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Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Wain LV; Verwoert GC; O'Reilly PF; Shi G; Johnson T; Johnson AD; Bochud M; Rice KM; Henneman P; Smith AV; Ehret GB; Amin N; Larson MG; Mooser V; Hadley D; Dörr M; Bis JC; Aspelund T; Esko T; Janssens AC; Zhao JH; Heath S; Laan M; Fu J; Pistis G; Luan J; Arora P; Lucas G; Pirastu N; Pichler I; Jackson AU; Webster RJ; Zhang F; Peden JF; Schmidt H; Tanaka T; Campbell H; Igl W; Milaneschi Y; Hottenga JJ; Vitart V; Chasman DI; Trompet S; Bragg-Gresham JL; Alizadeh BZ; Chambers JC; Guo X; Lehtimäki T; Kühnel B; Lopez LM; Polašek O; Boban M; Nelson CP; Morrison AC; Pihur V; Ganesh SK; Hofman A; Kundu S; Mattace-Raso FU; Rivadeneira F; Sijbrands EJ; Uitterlinden AG; Hwang SJ; Vasan RS; Wang TJ; Bergmann S; Vollenweider P; Waeber G; Laitinen J; Pouta A; Zitting P; McArdle WL; Kroemer HK; Völker U; Völzke H; Glazer NL; Taylor KD; Harris TB; Alavere H; Haller T; Keis A; Tammesoo ML; Aulchenko Y; Barroso I; Khaw KT; Galan P; Hercberg S; Lathrop M; Eyheramendy S; Org E; Sõber S; Lu X; Nolte IM; Penninx BW; Corre T; Masciullo C; Sala C; Groop L; Voight BF; Melander O; O'Donnell CJ; Salomaa V; D'Adamo AP; Fabretto A; Faletra F; Ulivi S; Del Greco M F; Facheris M; Collins FS; Bergman RN; Beilby JP; Hung J; Musk AW; Mangino M; Shin SY; Soranzo N; Watkins H; Goel A; Hamsten A; Gider P; Loitfelder M; Zeginigg M; Hernandez D; Najjar SS; Navarro P; Wild SH; Corsi AM; Singleton A; de Geus EJ; Willemsen G; Parker AN; Rose LM; Buckley B; Stott D; Orru M; Uda M; LifeLines Cohort Study; van der Klauw MM; Zhang W; Li X; Scott J; Chen YD; Burke GL; Kähönen M; Viikari J; Döring A; Meitinger T; Davies G; Starr JM; Emilsson V; Plump A; Lindeman JH; Hoen PA; König IR; EchoGen consortium; Felix JF; Clarke R; Hopewell JC; Ongen H; Breteler M; Debette S; DeStefano AL; Fornage M; AortaGen Consortium; Mitchell GF; CHARGE Consortium Heart Failure Working Group; Smith NL; KidneyGen consortium; Holm H; Stefansson K; Thorleifsson G; Thorsteinsdottir U; CKDGen Consortium; Cardiogenics consortium; CARDIoGRAM Consortium; Samani NJ; Preuss M; Rudan I; Hayward C; Deary IJ; Wichmann HE; Raitakari OT; Palmas W; Kooner JS; Stolk RP; Jukema JW; Wright AF; Boomsma DI; Bandinelli S; Gyllensten UB; Wilson JF; Ferrucci L; Schmidt R; Farrall M; Spector TD; Palmer LJ; Tuomilehto J; Pfeufer A; Gasparini P; Siscovick D; Altshuler D; Loos RJ; Toniolo D; Snieder H; Gieger C; Meneton P; Wareham NJ; Oostra BA; Metspalu A; Launer L; Rettig R; Strachan DP; Beckmann JS; Witteman JC; Erdmann J; van Dijk KW; Boerwinkle E; Boehnke M; Ridker PM; Jarvelin MR; Chakravarti A; Abecasis GR; Gudnason V; Newton-Cheh C; Levy D; Munroe PB; Psaty BM; Caulfield MJ; Rao DC; Tobin MD; Elliott P; van Duijn CM (2011)
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure ...
