Now showing items 1-5 of 5

    • Associations of autozygosity with a broad range of human phenotypes 

      Clark DW; Okada Y; Moore KHS; Mason D; Pirastu N; Gandin I; Mattsson H; Barnes CLK; Lin K; Zhao JH; Deelen P; Rohde R; Schurmann C; Guo X; Giulianini F; Zhang W; Medina-Gomez C; Karlsson R; Bao Y; Bartz TM; Baumbach C; Biino G; Bixley MJ; Brumat M; Chai JF; Corre T; Cousminer DL; Dekker AM; Eccles DA; van Eijk KR; Fuchsberger C; Gao H; Germain M; Gordon SD; de Haan HG; Harris SE; Hofer E; Huerta-Chagoya A; Igartua C; Jansen IE; Jia Y; Kacprowski T; Karlsson T; Kleber ME; Li SA; Li-Gao R; Mahajan A; Matsuda K; Meidtner K; Meng W; Montasser ME; van der Most PJ; Munz M; Nutile T; Palviainen T; Prasad G; Prasad RB; Priyanka TDS; Rizzi F; Salvi E; Sapkota BR; Shriner D; Skotte L; Smart MC; Smith AV; van der Spek A; Spracklen CN; Strawbridge RJ; Tajuddin SM; Trompet S; Turman C; Verweij N; Viberti C; Wang L; Warren HR; Wootton RE; Yanek LR; Yao J; Yousri NA; Zhao W; Adeyemo AA; Afaq S; Aguilar-Salinas CA; Akiyama M; Albert ML; Allison MA; Alver M; Aung T; Azizi F; Bentley AR; Boeing H; Boerwinkle E; Borja JB; de Borst GJ; Bottinger EP; Broer L; Campbell H; Chanock S; Chee ML; Chen G; Chen YI; Chen Z; Chiu YF; Cocca M; Collins FS; Concas MP; Corley J; Cugliari G; van Dam RM; Damulina A; Daneshpour MS; Day FR; Delgado GE; Dhana K; Doney ASF; Dörr M; Doumatey AP; Dzimiri N; Ebenesersdóttir SS; Elliott J; Elliott P; Ewert R; Felix JF; Fischer K; Freedman BI; Girotto G; Goel A; Gögele M; Goodarzi MO; Graff M; Granot-Hershkovitz E; Grodstein F; Guarrera S; Gudbjartsson DF; Guity K; Gunnarsson B; Guo Y; Hagenaars SP; Haiman CA; Halevy A; Harris TB; Hedayati M; van Heel DA; Hirata M; Höfer I; Hsiung CA; Huang J; Hung YJ; Ikram MA; Jagadeesan A; Jousilahti P; Kamatani Y; Kanai M; Kerrison ND; Kessler T; Khaw KT; Khor CC; de Kleijn DPV; Koh WP; Kolcic I; Kraft P; Krämer BK; Kutalik Z; Kuusisto J; Langenberg C; Launer LJ; Lawlor DA; Lee IT; Lee WJ; Lerch MM; Li L; Liu J; Loh M; London SJ; Loomis S; Lu Y; Luan J; Mägi R; Manichaikul AW; Manunta P; Másson G; Matoba N; Mei XW; Meisinger C; Meitinger T; Mezzavilla M; Milani L; Millwood IY; Momozawa Y; Moore A; Morange PE; Moreno-Macías H; Mori TA; Morrison AC; Muka T; Murakami Y; Murray AD; de Mutsert R; Mychaleckyj JC; Nalls MA; Nauck M; Neville MJ; Nolte IM; Ong KK; Orozco L; Padmanabhan S; Pálsson G; Pankow JS; Pattaro C; Pattie A; Polasek O; Poulter N; Pramstaller PP; Quintana-Murci L; Räikkönen K; Ralhan S; Rao DC; van Rheenen W; Rich SS; Ridker PM; Rietveld CA; Robino A; van Rooij FJA; Ruggiero D; Saba Y; Sabanayagam C; Sabater-Lleal M; Sala CF; Salomaa V; Sandow K; Schmidt H; Scott LJ; Scott WR; Sedaghati-Khayat B; Sennblad B; van Setten J; Sever PJ; Sheu WH; Shi Y; Shrestha S; Shukla SR; Sigurdsson JK; Sikka TT; Singh JR; Smith BH; Stančáková A; Stanton A; Starr JM; Stefansdottir L; Straker L; Sulem P; Sveinbjornsson G; Swertz MA; Taylor AM; Taylor KD; Terzikhan N; Tham YC; Thorleifsson G; Thorsteinsdottir U; Tillander A; Tracy RP; Tusié-Luna T; Tzoulaki I; Vaccargiu S; Vangipurapu J; Veldink JH; Vitart V; Völker U; Vuoksimaa E; Wakil SM; Waldenberger M; Wander GS; Wang YX; Wareham NJ; Wild S; Yajnik CS; Yuan JM; Zeng L; Zhang L; Zhou J; Amin N; Asselbergs FW; Bakker SJL; Becker DM; Lehne B; Bennett DA; van den Berg LH; Berndt SI; Bharadwaj D; Bielak LF; Bochud M; Boehnke M; Bouchard C; Bradfield JP; Brody JA; Campbell A; Carmi S; Caulfield MJ; Cesarini D; Chambers JC; Chandak GR; Cheng CY; Ciullo M; Cornelis M; Cusi D; Smith GD; Deary IJ; Dorajoo R; van Duijn CM; Ellinghaus D; Erdmann J; Eriksson JG; Evangelou E; Evans MK; Faul JD; Feenstra B; Feitosa M; Foisy S; Franke A; Friedlander Y; Gasparini P; Gieger C; Gonzalez C; Goyette P; Grant SFA; Griffiths LR; Groop L; Gudnason V; Gyllensten U; Hakonarson H; Hamsten A; van der Harst P; Heng CK; Hicks AA; Hochner H; Huikuri H; Hunt SC; Jaddoe VWV; De Jager PL; Johannesson M; Johansson Å; Jonas JB; Jukema JW; Junttila J; Kaprio J; Kardia SLR; Karpe F; Kumari M; Laakso M; van der Laan SW; Lahti J; Laudes M; Lea RA; Lieb W; Lumley T; Martin NG; März W; Matullo G; McCarthy MI; Medland SE; Merriman TR; Metspalu A; Meyer BF; Mohlke KL; Montgomery GW; Mook-Kanamori D; Munroe PB; North KE; Nyholt DR; O'connell JR; Ober C; Oldehinkel AJ; Palmas W; Palmer C; Pasterkamp GG; Patin E; Pennell CE; Perusse L; Peyser PA; Pirastu M; Polderman TJC; Porteous DJ; Posthuma D; Psaty BM; Rioux JD; Rivadeneira F; Rotimi C; Rotter JI; Rudan I; Den Ruijter HM; Sanghera DK; Sattar N; Schmidt R; Schulze MB; Schunkert H; Scott RA; Shuldiner AR; Sim X; Small N; Smith JA; Sotoodehnia N; Tai ES; Teumer A; Timpson NJ; Toniolo D; Tregouet DA; Tuomi T; Vollenweider P; Wang CA; Weir DR; Whitfield JB; Wijmenga C; Wong TY; Wright J; Yang J; Yu L; Zemel BS; Zonderman AB; Perola M; Magnusson PKE; Uitterlinden AG; Kooner JS; Chasman DI; Loos RJF; Franceschini N; Franke L; Haley CS; Hayward C; Walters RG; Perry JRB; Esko T; Helgason A; Stefansson K; Joshi PK; Kubo M; Wilson JF (2019)
      In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction ...
