Browsing Journal article - Institute for Biomedicine by Title
Now showing items 265-284 of 422
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Mannose and fructose metabolism in red blood cells during cold storage in SAGM
(2017)BACKGROUND: Alternate sugar metabolism during red blood cell (RBC) storage is not well understood. Here we report fructose and mannose metabolism in RBCs during cold storage in SAGM and the impact that these monosaccharides ... -
Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci
(2013)Nearly three-quarters of the 143 genetic signals associated with platelet and erythrocyte phenotypes identified by meta-analyses of genome-wide association (GWA) studies are located at non-protein-coding regions. Here, we ... -
A marker for the end of adolescence
(2004)Between childhood and adulthood, we go through puberty and adolescence. While the end of puberty is defined as the point of cessation of bone growth (epiphyseal closure; girls: 16 y; boys: 17.5 y), the end of adolescence ... -
Mendelian Randomization as an Approach to Assess Causality Using Observational Data
(2016)Mendelian randomization refers to an analytic approach to assess the causality of an observed association between a modifiable exposure or risk factor and a clinically relevant outcome. It presents a valuable tool, especially ... -
Mendelian randomization incorporating uncertainty about pleiotropy
(2017)Mendelian randomization (MR) requires strong assumptions about the genetic instruments, of which the most difficult to justify relate to pleiotropy. In a two-sample MR, different methods of analysis are available if we are ... -
Mendelian Randomization using Public Data from Genetic Consortia
(2016)Mendelian randomization (MR) is a technique that seeks to establish causation between an exposure and an outcome using observational data. It is an instrumental variable analysis in which genetic variants are used as the ... -
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
(2010)Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. ... -
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci
(2016)Meta-analyses of association results for blood pressure using exome-centric single-variant and gene-based tests identified 31 new loci in a discovery stage among 146,562 individuals, with follow-up and meta-analysis in ... -
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations
(2012)Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a ... -
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations
(2009)Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis of genome-wide association ... -
Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics
(2013)Meta-analysis of genome-wide association studies (GWASs) has led to the discoveries of many common variants associated with complex human diseases. There is a growing recognition that identifying "causal" rare variants ... -
Meta-analysis of genetic association studies: magic tool or dangerous black box?
(2010)In the field of genetic epidemiology, where primary studies are often underpowered to detect small genetic effects and where conflicting results and non-replication of initial findings are often encountered [1], the ... -
The meta-analysis of genome-wide association studies
(2011)The pressure to publish novel genetic associations has meant that meta-analysis has been applied to genome-wide association studies without the time for a careful consideration of the methods that are used. This review ... -
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
(2011)We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases ... -
Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels
(2014)Osteoprotegerin (OPG) is involved in bone homeostasis and tumor cell survival. Circulating OPG levels are also important biomarkers of various clinical traits, such as cancers and atherosclerosis. OPG levels were measured ... -
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels
(2011)BACKGROUND: C-reactive protein (CRP) is a heritable marker of chronic inflammation that is strongly associated with cardiovascular disease. We sought to identify genetic variants that are associated with CRP levels. METHODS ... -
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes
(2014)Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by ... -
A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level
(2010)BACKGROUND: Serum creatinine (S CR) is the most important biomarker for a quick and non-invasive assessment of kidney function in population-based surveys. A substantial proportion of the inter-individual variability in ...