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Now showing items 21-30 of 30
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Genome-wide linkage analysis of serum creatinine in three isolated European populations
(2009)There is increasing evidence for a role of genetic predisposition in the etiology of kidney disease, but linkage scans have been poorly replicated. Here we performed a genome-wide linkage analysis of serum creatinine on ... -
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
(2010)Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. ... -
Discovery and fine mapping of serum protein loci through transethnic meta-analysis
(2012)Many disorders are associated with altered serum protein concentrations, including malnutrition, cancer, and cardiovascular, kidney, and inflammatory diseases. Although these protein concentrations are highly heritable, ... -
Evidence of inbreeding depression on human height
(2012)Stature is a classical and highly heritable complex trait, with 80%-90% of variation explained by genetic factors. In recent years, genome-wide association studies (GWAS) have successfully identified many common additive ... -
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations
(2012)Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their ... -
FTO genotype is associated with phenotypic variability of body mass index
(2012)There is evidence across several species for genetic control of phenotypic variation of complex traits, such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important ... -
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
(2012)Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci ... -
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
(2010)Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and ... -
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene
(2010)As major risk-factors for diabetes and cardiovascular diseases, the genetic contribution to obesity-related traits has been of interest for decades. Recently, a limited number of common genetic variants, which have replicated ... -
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
(2018)High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in ...
