Now showing items 1-12 of 12

    • Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits 

      Evangelou E; Warren HR; Mosen-Ansorena D; Mifsud B; Pazoki R; Gao H; Ntritsos G; Dimou N; Cabrera CP; Karaman I; Ng FL; Evangelou M; Witkowska K; Tzanis E; Hellwege JN; Giri A; Velez Edwards DR; Sun YV; Cho K; Gaziano JM; Wilson PWF; Tsao PS; Kovesdy CP; Esko T; Mägi R; Milani L; Almgren P; Boutin T; Debette S; Ding J; Giulianini F; Holliday EG; Jackson AU; Li-Gao R; Lin WY; Luan J; Mangino M; Oldmeadow C; Prins BP; Qian Y; Sargurupremraj M; Shah N; Surendran P; Thériault S; Verweij N; Willems SM; Zhao JH; Amouyel P; Connell J; de Mutsert R; Doney ASF; Farrall M; Menni C; Morris AD; Noordam R; Paré G; Poulter NR; Shields DC; Stanton A; Thom S; Abecasis G; Amin N; Arking DE; Ayers KL; Barbieri CM; Batini C; Bis JC; Blake T; Bochud M; Boehnke M; Boerwinkle E; Boomsma DI; Bottinger EP; Braund PS; Brumat M; Campbell A; Campbell H; Chakravarti A; Chambers JC; Chauhan G; Ciullo M; Cocca M; Collins F; Cordell HJ; Davies G; Borst MH; Geus EJ; Deary IJ; Deelen J; Del Greco M F; Demirkale CY; Dörr M; Ehret GB; Elosua R; Enroth S; Erzurumluoglu AM; Ferreira T; Frånberg M; Franco OH; Gandin I; Gasparini P; Giedraitis V; Gieger C; Girotto G; Goel A; Gow AJ; Gudnason V; Guo X; Gyllensten U; Hamsten A; Harris TB; Harris SE; Hartman CA; Havulinna AS; Hicks AA; Hofer E; Hofman A; Hottenga JJ; Huffman JE; Hwang SJ; Ingelsson E; James A; Jansen R; Jarvelin MR; Joehanes R; Johansson Å; Johnson AD; Joshi PK; Jousilahti P; Jukema JW; Jula A; Kähönen M; Kathiresan S; Keavney BD; Khaw KT; Knekt P; Knight J; Kolcic I; Kooner JS; Koskinen S; Kristiansson K; Kutalik Z; Laan M; Larson M; Launer LJ; Lehne B; Lehtimäki T; Liewald DCM; Lin L; Lind L; Lindgren CM; Liu Y; Loos RJF; Lopez LM; Lu Y; Lyytikäinen LP; Mahajan A; Mamasoula C; Marrugat J; Marten J; Milaneschi Y; Morgan A; Morris AP; Morrison AC; Munson PJ; Nalls MA; Nandakumar P; Nelson CP; Niiranen T; Nolte IM; Nutile T; Oldehinkel AJ; Oostra BA; O'Reilly PF; Org E; Padmanabhan S; Palmas W; Palotie A; Pattie A; Penninx BWJH; Perola M; Peters A; Polasek O; Pramstaller PP; Nguyen QT; Raitakari OT; Ren M; Rettig R; Rice K; Ridker PM; Ried JS; Riese H; Ripatti S; Robino A; Rose LM; Rotter JI; Rudan I; Ruggiero D; Saba Y; Sala CF; Salomaa V; Samani NJ; Sarin AP; Schmidt R; Schmidt H; Shrine N; Siscovick D; Smith AV; Snieder H; Sõber S; Sorice R; Starr JM; Stott DJ; Strachan DP; Strawbridge RJ; Sundström J; Swertz MA; Taylor KD; Teumer A; Tobin MD; Tomaszewski M; Toniolo D; Traglia M; Trompet S; Tuomilehto J; Tzourio C; Uitterlinden AG; Vaez A; van der Most PJ; van Duijn CM; Vergnaud AC; Verwoert GC; Vitart V; Völker U; Vollenweider P; Vuckovic D; Watkins H; Wild SH; Willemsen G; Wilson JF; Wright AF; Yao J; Zemunik T; Zhang W; Attia JR; Butterworth AS; Chasman DI; Conen D; Cucca F; Danesh J; Hayward C; Howson JMM; Laakso M; Lakatta EG; Langenberg C; Melander O; Mook-Kanamori DO; Palmer CNA; Risch L; Scott RA; Scott RJ; Sever P; Spector TD; van der Harst P; Wareham NJ; Zeggini E; Levy D; Munroe PB; Newton-Cheh C; Brown MJ; Metspalu A; Hung AM; O'Donnell CJ; Edwards TL; Million Veteran Program; Psaty BM; Tzoulaki I; Barnes MR; Wain LV; Elliott P; Caulfield MJ (2018)
      High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in ...
    • Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization 

      Arking DE; Pulit SL; Crotti L; van der Harst P; Munroe PB; Koopmann TT; Sotoodehnia N; Rossin EJ; Morley M; Wang X; Johnson AD; Lundby A; Gudbjartsson DF; Noseworthy PA; Eijgelsheim M; Bradford Y; Tarasov KV; Dörr M; Müller-Nurasyid M; Lahtinen AM; Nolte IM; Smith AV; Bis JC; Isaacs A; Newhouse SJ; Evans DS; Post WS; Waggott D; Lyytikäinen LP; Hicks AA; Eisele L; Ellinghaus D; Hayward C; Navarro P; Ulivi S; Tanaka T; Tester DJ; Chatel S; Gustafsson S; Kumari M; Morris RW; Naluai ÅT; Padmanabhan S; Kluttig A; Strohmer B; Panayiotou AG; Torres M; Knoflach M; Hubacek JA; Slowikowski K; Raychaudhuri S; Kumar RD; Harris TB; Launer LJ; Shuldiner AR; Alonso A; Bader JS; Ehret G; Huang H; Kao WH; Strait JB; Macfarlane PW; Brown M; Caulfield MJ; Samani NJ; Kronenberg F; Willeit J; CARe Consortium; COGENT Consortium; Smith JG; Greiser KH; Meyer Zu Schwabedissen H; Werdan K; Carella M; Zelante L; Heckbert SR; Psaty BM; Rotter JI; Kolcic I; Polašek O; Wright AF; Griffin M; Daly MJ; DCCT/EDIC; Arnar DO; Hólm H; Thorsteinsdottir U; eMERGE Consortium; Denny JC; Roden DM; Zuvich RL; Emilsson V; Plump AS; Larson MG; O'Donnell CJ; Yin X; Bobbo M; D'Adamo AP; Iorio A; Sinagra G; Carracedo A; Cummings SR; Nalls MA; Jula A; Kontula KK; Marjamaa A; Oikarinen L; Perola M; Porthan K; Erbel R; Hoffmann P; Jöckel KH; Kälsch H; Nöthen MM; HRGEN Consortium; den Hoed M; Loos RJ; Thelle DS; Gieger C; Meitinger T; Perz S; Peters A; Prucha H; Sinner MF; Waldenberger M; de Boer RA; Franke L; van der Vleuten PA; Beckmann BM; Martens E; Bardai A; Hofman N; Wilde AA; Behr ER; Dalageorgou C; Giudicessi JR; Medeiros-Domingo A; Barc J; Kyndt F; Probst V; Ghidoni A; Insolia R; Hamilton RM; Scherer SW; Brandimarto J; Margulies K; Moravec CE; Del Greco M F; Fuchsberger C; O'Connell JR; Lee WK; Watt GC; Campbell H; Wild SH; El Mokhtari NE; Frey N; Asselbergs FW; Mateo Leach I; Navis G; van den Berg MP; van Veldhuisen DJ; Kellis M; Krijthe BP; Franco OH; Hofman A; Kors JA; Uitterlinden AG; Witteman JC; Kedenko L; Lamina C; Oostra BA; Abecasis GR; Lakatta EG; Mulas A; Orrú M; Schlessinger D; Uda M; Markus MR; Völker U; Snieder H; Spector TD; Ärnlöv J; Lind L; Sundström J; Syvänen AC; Kivimaki M; Kähönen M; Mononen N; Raitakari OT; Viikari JS; Adamkova V; Kiechl S; Brion M; Nicolaides AN; Paulweber B; Haerting J; Dominiczak AF; Nyberg F; Whincup PH; Hingorani AD; Schott JJ; Bezzina CR; Ingelsson E; Ferrucci L; Gasparini P; Wilson JF; Rudan I; Franke A; Mühleisen TW; Pramstaller PP; Lehtimäki TJ; Paterson AD; Parsa A; Liu Y; van Duijn CM; Siscovick DS; Gudnason V; Jamshidi Y; Salomaa V; Felix SB; Sanna S; Ritchie MD; Stricker BH; Stefansson K; Boyer LA; Cappola TP; Olsen JV; Lage K; Schwartz PJ; Kääb S; Chakravarti A; Ackerman MJ; Pfeufer A; de Bakker PI; Newton-Cheh C (2014)
      The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate ...
    • Genetic studies of body mass index yield new insights for obesity biology 

      Locke AE; Kahali B; Berndt SI; Justice AE; Pers TH; Day FR; Powell C; Vedantam S; Buchkovich ML; Yang J; Croteau-Chonka DC; Esko T; Fall T; Ferreira T; Gustafsson S; Kutalik Z; Luan J; Mägi R; Randall JC; Winkler TW; Wood AR; Workalemahu T; Faul JD; Smith JA; Hua Zhao J; Zhao W; Chen J; Fehrmann R; Hedman ÅK; Karjalainen J; Schmidt EM; Absher D; Amin N; Anderson D; Beekman M; Bolton JL; Bragg-Gresham JL; Buyske S; Demirkan A; Deng G; Ehret GB; Feenstra B; Feitosa MF; Fischer K; Goel A; Gong J; Jackson AU; Kanoni S; Kleber ME; Kristiansson K; Lim U; Lotay V; Mangino M; Mateo Leach I; Medina-Gomez C; Medland SE; Nalls MA; Palmer CD; Pasko D; Pechlivanis S; Peters MJ; Prokopenko I; Shungin D; Stančáková A; Strawbridge RJ; Ju Sung Y; Tanaka T; Teumer A; Trompet S; van der Laan SW; van Setten J; van Vliet-Ostaptchouk JV; Wang Z; Yengo L; Zhang W; Isaacs A; Albrecht E; Ärnlöv J; Arscott GM; Attwood AP; Bandinelli S; Barrett A; Bas IN; Bellis C; Bennett AJ; Berne C; Blagieva R; Blüher M; Böhringer S; Bonnycastle LL; Böttcher Y; Boyd HA; Bruinenberg M; Caspersen IH; Ida Chen YD; Clarke R; Daw EW; de Craen AJ; Delgado G; Dimitriou M; Doney AS; Eklund N; Estrada K; Eury E; Folkersen L; Fraser RM; Garcia ME; Geller F; Giedraitis V; Gigante B; Go AS; Golay A; Goodall AH; Gordon SD; Gorski M; Grabe HJ; Grallert H; Grammer TB; Gräßler J; Grönberg H; Groves CJ; Gusto G; Haessler J; Hall P; Haller T; Hallmans G; Hartman CA; Hassinen M; Hayward C; Heard-Costa NL; Helmer Q; Hengstenberg C; Holmen O; Hottenga JJ; James AL; Jeff JM; Johansson Å; Jolley J; Juliusdottir T; Kinnunen L; Koenig W; Koskenvuo M; Kratzer W; Laitinen J; Lamina C; Leander K; Lee NR; Lichtner P; Lind L; Lindström J; Sin Lo K; Lobbens S; Lorbeer R; Lu Y; Mach F; Magnusson PK; Mahajan A; McArdle WL; McLachlan S; Menni C; Merger S; Mihailov E; Milani L; Moayyeri A; Monda KL; Morken MA; Mulas A; Müller G; Müller-Nurasyid M; Musk AW; Nagaraja R; Nöthen MM; Nolte IM; Pilz S; Rayner NW; Renstrom F; Rettig R; Ried JS; Ripke S; Robertson NR; Rose LM; Sanna S; Scharnagl H; Scholtens S; Schumacher FR; Scott WR; Seufferlein T; Shi J; Vernon Smith A; Smolonska J; Stanton AV; Steinthorsdottir V; Stirrups K; Stringham HM; Sundström J; Swertz MA; Swift AJ; Syvänen AC; Tan ST; Tayo BO; Thorand B; Thorleifsson G; Tyrer JP; Uh HW; Vandenput L; Verhulst FC; Vermeulen SH; Verweij N; Vonk JM; Waite LL; Warren HR; Waterworth D; Weedon MN; Wilkens LR; Willenborg C; Wilsgaard T; Wojczynski MK; Wong A; Wright AF; Zhang Q; LifeLines Cohort Study; Brennan EP; Choi M; Dastani Z; Drong AW; Eriksson P; Franco-Cereceda A; Gådin JR; Gharavi AG; Goddard ME; Handsaker RE; Huang J; Karpe F; Kathiresan S; Keildson S; Kiryluk K; Kubo M; Lee JY; Liang L; Lifton RP; Ma B; McCarroll SA; McKnight AJ; Min JL; Moffatt MF; Montgomery GW; Murabito JM; Nicholson G; Nyholt DR; Okada Y; Perry JR; Dorajoo R; Reinmaa E; Salem RM; Sandholm N; Scott RA; Stolk L; Takahashi A; Van't Hooft FM; Vinkhuyzen AA; Westra HJ; Zheng W; Zondervan KT; ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium; Heath AC; Arveiler D; Bakker SJ; Beilby J; Bergman RN; Blangero J; Bovet P; Campbell H; Caulfield MJ; Cesana G; Chakravarti A; Chasman DI; Chines PS; Collins FS; Crawford DC; Cupples LA; Cusi D; Danesh J; de Faire U; den Ruijter HM; Dominiczak AF; Erbel R; Erdmann J; Eriksson JG; Farrall M; Felix SB; Ferrannini E; Ferrières J; Ford I; Forouhi NG; Forrester T; Franco OH; Gansevoort RT; Gejman PV; Gieger C; Gottesman O; Gudnason V; Gyllensten U; Hall AS; Harris TB; Hattersley AT; Hicks AA; Hindorff LA; Hingorani AD; Hofman A; Homuth G; Hovingh GK; Humphries SE; Hunt SC; Hyppönen E; Illig T; Jacobs KB; Jarvelin MR; Jöckel KH; Johansen B; Jousilahti P; Jukema JW; Jula AM; Kaprio J; Kastelein JJ; Keinanen-Kiukaanniemi SM; Kiemeney LA; Knekt P; Kooner JS; Kooperberg C; Kovacs P; Kraja AT; Kumari M; Kuusisto J; Lakka TA; Langenberg C; Le Marchand L; Lehtimäki T; Lyssenko V; Männistö S; Marette A; Matise TC; McKenzie CA; McKnight B; Moll FL; Morris AD; Morris AP; Murray JC; Nelis M; Ohlsson C; Oldehinkel AJ; Ong KK; Madden PA; Pasterkamp G; Peden JF; Peters A; Postma DS; Pramstaller PP; Price JF; Qi L; Raitakari OT; Rankinen T; Rao DC; Rice TK; Ridker PM; Rioux JD; Ritchie MD; Rudan I; Salomaa V; Samani NJ; Saramies J; Sarzynski MA; Schunkert H; Schwarz PE; Sever P; Shuldiner AR; Sinisalo J; Stolk RP; Strauch K; Tönjes A; Trégouët DA; Tremblay A; Tremoli E; Virtamo J; Vohl MC; Völker U; Waeber G; Willemsen G; Witteman JC; Zillikens MC; Adair LS; Amouyel P; Asselbergs FW; Assimes TL; Bochud M; Boehm BO; Boerwinkle E; Bornstein SR; Bottinger EP; Bouchard C; Cauchi S; Chambers JC; Chanock SJ; Cooper RS; de Bakker PI; Dedoussis G; Ferrucci L; Franks PW; Froguel P; Groop LC; Haiman CA; Hamsten A; Hui J; Hunter DJ; Hveem K; Kaplan RC; Kivimaki M; Kuh D; Laakso M; Liu Y; Martin NG; März W; Melbye M; Metspalu A; Moebus S; Munroe PB; Njølstad I; Oostra BA; Palmer CN; Pedersen NL; Perola M; Pérusse L; Peters U; Power C; Quertermous T; Rauramaa R; Rivadeneira F; Saaristo TE; Saleheen D; Sattar N; Schadt EE; Schlessinger D; Slagboom PE; Snieder H; Spector TD; Thorsteinsdottir U; Stumvoll M; Tuomilehto J; Uitterlinden AG; Uusitupa M; van der Harst P; Walker M; Wallaschofski H; Wareham NJ; Watkins H; Weir DR; Wichmann HE; Wilson JF; Zanen P; Borecki IB; Deloukas P; Fox CS; Heid IM; O'Connell JR; Strachan DP; Stefansson K; van Duijn CM; Abecasis GR; Franke L; Frayling TM; McCarthy MI; Visscher PM; Scherag A; Willer CJ; Boehnke M; Mohlke KL; Lindgren CM; Beckmann JS; Barroso I; North KE; Ingelsson E; Hirschhorn JN; Loos RJ; Speliotes EK (2015)
      Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure ...
    • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk 

      International Consortium for Blood Pressure Genome-Wide Association Studies; Ehret GB; Munroe PB; Rice KM; Bochud M; Johnson AD; Chasman DI; Smith AV; Tobin MD; Verwoert GC; Hwang SJ; Pihur V; Vollenweider P; O'Reilly PF; Amin N; Bragg-Gresham JL; Teumer A; Glazer NL; Launer L; Zhao JH; Aulchenko Y; Heath S; Sõber S; Parsa A; Luan J; Arora P; Dehghan A; Zhang F; Lucas G; Hicks AA; Jackson AU; Peden JF; Tanaka T; Wild SH; Rudan I; Igl W; Milaneschi Y; Parker AN; Fava C; Chambers JC; Fox ER; Kumari M; Go MJ; van der Harst P; Kao WH; Sjögren M; Vinay DG; Alexander M; Tabara Y; Shaw-Hawkins S; Whincup PH; Liu Y; Shi G; Kuusisto J; Tayo B; Seielstad M; Sim X; Nguyen KD; Lehtimäki T; Matullo G; Wu Y; Gaunt TR; Onland-Moret NC; Cooper MN; Platou CG; Org E; Hardy R; Dahgam S; Palmen J; Vitart V; Braund PS; Kuznetsova T; Uiterwaal CS; Adeyemo A; Palmas W; Campbell H; Ludwig B; Tomaszewski M; Tzoulaki I; Palmer ND; CARDIoGRAM Consortium; CKDGen Consortium; KidneyGen Consortium; EchoGen consortium; CHARGE-HF consortium; Aspelund T; Garcia M; Chang YP; O'Connell JR; Steinle NI; Grobbee DE; Arking DE; Kardia SL; Morrison AC; Hernandez D; Najjar S; McArdle WL; Hadley D; Brown MJ; Connell JM; Hingorani AD; Day IN; Lawlor DA; Beilby JP; Lawrence RW; Clarke R; Hopewell JC; Ongen H; Dreisbach AW; Li Y; Young JH; Bis JC; Kähönen M; Viikari J; Adair LS; Lee NR; Chen MH; Olden M; Pattaro C; Bolton JA; Köttgen A; Bergmann S; Mooser V; Chaturvedi N; Frayling TM; Islam M; Jafar TH; Erdmann J; Kulkarni SR; Bornstein SR; Grässler J; Groop L; Voight BF; Kettunen J; Howard P; Taylor A; Guarrera S; Ricceri F; Emilsson V; Plump A; Barroso I; Khaw KT; Weder AB; Hunt SC; Sun YV; Bergman RN; Collins FS; Bonnycastle LL; Scott LJ; Stringham HM; Peltonen L; Perola M; Vartiainen E; Brand SM; Staessen JA; Wang TJ; Burton PR; Soler Artigas M; Dong Y; Snieder H; Wang X; Zhu H; Lohman KK; Rudock ME; Heckbert SR; Smith NL; Wiggins KL; Doumatey A; Shriner D; Veldre G; Viigimaa M; Kinra S; Prabhakaran D; Tripathy V; Langefeld CD; Rosengren A; Thelle DS; Corsi AM; Singleton A; Forrester T; Hilton G; McKenzie CA; Salako T; Iwai N; Kita Y; Ogihara T; Ohkubo T; Okamura T; Ueshima H; Umemura S; Eyheramendy S; Meitinger T; Wichmann HE; Cho YS; Kim HL; Lee JY; Scott J; Sehmi JS; Zhang W; Hedblad B; Nilsson P; Smith GD; Wong A; Narisu N; Stancáková A; Raffel LJ; Yao J; Kathiresan S; O'Donnell CJ; Schwartz SM; Ikram MA; Longstreth WT; Mosley TH; Seshadri S; Shrine NR; Wain LV; Morken MA; Swift AJ; Laitinen J; Prokopenko I; Zitting P; Cooper JA; Humphries SE; Danesh J; Rasheed A; Goel A; Hamsten A; Watkins H; Bakker SJ; van Gilst WH; Janipalli CS; Mani KR; Yajnik CS; Hofman A; Mattace-Raso FU; Oostra BA; Demirkan A; Isaacs A; Rivadeneira F; Lakatta EG; Orru M; Scuteri A; Ala-Korpela M; Kangas AJ; Lyytikäinen LP; Soininen P; Tukiainen T; Würtz P; Ong RT; Dörr M; Kroemer HK; Völker U; Völzke H; Galan P; Hercberg S; Lathrop M; Zelenika D; Deloukas P; Mangino M; Spector TD; Zhai G; Meschia JF; Nalls MA; Sharma P; Terzic J; Kumar MV; Denniff M; Zukowska-Szczechowska E; Wagenknecht LE; Fowkes FG; Charchar FJ; Schwarz PE; Hayward C; Guo X; Rotimi C; Bots ML; Brand E; Samani NJ; Polasek O; Talmud PJ; Nyberg F; Kuh D; Laan M; Hveem K; Palmer LJ; van der Schouw YT; Casas JP; Mohlke KL; Vineis P; Raitakari O; Ganesh SK; Wong TY; Tai ES; Cooper RS; Laakso M; Rao DC; Harris TB; Morris RW; Dominiczak AF; Kivimaki M; Marmot MG; Miki T; Saleheen D; Chandak GR; Coresh J; Navis G; Salomaa V; Han BG; Zhu X; Kooner JS; Melander O; Ridker PM; Bandinelli S; Gyllensten UB; Wright AF; Wilson JF; Ferrucci L; Farrall M; Tuomilehto J; Pramstaller PP; Elosua R; Soranzo N; Sijbrands EJ; Altshuler D; Loos RJ; Shuldiner AR; Gieger C; Meneton P; Uitterlinden AG; Wareham NJ; Gudnason V; Rotter JI; Rettig R; Uda M; Strachan DP; Witteman JC; Hartikainen AL; Beckmann JS; Boerwinkle E; Vasan RS; Boehnke M; Larson MG; Järvelin MR; Psaty BM; Abecasis GR; Chakravarti A; Elliott P; van Duijn CM; Newton-Cheh C; Levy D; Caulfield MJ; Johnson T (2011)
      Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg ...
