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Directional dominance on stature and cognition in diverse human populations
Joshi PK; Esko T; Mattsson H; Eklund N; Gandin I; Nutile T; Jackson AU; Schurmann C; Smith AV; Zhang W; Okada Y; Stančáková A; Faul JD; Zhao W; Bartz TM; Concas MP; Franceschini N; Enroth S; Vitart V; Trompet S; Guo X; Chasman DI; O'Connel JR; Corre T; Nongmaithem SS; Chen Y; Mangino M; Ruggiero D; Traglia M; Farmaki AE; Kacprowski T; Bjonnes A; van der Spek A; Wu Y; Giri AK; Yanek LR; Wang L; Hofer E; Rietveld CA; McLeod O; Cornelis MC; Pattaro C; Verweij N; Baumbach C; Abdellaoui A; Warren HR; Vuckovic D; Mei H; Bouchard C; Perry JR; Cappellani S; Mirza SS; Benton MC; Broeckel U; Medland SE; Lind PA; Malerba G; Drong A; Yengo L; Bielak LF; Zhi D; van der Most PJ; Shriner D; Mägi R; Hemani G; Karaderi T; Wang Z; Liu T; Demuth I; Zhao JH; Meng W; Lataniotis L; van der Laan SW; Bradfield JP; Wood AR; Bonnefond A; Ahluwalia TS; Hall LM; Salvi E; Yazar S; Carstensen L; de Haan HG; Abney M; Afzal U; Allison MA; Amin N; Asselbergs FW; Bakker SJ; Barr RG; Baumeister SE; Benjamin DJ; Bergmann S; Boerwinkle E; Bottinger EP; Campbell A; Chakravarti A; Chan Y; Chanock SJ; Chen C; Chen YD; Collins FS; Connell J; Correa A; Cupples LA; Smith GD; Davies G; Dörr M; Ehret G; Ellis SB; Feenstra B; Feitosa MF; Ford I; Fox CS; Frayling TM; Friedrich N; Geller F; Scotland G; Gillham-Nasenya I; Gottesman O; Graff M; Grodstein F; Gu C; Haley C; Hammond CJ; Harris SE; Harris TB; Hastie ND; Heard-Costa NL; Heikkilä K; Hocking LJ; Homuth G; Hottenga JJ; Huang J; Huffman JE; Hysi PG; Ikram MA; Ingelsson E; Joensuu A; Johansson Å; Jousilahti P; Jukema JW; Kähönen M; Kamatani Y; Kanoni S; Kerr SM; Khan NM; Koellinger P; Koistinen HA; Kooner MK; Kubo M; Kuusisto J; Lahti J; Launer LJ; Lea RA; Lehne B; Lehtimäki T; Liewald DC; Lind L; Loh M; Lokki ML; London SJ; Loomis SJ; Loukola A; Lu Y; Lumley T; Lundqvist A; Männistö S; Marques-Vidal P; Masciullo C; Matchan A; Mathias RA; Matsuda K; Meigs JB; Meisinger C; Meitinger T; Menni C; Mentch FD; Mihailov E; Milani L; Montasser ME; Montgomery GW; Morrison A; Myers RH; Nadukuru R; Navarro P; Nelis M; Nieminen MS; Nolte IM; O'Connor GT; Ogunniyi A; Padmanabhan S; Palmas WR; Pankow JS; Patarcic I; Pavani F; Peyser PA; Pietilainen K; Poulter N; Prokopenko I; Ralhan S; Redmond P; Rich SS; Rissanen H; Robino A; Rose LM; Rose R; Sala C; Salako B; Salomaa V; Sarin AP; Saxena R; Schmidt H; Scott LJ; Scott WR; Sennblad B; Seshadri S; Sever P; Shrestha S; Smith BH; Smith JA; Soranzo N; Sotoodehnia N; Southam L; Stanton AV; Stathopoulou MG; Strauch K; Strawbridge RJ; Suderman MJ; Tandon N; Tang ST; Taylor KD; Tayo BO; Töglhofer AM; Tomaszewski M; Tšernikova N; Tuomilehto J; Uitterlinden AG; Vaidya D; van Hylckama Vlieg A; van Setten J; Vasankari T; Vedantam S; Vlachopoulou E; Vozzi D; Vuoksimaa E; Waldenberger M; Ware EB; Wentworth-Shields W; Whitfield JB; Wild S; Willemsen G; Yajnik CS; Yao J; Zaza G; Zhu X; BioBank Japan Project; Salem