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Association of common variants in arrhythmogenic cardiomyopathy desmosomal genes with ECG traits in the general population
Purpose Arrhythmogenic cardiomyopathy (AC) is a rare condition, with familial inheritance, featuring life-threatening arrhythmias and cardiomyocite replacement with fibro-fatty cells. Such alterations are reflected in ...
Confounding and reverse causality have prevented us from drawing meaningful clinical interpretation even in well-powered observational studies. Confounding may be attributed to our inability to randomize the exposure ...
NOS1AP Variant rs7539120 is Associated with Appropriate Implantable Cardioverter Defibrillators (ICD) Shock
Implantable cardioverter defibrillators (ICD) are used to prevent Sudden Cardiac Death (SCD) in patients with heart failure, but currently only 30% of them experience an appropriate ICD activation during their life. ...
Bioinformatic and mendelian randomization analyses characterize variants in desmosomal genes associated with ECG traits in the general population
Introduction: Arrhythmogenic cardiomyopathy is caused by mutations in desmosomal genes. We previously tested association of common variants in such genes with physiological cardiac conduction traits. From an analysis of ...