Now showing items 1-7 of 7

    • Directional dominance on stature and cognition in diverse human populations 

      Joshi PK; Esko T; Mattsson H; Eklund N; Gandin I; Nutile T; Jackson AU; Schurmann C; Smith AV; Zhang W; Okada Y; Stančáková A; Faul JD; Zhao W; Bartz TM; Concas MP; Franceschini N; Enroth S; Vitart V; Trompet S; Guo X; Chasman DI; O'Connel JR; Corre T; Nongmaithem SS; Chen Y; Mangino M; Ruggiero D; Traglia M; Farmaki AE; Kacprowski T; Bjonnes A; van der Spek A; Wu Y; Giri AK; Yanek LR; Wang L; Hofer E; Rietveld CA; McLeod O; Cornelis MC; Pattaro C; Verweij N; Baumbach C; Abdellaoui A; Warren HR; Vuckovic D; Mei H; Bouchard C; Perry JR; Cappellani S; Mirza SS; Benton MC; Broeckel U; Medland SE; Lind PA; Malerba G; Drong A; Yengo L; Bielak LF; Zhi D; van der Most PJ; Shriner D; Mägi R; Hemani G; Karaderi T; Wang Z; Liu T; Demuth I; Zhao JH; Meng W; Lataniotis L; van der Laan SW; Bradfield JP; Wood AR; Bonnefond A; Ahluwalia TS; Hall LM; Salvi E; Yazar S; Carstensen L; de Haan HG; Abney M; Afzal U; Allison MA; Amin N; Asselbergs FW; Bakker SJ; Barr RG; Baumeister SE; Benjamin DJ; Bergmann S; Boerwinkle E; Bottinger EP; Campbell A; Chakravarti A; Chan Y; Chanock SJ; Chen C; Chen YD; Collins FS; Connell J; Correa A; Cupples LA; Smith GD; Davies G; Dörr M; Ehret G; Ellis SB; Feenstra B; Feitosa MF; Ford I; Fox CS; Frayling TM; Friedrich N; Geller F; Scotland G; Gillham-Nasenya I; Gottesman O; Graff M; Grodstein F; Gu C; Haley C; Hammond CJ; Harris SE; Harris TB; Hastie ND; Heard-Costa NL; Heikkilä K; Hocking LJ; Homuth G; Hottenga JJ; Huang J; Huffman JE; Hysi PG; Ikram MA; Ingelsson E; Joensuu A; Johansson Å; Jousilahti P; Jukema JW; Kähönen M; Kamatani Y; Kanoni S; Kerr SM; Khan NM; Koellinger P; Koistinen HA; Kooner MK; Kubo M; Kuusisto J; Lahti J; Launer LJ; Lea RA; Lehne B; Lehtimäki T; Liewald DC; Lind L; Loh M; Lokki ML; London SJ; Loomis SJ; Loukola A; Lu Y; Lumley T; Lundqvist A; Männistö S; Marques-Vidal P; Masciullo C; Matchan A; Mathias RA; Matsuda K; Meigs JB; Meisinger C; Meitinger T; Menni C; Mentch FD; Mihailov E; Milani L; Montasser ME; Montgomery GW; Morrison A; Myers RH; Nadukuru R; Navarro P; Nelis M; Nieminen MS; Nolte IM; O'Connor GT; Ogunniyi A; Padmanabhan S; Palmas WR; Pankow JS; Patarcic I; Pavani F; Peyser PA; Pietilainen K; Poulter N; Prokopenko I; Ralhan S; Redmond P; Rich SS; Rissanen H; Robino A; Rose LM; Rose R; Sala C; Salako B; Salomaa V; Sarin AP; Saxena R; Schmidt H; Scott LJ; Scott WR; Sennblad B; Seshadri S; Sever P; Shrestha S; Smith BH; Smith JA; Soranzo N; Sotoodehnia N; Southam L; Stanton AV; Stathopoulou MG; Strauch K; Strawbridge RJ; Suderman MJ; Tandon N; Tang ST; Taylor KD; Tayo BO; Töglhofer AM; Tomaszewski M; Tšernikova N; Tuomilehto J; Uitterlinden AG; Vaidya D; van Hylckama Vlieg A; van Setten J; Vasankari T; Vedantam S; Vlachopoulou E; Vozzi D; Vuoksimaa E; Waldenberger M; Ware EB; Wentworth-Shields W; Whitfield JB; Wild S; Willemsen G; Yajnik CS; Yao J; Zaza G; Zhu X; BioBank Japan Project; Salem RM; Melbye M; Bisgaard H; Samani NJ; Cusi D; Mackey DA; Cooper RS; Froguel P; Pasterkamp G; Grant SF; Hakonarson H; Ferrucci L; Scott RA; Morris AD; Palmer CN; Dedoussis G; Deloukas P; Bertram L; Lindenberger U; Berndt SI; Lindgren CM; Timpson NJ; Tönjes A; Munroe PB; Sørensen TI; Rotimi CN; Arnett DK; Oldehinkel AJ; Kardia SL; Balkau B; Gambaro G; Morris AP; Eriksson JG; Wright MJ; Martin NG; Hunt SC; Starr JM; Deary IJ; Griffiths LR; Tiemeier H; Pirastu N; Kaprio J; Wareham NJ; Pérusse L; Wilson JG; Girotto G; Caulfield MJ; Raitakari O; Boomsma DI; Gieger C; van der Harst P; Hicks AA; Kraft P; Sinisalo J; Knekt P; Johannesson M; Magnusson PK; Hamsten A; Schmidt R; Borecki IB; Vartiainen E; Becker DM; Bharadwaj D; Mohlke KL; Boehnke M; van Duijn CM; Sanghera DK; Teumer A; Zeggini E; Metspalu A; Gasparini P; Ulivi S; Ober C; Toniolo D; Rudan I; Porteous DJ; Ciullo M; Spector TD; Hayward C; Dupuis J; Loos RJ; Wright AF; Chandak GR; Vollenweider P; Shuldiner AR; Ridker PM; Rotter JI; Sattar N; Gyllensten U; North KE; Pirastu M; Psaty BM; Weir DR; Laakso M; Gudnason V; Takahashi A; Chambers JC; Kooner JS; Strachan DP; Campbell H; Hirschhorn JN; Perola M; Polašek O; Wilson JF (2015)
      Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant ...
    • Discovery and fine mapping of serum protein loci through transethnic meta-analysis 

      Franceschini N; van Rooij FJ; Prins BP; Feitosa MF; Karakas M; Eckfeldt JH; Folsom AR; Kopp J; Vaez A; Andrews JS; Baumert J; Boraska V; Broer L; Hayward C; Ngwa JS; Okada Y; Polasek O; Westra HJ; Wang YA; Del Greco M F; Glazer NL; Kapur K; Kema IP; Lopez LM; Schillert A; Smith AV; Winkler CA; Zgaga L; LifeLines Cohort Study; Bandinelli S; Bergmann S; Boban M; Bochud M; Chen YD; Davies G; Dehghan A; Ding J; Doering A; Durda JP; Ferrucci L; Franco OH; Franke L; Gunjaca G; Hofman A; Hsu FC; Kolcic I; Kraja A; Kubo M; Lackner KJ; Launer L; Loehr LR; Li G; Meisinger C; Nakamura Y; Schwienbacher C; Starr JM; Takahashi A; Torlak V; Uitterlinden AG; Vitart V; Waldenberger M; Wild PS; Kirin M; Zeller T; Zemunik T; Zhang Q; Ziegler A; Blankenberg S; Boerwinkle E; Borecki IB; Campbell H; Deary IJ; Frayling TM; Gieger C; Harris TB; Hicks AA; Koenig W; O' Donnell CJ; Fox CS; Pramstaller PP; Psaty BM; Reiner AP; Rotter JI; Rudan I; Snieder H; Tanaka T; van Duijn CM; Vollenweider P; Waeber G; Wilson JF; Witteman JC; Wolffenbuttel BH; Wright AF; Wu Q; Liu Y; Jenny NS; North KE; Felix JF; Alizadeh BZ; Cupples LA; Perry JR; Morris AP (2012)
      Many disorders are associated with altered serum protein concentrations, including malnutrition, cancer, and cardiovascular, kidney, and inflammatory diseases. Although these protein concentrations are highly heritable, ...
    • Discovery and fine mapping of serum protein loci through transethnic meta-analysis 

      Franceschini N; van Rooij FJ; Prins BP; Feitosa MF; Karakas M; Eckfeldt JH; Folsom AR; Kopp J; Vaez A; Andrews JS; Baumert J; Boraska V; Broer L; Hayward C; Ngwa JS; Okada Y; Polasek O; Westra HJ; Wang YA; Del Greco M F; Glazer NL; Kapur K; Kema IP; Lopez LM; Schillert A; Smith AV; Winkler CA; Zgaga L; LifeLines Cohort Study; Bandinelli S; Bergmann S; Boban M; Bochud M; Chen YD; Davies G; Dehghan A; Ding J; Doering A; Durda JP; Ferrucci L; Franco OH; Franke L; Gunjaca G; Hofman A; Hsu FC; Kolcic I; Kraja A; Kubo M; Lackner KJ; Launer L; Loehr LR; Li G; Meisinger C; Nakamura Y; Schwienbacher C; Starr JM; Takahashi A; Torlak V; Uitterlinden AG; Vitart V; Waldenberger M; Wild PS; Kirin M; Zeller T; Zemunik T; Zhang Q; Ziegler A; Blankenberg S; Boerwinkle E; Borecki IB; Campbell H; Deary IJ; Frayling TM; Gieger C; Harris TB; Hicks AA; Koenig W; O' Donnell CJ; Fox CS; Pramstaller PP; Psaty BM; Reiner AP; Rotter JI; Rudan I; Snieder H; Tanaka T; van Duijn CM; Vollenweider P; Waeber G; Wilson JF; Witteman JC; Wolffenbuttel BH; Wright AF; Wu Q; Liu Y; Jenny NS; North KE; Felix JF; Alizadeh BZ; Cupples LA; Perry JR; Morris AP (2012)
      Many disorders are associated with altered serum protein concentrations, including malnutrition, cancer, and cardiovascular, kidney, and inflammatory diseases. Although these protein concentrations are highly heritable, ...
    • Genetic studies of body mass index yield new insights for obesity biology 

      Locke AE; Kahali B; Berndt SI; Justice AE; Pers TH; Day FR; Powell C; Vedantam S; Buchkovich ML; Yang J; Croteau-Chonka DC; Esko T; Fall T; Ferreira T; Gustafsson S; Kutalik Z; Luan J; Mägi R; Randall JC; Winkler TW; Wood AR; Workalemahu T; Faul JD; Smith JA; Hua Zhao J; Zhao W; Chen J; Fehrmann R; Hedman ÅK; Karjalainen J; Schmidt EM; Absher D; Amin N; Anderson D; Beekman M; Bolton JL; Bragg-Gresham JL; Buyske S; Demirkan A; Deng G; Ehret GB; Feenstra B; Feitosa MF; Fischer K; Goel A; Gong J; Jackson AU; Kanoni S; Kleber ME; Kristiansson K; Lim U; Lotay V; Mangino M; Mateo Leach I; Medina-Gomez C; Medland SE; Nalls MA; Palmer CD; Pasko D; Pechlivanis S; Peters MJ; Prokopenko I; Shungin D; Stančáková A; Strawbridge RJ; Ju Sung Y; Tanaka T; Teumer A; Trompet S; van der Laan SW; van Setten J; van Vliet-Ostaptchouk JV; Wang Z; Yengo L; Zhang W; Isaacs A; Albrecht E; Ärnlöv J; Arscott GM; Attwood AP; Bandinelli S; Barrett A; Bas IN; Bellis C; Bennett AJ; Berne C; Blagieva R; Blüher M; Böhringer S; Bonnycastle LL; Böttcher Y; Boyd HA; Bruinenberg M; Caspersen IH; Ida Chen YD; Clarke R; Daw EW; de Craen AJ; Delgado G; Dimitriou M; Doney AS; Eklund N; Estrada K; Eury E; Folkersen L; Fraser RM; Garcia ME; Geller F; Giedraitis V; Gigante B; Go AS; Golay A; Goodall AH; Gordon SD; Gorski M; Grabe HJ; Grallert H; Grammer TB; Gräßler J; Grönberg H; Groves CJ; Gusto G; Haessler J; Hall P; Haller T; Hallmans G; Hartman CA; Hassinen M; Hayward C; Heard-Costa NL; Helmer Q; Hengstenberg C; Holmen O; Hottenga JJ; James AL; Jeff JM; Johansson Å; Jolley J; Juliusdottir T; Kinnunen L; Koenig W; Koskenvuo M; Kratzer W; Laitinen J; Lamina C; Leander K; Lee NR; Lichtner P; Lind L; Lindström J; Sin Lo K; Lobbens S; Lorbeer R; Lu Y; Mach F; Magnusson PK; Mahajan A; McArdle WL; McLachlan S; Menni C; Merger S; Mihailov E; Milani L; Moayyeri A; Monda KL; Morken MA; Mulas A; Müller G; Müller-Nurasyid M; Musk AW; Nagaraja R; Nöthen MM; Nolte IM; Pilz S; Rayner NW; Renstrom F; Rettig R; Ried JS; Ripke S; Robertson NR; Rose LM; Sanna S; Scharnagl H; Scholtens S; Schumacher FR; Scott WR; Seufferlein T; Shi J; Vernon Smith A; Smolonska J; Stanton AV; Steinthorsdottir V; Stirrups K; Stringham HM; Sundström J; Swertz MA; Swift AJ; Syvänen AC; Tan ST; Tayo BO; Thorand B; Thorleifsson G; Tyrer JP; Uh HW; Vandenput L; Verhulst FC; Vermeulen SH; Verweij N; Vonk JM; Waite LL; Warren HR; Waterworth D; Weedon MN; Wilkens LR; Willenborg C; Wilsgaard T; Wojczynski MK; Wong A; Wright AF; Zhang Q; LifeLines Cohort Study; Brennan EP; Choi M; Dastani Z; Drong AW; Eriksson P; Franco-Cereceda A; Gådin JR; Gharavi AG; Goddard ME; Handsaker RE; Huang J; Karpe F; Kathiresan S; Keildson S; Kiryluk K; Kubo M; Lee JY; Liang L; Lifton RP; Ma B; McCarroll SA; McKnight AJ; Min JL; Moffatt MF; Montgomery GW; Murabito JM; Nicholson G; Nyholt DR; Okada Y; Perry JR; Dorajoo R; Reinmaa E; Salem RM; Sandholm N; Scott RA; Stolk L; Takahashi A; Van't Hooft FM; Vinkhuyzen AA; Westra HJ; Zheng W; Zondervan KT; ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium; Heath AC; Arveiler D; Bakker SJ; Beilby J; Bergman RN; Blangero J; Bovet P; Campbell H; Caulfield MJ; Cesana G; Chakravarti A; Chasman DI; Chines PS; Collins FS; Crawford DC; Cupples LA; Cusi D; Danesh J; de Faire U; den Ruijter HM; Dominiczak AF; Erbel R; Erdmann J; Eriksson JG; Farrall M; Felix SB; Ferrannini E; Ferrières J; Ford I; Forouhi NG; Forrester T; Franco OH; Gansevoort RT; Gejman PV; Gieger C; Gottesman O; Gudnason V; Gyllensten U; Hall AS; Harris TB; Hattersley AT; Hicks AA; Hindorff LA; Hingorani AD; Hofman A; Homuth G; Hovingh GK; Humphries SE; Hunt SC; Hyppönen E; Illig T; Jacobs KB; Jarvelin MR; Jöckel KH; Johansen