Now showing items 1-7 of 7

    • Family-based studies to the rescue of genome-wide association studies in renal function 

      Pattaro C; Saint-Pierre A (2013)
      Contrary to the apparent impossibility of replicating linkage results across studies on renal outcomes, and denying the general difficulty of identifying meaningful association signals under previously identified linkage ...
    • Genomewide meta-analysis identifies loci associated with IGF-I and IGEBP-3 levels with impact on age-related traits (vol 15, pg 811, 2016) [erratum] 

      Teumer A; Qi Q; Nethander M; Aschard H; Bandinelli S; Beekman M; Berndt SI; Bidlingmaier M; Broer L; CHARGE Longevity Working Group; Cappola A; Ceda GP; Chanock S; Chen MH; Chen TC; Chen YD; Chung J; Del Greco M F; Eriksson J; Ferrucci L; Friedrich N; Gnewuch C; Goodarzi MO; Grarup N; Guo T; Hammer E; Hayes RB; Hicks AA; Hofman A; Houwing-Duistermaat JJ; Hu F; Hunter DJ; Husemoen LL; Isaacs A; Jacobs KB; Janssen JA; Jansson JO; Jehmlich N; Johnson S; Juul A; Karlsson M; Kilpelainen TO; Kovacs P; Kraft P; Li C; Linneberg A; Liu Y; Loos RJ; Body Composition Genetics Consortium; Lorentzon M; Lu Y; Maggio M; Magi R; Meigs J; Mellström D; Nauck M; Newman AB; Pollak MN; Pramstaller PP; Prokopenko I; Psaty BM; Reincke M; Rimm EB; Rotter JI; Saint-Pierre A; Schurmann C; Seshadri S; Sjögren K; Slagboom P; Strickler HD; Stumvoll M; Suh Y; Sun Q; Zhang C; Svensson J; Tanaka T; Tare A; Tönjes A; Uh HW; van Duijn CM; van Heemst D; Vandenput L; Vasan RS; Völker U; Willems SM; Ohlsson C; Wallaschofski H; Kaplan RC (2017)
      The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in ...
    • Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits 

      Teumer A; Qi Q; Nethander M; Aschard H; Bandinelli S; Beekman M; Berndt SI; Bidlingmaier M; Broer L; CHARGE Longevity Working Group; Cappola A; Ceda GP; Chanock S; Chen MH; Chen TC; Chen YD; Chung J; Del Greco M F; Eriksson J; Ferrucci L; Friedrich N; Gnewuch C; Goodarzi MO; Grarup N; Guo T; Hammer E; Hayes RB; Hicks AA; Hofman A; Houwing-Duistermaat JJ; Hu F; Hunter DJ; Husemoen LL; Isaacs A; Jacobs KB; Janssen JA; Jansson JO; Jehmlich N; Johnson S; Juul A; Karlsson M; Kilpelainen TO; Kovacs P; Kraft P; Li C; Linneberg A; Liu Y; Loos RJ; Body Composition Genetics Consortium; Lorentzon M; Lu Y; Maggio M; Magi R; Meigs J; Mellström D; Nauck M; Newman AB; Pollak MN; Pramstaller PP; Prokopenko I; Psaty BM; Reincke M; Rimm EB; Rotter JI; Saint-Pierre A; Schurmann C; Seshadri S; Sjögren K; Slagboom PE; Strickler HD; Stumvoll M; Suh Y; Sun Q; Zhang C; Svensson J; Tanaka T; Tare A; Tönjes A; Uh HW; van Duijn CM; van Heemst D; Vandenput L; Vasan RS; Völker U; Willems SM; Ohlsson C; Wallaschofski H; Kaplan RC (2016)
      The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in ...
    • Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels 

      Kwan JS; Hsu YH; Cheung CL; Dupuis J; Saint-Pierre A; Eriksson J; Handelman SK; Aragaki A; Karasik D; Pramstaller PP; Kooperberg C; Lacroix AZ; Larson MG; Lau KS; Lorentzon M; Pichler I; Sham PC; Taliun D; Vandenput L; Kiel DP; Hicks AA; Jackson RD; Ohlsson C; Benjamin EJ; Kung AW (2014)
      Osteoprotegerin (OPG) is involved in bone homeostasis and tumor cell survival. Circulating OPG levels are also important biomarkers of various clinical traits, such as cancers and atherosclerosis. OPG levels were measured ...
    • Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney 

      Wain LV; Vaez A; Jansen R; Joehanes R; van der Most PJ; Erzurumluoglu AM; O'Reilly PF; Cabrera CP; Warren HR; Rose LM; Verwoert GC; Hottenga JJ; Strawbridge RJ; Esko T; Arking DE; Hwang SJ; Guo X; Kutalik Z; Trompet S; Shrine N; Teumer A; Ried JS; Bis JC; Smith AV; Amin N; Nolte IM; Lyytikäinen LP; Mahajan A; Wareham NJ; Hofer E; Joshi PK; Kristiansson K; Traglia M; Havulinna AS; Goel A; Nalls MA; Sõber S; Vuckovic D; Luan J; Del Greco M F; Ayers KL; Marrugat J; Ruggiero D; Lopez LM; Niiranen T; Enroth S; Jackson AU; Nelson CP; Huffman JE; Zhang W; Marten J; Gandin I; Harris SE; Zemunik T; Lu Y; Evangelou E; Shah N; de Borst MH; Mangino M; Prins BP; Campbell A; Li-Gao R; Chauhan G; Oldmeadow C; Abecasis G; Abedi M; Barbieri CM; Barnes MR; Batini C; Beilby J; Blake T; Boehnke M; Bottinger EP; Braund PS; Brown M; Brumat M; Campbell H; Chambers JC; Cocca M; Collins F; Connell J; Cordell HJ; Damman JJ; Davies G; de Geus EJ; de Mutsert R; Deelen J; Demirkale Y; Doney ASF; Dörr M; Farrall M; Ferreira T; Frånberg M; Gao H; Giedraitis V; Gieger C; Giulianini F; Gow AJ; Hamsten A; Harris TB; Hofman A; Holliday EG; Hui J; Jarvelin MR; Johansson Å; Johnson AD; Jousilahti P; Jula A; Kähönen M; Kathiresan S; Khaw KT; Kolcic I; Koskinen S; Langenberg C; Larson M; Launer LJ; Lehne B; Liewald DCM; Lin L; Lind L; Mach F; Mamasoula C; Menni C; Mifsud B; Milaneschi Y; Morgan A; Morris AD; Morrison AC; Munson PJ; Nandakumar P; Nguyen QT; Nutile T; Oldehinkel AJ; Oostra BA; Org E; Padmanabhan S; Palotie A; Paré G; Pattie A; Penninx BWJH; Poulter N; Pramstaller PP; Raitakari OT; Ren M; Rice K; Ridker PM; Riese H; Ripatti S; Robino A; Rotter JI; Rudan I; Saba Y; Saint-Pierre A; Sala CF; Sarin AP; Schmidt R; Scott R; Seelen MA; Shields DC; Siscovick D; Sorice R; Stanton A; Stott DJ; Sundström J; Swertz M; Taylor KD; Thom S; Tzoulaki I; Tzourio C; Uitterlinden AG; Völker U; Vollenweider P; Wild S; Willemsen G; Wright AF; Yao J; Thériault S; Conen D; Attia J; Sever P; Debette S; Mook-Kanamori DO; Zeggini E; Spector TD; van der Harst P; Palmer CNA; Vergnaud AC; Loos RJF; Polasek O; Starr JM; Girotto G; Hayward C; Kooner JS; Lindgren CM; Vitart V; Samani NJ; Tuomilehto J; Gyllensten U; Knekt P; Deary IJ; Ciullo M; Elosua R; Keavney BD; Hicks AA; Scott RA; Gasparini P; Laan M; Liu Y; Watkins H; Hartman CA; Salomaa V; Toniolo D; Perola M; Wilson JF; Schmidt H; Zhao JH; Lehtimäki T; van Duijn CM; Gudnason V; Psaty BM; Peters A; Rettig R; James A; Jukema JW; Strachan DP; Palmas W; Metspalu A; Ingelsson E; Boomsma DI; Franco OH; Bochud M; Newton-Cheh C; Munroe PB; Elliott P; Chasman DI; Chakravarti A; Knight J; Morris AP; Levy D; Tobin MD; Snieder H; Caulfield MJ; Ehret GB (2017)
      Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets ...
    • Seventy-five genetic loci influencing the human red blood cell 

      van der Harst P; Zhang W; Mateo Leach I; Rendon A; Verweij N; Sehmi J; Paul DS; Elling U; Allayee H; Li X; Radhakrishnan A; Tan ST; Voss K; Weichenberger CX; Albers CA; Al-Hussani A; Asselbergs FW; Ciullo M; Danjou F; Dina C; Esko T; Evans DM; Franke L; Gögele M; Hartiala J; Hersch M; Holm H; Hottenga JJ; Kanoni S; Kleber ME; Lagou V; Langenberg C; Lopez LM; Lyytikäinen LP; Melander O; Murgia F; Nolte IM; O'Reilly PF; Padmanabhan S; Parsa A; Pirastu N; Porcu E; Portas L; Prokopenko I; Ried JS; Shin SY; Tang CS; Teumer A; Traglia M; Ulivi S; Westra HJ; Yang J; Zhao JH; Anni F; Abdellaoui A; Attwood A; Balkau B; Bandinelli S; Bastardot F; Benyamin B; Boehm BO; Cookson WO; Das D; de Bakker PI; de Boer RA; de Geus EJ; de Moor MH; Dimitriou M; Domingues FS; Döring A; Engström G; Eyjolfsson GI; Ferrucci L; Fischer K; Galanello R; Garner SF; Genser B; Gibson QD; Girotto G; Gudbjartsson DF; Harris SE; Hartikainen AL; Hastie CE; Hedblad B; Illig T; Jolley J; Kähönen M; Kema IP; Kemp JP; Liang L; Lloyd-Jones H; Loos RJ; Meacham S; Medland SE; Meisinger C; Memari Y; Mihailov E; Miller K; Moffatt MF; Nauck M; Novatchkova M; Nutile T; Olafsson I; Onundarson PT; Parracciani D; Penninx BW; Perseu L; Piga A; Pistis G; Pouta A; Puc U; Raitakari O; Ring SM; Robino A; Ruggiero D; Ruokonen A; Saint-Pierre A; Sala C; Salumets A; Sambrook J; Schepers H; Schmidt CO; Silljé HH; Sladek R; Smit JH; Starr JM; Stephens J; Sulem P; Tanaka T; Thorsteinsdottir U; Tragante V; van Gilst WH; van Pelt LJ; van Veldhuisen DJ; Völker U; Whitfield JB; Willemsen G; Winkelmann BR; Wirnsberger G; Algra A; Cucca F; D'Adamo AP; Danesh J; Deary IJ; Dominiczak AF; Elliott P; Fortina P; Froguel P; Gasparini P; Greinacher A; Hazen SL; Jarvelin MR; Khaw KT; Lehtimäki T; Maerz W; Martin NG; Metspalu A; Mitchell BD; Montgomery GW; Moore C; Navis G; Pirastu M; Pramstaller PP; Ramirez-Solis R; Schadt E; Scott J; Shuldiner AR; Smith GD; Smith JG; Snieder H; Sorice R; Spector TD; Stefansson K; Stumvoll M; Tang WH; Toniolo D; Tönjes A; Visscher PM; Vollenweider P; Wareham NJ; Wolffenbuttel BH; Boomsma DI; Beckmann JS; Dedoussis GV; Deloukas P; Ferreira MA; Sanna S; Uda M; Hicks AA; Penninger JM; Gieger C; Kooner JS; Ouwehand WH; Soranzo N; Chambers JC (2012)
      Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried ...
    • SNP-based linkage analysis in extended pedigrees: comparison between two alternative approaches 

      Saint-Pierre A; D'Elia Y; Ciullo M; Pramstaller PP; Pattaro C (2014)
      BACKGROUND: Linkage analysis on extended pedigrees is often challenged by the high computational demand of exact identity-by-descent (IBD) matrix reconstruction. When such an analysis becomes not feasible, two alternative ...