Now showing items 1-10 of 10

    • Common variants associated with plasma triglycerides and risk for coronary artery disease 

      Do R; Willer CJ; Schmidt EM; Sengupta S; Gao C; Peloso GM; Gustafsson S; Kanoni S; Ganna A; Chen J; Buchkovich ML; Mora S; Beckmann JS; Bragg-Gresham JL; Chang HY; Demirkan A; Den Hertog HM; Donnelly LA; Ehret GB; Esko T; Feitosa MF; Ferreira T; Fischer K; Fontanillas P; Fraser RM; Freitag DF; Gurdasani D; Heikkilä K; Hyppönen E; Isaacs A; Jackson AU; Johansson A; Johnson T; Kaakinen M; Kettunen J; Kleber ME; Li X; Luan J; Lyytikäinen LP; Magnusson PK; Mangino M; Mihailov E; Montasser ME; Müller-Nurasyid M; Nolte IM; O'Connell JR; Palmer CD; Perola M; Petersen AK; Sanna S; Saxena R; Service SK; Shah S; Shungin D; Sidore C; Song C; Strawbridge RJ; Surakka I; Tanaka T; Teslovich TM; Thorleifsson G; Van den Herik EG; Voight BF; Volcik KA; Waite LL; Wong A; Wu Y; Zhang W; Absher D; Asiki G; Barroso I; Been LF; Bolton JL; Bonnycastle LL; Brambilla P; Burnett MS; Cesana G; Dimitriou M; Doney AS; Döring A; Elliott P; Epstein SE; Eyjolfsson GI; Gigante B; Goodarzi MO; Grallert H; Gravito ML; Groves CJ; Hallmans G; Hartikainen AL; Hayward C; Hernandez D; Hicks AA; Holm H; Hung YJ; Illig T; Jones MR; Kaleebu P; Kastelein JJ; Khaw KT; Kim E; Klopp N; Komulainen P; Kumari M; Langenberg C; Lehtimäki T; Lin SY; Lindström J; Loos RJ; Mach F; McArdle WL; Meisinger C; Mitchell BD; Müller G; Nagaraja R; Narisu N; Nieminen TV; Nsubuga RN; Olafsson I; Ong KK; Palotie A; Papamarkou T; Pomilla C; Pouta A; Rader DJ; Reilly MP; Ridker PM; Rivadeneira F; Rudan I; Ruokonen A; Samani N; Scharnagl H; Seeley J; Silander K; Stancáková A; Stirrups K; Swift AJ; Tiret L; Uitterlinden AG; van Pelt LJ; Vedantam S; Wainwright N; Wijmenga C; Wild SH; Willemsen G; Wilsgaard T; Wilson JF; Young EH; Zhao JH; Adair LS; Arveiler D; Assimes TL; Bandinelli S; Bennett F; Bochud M; Boehm BO; Boomsma DI; Borecki IB; Bornstein SR; Bovet P; Burnier M; Campbell H; Chakravarti A; Chambers JC; Chen YD; Collins FS; Cooper RS; Danesh J; Dedoussis G; de Faire U; Feranil AB; Ferrières J; Ferrucci L; Freimer NB; Gieger C; Groop LC; Gudnason V; Gyllensten U; Hamsten A; Harris TB; Hingorani A; Hirschhorn JN; Hofman A; Hovingh GK; Hsiung CA; Humphries SE; Hunt SC; Hveem K; Iribarren C; Järvelin MR; Jula A; Kähönen M; Kaprio J; Kesäniemi A; Kivimaki M; Kooner JS; Koudstaal PJ; Krauss RM; Kuh D; Kuusisto J; Kyvik KO; Laakso M; Lakka TA; Lind L; Lindgren CM; Martin NG; März W; McCarthy MI; McKenzie CA; Meneton P; Metspalu A; Moilanen L; Morris AD; Munroe PB; Njølstad I; Pedersen NL; Power C; Pramstaller PP; Price JF; Psaty BM; Quertermous T; Rauramaa R; Saleheen D; Salomaa V; Sanghera DK; Saramies J; Schwarz PE; Sheu WH; Shuldiner AR; Siegbahn A; Spector TD; Stefansson K; Strachan DP; Tayo BO; Tremoli E; Tuomilehto J; Uusitupa M; van Duijn CM; Vollenweider P; Wallentin L; Wareham NJ; Whitfield JB; Wolffenbuttel BH; Altshuler D; Ordovas JM; Boerwinkle E; Palmer CN; Thorsteinsdottir U; Chasman DI; Rotter JI; Franks PW; Ripatti S; Cupples LA; Sandhu MS; Rich SS; Boehnke M; Deloukas P; Mohlke KL; Ingelsson E; Abecasis GR; Daly MJ; Neale BM; Kathiresan S (2013)
      Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is ...
    • Discovery and refinement of loci associated with lipid levels 

      Global Lipids Genetics Consortium; Willer CJ; Schmidt EM; Sengupta S; Peloso GM; Gustafsson S; Kanoni S; Ganna A; Chen J; Buchkovich ML; Mora S; Beckmann JS; Bragg-Gresham JL; Chang HY; Demirkan A; Den Hertog HM; Do R; Donnelly LA; Ehret GB; Esko T; Feitosa MF; Ferreira T; Fischer K; Fontanillas P; Fraser RM; Freitag DF; Gurdasani D; Heikkilä K; Hyppönen E; Isaacs A; Jackson AU; Johansson A; Johnson T; Kaakinen M; Kettunen J; Kleber ME; Li X; Luan J; Lyytikäinen LP; Magnusson PK; Mangino M; Mihailov E; Montasser ME; Müller-Nurasyid M; Nolte IM; O'Connell JR; Palmer CD; Perola M; Petersen AK; Sanna S; Saxena R; Service SK; Shah S; Shungin D; Sidore C; Song C; Strawbridge RJ; Surakka I; Tanaka T; Teslovich TM; Thorleifsson G; Van den Herik EG; Voight BF; Volcik KA; Waite LL; Wong A; Wu Y; Zhang W; Absher D; Asiki G; Barroso I; Been LF; Bolton JL; Bonnycastle LL; Brambilla P; Burnett MS; Cesana G; Dimitriou M; Doney AS; Döring A; Elliott P; Epstein SE; Eyjolfsson GI; Gigante B; Goodarzi MO; Grallert H; Gravito ML; Groves CJ; Hallmans G; Hartikainen AL; Hayward C; Hernandez D; Hicks AA; Holm H; Hung YJ; Illig T; Jones MR; Kaleebu P; Kastelein JJ; Khaw KT; Kim E; Klopp N; Komulainen P; Kumari M; Langenberg C; Lehtimäki T; Lin SY; Lindström J; Loos RJ; Mach F; McArdle WL; Meisinger C; Mitchell BD; Müller G; Nagaraja R; Narisu N; Nieminen TV; Nsubuga RN; Olafsson I; Ong KK; Palotie A; Papamarkou T; Pomilla C; Pouta A; Rader DJ; Reilly MP; Ridker PM; Rivadeneira F; Rudan I; Ruokonen A; Samani N; Scharnagl H; Seeley J; Silander K; Stancáková A; Stirrups K; Swift AJ; Tiret L; Uitterlinden AG; van Pelt LJ; Vedantam S; Wainwright N; Wijmenga C; Wild SH; Willemsen G; Wilsgaard T; Wilson JF; Young EH; Zhao JH; Adair LS; Arveiler D; Assimes TL; Bandinelli S; Bennett F; Bochud M; Boehm BO; Boomsma DI; Borecki IB; Bornstein SR; Bovet P; Burnier M; Campbell H; Chakravarti A; Chambers JC; Chen YD; Collins FS; Cooper RS; Danesh J; Dedoussis G; de Faire U; Feranil AB; Ferrières J; Ferrucci L; Freimer NB; Gieger C; Groop LC; Gudnason V; Gyllensten U; Hamsten A; Harris TB; Hingorani A; Hirschhorn JN; Hofman A; Hovingh GK; Hsiung CA; Humphries SE; Hunt SC; Hveem K; Iribarren C; Järvelin MR; Jula A; Kähönen M; Kaprio J; Kesäniemi A; Kivimaki M; Kooner JS; Koudstaal PJ; Krauss RM; Kuh D; Kuusisto J; Kyvik KO; Laakso M; Lakka TA; Lind L; Lindgren CM; Martin NG; März W; McCarthy MI; McKenzie CA; Meneton P; Metspalu A; Moilanen L; Morris AD; Munroe PB; Njølstad I; Pedersen NL; Power C; Pramstaller PP; Price JF; Psaty BM; Quertermous T; Rauramaa R; Saleheen D; Salomaa V; Sanghera DK; Saramies J; Schwarz PE; Sheu WH; Shuldiner AR; Siegbahn A; Spector TD; Stefansson K; Strachan DP; Tayo BO; Tremoli E; Tuomilehto J; Uusitupa M; van Duijn CM; Vollenweider P; Wallentin L; Wareham NJ; Whitfield JB; Wolffenbuttel BH; Ordovas JM; Boerwinkle E; Palmer CN; Thorsteinsdottir U; Chasman DI; Rotter JI; Franks PW; Ripatti S; Cupples LA; Sandhu MS; Rich SS; Boehnke M; Deloukas P; Kathiresan S; Mohlke KL; Ingelsson E; Abecasis GR (2013)
      Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci ...
    • Genetic studies of body mass index yield new insights for obesity biology 

      Locke AE; Kahali B; Berndt SI; Justice AE; Pers TH; Day FR; Powell C; Vedantam S; Buchkovich ML; Yang J; Croteau-Chonka DC; Esko T; Fall T; Ferreira T; Gustafsson S; Kutalik Z; Luan J; Mägi R; Randall JC; Winkler TW; Wood AR; Workalemahu T; Faul JD; Smith JA; Hua Zhao J; Zhao W; Chen J; Fehrmann R; Hedman ÅK; Karjalainen J; Schmidt EM; Absher D; Amin N; Anderson D; Beekman M; Bolton JL; Bragg-Gresham JL; Buyske S; Demirkan A; Deng G; Ehret GB; Feenstra B; Feitosa MF; Fischer K; Goel A; Gong J; Jackson AU; Kanoni S; Kleber ME; Kristiansson K; Lim U; Lotay V; Mangino M; Mateo Leach I; Medina-Gomez C; Medland SE; Nalls MA; Palmer CD; Pasko D; Pechlivanis S; Peters MJ; Prokopenko I; Shungin D; Stančáková A; Strawbridge RJ; Ju Sung Y; Tanaka T; Teumer A; Trompet S; van der Laan SW; van Setten J; van Vliet-Ostaptchouk JV; Wang Z; Yengo L; Zhang W; Isaacs A; Albrecht E; Ärnlöv J; Arscott GM; Attwood AP; Bandinelli S; Barrett A; Bas IN; Bellis C; Bennett AJ; Berne C; Blagieva R; Blüher M; Böhringer S; Bonnycastle LL; Böttcher Y; Boyd HA; Bruinenberg M; Caspersen IH; Ida Chen YD; Clarke R; Daw EW; de Craen AJ; Delgado G; Dimitriou M; Doney AS; Eklund N; Estrada K; Eury E; Folkersen L; Fraser RM; Garcia ME; Geller F; Giedraitis V; Gigante B; Go AS; Golay A; Goodall AH; Gordon SD; Gorski M; Grabe HJ; Grallert H; Grammer TB; Gräßler J; Grönberg H; Groves CJ; Gusto G; Haessler J; Hall P; Haller T; Hallmans G; Hartman CA; Hassinen M; Hayward C; Heard-Costa NL; Helmer Q; Hengstenberg C; Holmen O; Hottenga JJ; James AL; Jeff JM; Johansson Å; Jolley J; Juliusdottir T; Kinnunen L; Koenig W; Koskenvuo M; Kratzer W; Laitinen J; Lamina C; Leander K; Lee NR; Lichtner P; Lind L; Lindström J; Sin Lo K; Lobbens S; Lorbeer R; Lu Y; Mach F; Magnusson PK; Mahajan A; McArdle WL; McLachlan S; Menni C; Merger S; Mihailov E; Milani L; Moayyeri A; Monda KL; Morken MA; Mulas A; Müller G; Müller-Nurasyid M; Musk AW; Nagaraja R; Nöthen MM; Nolte IM; Pilz S; Rayner NW; Renstrom F; Rettig R; Ried JS; Ripke S; Robertson NR; Rose LM; Sanna S; Scharnagl H; Scholtens S; Schumacher FR; Scott WR; Seufferlein T; Shi J; Vernon Smith A; Smolonska J; Stanton AV; Steinthorsdottir V; Stirrups K; Stringham HM; Sundström J; Swertz MA; Swift AJ; Syvänen AC; Tan ST; Tayo BO; Thorand B; Thorleifsson G; Tyrer JP; Uh HW; Vandenput L; Verhulst FC; Vermeulen SH; Verweij N; Vonk JM; Waite LL; Warren HR; Waterworth D; Weedon MN; Wilkens LR; Willenborg C; Wilsgaard T; Wojczynski MK; Wong A; Wright AF; Zhang Q; LifeLines Cohort Study; Brennan EP; Choi M; Dastani Z; Drong AW; Eriksson P; Franco-Cereceda A; Gådin JR; Gharavi AG; Goddard ME; Handsaker RE; Huang J; Karpe F; Kathiresan S; Keildson S; Kiryluk K; Kubo M; Lee JY; Liang L; Lifton RP; Ma B; McCarroll SA; McKnight AJ; Min JL; Moffatt MF; Montgomery GW; Murabito JM; Nicholson G; Nyholt DR; Okada Y; Perry JR; Dorajoo R; Reinmaa E; Salem RM; Sandholm N; Scott RA; Stolk L; Takahashi A; Van't Hooft FM; Vinkhuyzen AA; Westra HJ; Zheng W; Zondervan KT; ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium; Heath AC; Arveiler D; Bakker SJ; Beilby J; Bergman RN; Blangero J; Bovet P; Campbell H; Caulfield MJ; Cesana G; Chakravarti A; Chasman DI; Chines PS; Collins FS; Crawford DC; Cupples LA; Cusi D; Danesh J; de Faire U; den Ruijter HM; Dominiczak AF; Erbel R; Erdmann J; Eriksson JG; Farrall M; Felix SB; Ferrannini E; Ferrières J; Ford I; Forouhi NG; Forrester T; Franco OH; Gansevoort RT; Gejman PV; Gieger C; Gottesman O; Gudnason V; Gyllensten U; Hall AS; Harris TB; Hattersley AT; Hicks AA; Hindorff LA; Hingorani AD; Hofman A; Homuth G; Hovingh GK; Humphries SE; Hunt SC; Hyppönen E; Illig T; Jacobs KB; Jarvelin MR; Jöckel KH; Johansen B; Jousilahti P; Jukema JW; Jula AM; Kaprio J; Kastelein JJ; Keinanen-Kiukaanniemi SM; Kiemeney LA; Knekt P; Kooner JS; Kooperberg C; Kovacs P; Kraja AT; Kumari M; Kuusisto J; Lakka TA; Langenberg C; Le Marchand L; Lehtimäki T; Lyssenko V; Männistö S; Marette A; Matise TC; McKenzie CA; McKnight B; Moll FL; Morris AD; Morris AP; Murray JC; Nelis M; Ohlsson C; Oldehinkel AJ; Ong KK; Madden PA; Pasterkamp G; Peden JF; Peters A; Postma DS; Pramstaller PP; Price JF; Qi L; Raitakari OT; Rankinen T; Rao DC; Rice TK; Ridker PM; Rioux JD; Ritchie MD; Rudan I; Salomaa V; Samani NJ; Saramies J; Sarzynski MA; Schunkert H; Schwarz PE; Sever P; Shuldiner AR; Sinisalo J; Stolk RP; Strauch K; Tönjes A; Trégouët DA; Tremblay A; Tremoli E; Virtamo J; Vohl MC; Völker U; Waeber G; Willemsen G; Witteman JC; Zillikens MC; Adair LS; Amouyel P; Asselbergs FW; Assimes TL; Bochud M; Boehm BO; Boerwinkle E; Bornstein SR; Bottinger EP; Bouchard C; Cauchi S; Chambers JC; Chanock SJ; Cooper RS; de Bakker PI; Dedoussis G; Ferrucci L; Franks PW; Froguel P; Groop LC; Haiman CA; Hamsten A; Hui J; Hunter DJ; Hveem K; Kaplan RC; Kivimaki M; Kuh D; Laakso M; Liu Y; Martin NG; März W; Melbye M; Metspalu A; Moebus S; Munroe PB; Njølstad I; Oostra BA; Palmer CN; Pedersen NL; Perola M; Pérusse L; Peters U; Power C; Quertermous T; Rauramaa R; Rivadeneira F; Saaristo TE; Saleheen D; Sattar N; Schadt EE; Schlessinger D; Slagboom PE; Snieder H; Spector TD; Thorsteinsdottir U; Stumvoll M; Tuomilehto J; Uitterlinden AG; Uusitupa M; van der Harst P; Walker M; Wallaschofski H; Wareham NJ; Watkins H; Weir DR; Wichmann HE; Wilson JF; Zanen P; Borecki IB; Deloukas P; Fox CS; Heid IM; O'Connell JR; Strachan DP; Stefansson K; van Duijn CM; Abecasis GR; Franke L; Frayling TM; McCarthy MI; Visscher PM; Scherag A; Willer CJ; Boehnke M; Mohlke KL; Lindgren CM; Beckmann JS; Barroso I; North KE; Ingelsson E; Hirschhorn JN; Loos RJ; Speliotes EK (2015)
      Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure ...
    • Genome-wide association analyses identify 18 new loci associated with serum urate concentrations 

      Köttgen A; Albrecht E; Teumer A; Vitart V; Krumsiek J; Hundertmark C; Pistis G; Ruggiero D; O'Seaghdha CM; Haller T; Yang Q; Tanaka T; Johnson AD; Kutalik Z; Smith AV; Shi J; Struchalin M; Middelberg RP; Brown MJ; Gaffo AL; Pirastu N; Li G; Hayward C; Zemunik T; Huffman J; Yengo L; Zhao JH; Demirkan A; Feitosa MF; Liu X; Malerba G; Lopez LM; van der Harst P; Li X; Kleber ME; Hicks AA; Nolte IM; Johansson A; Murgia F; Wild SH; Bakker SJ; Peden JF; Dehghan A; Steri M; Tenesa A; Lagou V; Salo P; Mangino M; Rose LM; Lehtimäki T; Woodward OM; Okada Y; Tin A; Müller C; Oldmeadow C; Putku M; Czamara D; Kraft P; Frogheri L; Thun GA; Grotevendt A; Gislason GK; Harris TB; Launer LJ; McArdle P; Shuldiner AR; Boerwinkle E; Coresh J; Schmidt H; Schallert M; Martin NG; Montgomery GW; Kubo M; Nakamura Y; Munroe PB; Samani NJ; Jacobs DR; Liu K; D'Adamo P; Ulivi S; Rotter JI; Psaty BM; Vollenweider P; Waeber G; Campbell S; Devuyst O; Navarro P; Kolcic I; Hastie N; Balkau B; Froguel P; Esko T; Salumets A; Khaw KT; Langenberg C; Wareham NJ; Isaacs A; Kraja A; Zhang Q; Wild PS; Scott RJ; Holliday EG; Org E; Viigimaa M; Bandinelli S; Metter JE; Lupo A; Trabetti E; Sorice R; Döring A; Lattka E; Strauch K; Theis F; Waldenberger M; Wichmann HE; Davies G; Gow AJ; Bruinenberg M; LifeLines Cohort Study; Stolk RP; Kooner JS; Zhang W; Winkelmann BR; Boehm BO; Lucae S; Penninx BW; Smit JH; Curhan G; Mudgal P; Plenge RM; Portas L; Persico I; Kirin M; Wilson JF; Mateo Leach I; van Gilst WH; Goel A; Ongen H; Hofman A; Rivadeneira F; Uitterlinden AG; Imboden M; von Eckardstein A; Cucca F; Nagaraja R; Piras MG; Nauck M; Schurmann C; Budde K; Ernst F; Farrington SM; Theodoratou E; Prokopenko I; Stumvoll M; Jula A; Perola M; Salomaa V; Shin SY; Spector TD; Sala C; Ridker PM; Kähönen M; Viikari J; Hengstenberg C; Nelson CP; CARDIoGRAM Consortium; DIAGRAM Consortium; ICBP Consortium; MAGIC Consortium; Meschia JF; Nalls MA; Sharma P; Singleton AB; Kamatani N; Zeller T; Burnier M; Attia J; Laan M; Klopp N; Hillege HL; Kloiber S; Choi H; Pirastu M; Tore S; Probst-Hensch NM; Völzke H; Gudnason V; Parsa A; Schmidt R; Whitfield JB; Fornage M; Gasparini P; Siscovick DS; Polašek O; Campbell H; Rudan I; Bouatia-Naji N; Metspalu A; Loos RJ; van Duijn CM; Borecki IB; Ferrucci L; Gambaro G; Deary IJ; Wolffenbuttel BH; Chambers JC; März W; Pramstaller PP; Snieder H; Gyllensten U; Wright AF; Navis G; Watkins H; Witteman JC; Sanna S; Schipf S; Dunlop MG; Tönjes A; Ripatti S; Soranzo N; Toniolo D; Chasman DI; Raitakari O; Kao WH; Ciullo M; Fox CS; Caulfield M; Bochud M; Gieger C (2013)
      Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we ...
    • Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways 

      Scott RA; Lagou V; Welch RP; Wheeler E; Montasser ME; Luan J; Mägi R; Strawbridge RJ; Rehnberg E; Gustafsson S; Kanoni S; Rasmussen-Torvik LJ; Yengo L; Lecoeur C; Shungin D; Sanna S; Sidore C; Johnson PC; Jukema JW; Johnson T; Mahajan A; Verweij N; Thorleifsson G; Hottenga JJ; Shah S; Smith AV; Sennblad B; Gieger C; Salo P; Perola M; Timpson NJ; Evans DM; Pourcain BS; Wu Y; Andrews JS; Hui J; Bielak LF; Zhao W; Horikoshi M; Navarro P; Isaacs A; O'Connell JR; Stirrups K; Vitart V; Hayward C; Esko T; Mihailov E; Fraser RM; Fall T; Voight BF; Raychaudhuri S; Chen H; Lindgren CM; Morris AP; Rayner NW; Robertson N; Rybin D; Liu CT; Beckmann JS; Willems SM; Chines PS; Jackson AU; Kang HM; Stringham HM; Song K; Tanaka T; Peden JF; Goel A; Hicks AA; An P; Müller-Nurasyid M; Franco-Cereceda A; Folkersen L; Marullo L; Jansen H; Oldehinkel AJ; Bruinenberg M; Pankow JS; North KE; Forouhi NG; Loos RJ; Edkins S; Varga TV; Hallmans G; Oksa H; Antonella M; Nagaraja R; Trompet S; Ford I; Bakker SJ; Kong A; Kumari M; Gigante B; Herder C; Munroe PB; Caulfield M; Antti J; Mangino M; Small K; Miljkovic I; Liu Y; Atalay M; Kiess W; James AL; Rivadeneira F; Uitterlinden AG; Palmer CN; Doney AS; Willemsen G; Smit JH; Campbell S; Polasek O; Bonnycastle LL; Hercberg S; Dimitriou M; Bolton JL; Fowkes GR; Kovacs P; Lindström J; Zemunik T; Bandinelli S; Wild SH; Basart HV; Rathmann W; Grallert H; DIAGRAM Consortium; Maerz W; Kleber ME; Boehm BO; Peters A; Pramstaller PP; Province MA; Borecki IB; Hastie ND; Rudan I; Campbell H; Watkins H; Farrall M; Stumvoll M; Ferrucci L; Waterworth DM; Bergman RN; Collins FS; Tuomilehto J; Watanabe RM; de Geus EJ; Penninx BW; Hofman A; Oostra BA; Psaty BM; Vollenweider P; Wilson JF; Wright AF; Hovingh GK; Metspalu A; Uusitupa M; Magnusson PK; Kyvik KO; Kaprio J; Price JF; Dedoussis GV; Deloukas P; Meneton P; Lind L; Boehnke M; Shuldiner AR; van Duijn CM; Morris AD; Toenjes A; Peyser PA; Beilby JP; Körner A; Kuusisto J; Laakso M; Bornstein SR; Schwarz PE; Lakka TA; Rauramaa R; Adair LS; Smith GD; Spector TD; Illig T; de Faire U; Hamsten A; Gudnason V; Kivimaki M; Hingorani A; Keinanen-Kiukaanniemi SM; Saaristo TE; Boomsma DI; Stefansson K; van der Harst P; Dupuis J; Pedersen NL; Sattar N; Harris TB; Cucca F; Ripatti S; Salomaa V; Mohlke KL; Balkau B; Froguel P; Pouta A; Jarvelin MR; Wareham NJ; Bouatia-Naji N; McCarthy MI; Franks PW; Meigs JB; Teslovich TM; Florez JC; Langenberg C; Ingelsson E; Prokopenko I; Barroso I (2012)
      Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci ...
    • Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations 

      Kolz M; Johnson T; Sanna S; Teumer A; Vitart V; Perola M; Mangino M; Albrecht E; Wallace C; Farrall M; Johansson A; Nyholt DR; Aulchenko Y; Beckmann JS; Bergmann S; Bochud M; Brown M; Campbell H; EUROSPAN Consortium; Connell J; Dominiczak A; Homuth G; Lamina C; McCarthy MI; ENGAGE Consortium; Meitinger T; Mooser V; Munroe P; Nauck M; Peden J; Prokisch H; Salo P; Salomaa V; Samani NJ; Schlessinger D; Uda M; Völker U; Waeber G; Waterworth D; Wang-Sattler R; Wright AF; Adamski J; Whitfield JB; Gyllensten U; Wilson JF; Rudan I; Pramstaller P; Watkins H; PROCARDIS Consortium; Doering A; Wichmann HE; KORA Study; Spector TD; Peltonen L; Völzke H; Nagaraja R; Vollenweider P; Caulfield M; WTCCC; Illig T; Gieger C (2009)
      Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis of genome-wide association ...
    • A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function 

      Porcu E; Medici M; Pistis G; Volpato CB; Wilson SG; Cappola AR; Bos SD; Deelen J; den Heijer M; Freathy RM; Lahti J; Liu C; Lopez LM; Nolte IM; O'Connell JR; Tanaka T; Trompet S; Arnold A; Bandinelli S; Beekman M; Böhringer S; Brown SJ; Buckley BM; Camaschella C; de Craen AJ; Davies G; de Visser MC; Ford I; Forsen T; Frayling TM; Fugazzola L; Gögele M; Hattersley AT; Hermus AR; Hofman A; Houwing-Duistermaat JJ; Jensen RA; Kajantie E; Kloppenburg M; Lim EM; Masciullo C; Mariotti S; Minelli C; Mitchell BD; Nagaraja R; Netea-Maier RT; Palotie A; Persani L; Piras MG; Psaty BM; Räikkönen K; Richards JB; Rivadeneira F; Sala C; Sabra MM; Sattar N; Shields BM; Soranzo N; Starr JM; Stott DJ; Sweep FC; Usala G; van der Klauw MM; van Heemst D; van Mullem A; Vermeulen SH; Visser WE; Walsh JP; Westendorp RG; Widen E; Zhai G; Cucca F; Deary IJ; Eriksson JG; Ferrucci L; Fox CS; Jukema JW; Kiemeney LA; Pramstaller PP; Schlessinger D; Shuldiner AR; Slagboom EP; Uitterlinden AG; Vaidya B; Visser TJ; Wolffenbuttel BH; Meulenbelt I; Rotter JI; Spector TD; Hicks AA; Toniolo D; Sanna S; Peeters RP; Naitza S (2013)
      Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyroid function lead to common endocrine disorders affecting approximately 10% of individuals over their life span. In addition, ...
    • The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits 

      Voight BF; Kang HM; Ding J; Palmer CD; Sidore C; Chines PS; Burtt NP; Fuchsberger C; Li Y; Erdmann J; Frayling TM; Heid IM; Jackson AU; Johnson T; Kilpeläinen TO; Lindgren CM; Morris AP; Prokopenko I; Randall JC; Saxena R; Soranzo N; Speliotes EK; Teslovich TM; Wheeler E; Maguire J; Parkin M; Potter S; Rayner NW; Robertson N; Stirrups K; Winckler W; Sanna S; Mulas A; Nagaraja R; Cucca F; Barroso I; Deloukas P; Loos RJ; Kathiresan S; Munroe PB; Newton-Cheh C; Pfeufer A; Samani NJ; Schunkert H; Hirschhorn JN; Altshuler D; McCarthy MI; Abecasis GR; Boehnke M (2012)
      Genome-wide association studies have identified hundreds of loci for type 2 diabetes, coronary artery disease and myocardial infarction, as well as for related traits such as body mass index, glucose and insulin levels, ...
    • Modulation of genetic associations with serum urate levels by body-mass-index in humans 

      Huffman JE; Albrecht E; Teumer A; Mangino M; Kapur K; Johnson T; Kutalik Z; Pirastu N; Pistis G; Lopez LM; Haller T; Salo P; Goel A; Li M; Tanaka T; Dehghan A; Ruggiero D; Malerba G; Smith AV; Nolte IM; Portas L; Phipps-Green A; Boteva L; Navarro P; Johansson A; Hicks AA; Polasek O; Esko T; Peden JF; Harris SE; Murgia F; Wild SH; Tenesa A; Tin A; Mihailov E; Grotevendt A; Gislason GK; Coresh J; D'Adamo P; Ulivi S; Vollenweider P; Waeber G; Campbell S; Kolcic I; Fisher K; Viigimaa M; Metter JE; Masciullo C; Trabetti E; Bombieri C; Sorice R; Döring A; Reischl E; Strauch K; Hofman A; Uitterlinden AG; Waldenberger M; Wichmann HE; Davies G; Gow AJ; Dalbeth N; Stamp L; Smit JH; Kirin M; Nagaraja R; Nauck M; Schurmann C; Budde K; Farrington SM; Theodoratou E; Jula A; Salomaa V; Sala C; Hengstenberg C; Burnier M; Mägi R; Klopp N; Kloiber S; Schipf S; Ripatti S; Cabras S; Soranzo N; Homuth G; Nutile T; Munroe PB; Hastie N; Campbell H; Rudan I; Cabrera C; Haley C; Franco OH; Merriman TR; Gudnason V; Pirastu M; Penninx BW; Snieder H; Metspalu A; Ciullo M; Pramstaller PP; van Duijn CM; Ferrucci L; Gambaro G; Deary IJ; Dunlop MG; Wilson JF; Gasparini P; Gyllensten U; Spector TD; Wright AF; Hayward C; Watkins H; Perola M; Bochud M; Kao WH; Caulfield M; Toniolo D; Völzke H; Gieger C; Köttgen A; Vitart V (2015)
      We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, ...
    • New genetic loci link adipose and insulin biology to body fat distribution 

      Shungin D; Winkler TW; Croteau-Chonka DC; Ferreira T; Locke AE; Mägi R; Strawbridge RJ; Pers TH; Fischer K; Justice AE; Workalemahu T; Wu JM; Buchkovich ML; Heard-Costa NL; Roman TS; Drong AW; Song C; Gustafsson S; Day FR; Esko T; Fall T; Kutalik Z; Luan J; Randall JC; Scherag A; Vedantam S; Wood AR; Chen J; Fehrmann R; Karjalainen J; Kahali B; Liu CT; Schmidt EM; Absher D; Amin N; Anderson D; Beekman M; Bragg-Gresham JL; Buyske S; Demirkan A; Ehret GB; Feitosa MF; Goel A; Jackson AU; Johnson T; Kleber ME; Kristiansson K; Mangino M; Mateo Leach I; Medina-Gomez C; Palmer CD; Pasko D; Pechlivanis S; Peters MJ; Prokopenko I; Stančáková A; Ju Sung Y; Tanaka T; Teumer A; van Vliet-Ostaptchouk JV; Yengo L; Zhang W; Albrecht E; Ärnlöv J; Arscott GM; Bandinelli S; Barrett A; Bellis C; Bennett AJ; Berne C; Blüher M; Böhringer S; Bonnet F; Böttcher Y; Bruinenberg M; Carba DB; Caspersen IH; Clarke R; Daw EW; Deelen J; Deelman E; Delgado G; Doney AS; Eklund N; Erdos MR; Estrada K; Eury E; Friedrich N; Garcia ME; Giedraitis V; Gigante B; Go AS; Golay A; Grallert H; Grammer TB; Gräßler J; Grewal J; Groves CJ; Haller T; Hallmans G; Hartman CA; Hassinen M; Hayward C; Heikkilä K; Herzig KH; Helmer Q; Hillege HL; Holmen O; Hunt SC; Isaacs A; Ittermann T; James AL; Johansson I; Juliusdottir T; Kalafati IP; Kinnunen L; Koenig W; Kooner IK; Kratzer W; Lamina C; Leander K; Lee NR; Lichtner P; Lind L; Lindström J; Lobbens S; Lorentzon M; Mach F; Magnusson PK; Mahajan A; McArdle WL; Menni C; Merger S; Mihailov E; Milani L; Mills R; Moayyeri A; Monda KL; Mooijaart SP; Mühleisen TW; Mulas A; Müller G; Müller-Nurasyid M; Nagaraja R; Nalls MA; Narisu N; Glorioso N; Nolte IM; Olden M; Rayner NW; Renstrom F; Ried JS; Robertson NR; Rose LM; Sanna S; Scharnagl H; Scholtens S; Sennblad B; Seufferlein T; Sitlani CM; Vernon Smith A; Stirrups K; Stringham HM; Sundström J; Swertz MA; Swift AJ; Syvänen AC; Tayo BO; Thorand B; Thorleifsson G; Tomaschitz A; Troffa C; van Oort FV; Verweij N; Vonk JM; Waite LL; Wennauer R; Wilsgaard T; Wojczynski MK; Wong A; Zhang Q; Hua Zhao J; Brennan EP; Choi M; Eriksson P; Folkersen L; Franco-Cereceda A; Gharavi AG; Hedman ÅK; Hivert MF; Huang J; Kanoni S; Karpe F; Keildson S; Kiryluk K; Liang L; Lifton RP; Ma B; McKnight AJ; McPherson R; Metspalu A; Min JL; Moffatt MF; Montgomery GW; Murabito JM; Nicholson G; Nyholt DR; Olsson C; Perry JR; Reinmaa E; Salem RM; Sandholm N; Schadt EE; Scott RA; Stolk L; Vallejo EE; Westra HJ; Zondervan KT; ADIPOGen Consortium; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GEFOS Consortium; GENIE Consortium; GLGC; ICBP; International Endogene Consortium; LifeLines Cohort Study; MAGIC Investigators; MuTHER Consortium; PAGE Consortium; ReproGen Consortium; Amouyel P; Arveiler D; Bakker SJ; Beilby J; Bergman RN; Blangero J; Brown MJ; Burnier M; Campbell H; Chakravarti A; Chines PS; Claudi-Boehm S; Collins FS; Crawford DC; Danesh J; de Faire U; de Geus EJ; Dörr M; Erbel R; Eriksson JG; Farrall M; Ferrannini E; Ferrières J; Forouhi NG; Forrester T; Franco OH; Gansevoort RT; Gieger C; Gudnason V; Haiman CA; Harris TB; Hattersley AT; Heliövaara M; Hicks AA; Hingorani AD; Hoffmann W; Hofman A; Homuth G; Humphries SE; Hyppönen E; Illig T; Jarvelin MR; Johansen B; Jousilahti P; Jula AM; Kaprio J; Kee F; Keinanen-Kiukaanniemi SM; Kooner JS; Kooperberg C; Kovacs P; Kraja AT; Kumari M; Kuulasmaa K; Kuusisto J; Lakka TA; Langenberg C; Le Marchand L; Lehtimäki T; Lyssenko V; Männistö S; Marette A; Matise TC; McKenzie CA; McKnight B; Musk AW; Möhlenkamp S; Morris AD; Nelis M; Ohlsson C; Oldehinkel AJ; Ong KK; Palmer LJ; Penninx BW; Peters A; Pramstaller PP; Raitakari OT; Rankinen T; Rao DC; Rice TK; Ridker PM; Ritchie MD; Rudan I; Salomaa V; Samani NJ; Saramies J; Sarzynski MA; Schwarz PE; Shuldiner AR; Staessen JA; Steinthorsdottir V; Stolk RP; Strauch K; Tönjes A; Tremblay A; Tremoli E; Vohl MC; Völker U; Vollenweider P; Wilson JF; Witteman JC; Adair LS; Bochud M; Boehm BO; Bornstein SR; Bouchard C; Cauchi S; Caulfield MJ; Chambers JC; Chasman DI; Cooper RS; Dedoussis G; Ferrucci L; Froguel P; Grabe HJ; Hamsten A; Hui J; Hveem K; Jöckel KH; Kivimaki M; Kuh D; Laakso M; Liu Y; März W; Munroe PB; Njølstad I; Oostra BA; Palmer CN; Pedersen NL; Perola M; Pérusse L; Peters U; Power C; Quertermous T; Rauramaa R; Rivadeneira F; Saaristo TE; Saleheen D; Sinisalo J; Slagboom PE; Snieder H; Spector TD; Thorsteinsdottir U; Stumvoll M; Tuomilehto J; Uitterlinden AG; Uusitupa M; van der Harst P; Veronesi G; Walker M; Wareham NJ; Watkins H; Wichmann HE; Abecasis GR; Assimes TL; Berndt SI; Boehnke M; Borecki IB; Deloukas P; Franke L; Frayling TM; Groop LC; Hunter DJ; Kaplan RC; O'Connell JR; Qi L; Schlessinger D; Strachan DP; Stefansson K; van Duijn CM; Willer CJ; Visscher PM; Yang J; Hirschhorn JN; Zillikens MC; McCarthy MI; Speliotes EK; North KE; Fox CS; Barroso I; Franks PW; Ingelsson E; Heid IM; Loos RJ; Cupples LA; Morris AP; Lindgren CM; Mohlke KL (2015)
      Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and ...