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

vvan Setten J; Brody JA; Jamshidi Y; Swenson BR; Butler AM; Campbell H; Del Greco M F; Evans DS; Gibson Q; Gudbjartsson DF; Kerr KF; Krijthe BP; Lyytikäinen LP; Müller C; Müller-Nurasyid M; Nolte IM; Padmanabhan S; Ritchie MD; Robino A; Smith AV; Steri M; Tanaka T; Teumer A; Trompet S; Ulivi S; Verweij N; Yin X; Arnar DO; Asselbergs FW; Bader JS; Barnard J; Bis J; Blankenberg S; Boerwinkle E; Bradford Y; Buckley BM; Chung MK; Crawford D; den Hoed M; Denny JC; Dominiczak AF; Ehret GB; Eijgelsheim M; Ellinor PT; Felix SB; Franco OH; Franke L; Harris TB; Holm H; Ilaria G; Iorio A; Kähönen M; Kolcic I; Kors JA; Lakatta EG; Launer LJ; Lin H; Lin HJ; Loos RJF; Lubitz SA; Macfarlane PW; Magnani JW; Leach IM; Meitinger T; Mitchell BD; Munzel T; Papanicolaou GJ; Peters A; Pfeufer A; Pramstaller PP; Raitakari OT; Rotter JI; Rudan I; Samani NJ; Schlessinger D; Silva Aldana CT; Sinner MF; Smith JD; Snieder H; Soliman EZ; Spector TD; Stott DJ; Strauch K; Tarasov KV; Thorsteinsdottir U; Uitterlinden AG; Van Wagoner DR; Völker U; Völzke H; Waldenberger M; Jan Westra H; Wild PS; Zeller T; Alonso A; Avery CL; Bandinelli S; Benjamin EJ; Cucca F; Dörr M; Ferrucci L; Gasparini P; Gudnason V; Hayward C; Heckbert SR; Hicks AA; Jukema JW; Kääb S; Lehtimäki T; Liu Y; Munroe PB; Parsa A; Polasek O; Psaty BM; Roden DM; Schnabel RB; Sinagra G; Stefansson K; Stricker BH; van der Harst P; van Duijn CM; Wilson JF; Gharib SA; de Bakker PIW; Isaacs A; Arking DE; Sotoodehnia N (2018)
Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome-wide association study of over 92,000 ...
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

Chasman DI; Fuchsberger C; Pattaro C; Teumer A; Böger CA; Endlich K; Olden M; Chen MH; Tin A; Taliun D; Li M; Gao X; Gorski M; Yang Q; Hundertmark C; Foster MC; O'Seaghdha CM; Glazer N; Isaacs A; Liu CT; Smith AV; O'Connell JR; Struchalin M; Tanaka T; Li G; Johnson AD; Gierman HJ; Feitosa MF; Hwang SJ; Atkinson EJ; Lohman K; Cornelis MC; Johansson A; Tönjes A; Dehghan A; Lambert JC; Holliday EG; Sorice R; Kutalik Z; Lehtimäki T; Esko T; Deshmukh H; Ulivi S; Chu AY; Murgia F; Trompet S; Imboden M; Coassin S; Pistis G; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium; WTCCC2; Harris TB; Launer LJ; Aspelund T; Eiriksdottir G; Mitchell BD; Boerwinkle E; Schmidt H; Cavalieri M; Rao M; Hu F; Demirkan A; Oostra BA; de Andrade M; Turner ST; Ding J; Andrews JS; Freedman BI; Giulianini F; Koenig W; Illig T; Meisinger C; Gieger C; Zgaga L; Zemunik T; Boban M; Minelli C; Wheeler HE; Igl W; Zaboli G; Wild SH; Wright AF; Campbell H; Ellinghaus D; Nöthlings U; Jacobs G; Biffar R; Ernst F; Homuth G; Kroemer HK; Nauck M; Stracke S; Völker U; Völzke H; Kovacs P; Stumvoll M; Mägi R; Hofman A; Uitterlinden AG; Rivadeneira F; Aulchenko YS; Polasek O; Hastie N; Vitart V; Helmer C; Wang JJ; Stengel B; Ruggiero D; Bergmann S; Kähönen M; Viikari J; Nikopensius T; Province M; Ketkar S; Colhoun H; Doney A; Robino A; Krämer BK; Portas L; Ford I; Buckley BM; Adam M; Thun GA; Paulweber B; Haun M; Sala C; Mitchell P; Ciullo M; Kim SK; Vollenweider P; Raitakari O; Metspalu A; Palmer C; Gasparini P; Pirastu M; Jukema JW; Probst-Hensch NM; Kronenberg F; Toniolo D; Gudnason V; Shuldiner AR; Coresh J; Schmidt R; Ferrucci L; Siscovick DS; van Duijn CM; Borecki IB; Kardia SL; Liu Y; Curhan GC; Rudan I; Gyllensten U; Wilson JF; Franke A; Pramstaller PP; Rettig R; Prokopenko I; Witteman J; Hayward C; Ridker PM; Parsa A; Bochud M; Heid IM; Kao WH; Fox CS; Köttgen A (2012)
In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated ...
Discovery and fine mapping of serum protein loci through transethnic meta-analysis

Franceschini N; van Rooij FJ; Prins BP; Feitosa MF; Karakas M; Eckfeldt JH; Folsom AR; Kopp J; Vaez A; Andrews JS; Baumert J; Boraska V; Broer L; Hayward C; Ngwa JS; Okada Y; Polasek O; Westra HJ; Wang YA; Del Greco M F; Glazer NL; Kapur K; Kema IP; Lopez LM; Schillert A; Smith AV; Winkler CA; Zgaga L; LifeLines Cohort Study; Bandinelli S; Bergmann S; Boban M; Bochud M; Chen YD; Davies G; Dehghan A; Ding J; Doering A; Durda JP; Ferrucci L; Franco OH; Franke L; Gunjaca G; Hofman A; Hsu FC; Kolcic I; Kraja A; Kubo M; Lackner KJ; Launer L; Loehr LR; Li G; Meisinger C; Nakamura Y; Schwienbacher C; Starr JM; Takahashi A; Torlak V; Uitterlinden AG; Vitart V; Waldenberger M; Wild PS; Kirin M; Zeller T; Zemunik T; Zhang Q; Ziegler A; Blankenberg S; Boerwinkle E; Borecki IB; Campbell H; Deary IJ; Frayling TM; Gieger C; Harris TB; Hicks AA; Koenig W; O' Donnell CJ; Fox CS; Pramstaller PP; Psaty BM; Reiner AP; Rotter JI; Rudan I; Snieder H; Tanaka T; van Duijn CM; Vollenweider P; Waeber G; Wilson JF; Witteman JC; Wolffenbuttel BH; Wright AF; Wu Q; Liu Y; Jenny NS; North KE; Felix JF; Alizadeh BZ; Cupples LA; Perry JR; Morris AP (2012)
Many disorders are associated with altered serum protein concentrations, including malnutrition, cancer, and cardiovascular, kidney, and inflammatory diseases. Although these protein concentrations are highly heritable, ...
Genome-wide association and functional follow-up reveals new loci for kidney function

Pattaro C; Köttgen A; Teumer A; Garnaas M; Böger CA; Fuchsberger C; Olden M; Chen MH; Tin A; Taliun D; Li M; Gao X; Gorski M; Yang Q; Hundertmark C; Foster MC; O'Seaghdha CM; Glazer N; Isaacs A; Liu CT; Smith AV; O'Connell JR; Struchalin M; Tanaka T; Li G; Johnson AD; Gierman HJ; Feitosa M; Hwang SJ; Atkinson EJ; Lohman K; Cornelis MC; Johansson Å; Tönjes A; Dehghan A; Chouraki V; Holliday EG; Sorice R; Kutalik Z; Lehtimäki T; Esko T; Deshmukh H; Ulivi S; Chu AY; Murgia F; Trompet S; Imboden M; Kollerits B; Pistis G; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium; Wellcome Trust Case Control Consortium 2; Harris TB; Launer LJ; Aspelund T; Eiriksdottir G; Mitchell BD; Boerwinkle E; Schmidt H; Cavalieri M; Rao M; Hu FB; Demirkan A; Oostra BA; de Andrade M; Turner ST; Ding J; Andrews JS; Freedman BI; Koenig W; Illig T; Döring A; Wichmann HE; Kolcic I; Zemunik T; Boban M; Minelli C; Wheeler HE; Igl W; Zaboli G; Wild SH; Wright AF; Campbell H; Ellinghaus D; Nöthlings U; Jacobs G; Biffar R; Endlich K; Ernst F; Homuth G; Kroemer HK; Nauck M; Stracke S; Völker U; Völzke H; Kovacs P; Stumvoll M; Mägi R; Hofman A; Uitterlinden AG; Rivadeneira F; Aulchenko YS; Polasek O; Hastie N; Vitart V; Helmer C; Wang JJ; Ruggiero D; Bergmann S; Kähönen M; Viikari J; Nikopensius T; Province M; Ketkar S; Colhoun H; Doney A; Robino A; Giulianini F; Krämer BK; Portas L; Ford I; Buckley BM; Adam M; Thun GA; Paulweber B; Haun M; Sala C; Metzger M; Mitchell P; Ciullo M; Kim SK; Vollenweider P; Raitakari O; Metspalu A; Palmer C; Gasparini P; Pirastu M; Jukema JW; Probst-Hensch NM; Kronenberg F; Toniolo D; Gudnason V; Shuldiner AR; Coresh J; Schmidt R; Ferrucci L; Siscovick DS; van Duijn CM; Borecki I; Kardia SL; Liu Y; Curhan GC; Rudan I; Gyllensten U; Wilson JF; Franke A; Pramstaller PP; Rettig R; Prokopenko I; Witteman JC; Hayward C; Ridker P; Parsa A; Bochud M; Heid IM; Goessling W; Chasman DI; Kao WH; Fox CS (2012)
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD ...
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

Vimaleswaran KS; Berry DJ; Lu C; Tikkanen E; Pilz S; Hiraki LT; Cooper JD; Dastani Z; Li R; Houston DK; Wood AR; Michaëlsson K; Vandenput L; Zgaga L; Yerges-Armstrong LM; McCarthy MI; Dupuis J; Kaakinen M; Kleber ME; Jameson K; Arden N; Raitakari O; Viikari J; Lohman KK; Ferrucci L; Melhus H; Ingelsson E; Byberg L; Lind L; Lorentzon M; Salomaa V; Campbell H; Dunlop M; Mitchell BD; Herzig KH; Pouta A; Hartikainen AL; Genetic Investigation of Anthropometric Traits-GIANT Consortium; Streeten EA; Theodoratou E; Jula A; Wareham NJ; Ohlsson C; Frayling TM; Kritchevsky SB; Spector TD; Richards JB; Lehtimäki T; Ouwehand WH; Kraft P; Cooper C; März W; Power C; Loos RJ; Wang TJ; Järvelin MR; Whittaker JC; Hingorani AD; Hyppönen E (2013)
BACKGROUND: Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin ...
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Scott RA; Lagou V; Welch RP; Wheeler E; Montasser ME; Luan J; Mägi R; Strawbridge RJ; Rehnberg E; Gustafsson S; Kanoni S; Rasmussen-Torvik LJ; Yengo L; Lecoeur C; Shungin D; Sanna S; Sidore C; Johnson PC; Jukema JW; Johnson T; Mahajan A; Verweij N; Thorleifsson G; Hottenga JJ; Shah S; Smith AV; Sennblad B; Gieger C; Salo P; Perola M; Timpson NJ; Evans DM; Pourcain BS; Wu Y; Andrews JS; Hui J; Bielak LF; Zhao W; Horikoshi M; Navarro P; Isaacs A; O'Connell JR; Stirrups K; Vitart V; Hayward C; Esko T; Mihailov E; Fraser RM; Fall T; Voight BF; Raychaudhuri S; Chen H; Lindgren CM; Morris AP; Rayner NW; Robertson N; Rybin D; Liu CT; Beckmann JS; Willems SM; Chines PS; Jackson AU; Kang HM; Stringham HM; Song K; Tanaka T; Peden JF; Goel A; Hicks AA; An P; Müller-Nurasyid M; Franco-Cereceda A; Folkersen L; Marullo L; Jansen H; Oldehinkel AJ; Bruinenberg M; Pankow JS; North KE; Forouhi NG; Loos RJ; Edkins S; Varga TV; Hallmans G; Oksa H; Antonella M; Nagaraja R; Trompet S; Ford I; Bakker SJ; Kong A; Kumari M; Gigante B; Herder C; Munroe PB; Caulfield M; Antti J; Mangino M; Small K; Miljkovic I; Liu Y; Atalay M; Kiess W; James AL; Rivadeneira F; Uitterlinden AG; Palmer CN; Doney AS; Willemsen G; Smit JH; Campbell S; Polasek O; Bonnycastle LL; Hercberg S; Dimitriou M; Bolton JL; Fowkes GR; Kovacs P; Lindström J; Zemunik T; Bandinelli S; Wild SH; Basart HV; Rathmann W; Grallert H; DIAGRAM Consortium; Maerz W; Kleber ME; Boehm BO; Peters A; Pramstaller PP; Province MA; Borecki IB; Hastie ND; Rudan I; Campbell H; Watkins H; Farrall M; Stumvoll M; Ferrucci L; Waterworth DM; Bergman RN; Collins FS; Tuomilehto J; Watanabe RM; de Geus EJ; Penninx BW; Hofman A; Oostra BA; Psaty BM; Vollenweider P; Wilson JF; Wright AF; Hovingh GK; Metspalu A; Uusitupa M; Magnusson PK; Kyvik KO; Kaprio J; Price JF; Dedoussis GV; Deloukas P; Meneton P; Lind L; Boehnke M; Shuldiner AR; van Duijn CM; Morris AD; Toenjes A; Peyser PA; Beilby JP; Körner A; Kuusisto J; Laakso M; Bornstein SR; Schwarz PE; Lakka TA; Rauramaa R; Adair LS; Smith GD; Spector TD; Illig T; de Faire U; Hamsten A; Gudnason V; Kivimaki M; Hingorani A; Keinanen-Kiukaanniemi SM; Saaristo TE; Boomsma DI; Stefansson K; van der Harst P; Dupuis J; Pedersen NL; Sattar N; Harris TB; Cucca F; Ripatti S; Salomaa V; Mohlke KL; Balkau B; Froguel P; Pouta A; Jarvelin MR; Wareham NJ; Bouatia-Naji N; McCarthy MI; Franks PW; Meigs JB; Teslovich TM; Florez JC; Langenberg C; Ingelsson E; Prokopenko I; Barroso I (2012)
Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci ...
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Dupuis J; Langenberg C; Prokopenko I; Saxena R; Soranzo N; Jackson AU; Wheeler E; Glazer NL; Bouatia-Naji N; Gloyn AL; Lindgren CM; Mägi R; Morris AP; Randall J; Johnson T; Elliott P; Rybin D; Thorleifsson G; Steinthorsdottir V; Henneman P; Grallert H; Dehghan A; Hottenga JJ; Franklin CS; Navarro P; Song K; Goel A; Perry JR; Egan JM; Lajunen T; Grarup N; Sparsø T; Doney A; Voight BF; Stringham HM; Li M; Kanoni S; Shrader P; Cavalcanti-Proença C; Kumari M; Qi L; Timpson NJ; Gieger C; Zabena C; Rocheleau G; Ingelsson E; An P; O'Connell J; Luan J; Elliott A; McCarroll SA; Payne F; Roccasecca RM; Pattou F; Sethupathy P; Ardlie K; Ariyurek Y; Balkau B; Barter P; Beilby JP; Ben-Shlomo Y; Benediktsson R; Bennett AJ; Bergmann S; Bochud M; Boerwinkle E; Bonnefond A; Bonnycastle LL; Borch-Johnsen K; Böttcher Y; Brunner E; Bumpstead SJ; Charpentier G; Chen YD; Chines P; Clarke R; Coin LJ; Cooper MN; Cornelis M; Crawford G; Crisponi L; Day IN; de Geus EJ; Delplanque J; Dina C; Erdos MR; Fedson AC; Fischer-Rosinsky A; Forouhi NG; Fox CS; Frants R; Franzosi MG; Galan P; Goodarzi MO; Graessler J; Groves CJ; Grundy S; Gwilliam R; Gyllensten U; Hadjadj S; Hallmans G; Hammond N; Han X; Hartikainen AL; Hassanali N; Hayward C; Heath SC; Hercberg S; Herder C; Hicks AA; Hillman DR; Hingorani AD; Hofman A; Hui J; Hung J; Isomaa B; Johnson PR; Jørgensen T; Jula A; Kaakinen M; Kaprio J; Kesaniemi YA; Kivimaki M; Knight B; Koskinen S; Kovacs P; Kyvik KO; Lathrop GM; Lawlor DA; Le Bacquer O; Lecoeur C; Li Y; Lyssenko V; Mahley R; Mangino M; Manning AK; Martínez-Larrad MT; McAteer JB; McCulloch LJ; McPherson R; Meisinger C; Melzer D; Meyre D; Mitchell BD; Morken MA; Mukherjee S; Naitza S; Narisu N; Neville MJ; Oostra BA; Orrù M; Pakyz R; Palmer CN; Paolisso G; Pattaro C; Pearson D; Peden JF; Pedersen NL; Perola M; Pfeiffer AF; Pichler I; Polasek O; Posthuma D; Potter SC; Pouta A; Province MA; Psaty BM; Rathmann W; Rayner NW; Rice K; Ripatti S; Rivadeneira F; Roden M; Rolandsson O; Sandbaek A; Sandhu M; Sanna S; Sayer AA; Scheet P; Scott LJ; Seedorf U; Sharp SJ; Shields B; Sigurethsson G; Sijbrands EJ; Silveira A; Simpson L; Singleton A; Smith NL; Sovio U; Swift A; Syddall H; Syvänen AC; Tanaka T; Thorand B; Tichet J; Tönjes A; Tuomi T; Uitterlinden AG; van Dijk KW; van Hoek M; Varma D; Visvikis-Siest S; Vitart V; Vogelzangs N; Waeber G; Wagner PJ; Walley A; Walters GB; Ward KL; Watkins H; Weedon MN; Wild SH; Willemsen G; Witteman JC; Yarnell JW; Zeggini E; Zelenika D; Zethelius B; Zhai G; Zhao JH; Zillikens MC; DIAGRAM Consortium; GIANT Consortium; Global BPgen Consortium; Borecki IB; Loos RJ; Meneton P; Magnusson PK; Nathan DM; Williams GH; Hattersley AT; Silander K; Salomaa V; Smith