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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
(2012)Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin ... -
Discovery and fine mapping of serum protein loci through transethnic meta-analysis
(2012)Many disorders are associated with altered serum protein concentrations, including malnutrition, cancer, and cardiovascular, kidney, and inflammatory diseases. Although these protein concentrations are highly heritable, ... -
Localising loci underlying complex trait variation using Regional Genomic Relationship Mapping
(2012)The limited proportion of complex trait variance identified in genome-wide association studies may reflect the limited power of single SNP analyses to detect either rare causative alleles or those of small effect. Motivated ... -
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
(2012)In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated ... -
Discovery and fine mapping of serum protein loci through transethnic meta-analysis
(2012)Many disorders are associated with altered serum protein concentrations, including malnutrition, cancer, and cardiovascular, kidney, and inflammatory diseases. Although these protein concentrations are highly heritable, ... -
Evidence of inbreeding depression on human height
(2012)Stature is a classical and highly heritable complex trait, with 80%-90% of variation explained by genetic factors. In recent years, genome-wide association studies (GWAS) have successfully identified many common additive ... -
Genome-wide analysis of epistasis in body mass index using multiple human populations
(2012)We surveyed gene-gene interactions (epistasis) in human body mass index (BMI) in four European populations (n<1200) via exhaustive pair-wise genome scans where interactions were computed as F ratios by testing a linear ... -
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations
(2012)Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their ... -
Genome-wide association and functional follow-up reveals new loci for kidney function
(2012)Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD ... -
FTO genotype is associated with phenotypic variability of body mass index
(2012)There is evidence across several species for genetic control of phenotypic variation of complex traits, such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important ...
