Now showing items 1-8 of 8

    • FTO genotype is associated with phenotypic variability of body mass index 

      Yang J; Loos RJ; Powell JE; Medland SE; Speliotes EK; Chasman DI; Rose LM; Thorleifsson G; Steinthorsdottir V; Mägi R; Waite L; Smith AV; Yerges-Armstrong LM; Monda KL; Hadley D; Mahajan A; Li G; Kapur K; Vitart V; Huffman JE; Wang SR; Palmer C; Esko T; Fischer K; Zhao JH; Demirkan A; Isaacs A; Feitosa MF; Luan J; Heard-Costa NL; White C; Jackson AU; Preuss M; Ziegler A; Eriksson J; Kutalik Z; Frau F; Nolte IM; van Vliet-Ostaptchouk JV; Hottenga JJ; Jacobs KB; Verweij N; Goel A; Medina-Gomez C; Estrada K; Bragg-Gresham JL; Sanna S; Sidore C; Tyrer J; Teumer A; Prokopenko I; Mangino M; Lindgren CM; Assimes TL; Shuldiner AR; Hui J; Beilby JP; McArdle WL; Hall P; Haritunians T; Zgaga L; Kolcic I; Polasek O; Zemunik T; Oostra BA; Junttila MJ; Grönberg H; Schreiber S; Peters A; Hicks AA; Stephens J; Foad NS; Laitinen J; Pouta A; Kaakinen M; Willemsen G; Vink JM; Wild SH; Navis G; Asselbergs FW; Homuth G; John U; Iribarren C; Harris T; Launer L; Gudnason V; O'Connell JR; Boerwinkle E; Cadby G; Palmer LJ; James AL; Musk AW; Ingelsson E; Psaty BM; Beckmann JS; Waeber G; Vollenweider P; Hayward C; Wright AF; Rudan I; Groop LC; Metspalu A; Khaw KT; van Duijn CM; Borecki IB; Province MA; Wareham NJ; Tardif JC; Huikuri HV; Cupples LA; Atwood LD; Fox CS; Boehnke M; Collins FS; Mohlke KL; Erdmann J; Schunkert H; Hengstenberg C; Stark K; Lorentzon M; Ohlsson C; Cusi D; Staessen JA; van der Klauw MM; Pramstaller PP; Kathiresan S; Jolley JD; Ripatti S; Jarvelin MR; de Geus EJ; Boomsma DI; Penninx B; Wilson JF; Campbell H; Chanock SJ; van der Harst P; Hamsten A; Watkins H; Hofman A; Witteman JC; Zillikens MC; Uitterlinden AG; Rivadeneira F; Kiemeney LA; Vermeulen SH; Abecasis GR; Schlessinger D; Schipf S; Stumvoll M; Tönjes A; Spector TD; North KE; Lettre G; McCarthy MI; Berndt SI; Heath AC; Madden PA; Nyholt DR; Montgomery GW; Martin NG; McKnight B; Strachan DP; Hill WG; Snieder H; Ridker PM; Thorsteinsdottir U; Stefansson K; Frayling TM; Hirschhorn JN; Goddard ME; Visscher PM (2012)
      There is evidence across several species for genetic control of phenotypic variation of complex traits, such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important ...
