; Aschard H; Bandinelli S; Beekman M; Berndt SI; Bidlingmaier M; Broer L; CHARGE Longevity Working Group; Cappola A; Ceda GP; Chanock S; Chen MH; Chen TC; Chen YD; Chung J; Del Greco M F; Eriksson J; Ferrucci L; Friedrich N; Gnewuch C; Goodarzi MO; Grarup N; Guo T; Hammer E; Hayes RB; Hicks AA; Hofman A; Houwing-Duistermaat JJ; Hu F; Hunter DJ; Husemoen LL; Isaacs A; Jacobs KB; Janssen JA; Jansson JO; Jehmlich N; Johnson S; Juul A; Karlsson M; Kilpelainen TO; Kovacs P; Kraft P; Li C; Linneberg A; Liu Y; Loos RJ; Body Composition Genetics Consortium; Lorentzon M; Lu Y; Maggio M; Magi R; Meigs J; Mellström D; Nauck M; Newman AB; Pollak MN; Pramstaller PP; Prokopenko I; Psaty BM; Reincke M; Rimm EB; Rotter JI; Saint-Pierre A; Schurmann C; Seshadri S; Sjögren K; Slagboom PE; Strickler HD; Stumvoll M; Suh Y; Sun Q; Zhang C; Svensson J; Tanaka T; Tare A; Tönjes A; Uh HW; van Duijn CM; van Heemst D; Vandenput L; Vasan RS; Völker U; Willems SM; Ohlsson C; Wallaschofski H; Kaplan RC (2016)
      The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in ...