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ATP13A2 variants in early-onset Parkinson's disease patients and controls
(2009)Four genes responsible for recessively inherited forms of Parkinson's disease (PD) have been identified, including the recently discovered ATP13A2 (PARK9) gene. Our objective was to investigate the role of this gene in a ... -
Structural findings in the basal ganglia in genetically determined and idiopathic Parkinson's disease
(2009)A bilateral compensatory increase of basal ganglia (BG) gray matter value (GMV) was recently demonstrated in asymptomatic Parkin mutation carriers, who likely have an increased risk to develop Parkinson's disease (PD). We ... -
Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype
(2009)OBJECTIVE: To use a combined neurogenetic-neuroimaging approach to examine the functional consequences of preclinical dopaminergic nigrostriatal dysfunction in the human motor system. Specifically, we examined how a single ...