    • Genetic studies of body mass index yield new insights for obesity biology 

      Locke AE; Kahali B; Berndt SI; Justice AE; Pers TH; Day FR; Powell C; Vedantam S; Buchkovich ML; Yang J; Croteau-Chonka DC; Esko T; Fall T; Ferreira T; Gustafsson S; Kutalik Z; Luan J; Mägi R; Randall JC; Winkler TW; Wood AR; Workalemahu T; Faul JD; Smith JA; Hua Zhao J; Zhao W; Chen J; Fehrmann R; Hedman ÅK; Karjalainen J; Schmidt EM; Absher D; Amin N; Anderson D; Beekman M; Bolton JL; Bragg-Gresham JL; Buyske S; Demirkan A; Deng G; Ehret GB; Feenstra B; Feitosa MF; Fischer K; Goel A; Gong J; Jackson AU; Kanoni S; Kleber ME; Kristiansson K; Lim U; Lotay V; Mangino M; Mateo Leach I; Medina-Gomez C; Medland SE; Nalls MA; Palmer CD; Pasko D; Pechlivanis S; Peters MJ; Prokopenko I; Shungin D; Stančáková A; Strawbridge RJ; Ju Sung Y; Tanaka T; Teumer A; Trompet S; van der Laan SW; van Setten J; van Vliet-Ostaptchouk JV; Wang Z; Yengo L; Zhang W; Isaacs A; Albrecht E; Ärnlöv J; Arscott GM; Attwood AP; Bandinelli S; Barrett A; Bas IN; Bellis C; Bennett AJ; Berne C; Blagieva R; Blüher M; Böhringer S; Bonnycastle LL; Böttcher Y; Boyd HA; Bruinenberg M; Caspersen IH; Ida Chen YD; Clarke R; Daw EW; de Craen AJ; Delgado G; Dimitriou M; Doney AS; Eklund N; Estrada K; Eury E; Folkersen L; Fraser RM; Garcia ME; Geller F; Giedraitis V; Gigante B; Go AS; Golay A; Goodall AH; Gordon SD; Gorski M; Grabe HJ; Grallert H; Grammer TB; Gräßler J; Grönberg H; Groves CJ; Gusto G; Haessler J; Hall P; Haller T; Hallmans G; Hartman CA; Hassinen M; Hayward C; Heard-Costa NL; Helmer Q; Hengstenberg C; Holmen O; Hottenga JJ; James AL; Jeff JM; Johansson Å; Jolley J; Juliusdottir T; Kinnunen L; Koenig W; Koskenvuo M; Kratzer W; Laitinen J; Lamina C; Leander K; Lee NR; Lichtner P; Lind L; Lindström J; Sin Lo K; Lobbens S; Lorbeer R; Lu Y; Mach F; Magnusson PK; Mahajan A; McArdle WL; McLachlan S; Menni C; Merger S; Mihailov E; Milani L; Moayyeri A; Monda KL; Morken MA; Mulas A; Müller G; Müller-Nurasyid M; Musk AW; Nagaraja R; Nöthen MM; Nolte IM; Pilz S; Rayner NW; Renstrom F; Rettig R; Ried JS; Ripke S; Robertson NR; Rose LM; Sanna S; Scharnagl H; Scholtens S; Schumacher FR; Scott WR; Seufferlein T; Shi J; Vernon Smith A; Smolonska J; Stanton AV; Steinthorsdottir V; Stirrups K; Stringham HM; Sundström J; Swertz MA; Swift AJ; Syvänen AC; Tan ST; Tayo BO; Thorand B; Thorleifsson G; Tyrer JP; Uh HW; Vandenput L; Verhulst FC; Vermeulen SH; Verweij N; Vonk JM; Waite LL; Warren HR; Waterworth D; Weedon MN; Wilkens LR; Willenborg C; Wilsgaard T; Wojczynski MK; Wong A; Wright AF; Zhang Q; LifeLines Cohort Study; Brennan EP; Choi M; Dastani Z; Drong AW; Eriksson P; Franco-Cereceda A; Gådin JR; Gharavi AG; Goddard ME; Handsaker RE; Huang J; Karpe F; Kathiresan S; Keildson S; Kiryluk K; Kubo M; Lee JY; Liang L; Lifton RP; Ma B; McCarroll SA; McKnight AJ; Min JL; Moffatt MF; Montgomery GW; Murabito JM; Nicholson G; Nyholt DR; Okada Y; Perry JR; Dorajoo R; Reinmaa E; Salem RM; Sandholm N; Scott RA; Stolk L; Takahashi A; Van't Hooft FM; Vinkhuyzen AA; Westra HJ; Zheng W; Zondervan KT; ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium; Heath AC; Arveiler D; Bakker SJ; Beilby J; Bergman RN; Blangero J; Bovet P; Campbell H; Caulfield MJ; Cesana G; Chakravarti A; Chasman DI; Chines PS; Collins FS; Crawford DC; Cupples LA; Cusi D; Danesh J; de Faire U; den Ruijter HM; Dominiczak AF; Erbel R; Erdmann J; Eriksson JG; Farrall M; Felix SB; Ferrannini E; Ferrières J; Ford I; Forouhi NG; Forrester T; Franco OH; Gansevoort RT; Gejman PV; Gieger C; Gottesman O; Gudnason V; Gyllensten U; Hall AS; Harris TB; Hattersley AT; Hicks AA; Hindorff LA; Hingorani AD; Hofman A; Homuth G; Hovingh GK; Humphries SE; Hunt SC; Hyppönen E; Illig T; Jacobs KB; Jarvelin MR; Jöckel KH; Johansen B; Jousilahti P; Jukema JW; Jula AM; Kaprio J; Kastelein JJ; Keinanen-Kiukaanniemi SM; Kiemeney LA; Knekt P; Kooner JS; Kooperberg C; Kovacs P; Kraja AT; Kumari M; Kuusisto J; Lakka TA; Langenberg C; Le Marchand L; Lehtimäki T; Lyssenko V; Männistö S; Marette A; Matise TC; McKenzie CA; McKnight B; Moll FL; Morris AD; Morris AP; Murray JC; Nelis M; Ohlsson C; Oldehinkel AJ; Ong KK; Madden PA; Pasterkamp G; Peden JF; Peters A; Postma DS; Pramstaller PP; Price JF; Qi L; Raitakari OT; Rankinen T; Rao DC; Rice TK; Ridker PM; Rioux JD; Ritchie MD; Rudan I; Salomaa V; Samani NJ; Saramies J; Sarzynski MA; Schunkert H; Schwarz PE; Sever P; Shuldiner AR; Sinisalo J; Stolk RP; Strauch K; Tönjes A; Trégouët DA; Tremblay A; Tremoli E; Virtamo J; Vohl MC; Völker U; Waeber G; Willemsen G; Witteman JC; Zillikens MC; Adair LS; Amouyel P; Asselbergs FW; Assimes TL; Bochud M; Boehm BO; Boerwinkle E; Bornstein SR; Bottinger EP; Bouchard C; Cauchi S; Chambers JC; Chanock SJ; Cooper RS; de Bakker PI; Dedoussis G; Ferrucci L; Franks PW; Froguel P; Groop LC; Haiman CA; Hamsten A; Hui J; Hunter DJ; Hveem K; Kaplan RC; Kivimaki M; Kuh D; Laakso M; Liu Y; Martin NG; März W; Melbye M; Metspalu A; Moebus S; Munroe PB; Njølstad I; Oostra BA; Palmer CN; Pedersen NL; Perola M; Pérusse L; Peters U; Power C; Quertermous T; Rauramaa R; Rivadeneira F; Saaristo TE; Saleheen D; Sattar N; Schadt EE; Schlessinger D; Slagboom PE; Snieder H; Spector TD; Thorsteinsdottir U; Stumvoll M; Tuomilehto J; Uitterlinden AG; Uusitupa M; van der Harst P; Walker M; Wallaschofski H; Wareham NJ; Watkins H; Weir DR; Wichmann HE; Wilson JF; Zanen P; Borecki IB; Deloukas P; Fox CS; Heid IM; O'Connell JR; Strachan DP; Stefansson K; van Duijn CM; Abecasis GR; Franke L; Frayling TM; McCarthy MI; Visscher PM; Scherag A; Willer CJ; Boehnke M; Mohlke KL; Lindgren CM; Beckmann JS; Barroso I; North KE; Ingelsson E; Hirschhorn JN; Loos RJ; Speliotes EK (2015)
      Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure ...
    • Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture 

      Berndt SI; Gustafsson S; Mägi R; Ganna A; Wheeler E; Feitosa MF; Justice AE; Monda KL; Croteau-Chonka DC; Day FR; Esko T; Fall T; Ferreira T; Gentilini D; Jackson AU; Luan J; Randall JC; Vedantam S; Willer CJ; Winkler TW; Wood AR; Workalemahu T; Hu YJ; Lee SH; Liang L; Lin DY; Min JL; Neale BM; Thorleifsson G; Yang J; Albrecht E; Amin N; Bragg-Gresham JL; Cadby G; den Heijer M; Eklund N; Fischer K; Goel A; Hottenga JJ; Huffman JE; Jarick I; Johansson Å; Johnson T; Kanoni S; Kleber ME; König IR; Kristiansson K; Kutalik Z; Lamina C; Lecoeur C; Li G; Mangino M; McArdle WL; Medina-Gomez C; Müller-Nurasyid M; Ngwa JS; Nolte IM; Paternoster L; Pechlivanis S; Perola M; Peters MJ; Preuss M; Rose LM; Shi J; Shungin D; Smith AV; Strawbridge RJ; Surakka I; Teumer A; Trip MD; Tyrer J; van Vliet-Ostaptchouk JV; Vandenput L; Waite LL; Zhao JH; Absher D; Asselbergs FW; Atalay M; Attwood AP; Balmforth AJ; Basart H; Beilby J; Bonnycastle LL; Brambilla P; Bruinenberg M; Campbell H; Chasman DI; Chines PS; Collins FS; Connell JM; Cookson WO; de Faire U; de Vegt F; Dei M; Dimitriou M; Edkins S; Estrada K; Evans DM; Farrall M; Ferrario MM; Ferrières J; Franke L; Frau F; Gejman PV; Grallert H; Grönberg H; Gudnason V; Hall AS; Hall P; Hartikainen AL; Hayward C; Heard-Costa NL; Heath AC; Hebebrand J; Homuth G; Hu FB; Hunt SE; Hyppönen E; Iribarren C; Jacobs KB; Jansson JO; Jula A; Kähönen M; Kathiresan S; Kee F; Khaw KT; Kivimäki M; Koenig W; Kraja AT; Kumari M; Kuulasmaa K; Kuusisto J; Laitinen JH; Lakka TA; Langenberg C; Launer LJ; Lind L; Lindström J; Liu J; Liuzzi A; Lokki ML; Lorentzon M; Madden PA; Magnusson PK; Manunta P; Marek D; März W; Mateo Leach I; McKnight B; Medland SE; Mihailov E; Milani L; Montgomery GW; Mooser V; Mühleisen TW; Munroe PB; Musk AW; Narisu N; Navis G; Nicholson G; Nohr EA; Ong KK; Oostra BA; Palmer CN; Palotie A; Peden JF; Pedersen N; Peters A; Polasek O; Pouta A; Pramstaller PP; Prokopenko I; Pütter C; Radhakrishnan A; Raitakari O; Rendon A; Rivadeneira F; Rudan I; Saaristo TE; Sambrook JG; Sanders AR; Sanna S; Saramies J; Schipf S; Schreiber S; Schunkert H; Shin SY; Signorini S; Sinisalo J; Skrobek B; Soranzo N; Stancáková A; Stark K; Stephens JC; Stirrups K; Stolk RP; Stumvoll M; Swift AJ; Theodoraki EV; Thorand B; Tregouet DA; Tremoli E; van der Klauw MM; van Meurs JB; Vermeulen SH; Viikari J; Virtamo J; Vitart V; Waeber G; Wang Z; Widén E; Wild SH; Willemsen G; Winkelmann BR; Witteman JC; Wolffenbuttel BH; Wong A; Wright AF; Zillikens MC; Amouyel P; Boehm BO; Boerwinkle E; Boomsma DI; Caulfield MJ; Chanock SJ; Cupples LA; Cusi D; Dedoussis GV; Erdmann J; Eriksson JG; Franks PW; Froguel P; Gieger C; Gyllensten U; Hamsten A; Harris TB; Hengstenberg C; Hicks AA; Hingorani A; Hinney A; Hofman A; Hovingh KG; Hveem K; Illig T; Jarvelin MR; Jöckel KH; Keinanen-Kiukaanniemi SM; Kiemeney LA; Kuh D; Laakso M; Lehtimäki T; Levinson DF; Martin NG; Metspalu A; Morris AD; Nieminen MS; Njølstad I; Ohlsson C; Oldehinkel AJ; Ouwehand WH; Palmer LJ; Penninx B; Power C; Province MA; Psaty BM; Qi L; Rauramaa R; Ridker PM; Ripatti S; Salomaa V; Samani NJ; Snieder H; Sørensen TI; Spector TD; Stefansson K; Tönjes A; Tuomilehto J; Uitterlinden AG; Uusitupa M; van der Harst P; Vollenweider P; Wallaschofski H; Wareham NJ; Watkins H; Wichmann HE; Wilson JF; Abecasis GR; Assimes TL; Barroso I; Boehnke M; Borecki IB; Deloukas P; Fox CS; Frayling T; Groop LC; Haritunian T; Heid IM; Hunter D; Kaplan RC; Karpe F; Moffatt MF; Mohlke KL; O'Connell JR; Pawitan Y; Schadt EE; Schlessinger D; Steinthorsdottir V; Strachan DP; Thorsteinsdottir U; van Duijn CM; Visscher PM; Di Blasio AM; Hirschhorn JN; Lindgren CM; Morris AP; Meyre D; Scherag A; McCarthy MI; Speliotes EK; North KE; Loos RJ; Ingelsson E (2013)
      Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for ...
    • Genomewide meta-analysis identifies loci associated with IGF-I and IGEBP-3 levels with impact on age-related traits (vol 15, pg 811, 2016) [erratum] 

      Teumer A; Qi Q; Nethander M; Aschard H; Bandinelli S; Beekman M; Berndt SI; Bidlingmaier M; Broer L; CHARGE Longevity Working Group; Cappola A; Ceda GP; Chanock S; Chen MH; Chen TC; Chen YD; Chung J; Del Greco M F; Eriksson J; Ferrucci L; Friedrich N; Gnewuch C; Goodarzi MO; Grarup N; Guo T; Hammer E; Hayes RB; Hicks AA; Hofman A; Houwing-Duistermaat JJ; Hu F; Hunter DJ; Husemoen LL; Isaacs A; Jacobs KB; Janssen JA; Jansson JO; Jehmlich N; Johnson S; Juul A; Karlsson M; Kilpelainen TO; Kovacs P; Kraft P; Li C; Linneberg A; Liu Y; Loos RJ; Body Composition Genetics Consortium; Lorentzon M; Lu Y; Maggio M; Magi R; Meigs J; Mellström D; Nauck M; Newman AB; Pollak MN; Pramstaller PP; Prokopenko I; Psaty BM; Reincke M; Rimm EB; Rotter JI; Saint-Pierre A; Schurmann C; Seshadri S; Sjögren K; Slagboom P; Strickler HD; Stumvoll M; Suh Y; Sun Q; Zhang C; Svensson J; Tanaka T; Tare A; Tönjes A; Uh HW; van Duijn CM; van Heemst D; Vandenput L; Vasan RS; Völker U; Willems SM; Ohlsson C; Wallaschofski H; Kaplan RC (2017)
      The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in ...
    • Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits 

      Teumer A; Qi Q; Nethander M; Aschard H; Bandinelli S; Beekman M; Berndt SI; Bidlingmaier M; Broer L; CHARGE Longevity Working Group; Cappola A; Ceda GP; Chanock S; Chen MH; Chen TC; Chen YD; Chung J; Del Greco M F; Eriksson J; Ferrucci L; Friedrich N; Gnewuch C; Goodarzi MO; Grarup N; Guo T; Hammer E; Hayes RB; Hicks AA; Hofman A; Houwing-Duistermaat JJ; Hu F; Hunter DJ; Husemoen LL; Isaacs A; Jacobs KB; Janssen JA; Jansson JO; Jehmlich N; Johnson S; Juul A; Karlsson M; Kilpelainen TO; Kovacs P; Kraft P; Li C; Linneberg A; Liu Y; Loos RJ; Body Composition Genetics Consortium; Lorentzon M; Lu Y; Maggio M; Magi R; Meigs J; Mellström D; Nauck M; Newman AB; Pollak MN; Pramstaller PP; Prokopenko I; Psaty BM; Reincke M; Rimm EB; Rotter JI; Saint-Pierre A; Schurmann C; Seshadri S; Sjögren K; Slagboom PE; Strickler HD; Stumvoll M; Suh Y; Sun Q; Zhang C; Svensson J; Tanaka T; Tare A; Tönjes A; Uh HW; van Duijn CM; van Heemst D; Vandenput L; Vasan RS; Völker U; Willems SM; Ohlsson C; Wallaschofski H; Kaplan RC (2016)
      The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in ...
    • Hundreds of variants clustered in genomic loci and biological pathways affect human height 

      Lango Allen H; Estrada K; Lettre G; Berndt SI; Weedon MN; Rivadeneira F; Willer CJ; Jackson AU; Vedantam S; Raychaudhuri S; Ferreira T; Wood AR; Weyant RJ; Segrè AV; Speliotes EK; Wheeler E; Soranzo N; Park JH; Yang J; Gudbjartsson D; Heard-Costa NL; Randall JC; Qi L; Vernon Smith A; Mägi R; Pastinen T; Liang L; Heid IM; Luan J; Thorleifsson G; Winkler TW; Goddard ME; Sin Lo K; Palmer C; Workalemahu T; Aulchenko YS; Johansson A; Zillikens MC; Feitosa MF; Esko T; Johnson T; Ketkar S; Kraft P; Mangino M; Prokopenko I; Absher D; Albrecht E; Ernst F; Glazer NL; Hayward C; Hottenga JJ; Jacobs KB; Knowles JW; Kutalik Z; Monda KL; Polasek O; Preuss M; Rayner NW; Robertson NR; Steinthorsdottir V; Tyrer JP; Voight BF; Wiklund F; Xu J; Zhao JH; Nyholt DR; Pellikka N; Perola M; Perry JR; Surakka I; Tammesoo ML; Altmaier EL; Amin N; Aspelund T; Bhangale T; Boucher G; Chasman DI; Chen C; Coin L; Cooper MN; Dixon AL; Gibson Q; Grundberg E; Hao K; Juhani Junttila M; Kaplan LM; Kettunen J; König IR; Kwan T; Lawrence RW; Levinson DF; Lorentzon M; McKnight B; Morris AP; Müller M; Suh Ngwa J; Purcell S; Rafelt S; Salem RM; Salvi E; Sanna S; Shi J; Sovio U; Thompson JR; Turchin MC; Vandenput L; Verlaan DJ; Vitart V; White CC; Ziegler A; Almgren P; Balmforth AJ; Campbell H; Citterio L; De Grandi A; Dominiczak A; Duan J; Elliott P; Elosua R; Eriksson JG; Freimer NB; Geus EJ; Glorioso N; Haiqing S; Hartikainen AL; Havulinna AS; Hicks AA; Hui J; Igl W; Illig T; Jula A; Kajantie E; Kilpeläinen TO; Koiranen M; Kolcic I; Koskinen S; Kovacs P; Laitinen J; Liu J; Lokki ML; Marusic A; Maschio A; Meitinger T; Mulas A; Paré G; Parker AN; Peden JF; Petersmann A; Pichler I; Pietiläinen KH; Pouta A; Ridderstråle M; Rotter JI; Sambrook JG; Sanders AR; Schmidt CO; Sinisalo J; Smit JH; Stringham HM; Bragi Walters G; Widen E; Wild SH; Willemsen G; Zagato L; Zgaga L; Zitting P; Alavere H; Farrall M; McArdle WL; Nelis M; Peters MJ; Ripatti S; van Meurs JB; Aben KK; Ardlie KG; Beckmann JS; Beilby JP; Bergman RN; Bergmann S; Collins FS; Cusi D; den Heijer M; Eiriksdottir G; Gejman PV; Hall AS; Hamsten A; Huikuri HV; Iribarren C; Kähönen M; Kaprio J; Kathiresan S; Kiemeney L; Kocher T; Launer LJ; Lehtimäki T; Melander O; Mosley TH; Musk AW; Nieminen MS; O'Donnell CJ; Ohlsson C; Oostra B; Palmer LJ; Raitakari O; Ridker PM; Rioux JD; Rissanen A; Rivolta C; Schunkert H; Shuldiner AR; Siscovick DS; Stumvoll M; Tönjes A; Tuomilehto J; van Ommen GJ; Viikari J; Heath AC; Martin NG; Montgomery GW; Province MA; Kayser M; Arnold AM; Atwood LD; Boerwinkle E; Chanock SJ; Deloukas P; Gieger C; Grönberg H; Hall P; Hattersley AT; Hengstenberg C; Hoffman W; Lathrop GM; Salomaa V; Schreiber S; Uda M; Waterworth D; Wright AF; Assimes TL; Barroso I; Hofman A; Mohlke KL; Boomsma DI; Caulfield MJ; Cupples LA; Erdmann J; Fox CS; Gudnason V; Gyllensten U; Harris TB; Hayes RB; Jarvelin MR; Mooser V; Munroe PB; Ouwehand WH; Penninx BW; Pramstaller PP; Quertermous T; Rudan I; Samani NJ; Spector TD; Völzke H; Watkins H; Wilson JF; Groop LC; Haritunians T; Hu FB; Kaplan RC; Metspalu A; North KE; Schlessinger D; Wareham NJ; Hunter DJ; O'Connell JR; Strachan DP; Wichmann HE; Borecki IB; van Duijn CM; Schadt EE; Thorsteinsdottir U; Peltonen L; Uitterlinden AG; Visscher PM; Chatterjee N; Loos RJ; Boehnke M; McCarthy MI; Ingelsson E; Lindgren CM; Abecasis GR; Stefansson K; Frayling TM; Hirschhorn JN (2010)
      Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants ...
    • The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study 

      Winkler TW; Justice AE; Graff M; Barata L; Feitosa MF; Chu S; Czajkowski J; Esko T; Fall T; Kilpeläinen TO; Lu Y; Mägi R; Mihailov E; Pers TH; Rüeger S; Teumer A; Ehret GB; Ferreira T; Heard-Costa NL; Karjalainen J; Lagou V; Mahajan A; Neinast MD; Prokopenko I; Simino J; Teslovich TM; Jansen R; Westra HJ; White CC; Absher D; Ahluwalia TS; Ahmad S; Albrecht E; Alves AC; Bragg-Gresham JL; de Craen AJ; Bis JC; Bonnefond A; Boucher G; Cadby G; Cheng YC; Chiang CW; Delgado G; Demirkan A; Dueker N; Eklund N; Eiriksdottir G; Eriksson J; Feenstra B; Fischer K; Frau F; Galesloot TE; Geller F; Goel A; Gorski M; Grammer TB; Gustafsson S; Haitjema S; Hottenga JJ; Huffman JE; Jackson AU; Jacobs KB; Johansson Å; Kaakinen M; Kleber ME; Lahti J; Mateo Leach I; Lehne B; Liu Y; Lo KS; Lorentzon M; Luan J; Madden PA; Mangino M; McKnight B; Medina-Gomez C; Monda KL; Montasser ME; Müller G; Müller-Nurasyid M; Nolte IM; Panoutsopoulou K; Pascoe L; Paternoster L; Rayner NW; Renström F; Rizzi F; Rose LM; Ryan KA; Salo P; Sanna S; Scharnagl H; Shi J; Smith AV; Southam L; Stančáková A; Steinthorsdottir V; Strawbridge RJ; Sung YJ; Tachmazidou I; Tanaka T; Thorleifsson G; Trompet S; Pervjakova N; Tyrer JP; Vandenput L; van der Laan SW; van der Velde N; van Setten J; van Vliet-Ostaptchouk JV; Verweij N; Vlachopoulou E; Waite LL; Wang SR; Wang Z; Wild SH; Willenborg C; Wilson JF; Wong A; Yang J; Yengo L; Yerges-Armstrong LM; Yu L; Zhang W; Zhao JH; Andersson EA; Bakker SJ; Baldassarre D; Banasik K; Barcella M; Barlassina C; Bellis C; Benaglio P; Blangero J; Blüher M; Bonnet F; Bonnycastle LL; Boyd HA; Bruinenberg M; Buchman AS; Campbell H; Chen YD; Chines PS; Claudi-Boehm S; Cole J; Collins FS; de Geus EJ; de Groot LC; Dimitriou M; Duan J; Enroth S; Eury E; Farmaki AE; Forouhi NG; Friedrich N; Gejman PV; Gigante B; Glorioso N; Go AS; Gottesman O; Gräßler J; Grallert H; Grarup N; Gu YM; Broer L; Ham AC; Hansen T; Harris TB; Hartman CA; Hassinen M; Hastie N; Hattersley AT; Heath AC; Henders AK; 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Kaplan RC; McCarthy MI; Mohlke KL; O'Connell JR; Schlessinger D; Strachan DP; Stefansson K; van Duijn CM; Hirschhorn JN; Lindgren CM; Heid IM; North KE; Borecki IB; Kutalik Z; Loos RJ (2015)
      Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and ...
    • Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits 

      Randall JC; Winkler TW; Kutalik Z; Berndt SI; Jackson AU; Monda KL; Kilpeläinen TO; Esko T; Mägi R; Li S; Workalemahu T; Feitosa MF; Croteau-Chonka DC; Day FR; Fall T; Ferreira T; Gustafsson S; Locke AE; Mathieson I; Scherag A; Vedantam S; Wood AR; Liang L; Steinthorsdottir V; Thorleifsson G; Dermitzakis ET; Dimas AS; Karpe F; Min JL; Nicholson G; Clegg DJ; Person T; Krohn JP; Bauer S; Buechler C; Eisinger K; DIAGRAM Consortium; Bonnefond A; Froguel P; MAGIC Investigators; Hottenga JJ; Prokopenko I; Waite LL; Harris TB; Smith AV; Shuldiner AR; McArdle WL; Caulfield MJ; Munroe PB; Grönberg H; Chen YD; Li G; Beckmann JS; Johnson T; Thorsteinsdottir U; Teder-Laving M; Khaw KT; Wareham NJ; Zhao JH; Amin N; Oostra BA; Kraja AT; Province MA; Cupples LA; Heard-Costa NL; Kaprio J; Ripatti S; Surakka I; Collins FS; Saramies J; Tuomilehto J; Jula A; Salomaa V; Erdmann J; Hengstenberg C; Loley C; Schunkert H; Lamina C; Wichmann HE; Albrecht E; Gieger C; Hicks AA; Johansson A; Pramstaller PP; Kathiresan S; Speliotes EK; Penninx B; Hartikainen AL; Jarvelin MR; Gyllensten U; Boomsma DI; Campbell H; Wilson JF; Chanock SJ; Farrall M; Goel A; Medina-Gomez C; Rivadeneira F; Estrada K; Uitterlinden AG; Hofman A; Zillikens MC; den Heijer M; Kiemeney LA; Maschio A; Hall P; Tyrer J; Teumer A; Völzke H; Kovacs P; Tönjes A; Mangino M; Spector TD; Hayward C; Rudan I; Hall AS; Samani NJ; Attwood AP; Sambrook JG; Hung J; Palmer LJ; Lokki ML; Sinisalo J; Boucher G; Huikuri H; Lorentzon M; Ohlsson C; Eklund N; Eriksson JG; Barlassina C; Rivolta C; Nolte IM; Snieder H; van der Klauw MM; van Vliet-Ostaptchouk JV; Gejman PV; Shi J; Jacobs KB; Wang Z; Bakker SJ; Mateo Leach I; Navis G; van der Harst P; Martin NG; Medland SE; Montgomery GW; Yang J; Chasman DI; Ridker PM; Rose LM; Lehtimäki T; Raitakari O; Absher D; Iribarren C; Basart H; Hovingh KG; Hyppönen E; Power C; Anderson D; Beilby JP; Hui J; Jolley J; Sager H; Bornstein SR; Schwarz PE; Kristiansson K; Perola M; Lindström J; Swift AJ; Uusitupa M; Atalay M; Lakka TA; Rauramaa R; Bolton JL; Fowkes G; Fraser RM; Price JF; Fischer K; Krjutå Kov K; Metspalu A; Mihailov E; Langenberg C; Luan J; Ong KK; Chines PS; Keinanen-Kiukaanniemi SM; Saaristo TE; Edkins S; Franks PW; Hallmans G; Shungin D; Morris AD; Palmer CN; Erbel R; Moebus S; Nöthen MM; Pechlivanis S; Hveem K; Narisu N; Hamsten A; Humphries SE; Strawbridge RJ; Tremoli E; Grallert H; Thorand B; Illig T; Koenig W; Müller-Nurasyid M; Peters A; Boehm BO; Kleber ME; März W; Winkelmann BR; Kuusisto J; Laakso M; Arveiler D; Cesana G; Kuulasmaa K; Virtamo J; Yarnell JW; Kuh D; Wong A; Lind L; de Faire U; Gigante B; Magnusson PK; Pedersen NL; Dedoussis G; Dimitriou M; Kolovou G; Kanoni S; Stirrups K; Bonnycastle LL; Njølstad I; Wilsgaard T; Ganna A; Rehnberg E; Hingorani A; Kivimaki M; Kumari M; Assimes TL; Barroso I; Boehnke M; Borecki IB; Deloukas P; Fox CS; Frayling T; Groop LC; Haritunians T; Hunter D; Ingelsson E; Kaplan R; Mohlke KL; O'Connell JR; Schlessinger D; Strachan DP; Stefansson K; van Duijn CM; Abecasis GR; McCarthy MI; Hirschhorn JN; Qi L; Loos RJ; Lindgren CM; North KE; Heid IM (2013)
      Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass ...