Now showing items 1-6 of 6

    • Abnormal premotor-motor interaction in heterozygous Parkin- and Pink1 mutation carriers 

      Weissbach A; Bäumer T; Pramstaller PP; Brüggemann N; Tadic V; Chen R; Klein C; Münchau A (2017)
      OBJECTIVES: Mutations in the Parkin and PINK1 gene account for the majority of autosomal recessive early-onset Parkinson cases. There is increasing evidence that clinically asymptomatic subjects with single heterozygous ...
    • Autosomal dominant Parkinson's disease in a large German pedigree 

      Brüggemann N; Külper W; Hagenah J; Bauer P; Pattaro C; Tadic V; Lohnau T; Winkler S; Tönnies H; Sprenger A; Pramstaller P; Rolfs A; Siebert R; Riess O; Vieregge P; Lohmann K; Klein C (2012)
      OBJECTIVE: While several genes have been identified to cause Parkinson's disease (PD), monogenic forms explain only a small proportion of cases. We report clinical and genetic results in a large family with late-onset ...
    • Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease 

      Kertelge L; Brüggemann N; Schmidt A; Tadic V; Wisse C; Dankert S; Drude L; van der Vegt J; Siebner H; Pawlack H; Pramstaller PP; Behrens MI; Ramirez A; Reichel D; Buhmann C; Hagenah J; Klein C; Lohmann K; Kasten M (2010)
      Olfaction is typically impaired in idiopathic Parkinson's disease (IPD), but its role is uncertain in monogenic PD. Diminished color discrimination has been suggested as another early sign of dopaminergic dysfunction but ...
    • Influence of L-dopa on subtle motor signs in heterozygous Parkin- and PINK1 mutation carriers 

      Weissbach A; König IR; Hückelheim K; Pramstaller PP; Werner E; Brüggemann N; Tadic V; Lohmann K; Bäumer T; Münchau A; Kasten M; Klein C (2017)
      INTRODUCTION: A latent nigrostriatal deficit and its possible clinical consequences in asymptomatic heterozygous Parkin and PINK1 mutation carriers (AMC) have been a matter of investigation in recent years. Notably, mild ...
    • Nonmotor symptoms in Parkin gene-related parkinsonism 

      Kägi G; Klein C; Wood NW; Schneider SA; Pramstaller PP; Tadic V; Quinn NP; van de Warrenburg BP; Bhatia KP (2010)
      The aim of the study was to explore the prevalence and differences of nonmotor symptoms (NMSs) in patients with young-onset Parkinson's disease (YOPD) with and without mutations in the Parkin gene and late-onset Parkinson's ...
    • Structural imaging in the presymptomatic stage of genetically determined parkinsonism 

      Reetz K; Tadic V; Kasten M; Brüggemann N; Schmidt A; Hagenah J; Pramstaller PP; Ramirez A; Behrens MI; Siebner HR; Klein C; Binkofski F (2010)
      Several genes associated with monogenic forms of Parkinson's disease (PD) have been discovered, opening up new avenues for the investigation of presymptomatic stages of PD. Using voxel-based morphometry in 30 asymptomatic ...