RM; Melbye M; Bisgaard H; Samani NJ; Cusi D; Mackey DA; Cooper RS; Froguel P; Pasterkamp G; Grant SF; Hakonarson H; Ferrucci L; Scott RA; Morris AD; Palmer CN; Dedoussis G; Deloukas P; Bertram L; Lindenberger U; Berndt SI; Lindgren CM; Timpson NJ; Tönjes A; Munroe PB; Sørensen TI; Rotimi CN; Arnett DK; Oldehinkel AJ; Kardia SL; Balkau B; Gambaro G; Morris AP; Eriksson JG; Wright MJ; Martin NG; Hunt SC; Starr JM; Deary IJ; Griffiths LR; Tiemeier H; Pirastu N; Kaprio J; Wareham NJ; Pérusse L; Wilson JG; Girotto G; Caulfield MJ; Raitakari O; Boomsma DI; Gieger C; van der Harst P; Hicks AA; Kraft P; Sinisalo J; Knekt P; Johannesson M; Magnusson PK; Hamsten A; Schmidt R; Borecki IB; Vartiainen E; Becker DM; Bharadwaj D; Mohlke KL; Boehnke M; van Duijn CM; Sanghera DK; Teumer A; Zeggini E; Metspalu A; Gasparini P; Ulivi S; Ober C; Toniolo D; Rudan I; Porteous DJ; Ciullo M; Spector TD; Hayward C; Dupuis J; Loos RJ; Wright AF; Chandak GR; Vollenweider P; Shuldiner AR; Ridker PM; Rotter JI; Sattar N; Gyllensten U; North KE; Pirastu M; Psaty BM; Weir DR; Laakso M; Gudnason V; Takahashi A; Chambers JC; Kooner JS; Strachan DP; Campbell H; Hirschhorn JN; Perola M; Polašek O; Wilson JF (2015)Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant ... -
Genetic studies of body mass index yield new insights for obesity biology
Locke AE; Kahali B; Berndt SI; Justice AE; Pers TH; Day FR; Powell C; Vedantam S; Buchkovich ML; Yang J; Croteau-Chonka DC; Esko T; Fall T; Ferreira T; Gustafsson S; Kutalik Z; Luan J; Mägi R; Randall JC; Winkler TW; Wood AR; Workalemahu T; Faul JD; Smith JA; Hua Zhao J; Zhao W; Chen J; Fehrmann R; Hedman ÅK; Karjalainen J; Schmidt EM; Absher D; Amin N; Anderson D; Beekman M; Bolton JL; Bragg-Gresham JL; Buyske S; Demirkan A; Deng G; Ehret GB; Feenstra B; Feitosa MF; Fischer K; Goel A; Gong J; Jackson AU; Kanoni S; Kleber ME; Kristiansson K; Lim U; Lotay V; Mangino M; Mateo Leach I; Medina-Gomez C; Medland SE; Nalls MA; Palmer CD; Pasko D; Pechlivanis S; Peters MJ; Prokopenko I; Shungin D; Stančáková A; Strawbridge RJ; Ju Sung Y; Tanaka T; Teumer A; Trompet S; van der Laan SW; van Setten J; van Vliet-Ostaptchouk JV; Wang Z; Yengo L; Zhang W; Isaacs A; Albrecht E; Ärnlöv J; Arscott GM; Attwood AP; Bandinelli S; Barrett A; Bas IN; Bellis C; Bennett AJ; Berne C; Blagieva R; Blüher M; Böhringer S; Bonnycastle LL; Böttcher Y; Boyd HA; Bruinenberg M; Caspersen IH; Ida Chen YD; Clarke R; Daw EW; de Craen AJ; Delgado G; Dimitriou M; Doney AS; Eklund N; Estrada K; Eury E; Folkersen L; Fraser RM; Garcia ME; Geller F; Giedraitis V; Gigante B; Go AS; Golay A; Goodall AH; Gordon SD; Gorski M; Grabe HJ; Grallert H; Grammer TB; Gräßler J; Grönberg H; Groves CJ; Gusto G; Haessler J; Hall P; Haller T; Hallmans G; Hartman CA; Hassinen M; Hayward C; Heard-Costa NL; Helmer Q; Hengstenberg C; Holmen O; Hottenga JJ; James AL; Jeff JM; Johansson Å; Jolley J; Juliusdottir T; Kinnunen L; Koenig W; Koskenvuo M; Kratzer W; Laitinen J; Lamina C; Leander K; Lee NR; Lichtner P; Lind L; Lindström J; Sin Lo K; Lobbens S; Lorbeer R; Lu Y; Mach F; Magnusson PK; Mahajan A; McArdle WL; McLachlan S; Menni C; Merger S; Mihailov E; Milani L; Moayyeri A; Monda KL; Morken MA; Mulas A; Müller G; Müller-Nurasyid M; Musk AW; Nagaraja R; Nöthen MM; Nolte IM; Pilz S; Rayner NW; Renstrom F; Rettig R; Ried JS; Ripke S; Robertson NR; Rose LM; Sanna S; Scharnagl H; Scholtens S; Schumacher FR; Scott WR; Seufferlein T; Shi J; Vernon Smith A; Smolonska J; Stanton AV; Steinthorsdottir V; Stirrups K; Stringham HM; Sundström J; Swertz MA; Swift AJ; Syvänen AC; Tan ST; Tayo BO; Thorand B; Thorleifsson G; Tyrer JP; Uh HW; Vandenput L; Verhulst FC; Vermeulen SH; Verweij N; Vonk JM; Waite LL; Warren HR; Waterworth D; Weedon MN; Wilkens LR; Willenborg C; Wilsgaard T; Wojczynski MK; Wong A; Wright AF; Zhang Q; LifeLines Cohort Study; Brennan EP; Choi M; Dastani Z; Drong AW; Eriksson P; Franco-Cereceda A; Gådin JR; Gharavi AG; Goddard ME; Handsaker RE; Huang J; Karpe F; Kathiresan S; Keildson S; Kiryluk K; Kubo M; Lee JY; Liang L; Lifton RP; Ma B; McCarroll SA; McKnight AJ; Min JL; Moffatt MF; Montgomery GW; Murabito JM; Nicholson G; Nyholt DR; Okada Y; Perry JR; Dorajoo R; Reinmaa E; Salem RM; Sandholm N; Scott RA; Stolk L; Takahashi A; Van't Hooft FM; Vinkhuyzen AA; Westra HJ; Zheng W; Zondervan KT; ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium; Heath AC; Arveiler D; Bakker SJ; Beilby J; Bergman RN; Blangero J; Bovet P; Campbell H; Caulfield MJ; Cesana G; Chakravarti A; Chasman DI; Chines PS; Collins FS; Crawford DC; Cupples LA; Cusi D; Danesh J; de Faire U; den Ruijter HM; Dominiczak AF; Erbel R; Erdmann J; Eriksson JG; Farrall M; Felix SB; Ferrannini E; Ferrières J; Ford I; Forouhi NG; Forrester T; Franco OH; Gansevoort RT; Gejman PV; Gieger C; Gottesman O; Gudnason V; Gyllensten U; Hall AS; Harris TB; Hattersley AT; Hicks AA; Hindorff LA; Hingorani AD; Hofman A; Homuth G; Hovingh GK; Humphries SE; Hunt SC; Hyppönen E; Illig T; Jacobs KB; Jarvelin MR; Jöckel KH; Johansen B; Jousilahti P; Jukema JW; Jula AM; Kaprio J; Kastelein JJ; Keinanen-Kiukaanniemi SM; Kiemeney LA; Knekt P; Kooner JS; Kooperberg C; Kovacs P; Kraja AT; Kumari M; Kuusisto J; Lakka TA; Langenberg C; Le Marchand L; Lehtimäki T; Lyssenko V; Männistö S; Marette A; Matise TC; McKenzie CA; McKnight B; Moll FL; Morris AD; Morris AP; Murray JC; Nelis M; Ohlsson C; Oldehinkel AJ; Ong KK; Madden PA; Pasterkamp G; Peden JF; Peters A; Postma DS; Pramstaller PP; Price JF; Qi L; Raitakari OT; Rankinen T; Rao DC; Rice TK; Ridker PM; Rioux JD; Ritchie MD; Rudan I; Salomaa V; Samani NJ; Saramies J; Sarzynski MA; Schunkert H; Schwarz PE; Sever P; Shuldiner AR; Sinisalo J; Stolk RP; Strauch K; Tönjes A; Trégouët DA; Tremblay A; Tremoli E; Virtamo J; Vohl MC; Völker U; Waeber G; Willemsen G; Witteman JC; Zillikens MC; Adair LS; Amouyel P; Asselbergs FW; Assimes TL; Bochud M; Boehm BO; Boerwinkle E; Bornstein SR; Bottinger EP; Bouchard C; Cauchi S; Chambers JC; Chanock SJ; Cooper RS; de Bakker PI; Dedoussis G; Ferrucci L; Franks PW; Froguel P; Groop LC; Haiman CA; Hamsten A; Hui J; Hunter DJ; Hveem K; Kaplan RC; Kivimaki M; Kuh D; Laakso M; Liu Y; Martin NG; März W; Melbye M; Metspalu A; Moebus S; Munroe PB; Njølstad I; Oostra BA; Palmer CN; Pedersen NL; Perola M; Pérusse L; Peters U; Power C; Quertermous T; Rauramaa R; Rivadeneira F; Saaristo TE; Saleheen D; Sattar N; Schadt EE; Schlessinger D; Slagboom PE; Snieder H; Spector TD; Thorsteinsdottir U; Stumvoll M; Tuomilehto J; Uitterlinden AG; Uusitupa M; van der Harst P; Walker M; Wallaschofski H; Wareham NJ; Watkins H; Weir DR; Wichmann HE; Wilson JF; Zanen P; Borecki IB; Deloukas P; Fox CS; Heid IM; O'Connell JR; Strachan DP; Stefansson K; van Duijn CM; Abecasis GR; Franke L; Frayling TM; McCarthy MI; Visscher PM; Scherag A; Willer CJ; Boehnke M; Mohlke KL; Lindgren CM; Beckmann JS; Barroso I; North KE; Ingelsson E; Hirschhorn JN; Loos RJ; Speliotes EK (2015)Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure ... -
New genetic loci link adipose and insulin biology to body fat distribution
Shungin D; Winkler TW; Croteau-Chonka DC; Ferreira T; Locke AE; Mägi R; Strawbridge RJ; Pers TH; Fischer K; Justice AE; Workalemahu T; Wu JM; Buchkovich ML; Heard-Costa NL; Roman TS; Drong AW; Song C; Gustafsson S; Day FR; Esko T; Fall T; Kutalik Z; Luan J; Randall JC; Scherag A; Vedantam S; Wood AR; Chen J; Fehrmann R; Karjalainen J; Kahali B; Liu CT; Schmidt EM; Absher D; Amin N; Anderson D; Beekman M; Bragg-Gresham JL; Buyske S; Demirkan A; Ehret GB; Feitosa MF; Goel A; Jackson AU; Johnson T; Kleber ME; Kristiansson K; Mangino M; Mateo Leach I; Medina-Gomez C; Palmer CD; Pasko D; Pechlivanis S; Peters MJ; Prokopenko I; Stančáková A; Ju Sung Y; Tanaka T; Teumer A; van Vliet-Ostaptchouk JV; Yengo L; Zhang W; Albrecht E; Ärnlöv J; Arscott GM; Bandinelli S; Barrett A; Bellis C; Bennett AJ; Berne C; Blüher M; Böhringer S; Bonnet F; Böttcher Y; Bruinenberg M; Carba DB; Caspersen IH; Clarke R; Daw EW; Deelen J; Deelman E; Delgado G; Doney AS; Eklund N; Erdos MR; Estrada K; Eury E; Friedrich N; Garcia ME; Giedraitis V; Gigante B; Go AS; Golay A; Grallert H; Grammer TB; Gräßler J; Grewal J; Groves CJ; Haller T; Hallmans G; Hartman CA; Hassinen M; Hayward C; Heikkilä K; Herzig KH; Helmer Q; Hillege HL; Holmen O; Hunt SC; Isaacs A; Ittermann T; James AL; Johansson I; Juliusdottir T; Kalafati IP; Kinnunen L; Koenig W; Kooner IK; Kratzer W; Lamina C; Leander K; Lee NR; Lichtner P; Lind L; Lindström J; Lobbens S; Lorentzon M; Mach F; Magnusson PK; Mahajan A; McArdle WL; Menni C; Merger S; Mihailov E; Milani L; Mills R; Moayyeri A; Monda KL; Mooijaart SP; Mühleisen TW; Mulas A; Müller G; Müller-Nurasyid M; Nagaraja R; Nalls MA; Narisu N; Glorioso N; Nolte IM; Olden M; Rayner NW; Renstrom F; Ried JS; Robertson NR; Rose LM; Sanna S; Scharnagl H; Scholtens S; Sennblad B; Seufferlein T; Sitlani CM; Vernon Smith A; Stirrups K; Stringham HM; Sundström J; Swertz MA; Swift AJ; Syvänen AC; Tayo BO; Thorand B; Thorleifsson G; Tomaschitz A; Troffa C; van Oort FV; Verweij N; Vonk