B; Jousilahti P; Jukema JW; Jula AM; Kaprio J; Kastelein JJ; Keinanen-Kiukaanniemi SM; Kiemeney LA; Knekt P; Kooner JS; Kooperberg C; Kovacs P; Kraja AT; Kumari M; Kuusisto J; Lakka TA; Langenberg C; Le Marchand L; Lehtimäki T; Lyssenko V; Männistö S; Marette A; Matise TC; McKenzie CA; McKnight B; Moll FL; Morris AD; Morris AP; Murray JC; Nelis M; Ohlsson C; Oldehinkel AJ; Ong KK; Madden PA; Pasterkamp G; Peden JF; Peters A; Postma DS; Pramstaller PP; Price JF; Qi L; Raitakari OT; Rankinen T; Rao DC; Rice TK; Ridker PM; Rioux JD; Ritchie MD; Rudan I; Salomaa V; Samani NJ; Saramies J; Sarzynski MA; Schunkert H; Schwarz PE; Sever P; Shuldiner AR; Sinisalo J; Stolk RP; Strauch K; Tönjes A; Trégouët DA; Tremblay A; Tremoli E; Virtamo J; Vohl MC; Völker U; Waeber G; Willemsen G; Witteman JC; Zillikens MC; Adair LS; Amouyel P; Asselbergs FW; Assimes TL; Bochud M; Boehm BO; Boerwinkle E; Bornstein SR; Bottinger EP; Bouchard C; Cauchi S; Chambers JC; Chanock SJ; Cooper RS; de Bakker PI; Dedoussis G; Ferrucci L; Franks PW; Froguel P; Groop LC; Haiman CA; Hamsten A; Hui J; Hunter DJ; Hveem K; Kaplan RC; Kivimaki M; Kuh D; Laakso M; Liu Y; Martin NG; März W; Melbye M; Metspalu A; Moebus S; Munroe PB; Njølstad I; Oostra BA; Palmer CN; Pedersen NL; Perola M; Pérusse L; Peters U; Power C; Quertermous T; Rauramaa R; Rivadeneira F; Saaristo TE; Saleheen D; Sattar N; Schadt EE; Schlessinger D; Slagboom PE; Snieder H; Spector TD; Thorsteinsdottir U; Stumvoll M; Tuomilehto J; Uitterlinden AG; Uusitupa M; van der Harst P; Walker M; Wallaschofski H; Wareham NJ; Watkins H; Weir DR; Wichmann HE; Wilson JF; Zanen P; Borecki IB; Deloukas P; Fox CS; Heid IM; O'Connell JR; Strachan DP; Stefansson K; van Duijn CM; Abecasis GR; Franke L; Frayling TM; McCarthy MI; Visscher PM; Scherag A; Willer CJ; Boehnke M; Mohlke KL; Lindgren CM; Beckmann JS; Barroso I; North KE; Ingelsson E; Hirschhorn JN; Loos RJ; Speliotes EK (2015)
      Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure ...
    • Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations 

      Okada Y; Sim X; Go MJ; Wu JY; Gu D; Takeuchi F; Takahashi A; Maeda S; Tsunoda T; Chen P; Lim SC; Wong TY; Liu J; Young TL; Aung T; Seielstad M; Teo YY; Kim YJ; Lee JY; Han BG; Kang D; Chen CH; Tsai FJ; Chang LC; Fann SJ; Mei H; Rao DC; Hixson JE; Chen S; Katsuya T; Isono M; Ogihara T; Chambers JC; Zhang W; Kooner JS; KidneyGen Consortium; CKDGen Consortium; Albrecht E; GUGC consortium; Yamamoto K; Kubo M; Nakamura Y; Kamatani N; Kato N; He J; Chen YT; Cho YS; Tai ES; Tanaka T (2012)
      Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a ...
    • New gene functions in megakaryopoiesis and platelet formation 

      Gieger C; Radhakrishnan A; Cvejic A; Tang W; Porcu E; Pistis G; Serbanovic-Canic J; Elling U; Goodall AH; Labrune Y; Lopez LM; Mägi R; Meacham S; Okada Y; Pirastu N; Sorice R; Teumer A; Voss K; Zhang W; Ramirez-Solis R; Bis JC; Ellinghaus D; Gögele M; Hottenga JJ; Langenberg C; Kovacs P; O'Reilly PF; Shin SY; Esko T; Hartiala J; Kanoni S; Murgia F; Parsa A; Stephens J; van der Harst P; Ellen van der Schoot C; Allayee H; Attwood A; Balkau B; Bastardot F; Basu S; Baumeister SE; Biino G; Bomba L; Bonnefond A; Cambien F; Chambers JC; Cucca F; D'Adamo P; Davies G; de Boer RA; de Geus EJ; Döring A; Elliott P; Erdmann J; Evans DM; Falchi M; Feng W; Folsom AR; Frazer IH; Gibson QD; Glazer NL; Hammond C; Hartikainen AL; Heckbert SR; Hengstenberg C; Hersch M; Illig T; Loos RJ; Jolley J; Khaw KT; Kühnel B; Kyrtsonis MC; Lagou V; Lloyd-Jones H; Lumley T; Mangino M; Maschio A; Mateo Leach I; McKnight B; Memari Y; Mitchell BD; Montgomery GW; Nakamura Y; Nauck M; Navis G; Nöthlings U; Nolte IM; Porteous DJ; Pouta A; Pramstaller PP; Pullat J; Ring SM; Rotter JI; Ruggiero D; Ruokonen A; Sala C; Samani NJ; Sambrook J; Schlessinger D; Schreiber S; Schunkert H; Scott J; Smith NL; Snieder H; Starr JM; Stumvoll M; Takahashi A; Tang WH; Taylor K; Tenesa A; Lay Thein S; Tönjes A; Uda M; Ulivi S; van Veldhuisen DJ; Visscher PM; Völker U; Wichmann HE; Wiggins KL; Willemsen G; Yang TP; Hua Zhao J; Zitting P; Bradley JR; Dedoussis GV; Gasparini P; Hazen SL; Metspalu A; Pirastu M; Shuldiner AR; Joost van Pelt L; Zwaginga JJ; Boomsma DI; Deary IJ; Franke A; Froguel P; Ganesh SK; Jarvelin MR; Martin NG; Meisinger C; Psaty BM; Spector TD; Wareham NJ; Akkerman JW; Ciullo M; Deloukas P; Greinacher A; Jupe S; Kamatani N; Khadake J; Kooner JS; Penninger J; Prokopenko I; Stemple D; Toniolo D; Wernisch L; Sanna S; Hicks AA; Rendon A; Ferreira MA; Ouwehand WH; Soranzo N (2011)
      Platelets are the second most abundant cell type in blood and are essential for maintaining haemostasis. Their count and volume are tightly controlled within narrow physiological ranges, but there is only limited understanding ...
    • A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations 

      Imamura M; Maeda S; Yamauchi T; Hara K; Yasuda K; Morizono T; Takahashi A; Horikoshi M; Nakamura M; Fujita H; Tsunoda T; Kubo M; Watada H; Maegawa H; Okada-Iwabu M; Iwabu M; Shojima N; Ohshige T; Omori S; Iwata M; Hirose H; Kaku K; Ito C; Tanaka Y; Tobe K; Kashiwagi A; Kawamori R; Kasuga M; Kamatani N; DIAGRAM Consortium; Nakamura Y; Kadowaki T (2012)
      To identify a novel susceptibility locus for type 2 diabetes, we performed an imputation-based, genome-wide association study (GWAS) in a Japanese population using newly obtained imputed-genotype data for 2 229 890 ...