Now showing items 1-6 of 6
NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium
Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, we conducted a two-stage genome-wide association analysis for waist ...
Genetic determinants of circulating sphingolipid concentrations in European populations
Sphingolipids have essential roles as structural components of cell membranes and in cell signalling, and disruption of their metabolism causes several diseases, with diverse neurological, psychiatric, and metabolic ...
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations
Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis of genome-wide association ...
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Recent genome-wide association (GWA) studies of lipids have been conducted in samples ascertained for other phenotypes, particularly diabetes. Here we report the first GWA analysis of loci affecting total cholesterol (TC), ...
Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis
Genes for height have gained interest for decades, but only recently have candidate genes started to be identified. We have performed linkage analysis and genome-wide association for height in approximately 4000 individuals ...
Genome-wide linkage analysis of serum creatinine in three isolated European populations
There is increasing evidence for a role of genetic predisposition in the etiology of kidney disease, but linkage scans have been poorly replicated. Here we performed a genome-wide linkage analysis of serum creatinine on ...