Now showing items 1-3 of 3

    • Common variants at ten loci modulate the QT interval duration in the QTSCD Study 

      Pfeufer A; Sanna S; Arking DE; Müller M; Gateva V; Fuchsberger C; Ehret GB; Orrú M; Pattaro C; Köttgen A; Perz S; Usala G; Barbalic M; Li M; Pütz B; Scuteri A; Prineas RJ; Sinner MF; Gieger C; Najjar SS; Kao WH; Mühleisen TW; Dei M; Happle C; Möhlenkamp S; Crisponi L; Erbel R; Jöckel KH; Naitza S; Steinbeck G; Marroni F; Hicks AA; Lakatta E; Müller-Myhsok B; Pramstaller PP; Wichmann HE; Schlessinger D; Boerwinkle E; Meitinger T; Uda M; Coresh J; Kääb S; Abecasis GR; Chakravarti A (2009)
      The QT interval, a measure of cardiac repolarization, predisposes to ventricular arrhythmias and sudden cardiac death (SCD) when prolonged or shortened. A common variant in NOS1AP is known to influence repolarization. We ...
    • Genome-wide association analysis identifies multiple loci related to resting heart rate 

      Eijgelsheim M; Newton-Cheh C; Sotoodehnia N; de Bakker PI; Müller M; Morrison AC; Smith AV; Isaacs A; Sanna S; Dörr M; Navarro P; Fuchsberger C; Nolte IM; de Geus EJ; Estrada K; Hwang SJ; Bis JC; Rückert IM; Alonso A; Launer LJ; Hottenga JJ; Rivadeneira F; Noseworthy PA; Rice KM; Perz S; Arking DE; Spector TD; Kors JA; Aulchenko YS; Tarasov KV; Homuth G; Wild SH; Marroni F; Gieger C; Licht CM; Prineas RJ; Hofman A; Rotter JI; Hicks AA; Ernst F; Najjar SS; Wright AF; Peters A; Fox ER; Oostra BA; Kroemer HK; Couper D; Völzke H; Campbell H; Meitinger T; Uda M; Witteman JC; Psaty BM; Wichmann HE; Harris TB; Kääb S; Siscovick DS; Jamshidi Y; Uitterlinden AG; Folsom AR; Larson MG; Wilson JF; Penninx BW; Snieder H; Pramstaller PP; van Duijn CM; Lakatta EG; Felix SB; Gudnason V; Pfeufer A; Heckbert SR; Stricker BH; Boerwinkle E; O'Donnell CJ (2010)
      Higher resting heart rate is associated with increased cardiovascular disease and mortality risk. Though heritable factors play a substantial role in population variation, little is known about specific genetic determinants. ...
    • Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure 

      Wain LV; Verwoert GC; O'Reilly PF; Shi G; Johnson T; Johnson AD; Bochud M; Rice KM; Henneman P; Smith AV; Ehret GB; Amin N; Larson MG; Mooser V; Hadley D; Dörr M; Bis JC; Aspelund T; Esko T; Janssens AC; Zhao JH; Heath S; Laan M; Fu J; Pistis G; Luan J; Arora P; Lucas G; Pirastu N; Pichler I; Jackson AU; Webster RJ; Zhang F; Peden JF; Schmidt H; Tanaka T; Campbell H; Igl W; Milaneschi Y; Hottenga JJ; Vitart V; Chasman DI; Trompet S; Bragg-Gresham JL; Alizadeh BZ; Chambers JC; Guo X; Lehtimäki T; Kühnel B; Lopez LM; Polašek O; Boban M; Nelson CP; Morrison AC; Pihur V; Ganesh SK; Hofman A; Kundu S; Mattace-Raso FU; Rivadeneira F; Sijbrands EJ; Uitterlinden AG; Hwang SJ; Vasan RS; Wang TJ; Bergmann S; Vollenweider P; Waeber G; Laitinen J; Pouta A; Zitting P; McArdle WL; Kroemer HK; Völker U; Völzke H; Glazer NL; Taylor KD; Harris TB; Alavere H; Haller T; Keis A; Tammesoo ML; Aulchenko Y; Barroso I; Khaw KT; Galan P; Hercberg S; Lathrop M; Eyheramendy S; Org E; Sõber S; Lu X; Nolte IM; Penninx BW; Corre T; Masciullo C; Sala C; Groop L; Voight BF; Melander O; O'Donnell CJ; Salomaa V; D'Adamo AP; Fabretto A; Faletra F; Ulivi S; Del Greco M F; Facheris M; Collins FS; Bergman RN; Beilby JP; Hung J; Musk AW; Mangino M; Shin SY; Soranzo N; Watkins H; Goel A; Hamsten A; Gider P; Loitfelder M; Zeginigg M; Hernandez D; Najjar SS; Navarro P; Wild SH; Corsi AM; Singleton A; de Geus EJ; Willemsen G; Parker AN; Rose LM; Buckley B; Stott D; Orru M; Uda M; LifeLines Cohort Study; van der Klauw MM; Zhang W; Li X; Scott J; Chen YD; Burke GL; Kähönen M; Viikari J; Döring A; Meitinger T; Davies G; Starr JM; Emilsson V; Plump A; Lindeman JH; Hoen PA; König IR; EchoGen consortium; Felix JF; Clarke R; Hopewell JC; Ongen H; Breteler M; Debette S; DeStefano AL; Fornage M; AortaGen Consortium; Mitchell GF; CHARGE Consortium Heart Failure Working Group; Smith NL; KidneyGen consortium; Holm H; Stefansson K; Thorleifsson G; Thorsteinsdottir U; CKDGen Consortium; Cardiogenics consortium; CARDIoGRAM Consortium; Samani NJ; Preuss M; Rudan I; Hayward C; Deary IJ; Wichmann HE; Raitakari OT; Palmas W; Kooner JS; Stolk RP; Jukema JW; Wright AF; Boomsma DI; Bandinelli S; Gyllensten UB; Wilson JF; Ferrucci L; Schmidt R; Farrall M; Spector TD; Palmer LJ; Tuomilehto J; Pfeufer A; Gasparini P; Siscovick D; Altshuler D; Loos RJ; Toniolo D; Snieder H; Gieger C; Meneton P; Wareham NJ; Oostra BA; Metspalu A; Launer L; Rettig R; Strachan DP; Beckmann JS; Witteman JC; Erdmann J; van Dijk KW; Boerwinkle E; Boehnke M; Ridker PM; Jarvelin MR; Chakravarti A; Abecasis GR; Gudnason V; Newton-Cheh C; Levy D; Munroe PB; Psaty BM; Caulfield MJ; Rao DC; Tobin MD; Elliott P; van Duijn CM (2011)
      Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure ...