Now showing items 1-8 of 8

    • Associations of autozygosity with a broad range of human phenotypes 

      Clark DW; Okada Y; Moore KHS; Mason D; Pirastu N; Gandin I; Mattsson H; Barnes CLK; Lin K; Zhao JH; Deelen P; Rohde R; Schurmann C; Guo X; Giulianini F; Zhang W; Medina-Gomez C; Karlsson R; Bao Y; Bartz TM; Baumbach C; Biino G; Bixley MJ; Brumat M; Chai JF; Corre T; Cousminer DL; Dekker AM; Eccles DA; van Eijk KR; Fuchsberger C; Gao H; Germain M; Gordon SD; de Haan HG; Harris SE; Hofer E; Huerta-Chagoya A; Igartua C; Jansen IE; Jia Y; Kacprowski T; Karlsson T; Kleber ME; Li SA; Li-Gao R; Mahajan A; Matsuda K; Meidtner K; Meng W; Montasser ME; van der Most PJ; Munz M; Nutile T; Palviainen T; Prasad G; Prasad RB; Priyanka TDS; Rizzi F; Salvi E; Sapkota BR; Shriner D; Skotte L; Smart MC; Smith AV; van der Spek A; Spracklen CN; Strawbridge RJ; Tajuddin SM; Trompet S; Turman C; Verweij N; Viberti C; Wang L; Warren HR; Wootton RE; Yanek LR; Yao J; Yousri NA; Zhao W; Adeyemo AA; Afaq S; Aguilar-Salinas CA; Akiyama M; Albert ML; Allison MA; Alver M; Aung T; Azizi F; Bentley AR; Boeing H; Boerwinkle E; Borja JB; de Borst GJ; Bottinger EP; Broer L; Campbell H; Chanock S; Chee ML; Chen G; Chen YI; Chen Z; Chiu YF; Cocca M; Collins FS; Concas MP; Corley J; Cugliari G; van Dam RM; Damulina A; Daneshpour MS; Day FR; Delgado GE; Dhana K; Doney ASF; Dörr M; Doumatey AP; Dzimiri N; Ebenesersdóttir SS; Elliott J; Elliott P; Ewert R; Felix JF; Fischer K; Freedman BI; Girotto G; Goel A; Gögele M; Goodarzi MO; Graff M; Granot-Hershkovitz E; Grodstein F; Guarrera S; Gudbjartsson DF; Guity K; Gunnarsson B; Guo Y; Hagenaars SP; Haiman CA; Halevy A; Harris TB; Hedayati M; van Heel DA; Hirata M; Höfer I; Hsiung CA; Huang J; Hung YJ; Ikram MA; Jagadeesan A; Jousilahti P; Kamatani Y; Kanai M; Kerrison ND; Kessler T; Khaw KT; Khor CC; de Kleijn DPV; Koh WP; Kolcic I; Kraft P; Krämer BK; Kutalik Z; Kuusisto J; Langenberg C; Launer LJ; Lawlor DA; Lee IT; Lee WJ; Lerch MM; Li L; Liu J; Loh M; London SJ; Loomis S; Lu Y; Luan J; Mägi R; Manichaikul AW; Manunta P; Másson G; Matoba N; Mei XW; Meisinger C; Meitinger T; Mezzavilla M; Milani L; Millwood IY; Momozawa Y; Moore A; Morange PE; Moreno-Macías H; Mori TA; Morrison AC; Muka T; Murakami Y; Murray AD; de Mutsert R; Mychaleckyj JC; Nalls MA; Nauck M; Neville MJ; Nolte IM; Ong KK; Orozco L; Padmanabhan S; Pálsson G; Pankow JS; Pattaro C; Pattie A; Polasek O; Poulter N; Pramstaller PP; Quintana-Murci L; Räikkönen K; Ralhan S; Rao DC; van Rheenen W; Rich SS; Ridker PM; Rietveld CA; Robino A; van Rooij FJA; Ruggiero D; Saba Y; Sabanayagam C; Sabater-Lleal M; Sala CF; Salomaa V; Sandow K; Schmidt H; Scott LJ; Scott WR; Sedaghati-Khayat B; Sennblad B; van Setten J; Sever PJ; Sheu WH; Shi Y; Shrestha S; Shukla SR; Sigurdsson JK; Sikka TT; Singh JR; Smith BH; Stančáková A; Stanton A; Starr JM; Stefansdottir L; Straker L; Sulem P; Sveinbjornsson G; Swertz MA; Taylor AM; Taylor KD; Terzikhan N; Tham YC; Thorleifsson G; Thorsteinsdottir U; Tillander A; Tracy RP; Tusié-Luna T; Tzoulaki I; Vaccargiu S; Vangipurapu J; Veldink JH; Vitart V; Völker U; Vuoksimaa E; Wakil SM; Waldenberger M; Wander GS; Wang YX; Wareham NJ; Wild S; Yajnik CS; Yuan JM; Zeng L; Zhang L; Zhou J; Amin N; Asselbergs FW; Bakker SJL; Becker DM; Lehne B; Bennett DA; van den Berg LH; Berndt SI; Bharadwaj D; Bielak LF; Bochud M; Boehnke M; Bouchard C; Bradfield JP; Brody JA; Campbell A; Carmi S; Caulfield MJ; Cesarini D; Chambers JC; Chandak GR; Cheng CY; Ciullo M; Cornelis M; Cusi D; Smith GD; Deary IJ; Dorajoo R; van Duijn CM; Ellinghaus D; Erdmann J; Eriksson JG; Evangelou E; Evans MK; Faul JD; Feenstra B; Feitosa M; Foisy S; Franke A; Friedlander Y; Gasparini P; Gieger C; Gonzalez C; Goyette P; Grant SFA; Griffiths LR; Groop L; Gudnason V; Gyllensten U; Hakonarson H; Hamsten A; van der Harst P; Heng CK; Hicks AA; Hochner H; Huikuri H; Hunt SC; Jaddoe VWV; De Jager PL; Johannesson M; Johansson Å; Jonas JB; Jukema JW; Junttila J; Kaprio J; Kardia SLR; Karpe F; Kumari M; Laakso M; van der Laan SW; Lahti J; Laudes M; Lea RA; Lieb W; Lumley T; Martin NG; März W; Matullo G; McCarthy MI; Medland SE; Merriman TR; Metspalu A; Meyer BF; Mohlke KL; Montgomery GW; Mook-Kanamori D; Munroe PB; North KE; Nyholt DR; O'connell JR; Ober C; Oldehinkel AJ; Palmas W; Palmer C; Pasterkamp GG; Patin E; Pennell CE; Perusse L; Peyser PA; Pirastu M; Polderman TJC; Porteous DJ; Posthuma D; Psaty BM; Rioux JD; Rivadeneira F; Rotimi C; Rotter JI; Rudan I; Den Ruijter HM; Sanghera DK; Sattar N; Schmidt R; Schulze MB; Schunkert H; Scott RA; Shuldiner AR; Sim X; Small N; Smith JA; Sotoodehnia N; Tai ES; Teumer A; Timpson NJ; Toniolo D; Tregouet DA; Tuomi T; Vollenweider P; Wang CA; Weir DR; Whitfield JB; Wijmenga C; Wong TY; Wright J; Yang J; Yu L; Zemel BS; Zonderman AB; Perola M; Magnusson PKE; Uitterlinden AG; Kooner JS; Chasman DI; Loos RJF; Franceschini N; Franke L; Haley CS; Hayward C; Walters RG; Perry JRB; Esko T; Helgason A; Stefansson K; Joshi PK; Kubo M; Wilson JF (2019)
      In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction ...
    • A catalog of genetic loci associated with kidney function from analyses of a million individuals 

      Wuttke M; Li Y; Li M; Sieber KB; Feitosa MF; Gorski M; Tin A; Wang L; Chu AY; Hoppmann A; Kirsten H; Giri A; Chai JF; Sveinbjornsson G; Tayo BO; Nutile T; Fuchsberger C; Marten J; Cocca M; Ghasemi S; Xu Y; Horn K; Noce D; van der Most PJ; Sedaghat S; Yu Z; Akiyama M; Afaq S; Ahluwalia TS; Almgren P; Amin N; Ärnlöv J; Bakker SJL; Bansal N; Baptista D; Bergmann S; Biggs ML; Biino G; Boehnke M; Boerwinkle E; Boissel M; Bottinger EP; Boutin TS; Brenner H; Brumat M; Burkhardt R; Butterworth AS; Campana E; Campbell A; Campbell H; Canouil M; Carroll RJ; Catamo E; Chambers JC; Chee ML; Chen X; Cheng CY; Cheng Y; Christensen K; Cifkova R; Ciullo M; Concas MP; Cook JP; Coresh J; Corre T; Sala CF; Cusi D; Danesh J; Daw EW; de Borst MH; De Grandi A; de Mutsert R; de Vries APJ; Degenhardt F; Delgado G; Demirkan A; Di Angelantonio E; Dittrich K; Divers J; Dorajoo R; Eckardt KU; Ehret G; Elliott P; Endlich K; Evans MK; Felix JF; Foo VHX; Franco OH; Franke A; Freedman BI; Freitag-Wolf S; Friedlander Y; Froguel P; Gansevoort RT; Gao H; Gasparini P; Gaziano JM; Giedraitis V; Gieger C; Girotto G; Giulianini F; Gögele M; Gordon SD; Gudbjartsson DF; Gudnason V; Haller T; Hamet P; Harris TB; Hartman CA; Hayward C; Hellwege JN; Heng CK; Hicks AA; Hofer E; Huang W; Hutri-Kähönen N; Hwang SJ; Ikram MA; Indridason OS; Ingelsson E; Ising M; Jaddoe VWV; Jakobsdottir J; Jonas JB; Joshi PK; Josyula NS; Jung B; Kähönen M; Kamatani Y; Kammerer CM; Kanai M; Kastarinen M; Kerr SM; Khor CC; Kiess W; Kleber ME; Koenig W; Kooner JS; Körner A; Kovacs P; Kraja AT; Krajcoviechova A; Kramer H; Krämer BK; Kronenberg F; Kubo M; Kühnel B; Kuokkanen M; Kuusisto J; La Bianca M; Laakso M; Lange LA; Langefeld CD; Lee JJ; Lehne B; Lehtimäki T; Lieb W; Lim SC; Lind L; Lindgren CM; Liu J; Loeffler M; Loos RJF; Lucae S; Lukas MA; Lyytikäinen LP; Mägi R; Magnusson PKE; Mahajan A; Martin NG; Martins J; März W; Mascalzoni D; Matsuda K; Meisinger C; Meitinger T; Melander O; Metspalu A; Mikaelsdottir EK; Milaneschi Y; Miliku K; Mishra PP; Mohlke KL; Mononen N; Montgomery GW; Mook-Kanamori DO; Mychaleckyj JC; Nadkarni GN; Nalls MA; Nauck M; Nikus K; Ning B; Nolte IM; Noordam R; O'Connell J; O'Donoghue ML; Olafsson I; Oldehinkel AJ; Orho-Melander M; Ouwehand WH; Padmanabhan S; Palmer ND; Palsson R; Penninx BWJH; Perls T; Perola M; Pirastu M; Pirastu N; Pistis G; Podgornaia AI; Polasek O; Ponte B; Porteous DJ; Poulain T; Pramstaller PP; Preuss MH; Prins BP; Province MA; Rabelink TJ; Raffield LM; Raitakari OT; Reilly DF; Rettig R; Rheinberger M; Rice KM; Ridker PM; Rivadeneira F; Rizzi F; Roberts DJ; Robino A; Rossing P; Rudan I; Rueedi R; Ruggiero D; Ryan KA; Saba Y; Sabanayagam C; Salomaa V; Salvi E; Saum KU; Schmidt H; Schmidt R; Schöttker B; Schulz CA; Schupf N; Shaffer CM; Shi Y; Smith AV; Smith BH; Soranzo N; Spracklen CN; Strauch K; Stringham HM; Stumvoll M; Svensson PO; Szymczak S; Tai ES; Tajuddin SM; Tan NYQ; Taylor KD; Teren A; Tham YC; Thiery J; Thio CHL; Thomsen H; Thorleifsson G; Toniolo D; Tönjes A; Tremblay J; Tzoulaki I; Uitterlinden AG; Vaccargiu S; van Dam RM; van der Harst P; van Duijn CM; Velez Edward DR; Verweij N; Vogelezang S; Völker U; Vollenweider P; Waeber G; Waldenberger M; Wallentin L; Wang YX; Wang C; Waterworth DM; Bin Wei W; White H; Whitfield JB; Wild SH; Wilson JF; Wojczynski MK; Wong C; Wong TY; Xu L; Yang Q; Yasuda M; Yerges-Armstrong LM; Zhang W; Zonderman AB; Rotter JI; Bochud M; Psaty BM; Vitart V; Wilson JG; Dehghan A; Parsa A; Chasman DI; Ho K; Morris AP; Devuyst O; Akilesh S; Pendergrass SA; Sim X; Böger CA; Okada Y; Edwards TL; Snieder H; Stefansson K; Hung AM; Heid IM; Scholz M; Teumer A; Köttgen A; Pattaro C (2019)
      Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate ...
    • Directional dominance on stature and cognition in diverse human populations 

      Joshi PK; Esko T; Mattsson H; Eklund N; Gandin I; Nutile T; Jackson AU; Schurmann C; Smith AV; Zhang W; Okada Y; Stančáková A; Faul JD; Zhao W; Bartz TM; Concas MP; Franceschini N; Enroth S; Vitart V; Trompet S; Guo X; Chasman DI; O'Connel JR; Corre T; Nongmaithem SS; Chen Y; Mangino M; Ruggiero D; Traglia M; Farmaki AE; Kacprowski T; Bjonnes A; van der Spek A; Wu Y; Giri AK; Yanek LR; Wang L; Hofer E; Rietveld CA; McLeod O; Cornelis MC; Pattaro C; Verweij N; Baumbach C; Abdellaoui A; Warren HR; Vuckovic D; Mei H; Bouchard C; Perry JR; Cappellani S; Mirza SS; Benton MC; Broeckel U; Medland SE; Lind PA; Malerba G; Drong A; Yengo L; Bielak LF; Zhi D; van der Most PJ; Shriner D; Mägi R; Hemani G; Karaderi T; Wang Z; Liu T; Demuth I; Zhao JH; Meng W; Lataniotis L; van der Laan SW; Bradfield JP; Wood AR; Bonnefond A; Ahluwalia TS; Hall LM; Salvi E; Yazar S; Carstensen L; de Haan HG; Abney M; Afzal U; Allison MA; Amin N; Asselbergs FW; Bakker SJ; Barr RG; Baumeister SE; Benjamin DJ; Bergmann S; Boerwinkle E; Bottinger EP; Campbell A; Chakravarti A; Chan Y; Chanock SJ; Chen C; Chen YD; Collins FS; Connell J; Correa A; Cupples LA; Smith GD; Davies G; Dörr M; Ehret G; Ellis SB; Feenstra B; Feitosa MF; Ford I; Fox CS; Frayling TM; Friedrich N; Geller F; Scotland G; Gillham-Nasenya I; Gottesman O; Graff M; Grodstein F; Gu C; Haley C; Hammond CJ; Harris SE; Harris TB; Hastie ND; Heard-Costa NL; Heikkilä K; Hocking LJ; Homuth G; Hottenga JJ; Huang J; Huffman JE; Hysi PG; Ikram MA; Ingelsson E; Joensuu A; Johansson Å; Jousilahti P; Jukema JW; Kähönen M; Kamatani Y; Kanoni S; Kerr SM; Khan NM; Koellinger P; Koistinen HA; Kooner MK; Kubo M; Kuusisto J; Lahti J; Launer LJ; Lea RA; Lehne B; Lehtimäki T; Liewald DC; Lind L; Loh M; Lokki ML; London SJ; Loomis SJ; Loukola A; Lu Y; Lumley T; Lundqvist A; Männistö S; Marques-Vidal P; Masciullo C; Matchan A; Mathias RA; Matsuda K; Meigs JB; Meisinger C; Meitinger T; Menni C; Mentch FD; Mihailov E; Milani L; Montasser ME; Montgomery GW; Morrison A; Myers RH; Nadukuru R; Navarro P; Nelis M; Nieminen MS; Nolte IM; O'Connor GT; Ogunniyi A; Padmanabhan S; Palmas WR; Pankow JS; Patarcic I; Pavani F; Peyser PA; Pietilainen K; Poulter N; Prokopenko I; Ralhan S; Redmond P; Rich SS; Rissanen H; Robino A; Rose LM; Rose R; Sala C; Salako B; Salomaa V; Sarin AP; Saxena R; Schmidt H; Scott LJ; Scott WR; Sennblad B; Seshadri S; Sever P; Shrestha S; Smith BH; Smith JA; Soranzo N; Sotoodehnia N; Southam L; Stanton AV; Stathopoulou MG; Strauch K; Strawbridge RJ; Suderman MJ; Tandon N; Tang ST; Taylor KD; Tayo BO; Töglhofer AM; Tomaszewski M; Tšernikova N; Tuomilehto J; Uitterlinden AG; Vaidya D; van Hylckama Vlieg A; van Setten J; Vasankari T; Vedantam S; Vlachopoulou E; Vozzi D; Vuoksimaa E; Waldenberger M; Ware EB; Wentworth-Shields W; Whitfield JB; Wild S; Willemsen G; Yajnik CS; Yao J; Zaza G; Zhu X; BioBank Japan Project; Salem RM; Melbye M; Bisgaard H; Samani NJ; Cusi D; Mackey DA; Cooper RS; Froguel P; Pasterkamp G; Grant SF; Hakonarson H; Ferrucci L; Scott RA; Morris AD; Palmer CN; Dedoussis G; Deloukas P; Bertram L; Lindenberger U; Berndt SI; Lindgren CM; Timpson NJ; Tönjes A; Munroe PB; Sørensen TI; Rotimi CN; Arnett DK; Oldehinkel AJ; Kardia SL; Balkau B; Gambaro G; Morris AP; Eriksson JG; Wright MJ; Martin NG; Hunt SC; Starr JM; Deary IJ; Griffiths LR; Tiemeier H; Pirastu N; Kaprio J; Wareham NJ; Pérusse L; Wilson JG; Girotto G; Caulfield MJ; Raitakari O; Boomsma DI; Gieger C; van der Harst P; Hicks AA; Kraft P; Sinisalo J; Knekt P; Johannesson M; Magnusson PK; Hamsten A; Schmidt R; Borecki IB; Vartiainen E; Becker DM; Bharadwaj D; Mohlke KL; Boehnke M; van Duijn CM; Sanghera DK; Teumer A; Zeggini E; Metspalu A; Gasparini P; Ulivi S; Ober C; Toniolo D; Rudan I; Porteous DJ; Ciullo M; Spector TD; Hayward C; Dupuis J; Loos RJ; Wright AF; Chandak GR; Vollenweider P; Shuldiner AR; Ridker PM; Rotter JI; Sattar N; Gyllensten U; North KE; Pirastu M; Psaty BM; Weir DR; Laakso M; Gudnason V; Takahashi A; Chambers JC; Kooner JS; Strachan DP; Campbell H; Hirschhorn JN; Perola M; Polašek O; Wilson JF (2015)
      Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant ...
    • Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits 

      Evangelou E; Warren HR; Mosen-Ansorena D; Mifsud B; Pazoki R; Gao H; Ntritsos G; Dimou N; Cabrera CP; Karaman I; Ng FL; Evangelou M; Witkowska K; Tzanis E; Hellwege JN; Giri A; Velez Edwards DR; Sun YV; Cho K; Gaziano JM; Wilson PWF; Tsao PS; Kovesdy CP; Esko T; Mägi R; Milani L; Almgren P; Boutin T; Debette S; Ding J; Giulianini F; Holliday EG; Jackson AU; Li-Gao R; Lin WY; Luan J; Mangino M; Oldmeadow C; Prins BP; Qian Y; Sargurupremraj M; Shah N; Surendran P; Thériault S; Verweij N; Willems SM; Zhao JH; Amouyel P; Connell J; de Mutsert R; Doney ASF; Farrall M; Menni C; Morris AD; Noordam R; Paré G; Poulter NR; Shields DC; Stanton A; Thom S; Abecasis G; Amin N; Arking DE; Ayers KL; Barbieri CM; Batini C; Bis JC; Blake T; Bochud M; Boehnke M; Boerwinkle E; Boomsma DI; Bottinger EP; Braund PS; Brumat M; Campbell A; Campbell H; Chakravarti A; Chambers JC; Chauhan G; Ciullo M; Cocca M; Collins F; Cordell HJ; Davies G; Borst MH; Geus EJ; Deary IJ; Deelen J; Del Greco M F; Demirkale CY; Dörr M; Ehret GB; Elosua R; Enroth S; Erzurumluoglu AM; Ferreira T; Frånberg M; Franco OH; Gandin I; Gasparini P; Giedraitis V; Gieger C; Girotto G; Goel A; Gow AJ; Gudnason V; Guo X; Gyllensten U; Hamsten A; Harris TB; Harris SE; Hartman CA; Havulinna AS; Hicks AA; Hofer E; Hofman A; Hottenga JJ; Huffman JE; Hwang SJ; Ingelsson E; James A; Jansen R; Jarvelin MR; Joehanes R; Johansson Å; Johnson AD; Joshi PK; Jousilahti P; Jukema JW; Jula A; Kähönen M; Kathiresan S; Keavney BD; Khaw KT; Knekt P; Knight J; Kolcic I; Kooner JS; Koskinen S; Kristiansson K; Kutalik Z; Laan M; Larson M; Launer LJ; Lehne B; Lehtimäki T; Liewald DCM; Lin L; Lind L; Lindgren CM; Liu Y; Loos RJF; Lopez LM; Lu Y; Lyytikäinen LP; Mahajan A; Mamasoula C; Marrugat J; Marten J; Milaneschi Y; Morgan A; Morris AP; Morrison AC; Munson PJ; Nalls MA; Nandakumar P; Nelson CP; Niiranen T; Nolte IM; Nutile T; Oldehinkel AJ; Oostra BA; O'Reilly PF; Org E; Padmanabhan S; Palmas W; Palotie A; Pattie A; Penninx BWJH; Perola M; Peters A; Polasek O; Pramstaller PP; Nguyen QT; Raitakari OT; Ren M; Rettig R; Rice K; Ridker PM; Ried JS; Riese H; Ripatti S; Robino A; Rose LM; Rotter JI; Rudan I; Ruggiero D; Saba Y; Sala CF; Salomaa V; Samani NJ; Sarin AP; Schmidt R; Schmidt H; Shrine N; Siscovick D; Smith AV; Snieder H; Sõber S; Sorice R; Starr JM; Stott DJ; Strachan DP; Strawbridge RJ; Sundström J; Swertz MA; Taylor KD; Teumer A; Tobin MD; Tomaszewski M; Toniolo D; Traglia M; Trompet S; Tuomilehto J; Tzourio C; Uitterlinden AG; Vaez A; van der Most PJ; van Duijn CM; Vergnaud AC; Verwoert GC; Vitart V; Völker U; Vollenweider P; Vuckovic D; Watkins H; Wild SH; Willemsen G; Wilson JF; Wright AF; Yao J; Zemunik T; Zhang W; Attia JR; Butterworth AS; Chasman DI; Conen D; Cucca F; Danesh J; Hayward C; Howson JMM; Laakso M; Lakatta EG; Langenberg C; Melander O; Mook-Kanamori DO; Palmer CNA; Risch L; Scott RA; Scott RJ; Sever P; Spector TD; van der Harst P; Wareham NJ; Zeggini E; Levy D; Munroe PB; Newton-Cheh C; Brown MJ; Metspalu A; Hung AM; O'Donnell CJ; Edwards TL; Million Veteran Program; Psaty BM; Tzoulaki I; Barnes MR; Wain LV; Elliott P; Caulfield MJ (2018)
      High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in ...
    • Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity 

      Joshi PK; Pirastu N; Kentistou KA; Fischer K; Hofer E; Schraut KE; Clark DW; Nutile T; Barnes CLK; Timmers PRHJ; Shen X; Gandin I; McDaid AF; Hansen TF; Gordon SD; Giulianini F; Boutin TS; Abdellaoui A; Zhao W; Medina-Gomez C; Bartz TM; Trompet S; Lange LA; Raffield L; van der Spek A; Galesloot TE; Proitsi P; Yanek LR; Bielak LF; Payton A; Murgia F; Concas MP; Biino G; Tajuddin SM; Seppälä I; Amin N; Boerwinkle E; Børglum AD; Campbell A; Demerath EW; Demuth I; Faul JD; Ford I; Gialluisi A; Gögele M; Graff M; Hingorani A; Hottenga JJ; Hougaard DM; Hurme MA; Ikram MA; Jylhä M; Kuh D; Ligthart L; Lill CM; Lindenberger U; Lumley T; Mägi R; Marques-Vidal P; Medland SE; Milani L; Nagy R; Ollier WER; Peyser PA; Pramstaller PP; Ridker PM; Rivadeneira F; Ruggiero D; Saba Y; Schmidt R; Schmidt H; Slagboom PE; Smith BH; Smith JA; Sotoodehnia N; Steinhagen-Thiessen E; van Rooij FJA; Verbeek AL; Vermeulen SH; Vollenweider P; Wang Y; Werge T; Whitfield JB; Zonderman AB; Lehtimäki T; Evans MK; Pirastu M; Fuchsberger C; Bertram L; Pendleton N; Kardia SLR; Ciullo M; Becker DM; Wong A; Psaty BM; van Duijn CM; Wilson JG; Jukema JW; Kiemeney L; Uitterlinden AG; Franceschini N; North KE; Weir DR; Metspalu A; Boomsma DI; Hayward C; Chasman D; Martin NG; Sattar N; Campbell H; Esko T; Kutalik Z; Wilson JF (2017)
      Genomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of 606,059 parents' survival, we discover two regions associated with longevity ...
    • Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney 

      Wain LV; Vaez A; Jansen R; Joehanes R; van der Most PJ; Erzurumluoglu AM; O'Reilly PF; Cabrera CP; Warren HR; Rose LM; Verwoert GC; Hottenga JJ; Strawbridge RJ; Esko T; Arking DE; Hwang SJ; Guo X; Kutalik Z; Trompet S; Shrine N; Teumer A; Ried JS; Bis JC; Smith AV; Amin N; Nolte IM; Lyytikäinen LP; Mahajan A; Wareham NJ; Hofer E; Joshi PK; Kristiansson K; Traglia M; Havulinna AS; Goel A; Nalls MA; Sõber S; Vuckovic D; Luan J; Del Greco M F; Ayers KL; Marrugat J; Ruggiero D; Lopez LM; Niiranen T; Enroth S; Jackson AU; Nelson CP; Huffman JE; Zhang W; Marten J; Gandin I; Harris SE; Zemunik T; Lu Y; Evangelou E; Shah N; de Borst MH; Mangino M; Prins BP; Campbell A; Li-Gao R; Chauhan G; Oldmeadow C; Abecasis G; Abedi M; Barbieri CM; Barnes MR; Batini C; Beilby J; Blake T; Boehnke M; Bottinger EP; Braund PS; Brown M; Brumat M; Campbell H; Chambers JC; Cocca M; Collins F; Connell J; Cordell HJ; Damman JJ; Davies G; de Geus EJ; de Mutsert R; Deelen J; Demirkale Y; Doney ASF; Dörr M; Farrall M; Ferreira T; Frånberg M; Gao H; Giedraitis V; Gieger C; Giulianini F; Gow AJ; Hamsten A; Harris TB; Hofman A; Holliday EG; Hui J; Jarvelin MR; Johansson Å; Johnson AD; Jousilahti P; Jula A; Kähönen M; Kathiresan S; Khaw KT; Kolcic I; Koskinen S; Langenberg C; Larson M; Launer LJ; Lehne B; Liewald DCM; Lin L; Lind L; Mach F; Mamasoula C; Menni C; Mifsud B; Milaneschi Y; Morgan A; Morris AD; Morrison AC; Munson PJ; Nandakumar P; Nguyen QT; Nutile T; Oldehinkel AJ; Oostra BA; Org E; Padmanabhan S; Palotie A; Paré G; Pattie A; Penninx BWJH; Poulter N; Pramstaller PP; Raitakari OT; Ren M; Rice K; Ridker PM; Riese H; Ripatti S; Robino A; Rotter JI; Rudan I; Saba Y; Saint-Pierre A; Sala CF; Sarin AP; Schmidt R; Scott R; Seelen MA; Shields DC; Siscovick D; Sorice R; Stanton A; Stott DJ; Sundström J; Swertz M; Taylor KD; Thom S; Tzoulaki I; Tzourio C; Uitterlinden AG; Völker U; Vollenweider P; Wild S; Willemsen G; Wright AF; Yao J; Thériault S; Conen D; Attia J; Sever P; Debette S; Mook-Kanamori DO; Zeggini E; Spector TD; van der Harst P; Palmer CNA; Vergnaud AC; Loos RJF; Polasek O; Starr JM; Girotto G; Hayward C; Kooner JS; Lindgren CM; Vitart V; Samani NJ; Tuomilehto J; Gyllensten U; Knekt P; Deary IJ; Ciullo M; Elosua R; Keavney BD; Hicks AA; Scott RA; Gasparini P; Laan M; Liu Y; Watkins H; Hartman CA; Salomaa V; Toniolo D; Perola M; Wilson JF; Schmidt H; Zhao JH; Lehtimäki T; van Duijn CM; Gudnason V; Psaty BM; Peters A; Rettig R; James A; Jukema JW; Strachan DP; Palmas W; Metspalu A; Ingelsson E; Boomsma DI; Franco OH; Bochud M; Newton-Cheh C; Munroe PB; Elliott P; Chasman DI; Chakravarti A; Knight J; Morris AP; Levy D; Tobin MD; Snieder H; Caulfield MJ; Ehret GB (2017)
      Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets ...
    • SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function 

      Li M; Li Y; Weeks O; Mijatovic V; Teumer A; Huffman JE; Tromp G; Fuchsberger C; Gorski M; Lyytikäinen LP; Nutile T; Sedaghat S; Sorice R; Tin A; Yang Q; Ahluwalia TS; Arking DE; Bihlmeyer NA; Böger CA; Carroll RJ; Chasman DI; Cornelis MC; Dehghan A; Faul JD; Feitosa MF; Gambaro G; Gasparini P; Giulianini F; Heid I; Huang J; Imboden M; Jackson AU; Jeff J; Jhun MA; Katz R; Kifley A; Kilpeläinen TO; Kumar A; Laakso M; Li-Gao R; Lohman K; Lu Y; Mägi R; Malerba G; Mihailov E; Mohlke KL; Mook-Kanamori DO; Robino A; Ruderfer D; Salvi E; Schick UM; Schulz CA; Smith AV; Smith JA; Traglia M; Yerges-Armstrong LM; Zhao W; Goodarzi MO; Kraja AT; Liu C; Boerwinkle E; Borecki IB; Bork-Jensen J; Bottinger EP; Braga D; Brandslund I; Brody JA; Campbell A; Carey DJ; Christensen C; Coresh J; Crook E; Curhan GC; Cusi D; de Boer IH; de Vries AP; Denny JC; Devuyst O; Dreisbach AW; Endlich K; Esko T; Franco OH; Fulop T; Gerhard GS; Glümer C; Gottesman O; Grarup N; Gudnason V; Hansen T; Harris TB; Hayward C; Hocking L; Hofman A; Hu FB; Husemoen LL; Jackson RD; Jørgensen T; Jørgensen ME; Kähönen M; Kardia SL; König W; Kooperberg C; Kriebel J; Launer LJ; Lauritzen T; Lehtimäki T; Levy D; Linksted P; Linneberg A; Liu Y; Loos RJ; Lupo A; Meisinger C; Melander O; Metspalu A; Mitchell P; Nauck M; Nürnberg P; Orho-Melander M; Parsa A; Pedersen O; Peters A; Peters U; Polasek O; Porteous D; Probst-Hensch NM; Psaty BM; Qi L; Raitakari OT; Reiner AP; Rettig R; Ridker PM; Rivadeneira F; Rossouw JE; Schmidt F; Siscovick D; Soranzo N; Strauch K; Toniolo D; Turner ST; Uitterlinden AG; Ulivi S; Velayutham D; Völker U; Völzke H; Waldenberger M; Wang JJ; Weir DR; Witte D; Kuivaniemi H; Fox CS; Franceschini N; Goessling W; Köttgen A; Chu AY; Wessel J (2017)
      Genome-wide association studies have identified >50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analysis of associations ...
    • Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels 

      Tin A; Marten J; Halperin Kuhns VL; Li Y; Wuttke M; Kirsten H; Sieber KB; Qiu C; Gorski M; Yu Z; Giri A; Sveinbjornsson G; Li M; Chu AY; Hoppmann A; O'Connor LJ; Prins B; Nutile T; Noce D; Akiyama M; Cocca M; Ghasemi S; van der Most PJ; Horn K; Xu Y; Fuchsberger C; Sedaghat S; Afaq S; Amin N; Ärnlöv J; Bakker SJL; Bansal N; Baptista D; Bergmann S; Biggs ML; Biino G; Boerwinkle E; Bottinger EP; Boutin TS; Brumat M; Burkhardt R; Campana E; Campbell A; Campbell H; Carroll RJ; Catamo E; Chambers JC; Ciullo M; Concas MP; Coresh J; Corre T; Cusi D; Felicita SC; de Borst MH; De Grandi A; de Mutsert R; de Vries APJ; Delgado G; Demirkan A; Devuyst O; Dittrich K; Eckardt KU; Ehret G; Endlich K; Evans MK; Gansevoort RT; Gasparini P; Giedraitis V; Gieger C; Girotto G; Gögele M; Gordon SD; Gudbjartsson DF; Gudnason V; Haller T; Hamet P; Harris TB; Hayward C; Hicks AA; Hofer E; Holm H; Huang W; Hutri-Kähönen N; Hwang SJ; Ikram MA; Lewis RM; Ingelsson E; Jakobsdottir J; Jonsdottir I; Jonsson H; Joshi PK; Josyula NS; Jung B; Kähönen M; Kamatani Y; Kanai M; Kerr SM; Kiess W; Kleber ME; Koenig W; Kooner JS; Körner A; Kovacs P; Krämer BK; Kronenberg F; Kubo M; Kühnel B; La Bianca M; Lange LA; Lehne B; Lehtimäki T; Liu J; Loeffler M; Loos RJF; Lyytikäinen LP; Magi R; Mahajan A; Martin NG; März W; Mascalzoni D; Matsuda K; Meisinger C; Meitinger T; Metspalu A; Milaneschi Y; O'Donnell CJ; Wilson OD; Gaziano JM; Mishra PP; Mohlke KL; Mononen N; Montgomery GW; Mook-Kanamori DO; Müller-Nurasyid M; Nadkarni GN; Nalls MA; Nauck M; Nikus K; Ning B; Nolte IM; Noordam R; O'Connell JR; Olafsson I; Padmanabhan S; Penninx BWJH; Perls T; Peters A; Pirastu M; Pirastu N; Pistis G; Polasek O; Ponte B; Porteous DJ; Poulain T; Preuss MH; Rabelink TJ; Raffield LM; Raitakari OT; Rettig R; Rheinberger M; Rice KM; Rizzi F; Robino A; Rudan I; Krajcoviechova A; Cifkova R; Rueedi R; Ruggiero D; Ryan KA; Saba Y; Salvi E; Schmidt H; Schmidt R; Shaffer CM; Smith AV; Smith BH; Spracklen CN; Strauch K; Stumvoll M; Sulem P; Tajuddin SM; Teren A; Thiery J; Thio CHL; Thorsteinsdottir U; Toniolo D; Tönjes A; Tremblay J; Uitterlinden AG; Vaccargiu S; van der Harst P; van Duijn CM; Verweij N; Völker U; Vollenweider P; Waeber G; Waldenberger M; Whitfield JB; Wild SH; Wilson JF; Yang Q; Zhang W; Zonderman AB; Bochud M; Wilson JG; Pendergrass SA; Ho K; Parsa A; Pramstaller PP; Psaty BM; Böger CA; Snieder H; Butterworth AS; Okada Y; Edwards TL; Stefansson K; Susztak K; Scholz M; Heid IM; Hung AM; Teumer A; Pattaro C; Woodward OM; Vitart V; Köttgen A (2019)
      Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, ...