GD; Bornstein SR; Schwarz P; Spranger J; Karpe F; Shuldiner AR; Cooper C; Dedoussis GV; Serrano-Ríos M; Morris AD; Lind L; Palmer LJ; Hu FB; Franks PW; Ebrahim S; Marmot M; Kao WH; Pankow JS; Sampson MJ; Kuusisto J; Laakso M; Hansen T; Pedersen O; Pramstaller PP; Wichmann HE; Illig T; Rudan I; Wright AF; Stumvoll M; Campbell H; Wilson JF; Anders Hamsten on behalf of Procardis Consortium; MAGIC Investigators; Bergman RN; Buchanan TA; Collins FS; Mohlke KL; Tuomilehto J; Valle TT; Altshuler D; Rotter JI; Siscovick DS; Penninx BW; Boomsma DI; Deloukas P; Spector TD; Frayling TM; Ferrucci L; Kong A; Thorsteinsdottir U; Stefansson K; van Duijn CM; Aulchenko YS; Cao A; Scuteri A; Schlessinger D; Uda M; Ruokonen A; Jarvelin MR; Waterworth DM; Vollenweider P; Peltonen L; Mooser V; Abecasis GR; Wareham NJ; Sladek R; Froguel P; Watanabe RM; Meigs JB; Groop L; Boehnke M; McCarthy MI; Florez JC; Barroso I (2010)
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and ...
Genome-wide association meta-analysis of PR interval identifies 50 novel loci associated with atrial and atrioventricular electrical activity

van Setten J; Brody JA; Jamshidi Y; Swenson BR; Butler AM; Campbell H; Del Greco M F; Evans DS; Gibson Q; Gudbjartsson DF; Kerr KF; Krijthe BP; Lyytikäinen LP; Müller C; Müller-Nurasyid M; Nolte IM; Padmanabhan S; Ritchie MD; Robino A; Smith AV; Steri M; Tanaka T; Teumer A; Trompet S; Ulivi S; Verweij N; Yin X; Arnar DO; Asselbergs FW; Bader JS; Barnard J; Bis S; Blankenberg S; Boerwinkle E; Bradford Y; Buckley BM; Chung MK; Crawford D; den Hoed M; Denny JC; Dominiczak AF; Ehret GB; Eijgelsheim M; Ellinor PT; Felix SB; Franco OH; Franke L; Harris TB; Holm H; Gandin I; Iorio A; Kähönen M; Kolcic I; Kors JA; Lakatta EG; Launer LJ; Lin H; Lin HJ; Loos RJF; Lubitz SA; Macfarlane PW; Magnani JW; Mateo Leach I; Meitinger T; Mitchell BD; Munzel T; Papanicolaou GJ; Peters A; Pfeufer A; Pramstaller PP; Raitakari OT; Rotter JI; Rudan I; Samani NJ; Schlessinger D; Silva Aldana CT; Sinner MF; Smith JD; Snieder H; Soliman EZ; Spector TD; Stott DJ; Strauch K; Tarasov KV; Thorsteinsdottir U; Uitterlinden AG; Van Wagoner DR; Völker U; Völzke H; Waldenberger M; Jan Westra H; Wild PS; Zeller T; Alonso A; Avery CL; Bandinelli S; Benjamin EJ; Cucca F; Dörr M; Ferrucci L; Gasparini P; Gudnason V; Hayward C; Heckbert SR; Hicks AA; Wouter Jukema J; Kääb S; Lehtimäki T; Liu Y; Munroe PB; Parsa A; Polasek O; Psaty BM; Roden DM; Schnabel RB; Sinagra G; Stefansson K; Stricker BH; van der Harst P; van Duijn CM; Wilson JF; Gharib SA; de Bakker PIW; Isaacs A; Arking DE; Sotoodehnia N (2018)
Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome-wide association study of over 92,000 ...

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