JM; Waite LL; Wennauer R; Wilsgaard T; Wojczynski MK; Wong A; Zhang Q; Hua Zhao J; Brennan EP; Choi M; Eriksson P; Folkersen L; Franco-Cereceda A; Gharavi AG; Hedman ÅK; Hivert MF; Huang J; Kanoni S; Karpe F; Keildson S; Kiryluk K; Liang L; Lifton RP; Ma B; McKnight AJ; McPherson R; Metspalu A; Min JL; Moffatt MF; Montgomery GW; Murabito JM; Nicholson G; Nyholt DR; Olsson C; Perry JR; Reinmaa E; Salem RM; Sandholm N; Schadt EE; Scott RA; Stolk L; Vallejo EE; Westra HJ; Zondervan KT; ADIPOGen Consortium; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GEFOS Consortium; GENIE Consortium; GLGC; ICBP; International Endogene Consortium; LifeLines Cohort Study; MAGIC Investigators; MuTHER Consortium; PAGE Consortium; ReproGen Consortium; Amouyel P; Arveiler D; Bakker SJ; Beilby J; Bergman RN; Blangero J; Brown MJ; Burnier M; Campbell H; Chakravarti A; Chines PS; Claudi-Boehm S; Collins FS; Crawford DC; Danesh J; de Faire U; de Geus EJ; Dörr M; Erbel R; Eriksson JG; Farrall M; Ferrannini E; Ferrières J; Forouhi NG; Forrester T; Franco OH; Gansevoort RT; Gieger C; Gudnason V; Haiman CA; Harris TB; Hattersley AT; Heliövaara M; Hicks AA; Hingorani AD; Hoffmann W; Hofman A; Homuth G; Humphries SE; Hyppönen E; Illig T; Jarvelin MR; Johansen B; Jousilahti P; Jula AM; Kaprio J; Kee F; Keinanen-Kiukaanniemi SM; Kooner JS; Kooperberg C; Kovacs P; Kraja AT; Kumari M; Kuulasmaa K; Kuusisto J; Lakka TA; Langenberg C; Le Marchand L; Lehtimäki T; Lyssenko V; Männistö S; Marette A; Matise TC; McKenzie CA; McKnight B; Musk AW; Möhlenkamp S; Morris AD; Nelis M; Ohlsson C; Oldehinkel AJ; Ong KK; Palmer LJ; Penninx BW; Peters A; Pramstaller PP; Raitakari OT; Rankinen T; Rao DC; Rice TK; Ridker PM; Ritchie MD; Rudan I; Salomaa V; Samani NJ; Saramies J; Sarzynski MA; Schwarz PE; Shuldiner AR; Staessen JA; Steinthorsdottir V; Stolk RP; Strauch K; Tönjes A; Tremblay A; Tremoli E; Vohl MC; Völker U; Vollenweider P; Wilson JF; Witteman JC; Adair LS; Bochud M; Boehm BO; Bornstein SR; Bouchard C; Cauchi S; Caulfield MJ; Chambers JC; Chasman DI; Cooper RS; Dedoussis G; Ferrucci L; Froguel P; Grabe HJ; Hamsten A; Hui J; Hveem K; Jöckel KH; Kivimaki M; Kuh D; Laakso M; Liu Y; März W; Munroe PB; Njølstad I; Oostra BA; Palmer CN; Pedersen NL; Perola M; Pérusse L; Peters U; Power C; Quertermous T; Rauramaa R; Rivadeneira F; Saaristo TE; Saleheen D; Sinisalo J; Slagboom PE; Snieder H; Spector TD; Thorsteinsdottir U; Stumvoll M; Tuomilehto J; Uitterlinden AG; Uusitupa M; van der Harst P; Veronesi G; Walker M; Wareham NJ; Watkins H; Wichmann HE; Abecasis GR; Assimes TL; Berndt SI; Boehnke M; Borecki IB; Deloukas P; Franke L; Frayling TM; Groop LC; Hunter DJ; Kaplan RC; O'Connell JR; Qi L; Schlessinger D; Strachan DP; Stefansson K; van Duijn CM; Willer CJ; Visscher PM; Yang J; Hirschhorn JN; Zillikens MC; McCarthy MI; Speliotes EK; North KE; Fox CS; Barroso I; Franks PW; Ingelsson E; Heid IM; Loos RJ; Cupples LA; Morris AP; Lindgren CM; Mohlke KL (2015)Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and ...