    • Genome-wide association analyses identify 18 new loci associated with serum urate concentrations 

      Köttgen A; Albrecht E; Teumer A; Vitart V; Krumsiek J; Hundertmark C; Pistis G; Ruggiero D; O'Seaghdha CM; Haller T; Yang Q; Tanaka T; Johnson AD; Kutalik Z; Smith AV; Shi J; Struchalin M; Middelberg RP; Brown MJ; Gaffo AL; Pirastu N; Li G; Hayward C; Zemunik T; Huffman J; Yengo L; Zhao JH; Demirkan A; Feitosa MF; Liu X; Malerba G; Lopez LM; van der Harst P; Li X; Kleber ME; Hicks AA; Nolte IM; Johansson A; Murgia F; Wild SH; Bakker SJ; Peden JF; Dehghan A; Steri M; Tenesa A; Lagou V; Salo P; Mangino M; Rose LM; Lehtimäki T; Woodward OM; Okada Y; Tin A; Müller C; Oldmeadow C; Putku M; Czamara D; Kraft P; Frogheri L; Thun GA; Grotevendt A; Gislason GK; Harris TB; Launer LJ; McArdle P; Shuldiner AR; Boerwinkle E; Coresh J; Schmidt H; Schallert M; Martin NG; Montgomery GW; Kubo M; Nakamura Y; Munroe PB; Samani NJ; Jacobs DR; Liu K; D'Adamo P; Ulivi S; Rotter JI; Psaty BM; Vollenweider P; Waeber G; Campbell S; Devuyst O; Navarro P; Kolcic I; Hastie N; Balkau B; Froguel P; Esko T; Salumets A; Khaw KT; Langenberg C; Wareham NJ; Isaacs A; Kraja A; Zhang Q; Wild PS; Scott RJ; Holliday EG; Org E; Viigimaa M; Bandinelli S; Metter JE; Lupo A; Trabetti E; Sorice R; Döring A; Lattka E; Strauch K; Theis F; Waldenberger M; Wichmann HE; Davies G; Gow AJ; Bruinenberg M; LifeLines Cohort Study; Stolk RP; Kooner JS; Zhang W; Winkelmann BR; Boehm BO; Lucae S; Penninx BW; Smit JH; Curhan G; Mudgal P; Plenge RM; Portas L; Persico I; Kirin M; Wilson JF; Mateo Leach I; van Gilst WH; Goel A; Ongen H; Hofman A; Rivadeneira F; Uitterlinden AG; Imboden M; von Eckardstein A; Cucca F; Nagaraja R; Piras MG; Nauck M; Schurmann C; Budde K; Ernst F; Farrington SM; Theodoratou E; Prokopenko I; Stumvoll M; Jula A; Perola M; Salomaa V; Shin SY; Spector TD; Sala C; Ridker PM; Kähönen M; Viikari J; Hengstenberg C; Nelson CP; CARDIoGRAM Consortium; DIAGRAM Consortium; ICBP Consortium; MAGIC Consortium; Meschia JF; Nalls MA; Sharma P; Singleton AB; Kamatani N; Zeller T; Burnier M; Attia J; Laan M; Klopp N; Hillege HL; Kloiber S; Choi H; Pirastu M; Tore S; Probst-Hensch NM; Völzke H; Gudnason V; Parsa A; Schmidt R; Whitfield JB; Fornage M; Gasparini P; Siscovick DS; Polašek O; Campbell H; Rudan I; Bouatia-Naji N; Metspalu A; Loos RJ; van Duijn CM; Borecki IB; Ferrucci L; Gambaro G; Deary IJ; Wolffenbuttel BH; Chambers JC; März W; Pramstaller PP; Snieder H; Gyllensten U; Wright AF; Navis G; Watkins H; Witteman JC; Sanna S; Schipf S; Dunlop MG; Tönjes A; Ripatti S; Soranzo N; Toniolo D; Chasman DI; Raitakari O; Kao WH; Ciullo M; Fox CS; Caulfield M; Bochud M; Gieger C (2013)
      Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we ...
    • Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits 

      Speliotes EK; Yerges-Armstrong LM; Wu J; Hernaez R; Kim LJ; Palmer CD; Gudnason V; Eiriksdottir G; Garcia ME; Launer LJ; Nalls MA; Clark JM; Mitchell BD; Shuldiner AR; Butler JL; Tomas M; Hoffmann U; Hwang SJ; Massaro JM; O'Donnell CJ; Sahani DV; Salomaa V; Schadt EE; Schwartz SM; Siscovick DS; NASH CRN; GIANT Consortium; MAGIC Investigators; Voight BF; Carr JJ; Feitosa MF; Harris TB; Fox CS; Smith AV; Kao WH; Hirschhorn JN; Borecki IB; GOLD Consortium (2011)
      Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide ...
    • Genome-wide association studies of the PR interval in African Americans 

      Smith JG; Magnani JW; Palmer C; Meng YA; Soliman EZ; Musani SK; Kerr KF; Schnabel RB; Lubitz SA; Sotoodehnia N; Redline S; Pfeufer A; Müller M; Evans DS; Nalls MA; Liu Y; Newman AB; Zonderman AB; Evans MK; Deo R; Ellinor PT; Paltoo DN; Newton-Cheh C; Benjamin EJ; Mehra R; Alonso A; Heckbert SR; Fox ER; Candidate-gene Association Resource (CARe) Consortium (2011)
      The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction time. The PR interval is heritable, provides important information about arrhythmia risk, and has been suggested to differ among ...
    • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels 

      Kilpeläinen TO; Carli JF; Skowronski AA; Sun Q; Kriebel J; Feitosa MF; Hedman ÅK; Drong AW; Hayes JE; Zhao J; Pers TH; Schick U; Grarup N; Kutalik Z; Trompet S; Mangino M; Kristiansson K; Beekman M; Lyytikäinen LP; Eriksson J; Henneman P; Lahti J; Tanaka T; Luan J; Del Greco M F; Pasko D; Renström F; Willems SM; Mahajan A; Rose LM; Guo X; Liu Y; Kleber ME; Pérusse L; Gaunt T; Ahluwalia TS; Ju Sung Y; Ramos YF; Amin N; Amuzu A; Barroso I; Bellis C; Blangero J; Buckley BM; Böhringer S; I Chen YD; de Craen AJ; Crosslin DR; Dale CE; Dastani Z; Day FR; Deelen J; Delgado GE; Demirkan A; Finucane FM; Ford I; Garcia ME; Gieger C; Gustafsson S; Hallmans G; Hankinson SE; Havulinna AS; Herder C; Hernandez D; Hicks AA; Hunter DJ; Illig T; Ingelsson E; Ioan-Facsinay A; Jansson JO; Jenny NS; Jørgensen ME; Jørgensen T; Karlsson M; Koenig W; Kraft P; Kwekkeboom J; Laatikainen T; Ladwig KH; LeDuc CA; Lowe G; Lu Y; Marques-Vidal P; Meisinger C; Menni C; Morris AP; Myers RH; Männistö S; Nalls MA; Paternoster L; Peters A; Pradhan AD; Rankinen T; Rasmussen-Torvik LJ; Rathmann W; Rice TK; Brent Richards J; Ridker PM; Sattar N; Savage DB; Söderberg S; Timpson NJ; Vandenput L; van Heemst D; Uh HW; Vohl MC; Walker M; Wichmann HE; Widén E; Wood AR; Yao J; Zeller T; Zhang Y; Meulenbelt I; Kloppenburg M; Astrup A; Sørensen TI; Sarzynski MA; Rao DC; Jousilahti P; Vartiainen E; Hofman A; Rivadeneira F; Uitterlinden AG; Kajantie E; Osmond C; Palotie A; Eriksson JG; Heliövaara M; Knekt PB; Koskinen S; Jula A; Perola M; Huupponen RK; Viikari JS; Kähönen M; Lehtimäki T; Raitakari OT; Mellström D; Lorentzon M; Casas JP; Bandinelli S; März W; Isaacs A; van Dijk KW; van Duijn CM; Harris TB; Bouchard C; Allison MA; Chasman DI; Ohlsson C; Lind L; Scott RA; Langenberg C; Wareham NJ; Ferrucci L; Frayling TM; Pramstaller PP; Borecki IB; Waterworth DM; Bergmann S; Waeber G; Vollenweider P; Vestergaard H; Hansen T; Pedersen O; Hu FB; Eline Slagboom P; Grallert H; Spector TD; Jukema JW; Klein RJ; Schadt EE; Franks PW; Lindgren CM; Leibel RL; Loos RJ (2016)
      Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe ...
    • Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes 

      Ng MC; Shriner D; Chen BH; Li J; Chen WM; Guo X; Liu J; Bielinski SJ; Yanek LR; Nalls MA; Comeau ME; Rasmussen-Torvik LJ; Jensen RA; Evans DS; Sun YV; An P; Patel SR; Lu Y; Long J; Armstrong LL; Wagenknecht L; Yang L; Snively BM; Palmer ND; Mudgal P; Langefeld CD; Keene KL; Freedman BI; Mychaleckyj JC; Nayak U; Raffel LJ; Goodarzi MO; Chen YD; Taylor HA; Correa A; Sims M; Couper D (2014)
      Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by ...
    • New genetic loci link adipose and insulin biology to body fat distribution 

      Shungin D; Winkler TW; Croteau-Chonka DC; Ferreira T; Locke AE; Mägi R; Strawbridge RJ; Pers TH; Fischer K; Justice AE; Workalemahu T; Wu JM; Buchkovich ML; Heard-Costa NL; Roman TS; Drong AW; Song C; Gustafsson S; Day FR; Esko T; Fall T; Kutalik Z; Luan J; Randall JC; Scherag A; Vedantam S; Wood AR; Chen J; Fehrmann R; Karjalainen J; Kahali B; Liu CT; Schmidt EM; Absher D; Amin N; Anderson D; Beekman M; Bragg-Gresham JL; Buyske S; Demirkan A; Ehret GB; Feitosa MF; Goel A; Jackson AU; Johnson T; Kleber ME; Kristiansson K; Mangino M; Mateo Leach I; Medina-Gomez C; Palmer CD; Pasko D; Pechlivanis S; Peters MJ; Prokopenko I; Stančáková A; Ju Sung Y; Tanaka T; Teumer A; van Vliet-Ostaptchouk JV; Yengo L; Zhang W; Albrecht E; Ärnlöv J; Arscott GM; Bandinelli S; Barrett A; Bellis C; Bennett AJ; Berne C; Blüher M; Böhringer S; Bonnet F; Böttcher Y; Bruinenberg M; Carba DB; Caspersen IH; Clarke R; Daw EW; Deelen J; Deelman E; Delgado G; Doney AS; Eklund N; Erdos MR; Estrada K; Eury E; Friedrich N; Garcia ME; Giedraitis V; Gigante B; Go AS; Golay A; Grallert H; Grammer TB; Gräßler J; Grewal J; Groves CJ; Haller T; Hallmans G; Hartman CA; Hassinen M; Hayward C; Heikkilä K; Herzig KH; Helmer Q; Hillege HL; Holmen O; Hunt SC; Isaacs A; Ittermann T; James AL; Johansson I; Juliusdottir T; Kalafati IP; Kinnunen L; Koenig W; Kooner IK; Kratzer W; Lamina C; Leander K; Lee NR; Lichtner P; Lind L; Lindström J; Lobbens S; Lorentzon M; Mach F; Magnusson PK; Mahajan A; McArdle WL; Menni C; Merger S; Mihailov E; Milani L; Mills R; Moayyeri A; Monda KL; Mooijaart SP; Mühleisen TW; Mulas A; Müller G; Müller-Nurasyid M; Nagaraja R; Nalls MA; Narisu N; Glorioso N; Nolte IM; Olden M; Rayner NW; Renstrom F; Ried JS; Robertson NR; Rose LM; Sanna S; Scharnagl H; Scholtens S; Sennblad B; Seufferlein T; Sitlani CM; Vernon Smith A; Stirrups K; Stringham HM; Sundström J; Swertz MA; Swift AJ; Syvänen AC; Tayo BO; Thorand B; Thorleifsson G; Tomaschitz A; Troffa C; van Oort FV; Verweij N; Vonk JM; Waite LL; Wennauer R; Wilsgaard T; Wojczynski MK; Wong A; Zhang Q; Hua Zhao J; Brennan EP; Choi M; Eriksson P; Folkersen L; Franco-Cereceda A; Gharavi AG; Hedman ÅK; Hivert MF; Huang J; Kanoni S; Karpe F; Keildson S; Kiryluk K; Liang L; Lifton RP; Ma B; McKnight AJ; McPherson R; Metspalu A; Min JL; Moffatt MF; Montgomery GW; Murabito JM; Nicholson G; Nyholt DR; Olsson C; Perry JR; Reinmaa E; Salem RM; Sandholm N; Schadt EE; Scott RA; Stolk L; Vallejo EE; Westra HJ; Zondervan KT; ADIPOGen Consortium; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GEFOS Consortium; GENIE Consortium; GLGC; ICBP; International Endogene Consortium; LifeLines Cohort Study; MAGIC Investigators; MuTHER Consortium; PAGE Consortium; ReproGen Consortium; Amouyel P; Arveiler D; Bakker SJ; Beilby J; Bergman RN; Blangero J; Brown MJ; Burnier M; Campbell H; Chakravarti A; Chines PS; Claudi-Boehm S; Collins FS; Crawford DC; Danesh J; de Faire U; de Geus EJ; Dörr M; Erbel R; Eriksson JG; Farrall M; Ferrannini E; Ferrières J; Forouhi NG; Forrester T; Franco OH; Gansevoort RT; Gieger C; Gudnason V; Haiman CA; Harris TB; Hattersley AT; Heliövaara M; Hicks AA; Hingorani AD; Hoffmann W; Hofman A; Homuth G; Humphries SE; Hyppönen E; Illig T; Jarvelin MR; Johansen B; Jousilahti P; Jula AM; Kaprio J; Kee F; Keinanen-Kiukaanniemi SM; Kooner JS; Kooperberg C; Kovacs P; Kraja AT; Kumari M; Kuulasmaa K; Kuusisto J; Lakka TA; Langenberg C; Le Marchand L; Lehtimäki T; Lyssenko V; Männistö S; Marette A; Matise TC; McKenzie CA; McKnight B; Musk AW; Möhlenkamp S; Morris AD; Nelis M; Ohlsson C; Oldehinkel AJ; Ong KK; Palmer LJ; Penninx BW; Peters A; Pramstaller PP; Raitakari OT; Rankinen T; Rao DC; Rice TK; Ridker PM; Ritchie MD; Rudan I; Salomaa V; Samani NJ; Saramies J; Sarzynski MA; Schwarz PE; Shuldiner AR; Staessen JA; Steinthorsdottir V; Stolk RP; Strauch K; Tönjes A; Tremblay A; Tremoli E; Vohl MC; Völker U; Vollenweider P; Wilson JF; Witteman JC; Adair LS; Bochud M; Boehm BO; Bornstein SR; Bouchard C; Cauchi S; Caulfield MJ; Chambers JC; Chasman DI; Cooper RS; Dedoussis G; Ferrucci L; Froguel P; Grabe HJ; Hamsten A; Hui J; Hveem K; Jöckel KH; Kivimaki M; Kuh D; Laakso M; Liu Y; März W; Munroe PB; Njølstad I; Oostra BA; Palmer CN; Pedersen NL; Perola M; Pérusse L; Peters U; Power C; Quertermous T; Rauramaa R; Rivadeneira F; Saaristo TE; Saleheen D; Sinisalo J; Slagboom PE; Snieder H; Spector TD; Thorsteinsdottir U; Stumvoll M; Tuomilehto J; Uitterlinden AG; Uusitupa M; van der Harst P; Veronesi G; Walker M; Wareham NJ; Watkins H; Wichmann HE; Abecasis GR; Assimes TL; Berndt SI; Boehnke M; Borecki IB; Deloukas P; Franke L; Frayling TM; Groop LC; Hunter DJ; Kaplan RC; O'Connell JR; Qi L; Schlessinger D; Strachan DP; Stefansson K; van Duijn CM; Willer CJ; Visscher PM; Yang J; Hirschhorn JN; Zillikens MC; McCarthy MI; Speliotes EK; North KE; Fox CS; Barroso I; Franks PW; Ingelsson E; Heid IM; Loos RJ; Cupples LA; Morris AP; Lindgren CM; Mohlke KL (2015)
      Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and ...
    • NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality 

      Böger CA; Gorski M; McMahon GM; Xu H; Chang YC; van der Most PJ; Navis G; Nolte IM; de Borst MH; Zhang W; Lehne B; Loh M; Tan ST; Boerwinkle E; Grams ME; Sekula P; Li M; Wilmot B; Moon JG; Scheet P; Cucca F; Xiao X; Lyytikäinen LP; Delgado G; Grammer TB; Kleber ME; Sedaghat S; Rivadeneira F; Corre T; Kutalik Z; Bergmann S; Nielson CM; Srikanth P; Teumer A; Müller-Nurasyid M; Brockhaus AC; Pfeufer A; Rathmann W; Peters A; Matsumoto M; de Andrade M; Atkinson EJ; Robinson-Cohen C; de Boer IH; Hwang SJ; Heid IM; Gögele M; Concas MP; Tanaka T; Bandinelli S; Nalls MA; Singleton A; Tajuddin SM; Adeyemo A; Zhou J; Doumatey A; McWeeney S; Murabito J; Franceschini N; Flessner M; Shlipak M; Wilson JG; Chen G; Rotimi CN; Zonderman AB; Evans MK; Ferrucci L; Devuyst O; Pirastu M; Shuldiner A; Hicks AA; Pramstaller PP; Kestenbaum B; Kardia SL; Turner ST; Study LC; Briske TE; Gieger C; Strauch K; Meisinger C; Meitinger T; Völker U; Nauck M; Völzke H; Vollenweider P; Bochud M; Waeber G; Kähönen M; Lehtimäki T; März W; Dehghan A; Franco OH; Uitterlinden AG; Hofman A; Taylor HA; Chambers JC; Kooner JS; Fox CS; Hitzemann R; Orwoll ES; Pattaro C; Schlessinger D; Köttgen A; Snieder H; Parsa A; Cohen DM (2017)
      Disorders of water balance, an excess or deficit of total body water relative to body electrolyte content, are common and ascertained by plasma hypo- or hypernatremia, respectively. We performed a two-stage genome-wide ...
    • Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney 

      Wain LV; Vaez A; Jansen R; Joehanes R; van der Most PJ; Erzurumluoglu AM; O'Reilly PF; Cabrera CP; Warren HR; Rose LM; Verwoert GC; Hottenga JJ; Strawbridge RJ; Esko T; Arking DE; Hwang SJ; Guo X; Kutalik Z; Trompet S; Shrine N; Teumer A; Ried JS; Bis JC; Smith AV; Amin N; Nolte IM; Lyytikäinen LP; Mahajan A; Wareham NJ; Hofer E; Joshi PK; Kristiansson K; Traglia M; Havulinna AS; Goel A; Nalls MA; Sõber S; Vuckovic D; Luan J; Del Greco M F; Ayers KL; Marrugat J; Ruggiero D; Lopez LM; Niiranen T; Enroth S; Jackson AU; Nelson CP; Huffman JE; Zhang W; Marten J; Gandin I; Harris SE; Zemunik T; Lu Y; Evangelou E; Shah N; de Borst MH; Mangino M; Prins BP; Campbell A; Li-Gao R; Chauhan G; Oldmeadow C; Abecasis G; Abedi M; Barbieri CM; Barnes MR; Batini C; Beilby J; Blake T; Boehnke M; Bottinger EP; Braund PS; Brown M; Brumat M; Campbell H; Chambers JC; Cocca M; Collins F; Connell J; Cordell HJ; Damman JJ; Davies G; de Geus EJ; de Mutsert R; Deelen J; Demirkale Y; Doney ASF; Dörr M; Farrall M; Ferreira T; Frånberg M; Gao H; Giedraitis V; Gieger C; Giulianini F; Gow AJ; Hamsten A; Harris TB; Hofman A; Holliday EG; Hui J; Jarvelin MR; Johansson Å; Johnson AD; Jousilahti P; Jula A; Kähönen M; Kathiresan S; Khaw KT; Kolcic I; Koskinen S; Langenberg C; Larson M; Launer LJ; Lehne B; Liewald DCM; Lin L; Lind L; Mach F; Mamasoula C; Menni C; Mifsud B; Milaneschi Y; Morgan A; Morris AD; Morrison AC; Munson PJ; Nandakumar P; Nguyen QT; Nutile T; Oldehinkel AJ; Oostra BA; Org E; Padmanabhan S; Palotie A; Paré G; Pattie A; Penninx BWJH; Poulter N; Pramstaller PP; Raitakari OT; Ren M; Rice K; Ridker PM; Riese H; Ripatti S; Robino A; Rotter JI; Rudan I; Saba Y; Saint-Pierre A; Sala CF; Sarin AP; Schmidt R; Scott R; Seelen MA; Shields DC; Siscovick D; Sorice R; Stanton A; Stott DJ; Sundström J; Swertz M; Taylor KD; Thom S; Tzoulaki I; Tzourio C; Uitterlinden AG; Völker U; Vollenweider P; Wild S; Willemsen G; Wright AF; Yao J; Thériault S; Conen D; Attia J; Sever P; Debette S; Mook-Kanamori DO; Zeggini E; Spector TD; van der Harst P; Palmer CNA; Vergnaud AC; Loos RJF; Polasek O; Starr JM; Girotto G; Hayward C; Kooner JS; Lindgren CM; Vitart V; Samani NJ; Tuomilehto J; Gyllensten U; Knekt P; Deary IJ; Ciullo M; Elosua R; Keavney BD; Hicks AA; Scott RA; Gasparini P; Laan M; Liu Y; Watkins H; Hartman CA; Salomaa V; Toniolo D; Perola M; Wilson JF; Schmidt H; Zhao JH; Lehtimäki T; van Duijn CM; Gudnason V; Psaty BM; Peters A; Rettig R; James A; Jukema JW; Strachan DP; Palmas W; Metspalu A; Ingelsson E; Boomsma DI; Franco OH; Bochud M; Newton-Cheh C; Munroe PB; Elliott P; Chasman DI; Chakravarti A; Knight J; Morris AP; Levy D; Tobin MD; Snieder H; Caulfield MJ; Ehret GB (2017)
      Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets ...