Now showing items 1-4 of 4

    • A catalog of genetic loci associated with kidney function from analyses of a million individuals 

      Wuttke M; Li Y; Li M; Sieber KB; Feitosa MF; Gorski M; Tin A; Wang L; Chu AY; Hoppmann A; Kirsten H; Giri A; Chai JF; Sveinbjornsson G; Tayo BO; Nutile T; Fuchsberger C; Marten J; Cocca M; Ghasemi S; Xu Y; Horn K; Noce D; van der Most PJ; Sedaghat S; Yu Z; Akiyama M; Afaq S; Ahluwalia TS; Almgren P; Amin N; Ärnlöv J; Bakker SJL; Bansal N; Baptista D; Bergmann S; Biggs ML; Biino G; Boehnke M; Boerwinkle E; Boissel M; Bottinger EP; Boutin TS; Brenner H; Brumat M; Burkhardt R; Butterworth AS; Campana E; Campbell A; Campbell H; Canouil M; Carroll RJ; Catamo E; Chambers JC; Chee ML; Chen X; Cheng CY; Cheng Y; Christensen K; Cifkova R; Ciullo M; Concas MP; Cook JP; Coresh J; Corre T; Sala CF; Cusi D; Danesh J; Daw EW; de Borst MH; De Grandi A; de Mutsert R; de Vries APJ; Degenhardt F; Delgado G; Demirkan A; Di Angelantonio E; Dittrich K; Divers J; Dorajoo R; Eckardt KU; Ehret G; Elliott P; Endlich K; Evans MK; Felix JF; Foo VHX; Franco OH; Franke A; Freedman BI; Freitag-Wolf S; Friedlander Y; Froguel P; Gansevoort RT; Gao H; Gasparini P; Gaziano JM; Giedraitis V; Gieger C; Girotto G; Giulianini F; Gögele M; Gordon SD; Gudbjartsson DF; Gudnason V; Haller T; Hamet P; Harris TB; Hartman CA; Hayward C; Hellwege JN; Heng CK; Hicks AA; Hofer E; Huang W; Hutri-Kähönen N; Hwang SJ; Ikram MA; Indridason OS; Ingelsson E; Ising M; Jaddoe VWV; Jakobsdottir J; Jonas JB; Joshi PK; Josyula NS; Jung B; Kähönen M; Kamatani Y; Kammerer CM; Kanai M; Kastarinen M; Kerr SM; Khor CC; Kiess W; Kleber ME; Koenig W; Kooner JS; Körner A; Kovacs P; Kraja AT; Krajcoviechova A; Kramer H; Krämer BK; Kronenberg F; Kubo M; Kühnel B; Kuokkanen M; Kuusisto J; La Bianca M; Laakso M; Lange LA; Langefeld CD; Lee JJ; Lehne B; Lehtimäki T; Lieb W; Lim SC; Lind L; Lindgren CM; Liu J; Loeffler M; Loos RJF; Lucae S; Lukas MA; Lyytikäinen LP; Mägi R; Magnusson PKE; Mahajan A; Martin NG; Martins J; März W; Mascalzoni D; Matsuda K; Meisinger C; Meitinger T; Melander O; Metspalu A; Mikaelsdottir EK; Milaneschi Y; Miliku K; Mishra PP; Mohlke KL; Mononen N; Montgomery GW; Mook-Kanamori DO; Mychaleckyj JC; Nadkarni GN; Nalls MA; Nauck M; Nikus K; Ning B; Nolte IM; Noordam R; O'Connell J; O'Donoghue ML; Olafsson I; Oldehinkel AJ; Orho-Melander M; Ouwehand WH; Padmanabhan S; Palmer ND; Palsson R; Penninx BWJH; Perls T; Perola M; Pirastu M; Pirastu N; Pistis G; Podgornaia AI; Polasek O; Ponte B; Porteous DJ; Poulain T; Pramstaller PP; Preuss MH; Prins BP; Province MA; Rabelink TJ; Raffield LM; Raitakari OT; Reilly DF; Rettig R; Rheinberger M; Rice KM; Ridker PM; Rivadeneira F; Rizzi F; Roberts DJ; Robino A; Rossing P; Rudan I; Rueedi R; Ruggiero D; Ryan KA; Saba Y; Sabanayagam C; Salomaa V; Salvi E; Saum KU; Schmidt H; Schmidt R; Schöttker B; Schulz CA; Schupf N; Shaffer CM; Shi Y; Smith AV; Smith BH; Soranzo N; Spracklen CN; Strauch K; Stringham HM; Stumvoll M; Svensson PO; Szymczak S; Tai ES; Tajuddin SM; Tan NYQ; Taylor KD; Teren A; Tham YC; Thiery J; Thio CHL; Thomsen H; Thorleifsson G; Toniolo D; Tönjes A; Tremblay J; Tzoulaki I; Uitterlinden AG; Vaccargiu S; van Dam RM; van der Harst P; van Duijn CM; Velez Edward DR; Verweij N; Vogelezang S; Völker U; Vollenweider P; Waeber G; Waldenberger M; Wallentin L; Wang YX; Wang C; Waterworth DM; Bin Wei W; White H; Whitfield JB; Wild SH; Wilson JF; Wojczynski MK; Wong C; Wong TY; Xu L; Yang Q; Yasuda M; Yerges-Armstrong LM; Zhang W; Zonderman AB; Rotter JI; Bochud M; Psaty BM; Vitart V; Wilson JG; Dehghan A; Parsa A; Chasman DI; Ho K; Morris AP; Devuyst O; Akilesh S; Pendergrass SA; Sim X; Böger CA; Okada Y; Edwards TL; Snieder H; Stefansson K; Hung AM; Heid IM; Scholz M; Teumer A; Köttgen A; Pattaro C (2019)
      Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate ...
    • Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation 

      Teumer A; Chaker L; Groeneweg S; Li Y; Di Munno C; Barbieri C; Schultheiss UT; Traglia M; Ahluwalia TS; Akiyama M; Appel EVR; Arking DE; Arnold A; Astrup A; Beekman M; Beilby JP; Bekaert S; Boerwinkle E; Brown SJ; De Buyzere M; Campbell PJ; Ceresini G; Cerqueira C; Cucca F; Deary IJ; Deelen J; Eckardt KU; Ekici AB; Eriksson JG; Ferrrucci L; Fiers T; Fiorillo E; Ford I; Fox CS; Fuchsberger C; Galesloot TE; Gieger C; Gögele M; De Grandi A; Grarup N; Greiser KH; Haljas K; Hansen T; Harris SE; van Heemst D; den Heijer M; Hicks AA; den Hollander W; Homuth G; Hui J; Ikram MA; Ittermann T; Jensen RA; Jing J; Jukema JW; Kajantie E; Kamatani Y; Kasbohm E; Kaufman JM; Kiemeney LA; Kloppenburg M; Kronenberg F; Kubo M; Lahti J; Lapauw B; Li S; Liewald DCM; Lifelines Cohort Study; Lim EM; Linneberg A; Marina M; Mascalzoni D; Matsuda K; Medenwald D; Meisinger C; Meulenbelt I; De Meyer T; Meyer Zu Schwabedissen HE; Mikolajczyk R; Moed M; Netea-Maier RT; Nolte IM; Okada Y; Pala M; Pattaro C; Pedersen O; Petersmann A; Porcu E; Postmus I; Pramstaller PP; Psaty BM; Ramos YFM; Rawal R; Redmond P; Richards JB; Rietzschel ER; Rivadeneira F; Roef G; Rotter JI; Sala CF; Schlessinger D; Selvin E; Slagboom PE; Soranzo N; Sørensen TIA; Spector TD; Starr JM; Stott DJ; Taes Y; Taliun D; Tanaka T; Thuesen B; Tiller D; Toniolo D; Uitterlinden AG; Visser WE; Walsh JP; Wilson SG; Wolffenbuttel BHR; Yang Q; Zheng HF; Cappola A; Peeters RP; Naitza S; Völzke H; Sanna S; Köttgen A; Visser TJ; Medici M (2018)
      Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only ...
    • Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria 

      Teumer A; Li Y; Ghasemi S; Prins BP; Wuttke M; Hermle T; Giri A; Sieber KB; Qiu C; Kirsten H; Tin A; Chu AY; Bansal N; Feitosa MF; Wang L; Chai JF; Cocca M; Fuchsberger C; Gorski M; Hoppmann A; Horn K; Li M; Marten J; Noce D; Nutile T; Sedaghat S; Sveinbjornsson G; Tayo BO; van der Most PJ; Xu Y; Yu Z; Gerstner L; Ärnlöv J; Bakker SJL; Baptista D; Biggs ML; Boerwinkle E; Brenner H; Burkhardt R; Carroll RJ; Chee ML; Chen M; Cheng CY; Cook JP; Coresh J; Corre T; Danesh J; de Borst MH; De Grandi A; de Mutsert R; de Vries APJ; Degenhardt F; Dittrich K; Divers J; Eckardt KU; Ehret G; Endlich K; Felix JF; Franco OH; Franke A; Freedman BI; Freitag-Wolf S; Gansevoort RT; Giedraitis V; Gögele M; Grundner-Culemann F; Gudbjartsson DF; Gudnason V; Hamet P; Harris TB; Hicks AA; Holm H; Foo VHX; Hwang SJ; Ikram MA; Ingelsson E; Jaddoe VWV; Jakobsdottir J; Josyula NS; Jung B; Kähönen M; Khor CC; Kiess W; Koenig W; Körner A; Kovacs P; Kramer H; Krämer BK; Kronenberg F; Lange LA; Langefeld CD; Lee JJ; Lehtimäki T; Lieb W; Lim SC; Lind L; Lindgren CM; Liu J; Loeffler M; Lyytikäinen LP; Mahajan A; Maranville JC; Mascalzoni D; McMullen B; Meisinger C; Meitinger T; Miliku K; Mook-Kanamori DO; Müller-Nurasyid M; Mychaleckyj JC; Nauck M; Nikus K; Ning B; Noordam R; Connell JO; Olafsson I; Palmer ND; Peters A; Podgornaia AI; Ponte B; Poulain T; Pramstaller PP; Rabelink TJ; Raffield LM; Reilly DF; Rettig R; Rheinberger M; Rice KM; Rivadeneira F; Runz H; Ryan KA; Sabanayagam C; Saum KU; Schöttker B; Shaffer CM; Shi Y; Smith AV; Strauch K; Stumvoll M; Sun BB; Szymczak S; Tai ES; Tan NYQ; Taylor KD; Teren A; Tham YC; Thiery J; Thio CHL; Thomsen H; Thorsteinsdottir U; Tönjes A; Tremblay J; Uitterlinden AG; van der Harst P; Verweij N; Vogelezang S; Völker U; Waldenberger M; Wang C; Wilson OD; Wong C; Wong TY; Yang Q; Yasuda M; Akilesh S; Bochud M; Böger CA; Devuyst O; Edwards TL; Ho K; Morris AP; Parsa A; Pendergrass SA; Psaty BM; Rotter JI; Stefansson K; Wilson JG; Susztak K; Snieder H; Heid IM; Scholz M; Butterworth AS; Hung AM; Pattaro C; Köttgen A (2019)
      Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we ...
    • Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels 

      Tin A; Marten J; Halperin Kuhns VL; Li Y; Wuttke M; Kirsten H; Sieber KB; Qiu C; Gorski M; Yu Z; Giri A; Sveinbjornsson G; Li M; Chu AY; Hoppmann A; O'Connor LJ; Prins B; Nutile T; Noce D; Akiyama M; Cocca M; Ghasemi S; van der Most PJ; Horn K; Xu Y; Fuchsberger C; Sedaghat S; Afaq S; Amin N; Ärnlöv J; Bakker SJL; Bansal N; Baptista D; Bergmann S; Biggs ML; Biino G; Boerwinkle E; Bottinger EP; Boutin TS; Brumat M; Burkhardt R; Campana E; Campbell A; Campbell H; Carroll RJ; Catamo E; Chambers JC; Ciullo M; Concas MP; Coresh J; Corre T; Cusi D; Felicita SC; de Borst MH; De Grandi A; de Mutsert R; de Vries APJ; Delgado G; Demirkan A; Devuyst O; Dittrich K; Eckardt KU; Ehret G; Endlich K; Evans MK; Gansevoort RT; Gasparini P; Giedraitis V; Gieger C; Girotto G; Gögele M; Gordon SD; Gudbjartsson DF; Gudnason V; Haller T; Hamet P; Harris TB; Hayward C; Hicks AA; Hofer E; Holm H; Huang W; Hutri-Kähönen N; Hwang SJ; Ikram MA; Lewis RM; Ingelsson E; Jakobsdottir J; Jonsdottir I; Jonsson H; Joshi PK; Josyula NS; Jung B; Kähönen M; Kamatani Y; Kanai M; Kerr SM; Kiess W; Kleber ME; Koenig W; Kooner JS; Körner A; Kovacs P; Krämer BK; Kronenberg F; Kubo M; Kühnel B; La Bianca M; Lange LA; Lehne B; Lehtimäki T; Liu J; Loeffler M; Loos RJF; Lyytikäinen LP; Magi R; Mahajan A; Martin NG; März W; Mascalzoni D; Matsuda K; Meisinger C; Meitinger T; Metspalu A; Milaneschi Y; O'Donnell CJ; Wilson OD; Gaziano JM; Mishra PP; Mohlke KL; Mononen N; Montgomery GW; Mook-Kanamori DO; Müller-Nurasyid M; Nadkarni GN; Nalls MA; Nauck M; Nikus K; Ning B; Nolte IM; Noordam R; O'Connell JR; Olafsson I; Padmanabhan S; Penninx BWJH; Perls T; Peters A; Pirastu M; Pirastu N; Pistis G; Polasek O; Ponte B; Porteous DJ; Poulain T; Preuss MH; Rabelink TJ; Raffield LM; Raitakari OT; Rettig R; Rheinberger M; Rice KM; Rizzi F; Robino A; Rudan I; Krajcoviechova A; Cifkova R; Rueedi R; Ruggiero D; Ryan KA; Saba Y; Salvi E; Schmidt H; Schmidt R; Shaffer CM; Smith AV; Smith BH; Spracklen CN; Strauch K; Stumvoll M; Sulem P; Tajuddin SM; Teren A; Thiery J; Thio CHL; Thorsteinsdottir U; Toniolo D; Tönjes A; Tremblay J; Uitterlinden AG; Vaccargiu S; van der Harst P; van Duijn CM; Verweij N; Völker U; Vollenweider P; Waeber G; Waldenberger M; Whitfield JB; Wild SH; Wilson JF; Yang Q; Zhang W; Zonderman AB; Bochud M; Wilson JG; Pendergrass SA; Ho K; Parsa A; Pramstaller PP; Psaty BM; Böger CA; Snieder H; Butterworth AS; Okada Y; Edwards TL; Stefansson K; Susztak K; Scholz M; Heid IM; Hung AM; Teumer A; Pattaro C; Woodward OM; Vitart V; Köttgen A (2019)
      Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, ...