Now showing items 1-7 of 7

    • 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function 

      Gorski M; van der Most PJ; Teumer A; Chu AY; Li M; Mijatovic V; Nolte IM; Cocca M; Taliun D; Gomez F; Li Y; Tayo B; Tin A; Feitosa MF; Aspelund T; Attia J; Biffar R; Bochud M; Boerwinkle E; Borecki I; Bottinger EP; Chen MH; Chouraki V; Ciullo M; Coresh J; Cornelis MC; Curhan GC; D'Adamo AP; Dehghan A; Dengler L; Ding J; Eiriksdottir G; Endlich K; Enroth S; Esko T; Franco OH; Gasparini P; Gieger C; Girotto G; Gottesman O; Gudnason V; Gyllensten U; Hancock SJ; Harris TB; Helmer C; Höllerer S; Hofer E; Hofman A; Holliday EG; Homuth G; Hu FB; Huth C; Hutri-Kähönen N; Hwang SJ; Imboden M; Johansson Å; Kähönen M; König W; Kramer H; Krämer BK; Kumar A; Kutalik Z; Lambert JC; Launer LJ; Lehtimäki T; de Borst M; Navis G; Swertz M; Liu Y; Lohman K; Loos RJF; Lu Y; Lyytikäinen LP; McEvoy MA; Meisinger C; Meitinger T; Metspalu A; Metzger M; Mihailov E; Mitchell P; Nauck M; Oldehinkel AJ; Olden M; Wjh Penninx B; Pistis G; Pramstaller PP; Probst-Hensch N; Raitakari OT; Rettig R; Ridker PM; Rivadeneira F; Robino A; Rosas SE; Ruderfer D; Ruggiero D; Saba Y; Sala C; Schmidt H; Schmidt R; Scott RJ; Sedaghat S; Smith AV; Sorice R; Stengel B; Stracke S; Strauch K; Toniolo D; Uitterlinden AG; Ulivi S; Viikari JS; Völker U; Vollenweider P; Völzke H; Vuckovic D; Waldenberger M; Jin Wang J; Yang Q; Chasman DI; Tromp G; Snieder H; Heid IM; Fox CS; Köttgen A; Pattaro C; Böger CA; Fuchsberger C (2017)
      HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, ...
    • Common variants in Mendelian kidney disease genes and their association with renal function 

      Parsa A; Fuchsberger C; Köttgen A; O'Seaghdha CM; Pattaro C; de Andrade M; Chasman DI; Teumer A; Endlich K; Olden M; Chen MH; Tin A; Kim YJ; Taliun D; Li M; Feitosa M; Gorski M; Yang Q; Hundertmark C; Foster MC; Glazer N; Isaacs A; Rao M; Smith AV; O'Connell JR; Struchalin M; Tanaka T; Li G; Hwang SJ; Atkinson EJ; Lohman K; Cornelis MC; Johansson A; Tönjes A; Dehghan A; Couraki V; Holliday EG; Sorice R; Kutalik Z; Lehtimäki T; Esko T; Deshmukh H; Ulivi S; Chu AY; Murgia F; Trompet S; Imboden M; Kollerits B; Pistis G; Harris TB; Launer LJ; Aspelund T; Eiriksdottir G; Mitchell BD; Boerwinkle E; Schmidt H; Hofer E; Hu F; Demirkan A; Oostra BA; Turner ST; Ding J; Andrews JS; Freedman BI; Giulianini F; Koenig W; Illig T; Döring A; Wichmann HE; Zgaga L; Zemunik T; Boban M; Minelli C; Wheeler HE; Igl W; Zaboli G; Wild SH; Wright AF; Campbell H; Ellinghaus D; Nöthlings U; Jacobs G; Biffar R; Ernst F; Homuth G; Kroemer HK; Nauck M; Stracke S; Völker U; Völzke H; Kovacs P; Stumvoll M; Mägi R; Hofman A; Uitterlinden AG; Rivadeneira F; Aulchenko YS; Polasek O; Hastie N; Vitart V; Helmer C; Wang JJ; Stengel B; Ruggiero D; Bergmann S; Kähönen M; Viikari J; Nikopensius T; Province M; Colhoun H; Doney A; Robino A; Krämer BK; Portas L; Ford I; Buckley BM; Adam M; Thun GA; Paulweber B; Haun M; Sala C; Mitchell P; Ciullo M; Vollenweider P; Raitakari O; Metspalu A; Palmer C; Gasparini P; Pirastu M; Jukema JW; Probst-Hensch NM; Kronenberg F; Toniolo D; Gudnason V; Shuldiner AR; Coresh J; Schmidt R; Ferrucci L; van Duijn CM; Borecki I; Kardia SL; Liu Y; Curhan GC; Rudan I; Gyllensten U; Wilson JF; Franke A; Pramstaller PP; Rettig R; Prokopenko I; Witteman J; Hayward C; Ridker PM; Bochud M; Heid IM; Siscovick DS; Fox CS; Kao WL; Böger CA (2013)
      Many common genetic variants identified by genome-wide association studies for complex traits map to genes previously linked to rare inherited Mendelian disorders. A systematic analysis of common single-nucleotide polymorphisms ...
    • Genome-wide association analyses identify 18 new loci associated with serum urate concentrations 

      Köttgen A; Albrecht E; Teumer A; Vitart V; Krumsiek J; Hundertmark C; Pistis G; Ruggiero D; O'Seaghdha CM; Haller T; Yang Q; Tanaka T; Johnson AD; Kutalik Z; Smith AV; Shi J; Struchalin M; Middelberg RP; Brown MJ; Gaffo AL; Pirastu N; Li G; Hayward C; Zemunik T; Huffman J; Yengo L; Zhao JH; Demirkan A; Feitosa MF; Liu X; Malerba G; Lopez LM; van der Harst P; Li X; Kleber ME; Hicks AA; Nolte IM; Johansson A; Murgia F; Wild SH; Bakker SJ; Peden JF; Dehghan A; Steri M; Tenesa A; Lagou V; Salo P; Mangino M; Rose LM; Lehtimäki T; Woodward OM; Okada Y; Tin A; Müller C; Oldmeadow C; Putku M; Czamara D; Kraft P; Frogheri L; Thun GA; Grotevendt A; Gislason GK; Harris TB; Launer LJ; McArdle P; Shuldiner AR; Boerwinkle E; Coresh J; Schmidt H; Schallert M; Martin NG; Montgomery GW; Kubo M; Nakamura Y; Munroe PB; Samani NJ; Jacobs DR; Liu K; D'Adamo P; Ulivi S; Rotter JI; Psaty BM; Vollenweider P; Waeber G; Campbell S; Devuyst O; Navarro P; Kolcic I; Hastie N; Balkau B; Froguel P; Esko T; Salumets A; Khaw KT; Langenberg C; Wareham NJ; Isaacs A; Kraja A; Zhang Q; Wild PS; Scott RJ; Holliday EG; Org E; Viigimaa M; Bandinelli S; Metter JE; Lupo A; Trabetti E; Sorice R; Döring A; Lattka E; Strauch K; Theis F; Waldenberger M; Wichmann HE; Davies G; Gow AJ; Bruinenberg M; LifeLines Cohort Study; Stolk RP; Kooner JS; Zhang W; Winkelmann BR; Boehm BO; Lucae S; Penninx BW; Smit JH; Curhan G; Mudgal P; Plenge RM; Portas L; Persico I; Kirin M; Wilson JF; Mateo Leach I; van Gilst WH; Goel A; Ongen H; Hofman A; Rivadeneira F; Uitterlinden AG; Imboden M; von Eckardstein A; Cucca F; Nagaraja R; Piras MG; Nauck M; Schurmann C; Budde K; Ernst F; Farrington SM; Theodoratou E; Prokopenko I; Stumvoll M; Jula A; Perola M; Salomaa V; Shin SY; Spector TD; Sala C; Ridker PM; Kähönen M; Viikari J; Hengstenberg C; Nelson CP; CARDIoGRAM Consortium; DIAGRAM Consortium; ICBP Consortium; MAGIC Consortium; Meschia JF; Nalls MA; Sharma P; Singleton AB; Kamatani N; Zeller T; Burnier M; Attia J; Laan M; Klopp N; Hillege HL; Kloiber S; Choi H; Pirastu M; Tore S; Probst-Hensch NM; Völzke H; Gudnason V; Parsa A; Schmidt R; Whitfield JB; Fornage M; Gasparini P; Siscovick DS; Polašek O; Campbell H; Rudan I; Bouatia-Naji N; Metspalu A; Loos RJ; van Duijn CM; Borecki IB; Ferrucci L; Gambaro G; Deary IJ; Wolffenbuttel BH; Chambers JC; März W; Pramstaller PP; Snieder H; Gyllensten U; Wright AF; Navis G; Watkins H; Witteman JC; Sanna S; Schipf S; Dunlop MG; Tönjes A; Ripatti S; Soranzo N; Toniolo D; Chasman DI; Raitakari O; Kao WH; Ciullo M; Fox CS; Caulfield M; Bochud M; Gieger C (2013)
      Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we ...
    • Genome-wide association and functional follow-up reveals new loci for kidney function 

      Pattaro C; Köttgen A; Teumer A; Garnaas M; Böger CA; Fuchsberger C; Olden M; Chen MH; Tin A; Taliun D; Li M; Gao X; Gorski M; Yang Q; Hundertmark C; Foster MC; O'Seaghdha CM; Glazer N; Isaacs A; Liu CT; Smith AV; O'Connell JR; Struchalin M; Tanaka T; Li G; Johnson AD; Gierman HJ; Feitosa M; Hwang SJ; Atkinson EJ; Lohman K; Cornelis MC; Johansson Å; Tönjes A; Dehghan A; Chouraki V; Holliday EG; Sorice R; Kutalik Z; Lehtimäki T; Esko T; Deshmukh H; Ulivi S; Chu AY; Murgia F; Trompet S; Imboden M; Kollerits B; Pistis G; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium; Wellcome Trust Case Control Consortium 2; Harris TB; Launer LJ; Aspelund T; Eiriksdottir G; Mitchell BD; Boerwinkle E; Schmidt H; Cavalieri M; Rao M; Hu FB; Demirkan A; Oostra BA; de Andrade M; Turner ST; Ding J; Andrews JS; Freedman BI; Koenig W; Illig T; Döring A; Wichmann HE; Kolcic I; Zemunik T; Boban M; Minelli C; Wheeler HE; Igl W; Zaboli G; Wild SH; Wright AF; Campbell H; Ellinghaus D; Nöthlings U; Jacobs G; Biffar R; Endlich K; Ernst F; Homuth G; Kroemer HK; Nauck M; Stracke S; Völker U; Völzke H; Kovacs P; Stumvoll M; Mägi R; Hofman A; Uitterlinden AG; Rivadeneira F; Aulchenko YS; Polasek O; Hastie N; Vitart V; Helmer C; Wang JJ; Ruggiero D; Bergmann S; Kähönen M; Viikari J; Nikopensius T; Province M; Ketkar S; Colhoun H; Doney A; Robino A; Giulianini F; Krämer BK; Portas L; Ford I; Buckley BM; Adam M; Thun GA; Paulweber B; Haun M; Sala C; Metzger M; Mitchell P; Ciullo M; Kim SK; Vollenweider P; Raitakari O; Metspalu A; Palmer C; Gasparini P; Pirastu M; Jukema JW; Probst-Hensch NM; Kronenberg F; Toniolo D; Gudnason V; Shuldiner AR; Coresh J; Schmidt R; Ferrucci L; Siscovick DS; van Duijn CM; Borecki I; Kardia SL; Liu Y; Curhan GC; Rudan I; Gyllensten U; Wilson JF; Franke A; Pramstaller PP; Rettig R; Prokopenko I; Witteman JC; Hayward C; Ridker P; Parsa A; Bochud M; Heid IM; Goessling W; Chasman DI; Kao WH; Fox CS (2012)
      Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD ...
    • Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function 

      Chasman DI; Fuchsberger C; Pattaro C; Teumer A; Böger CA; Endlich K; Olden M; Chen MH; Tin A; Taliun D; Li M; Gao X; Gorski M; Yang Q; Hundertmark C; Foster MC; O'Seaghdha CM; Glazer N; Isaacs A; Liu CT; Smith AV; O'Connell JR; Struchalin M; Tanaka T; Li G; Johnson AD; Gierman HJ; Feitosa MF; Hwang SJ; Atkinson EJ; Lohman K; Cornelis MC; Johansson A; Tönjes A; Dehghan A; Lambert JC; Holliday EG; Sorice R; Kutalik Z; Lehtimäki T; Esko T; Deshmukh H; Ulivi S; Chu AY; Murgia F; Trompet S; Imboden M; Coassin S; Pistis G; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium; WTCCC2; Harris TB; Launer LJ; Aspelund T; Eiriksdottir G; Mitchell BD; Boerwinkle E; Schmidt H; Cavalieri M; Rao M; Hu F; Demirkan A; Oostra BA; de Andrade M; Turner ST; Ding J; Andrews JS; Freedman BI; Giulianini F; Koenig W; Illig T; Meisinger C; Gieger C; Zgaga L; Zemunik T; Boban M; Minelli C; Wheeler HE; Igl W; Zaboli G; Wild SH; Wright AF; Campbell H; Ellinghaus D; Nöthlings U; Jacobs G; Biffar R; Ernst F; Homuth G; Kroemer HK; Nauck M; Stracke S; Völker U; Völzke H; Kovacs P; Stumvoll M; Mägi R; Hofman A; Uitterlinden AG; Rivadeneira F; Aulchenko YS; Polasek O; Hastie N; Vitart V; Helmer C; Wang JJ; Stengel B; Ruggiero D; Bergmann S; Kähönen M; Viikari J; Nikopensius T; Province M; Ketkar S; Colhoun H; Doney A; Robino A; Krämer BK; Portas L; Ford I; Buckley BM; Adam M; Thun GA; Paulweber B; Haun M; Sala C; Mitchell P; Ciullo M; Kim SK; Vollenweider P; Raitakari O; Metspalu A; Palmer C; Gasparini P; Pirastu M; Jukema JW; Probst-Hensch NM; Kronenberg F; Toniolo D; Gudnason V; Shuldiner AR; Coresh J; Schmidt R; Ferrucci L; Siscovick DS; van Duijn CM; Borecki IB; Kardia SL; Liu Y; Curhan GC; Rudan I; Gyllensten U; Wilson JF; Franke A; Pramstaller PP; Rettig R; Prokopenko I; Witteman J; Hayward C; Ridker PM; Parsa A; Bochud M; Heid IM; Kao WH; Fox CS; Köttgen A (2012)
      In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated ...
    • New loci associated with kidney function and chronic kidney disease 

      Köttgen A; Pattaro C; Böger CA; Fuchsberger C; Olden M; Glazer NL; Parsa A; Gao X; Yang Q; Smith AV; O'Connell JR; Li M; Schmidt H; Tanaka T; Isaacs A; Ketkar S; Hwang SJ; Johnson AD; Dehghan A; Teumer A; Paré G; Atkinson EJ; Zeller T; Lohman K; Cornelis MC; Probst-Hensch NM; Kronenberg F; Tönjes A; Hayward C; Aspelund T; Eiriksdottir G; Launer LJ; Harris TB; Rampersaud E; Mitchell BD; Arking DE; Boerwinkle E; Struchalin M; Cavalieri M; Singleton A; Giallauria F; Metter J; de Boer IH; Haritunians T; Lumley T; Siscovick D; Psaty BM; Zillikens MC; Oostra BA; Feitosa M; Province M; de Andrade M; Turner ST; Schillert A; Ziegler A; Wild PS; Schnabel RB; Wilde S; Munzel TF; Leak TS; Illig T; Klopp N; Meisinger C; Wichmann HE; Koenig W; Zgaga L; Zemunik T; Kolcic I; Minelli C; Hu FB; Johansson A; Igl W; Zaboli G; Wild SH; Wright AF; Campbell H; Ellinghaus D; Schreiber S; Aulchenko YS; Felix JF; Rivadeneira F; Uitterlinden AG; Hofman A; Imboden M; Nitsch D; Brandstätter A; Kollerits B; Kedenko L; Mägi R; Stumvoll M; Kovacs P; Boban M; Campbell S; Endlich K; Völzke H; Kroemer HK; Nauck M; Völker U; Polasek O; Vitart V; Badola S; Parker AN; Ridker PM; Kardia SL; Blankenberg S; Liu Y; Curhan GC; Franke A; Rochat T; Paulweber B; Prokopenko I; Wang W; Gudnason V; Shuldiner AR; Coresh J; Schmidt R; Ferrucci L; Shlipak MG; van Duijn CM; Borecki I; Krämer BK; Rudan I; Gyllensten U; Wilson JF; Witteman JC; Pramstaller PP; Rettig R; Hastie N; Chasman DI; Kao WH; Heid IM; Fox CS (2010)
      Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association ...
    • SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function 

      Li M; Li Y; Weeks O; Mijatovic V; Teumer A; Huffman JE; Tromp G; Fuchsberger C; Gorski M; Lyytikäinen LP; Nutile T; Sedaghat S; Sorice R; Tin A; Yang Q; Ahluwalia TS; Arking DE; Bihlmeyer NA; Böger CA; Carroll RJ; Chasman DI; Cornelis MC; Dehghan A; Faul JD; Feitosa MF; Gambaro G; Gasparini P; Giulianini F; Heid I; Huang J; Imboden M; Jackson AU; Jeff J; Jhun MA; Katz R; Kifley A; Kilpeläinen TO; Kumar A; Laakso M; Li-Gao R; Lohman K; Lu Y; Mägi R; Malerba G; Mihailov E; Mohlke KL; Mook-Kanamori DO; Robino A; Ruderfer D; Salvi E; Schick UM; Schulz CA; Smith AV; Smith JA; Traglia M; Yerges-Armstrong LM; Zhao W; Goodarzi MO; Kraja AT; Liu C; Boerwinkle E; Borecki IB; Bork-Jensen J; Bottinger EP; Braga D; Brandslund I; Brody JA; Campbell A; Carey DJ; Christensen C; Coresh J; Crook E; Curhan GC; Cusi D; de Boer IH; de Vries AP; Denny JC; Devuyst O; Dreisbach AW; Endlich K; Esko T; Franco OH; Fulop T; Gerhard GS; Glümer C; Gottesman O; Grarup N; Gudnason V; Hansen T; Harris TB; Hayward C; Hocking L; Hofman A; Hu FB; Husemoen LL; Jackson RD; Jørgensen T; Jørgensen ME; Kähönen M; Kardia SL; König W; Kooperberg C; Kriebel J; Launer LJ; Lauritzen T; Lehtimäki T; Levy D; Linksted P; Linneberg A; Liu Y; Loos RJ; Lupo A; Meisinger C; Melander O; Metspalu A; Mitchell P; Nauck M; Nürnberg P; Orho-Melander M; Parsa A; Pedersen O; Peters A; Peters U; Polasek O; Porteous D; Probst-Hensch NM; Psaty BM; Qi L; Raitakari OT; Reiner AP; Rettig R; Ridker PM; Rivadeneira F; Rossouw JE; Schmidt F; Siscovick D; Soranzo N; Strauch K; Toniolo D; Turner ST; Uitterlinden AG; Ulivi S; Velayutham D; Völker U; Völzke H; Waldenberger M; Wang JJ; Weir DR; Witte D; Kuivaniemi H; Fox CS; Franceschini N; Goessling W; Köttgen A; Chu AY; Wessel J (2017)
      Genome-wide association studies have identified >50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analysis of associations ...