    • A catalog of genetic loci associated with kidney function from analyses of a million individuals 

      Wuttke M; Li Y; Li M; Sieber KB; Feitosa MF; Gorski M; Tin A; Wang L; Chu AY; Hoppmann A; Kirsten H; Giri A; Chai JF; Sveinbjornsson G; Tayo BO; Nutile T; Fuchsberger C; Marten J; Cocca M; Ghasemi S; Xu Y; Horn K; Noce D; van der Most PJ; Sedaghat S; Yu Z; Akiyama M; Afaq S; Ahluwalia TS; Almgren P; Amin N; Ärnlöv J; Bakker SJL; Bansal N; Baptista D; Bergmann S; Biggs ML; Biino G; Boehnke M; Boerwinkle E; Boissel M; Bottinger EP; Boutin TS; Brenner H; Brumat M; Burkhardt R; Butterworth AS; Campana E; Campbell A; Campbell H; Canouil M; Carroll RJ; Catamo E; Chambers JC; Chee ML; Chen X; Cheng CY; Cheng Y; Christensen K; Cifkova R; Ciullo M; Concas MP; Cook JP; Coresh J; Corre T; Sala CF; Cusi D; Danesh J; Daw EW; de Borst MH; De Grandi A; de Mutsert R; de Vries APJ; Degenhardt F; Delgado G; Demirkan A; Di Angelantonio E; Dittrich K; Divers J; Dorajoo R; Eckardt KU; Ehret G; Elliott P; Endlich K; Evans MK; Felix JF; Foo VHX; Franco OH; Franke A; Freedman BI; Freitag-Wolf S; Friedlander Y; Froguel P; Gansevoort RT; Gao H; Gasparini P; Gaziano JM; Giedraitis V; Gieger C; Girotto G; Giulianini F; Gögele M; Gordon SD; Gudbjartsson DF; Gudnason V; Haller T; Hamet P; Harris TB; Hartman CA; Hayward C; Hellwege JN; Heng CK; Hicks AA; Hofer E; Huang W; Hutri-Kähönen N; Hwang SJ; Ikram MA; Indridason OS; Ingelsson E; Ising M; Jaddoe VWV; Jakobsdottir J; Jonas JB; Joshi PK; Josyula NS; Jung B; Kähönen M; Kamatani Y; Kammerer CM; Kanai M; Kastarinen M; Kerr SM; Khor CC; Kiess W; Kleber ME; Koenig W; Kooner JS; Körner A; Kovacs P; Kraja AT; Krajcoviechova A; Kramer H; Krämer BK; Kronenberg F; Kubo M; Kühnel B; Kuokkanen M; Kuusisto J; La Bianca M; Laakso M; Lange LA; Langefeld CD; Lee JJ; Lehne B; Lehtimäki T; Lieb W; Lim SC; Lind L; Lindgren CM; Liu J; Loeffler M; Loos RJF; Lucae S; Lukas MA; Lyytikäinen LP; Mägi R; Magnusson PKE; Mahajan A; Martin NG; Martins J; März W; Mascalzoni D; Matsuda K; Meisinger C; Meitinger T; Melander O; Metspalu A; Mikaelsdottir EK; Milaneschi Y; Miliku K; Mishra PP; Mohlke KL; Mononen N; Montgomery GW; Mook-Kanamori DO; Mychaleckyj JC; Nadkarni GN; Nalls MA; Nauck M; Nikus K; Ning B; Nolte IM; Noordam R; O'Connell J; O'Donoghue ML; Olafsson I; Oldehinkel AJ; Orho-Melander M; Ouwehand WH; Padmanabhan S; Palmer ND; Palsson R; Penninx BWJH; Perls T; Perola M; Pirastu M; Pirastu N; Pistis G; Podgornaia AI; Polasek O; Ponte B; Porteous DJ; Poulain T; Pramstaller PP; Preuss MH; Prins BP; Province MA; Rabelink TJ; Raffield LM; Raitakari OT; Reilly DF; Rettig R; Rheinberger M; Rice KM; Ridker PM; Rivadeneira F; Rizzi F; Roberts DJ; Robino A; Rossing P; Rudan I; Rueedi R; Ruggiero D; Ryan KA; Saba Y; Sabanayagam C; Salomaa V; Salvi E; Saum KU; Schmidt H; Schmidt R; Schöttker B; Schulz CA; Schupf N; Shaffer CM; Shi Y; Smith AV; Smith BH; Soranzo N; Spracklen CN; Strauch K; Stringham HM; Stumvoll M; Svensson PO; Szymczak S; Tai ES; Tajuddin SM; Tan NYQ; Taylor KD; Teren A; Tham YC; Thiery J; Thio CHL; Thomsen H; Thorleifsson G; Toniolo D; Tönjes A; Tremblay J; Tzoulaki I; Uitterlinden AG; Vaccargiu S; van Dam RM; van der Harst P; van Duijn CM; Velez Edward DR; Verweij N; Vogelezang S; Völker U; Vollenweider P; Waeber G; Waldenberger M; Wallentin L; Wang YX; Wang C; Waterworth DM; Bin Wei W; White H; Whitfield JB; Wild SH; Wilson JF; Wojczynski MK; Wong C; Wong TY; Xu L; Yang Q; Yasuda M; Yerges-Armstrong LM; Zhang W; Zonderman AB; Rotter JI; Bochud M; Psaty BM; Vitart V; Wilson JG; Dehghan A; Parsa A; Chasman DI; Ho K; Morris AP; Devuyst O; Akilesh S; Pendergrass SA; Sim X; Böger CA; Okada Y; Edwards TL; Snieder H; Stefansson K; Hung AM; Heid IM; Scholz M; Teumer A; Köttgen A; Pattaro C (2019)
      Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate ...
    • Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity 

      Joshi PK; Pirastu N; Kentistou KA; Fischer K; Hofer E; Schraut KE; Clark DW; Nutile T; Barnes CLK; Timmers PRHJ; Shen X; Gandin I; McDaid AF; Hansen TF; Gordon SD; Giulianini F; Boutin TS; Abdellaoui A; Zhao W; Medina-Gomez C; Bartz TM; Trompet S; Lange LA; Raffield L; van der Spek A; Galesloot TE; Proitsi P; Yanek LR; Bielak LF; Payton A; Murgia F; Concas MP; Biino G; Tajuddin SM; Seppälä I; Amin N; Boerwinkle E; Børglum AD; Campbell A; Demerath EW; Demuth I; Faul JD; Ford I; Gialluisi A; Gögele M; Graff M; Hingorani A; Hottenga JJ; Hougaard DM; Hurme MA; Ikram MA; Jylhä M; Kuh D; Ligthart L; Lill CM; Lindenberger U; Lumley T; Mägi R; Marques-Vidal P; Medland SE; Milani L; Nagy R; Ollier WER; Peyser PA; Pramstaller PP; Ridker PM; Rivadeneira F; Ruggiero D; Saba Y; Schmidt R; Schmidt H; Slagboom PE; Smith BH; Smith JA; Sotoodehnia N; Steinhagen-Thiessen E; van Rooij FJA; Verbeek AL; Vermeulen SH; Vollenweider P; Wang Y; Werge T; Whitfield JB; Zonderman AB; Lehtimäki T; Evans MK; Pirastu M; Fuchsberger C; Bertram L; Pendleton N; Kardia SLR; Ciullo M; Becker DM; Wong A; Psaty BM; van Duijn CM; Wilson JG; Jukema JW; Kiemeney L; Uitterlinden AG; Franceschini N; North KE; Weir DR; Metspalu A; Boomsma DI; Hayward C; Chasman D; Martin NG; Sattar N; Campbell H; Esko T; Kutalik Z; Wilson JF (2017)
      Genomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of 606,059 parents' survival, we discover two regions associated with longevity ...
    • NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality 

      Böger CA; Gorski M; McMahon GM; Xu H; Chang YC; van der Most PJ; Navis G; Nolte IM; de Borst MH; Zhang W; Lehne B; Loh M; Tan ST; Boerwinkle E; Grams ME; Sekula P; Li M; Wilmot B; Moon JG; Scheet P; Cucca F; Xiao X; Lyytikäinen LP; Delgado G; Grammer TB; Kleber ME; Sedaghat S; Rivadeneira F; Corre T; Kutalik Z; Bergmann S; Nielson CM; Srikanth P; Teumer A; Müller-Nurasyid M; Brockhaus AC; Pfeufer A; Rathmann W; Peters A; Matsumoto M; de Andrade M; Atkinson EJ; Robinson-Cohen C; de Boer IH; Hwang SJ; Heid IM; Gögele M; Concas MP; Tanaka T; Bandinelli S; Nalls MA; Singleton A; Tajuddin SM; Adeyemo A; Zhou J; Doumatey A; McWeeney S; Murabito J; Franceschini N; Flessner M; Shlipak M; Wilson JG; Chen G; Rotimi CN; Zonderman AB; Evans MK; Ferrucci L; Devuyst O; Pirastu M; Shuldiner A; Hicks AA; Pramstaller PP; Kestenbaum B; Kardia SL; Turner ST; Study LC; Briske TE; Gieger C; Strauch K; Meisinger C; Meitinger T; Völker U; Nauck M; Völzke H; Vollenweider P; Bochud M; Waeber G; Kähönen M; Lehtimäki T; März W; Dehghan A; Franco OH; Uitterlinden AG; Hofman A; Taylor HA; Chambers JC; Kooner JS; Fox CS; Hitzemann R; Orwoll ES; Pattaro C; Schlessinger D; Köttgen A; Snieder H; Parsa A; Cohen DM (2017)
      Disorders of water balance, an excess or deficit of total body water relative to body electrolyte content, are common and ascertained by plasma hypo- or hypernatremia, respectively. We performed a two-stage genome-wide ...
    • Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels 

      Tin A; Marten J; Halperin Kuhns VL; Li Y; Wuttke M; Kirsten H; Sieber KB; Qiu C; Gorski M; Yu Z; Giri A; Sveinbjornsson G; Li M; Chu AY; Hoppmann A; O'Connor LJ; Prins B; Nutile T; Noce D; Akiyama M; Cocca M; Ghasemi S; van der Most PJ; Horn K; Xu Y; Fuchsberger C; Sedaghat S; Afaq S; Amin N; Ärnlöv J; Bakker SJL; Bansal N; Baptista D; Bergmann S; Biggs ML; Biino G; Boerwinkle E; Bottinger EP; Boutin TS; Brumat M; Burkhardt R; Campana E; Campbell A; Campbell H; Carroll RJ; Catamo E; Chambers JC; Ciullo M; Concas MP; Coresh J; Corre T; Cusi D; Felicita SC; de Borst MH; De Grandi A; de Mutsert R; de Vries APJ; Delgado G; Demirkan A; Devuyst O; Dittrich K; Eckardt KU; Ehret G; Endlich K; Evans MK; Gansevoort RT; Gasparini P; Giedraitis V; Gieger C; Girotto G; Gögele M; Gordon SD; Gudbjartsson DF; Gudnason V; Haller T; Hamet P; Harris TB; Hayward C; Hicks AA; Hofer E; Holm H; Huang W; Hutri-Kähönen N; Hwang SJ; Ikram MA; Lewis RM; Ingelsson E; Jakobsdottir J; Jonsdottir I; Jonsson H; Joshi PK; Josyula NS; Jung B; Kähönen M; Kamatani Y; Kanai M; Kerr SM; Kiess W; Kleber ME; Koenig W; Kooner JS; Körner A; Kovacs P; Krämer BK; Kronenberg F; Kubo M; Kühnel B; La Bianca M; Lange LA; Lehne B; Lehtimäki T; Liu J; Loeffler M; Loos RJF; Lyytikäinen LP; Magi R; Mahajan A; Martin NG; März W; Mascalzoni D; Matsuda K; Meisinger C; Meitinger T; Metspalu A; Milaneschi Y; O'Donnell CJ; Wilson OD; Gaziano JM; Mishra PP; Mohlke KL; Mononen N; Montgomery GW; Mook-Kanamori DO; Müller-Nurasyid M; Nadkarni GN; Nalls MA; Nauck M; Nikus K; Ning B; Nolte IM; Noordam R; O'Connell JR; Olafsson I; Padmanabhan S; Penninx BWJH; Perls T; Peters A; Pirastu M; Pirastu N; Pistis G; Polasek O; Ponte B; Porteous DJ; Poulain T; Preuss MH; Rabelink TJ; Raffield LM; Raitakari OT; Rettig R; Rheinberger M; Rice KM; Rizzi F; Robino A; Rudan I; Krajcoviechova A; Cifkova R; Rueedi R; Ruggiero D; Ryan KA; Saba Y; Salvi E; Schmidt H; Schmidt R; Shaffer CM; Smith AV; Smith BH; Spracklen CN; Strauch K; Stumvoll M; Sulem P; Tajuddin SM; Teren A; Thiery J; Thio CHL; Thorsteinsdottir U; Toniolo D; Tönjes A; Tremblay J; Uitterlinden AG; Vaccargiu S; van der Harst P; van Duijn CM; Verweij N; Völker U; Vollenweider P; Waeber G; Waldenberger M; Whitfield JB; Wild SH; Wilson JF; Yang Q; Zhang W; Zonderman AB; Bochud M; Wilson JG; Pendergrass SA; Ho K; Parsa A; Pramstaller PP; Psaty BM; Böger CA; Snieder H; Butterworth AS; Okada Y; Edwards TL; Stefansson K; Susztak K; Scholz M; Heid IM; Hung AM; Teumer A; Pattaro C; Woodward OM; Vitart V; Köttgen A (2019)
      Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, ...