Now showing items 1-3 of 3

    • The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism 

      Demetz E; Schroll A; Auer K; Heim C; Patsch JR; Eller P; Theurl M; Theurl I; Seifert M; Lener D; Stanzl U; Haschka D; Asshoff M; Dichtl S; Nairz M; Huber E; Stadlinger M; Moschen AR; Li X; Pallweber P; Scharnagl H; Stojakovic T; März W; Kleber ME; Garlaschelli K; Uboldi P; Catapano AL; Stellaard F; Rudling M; Kuba K; Imai Y; Arita M; Schuetz JD; Pramstaller PP; Tietge UJ; Trauner M; Norata GD; Claudel T; Hicks AA; Weiss G; Tancevski I (2014)
      Cholesterol metabolism is closely interrelated with cardiovascular disease in humans. Dietary supplementation with omega-6 polyunsaturated fatty acids including arachidonic acid (AA) was shown to favorably affect plasma ...
    • Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project 

      Tabara Y; Kohara K; Kita Y; Hirawa N; Katsuya T; Ohkubo T; Hiura Y; Tajima A; Morisaki T; Miyata T; Nakayama T; Takashima N; Nakura J; Kawamoto R; Takahashi N; Hata A; Soma M; Imai Y; Kokubo Y; Okamura T; Tomoike H; Iwai N; Ogihara T; Inoue I; Tokunaga K; Johnson T; Caulfield M; Munroe P; Global Blood Pressure Genetics Consortium; Umemura S; Ueshima H; Miki T (2010)
      Hypertension is one of the most common complex genetic disorders. We have described previously 38 single nucleotide polymorphisms (SNPs) with suggestive association with hypertension in Japanese individuals. In this study ...
    • A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function 

      Neely GG; Kuba K; Cammarato A; Isobe K; Amann S; Zhang L; Murata M; Elmén L; Gupta V; Arora S; Sarangi R; Dan D; Fujisawa S; Usami T; Xia CP; Keene AC; Alayari NN; Yamakawa H; Elling U; Berger C; Novatchkova M; Koglgruber R; Fukuda K; Nishina H; Isobe M; Pospisilik JA; Imai Y; Pfeufer A; Hicks AA; Pramstaller PP; Subramaniam S; Kimura A; Ocorr K; Bodmer R; Penninger JM (2010)
      Heart diseases are the most common causes of morbidity and death in humans. Using cardiac-specific RNAi-silencing in Drosophila, we knocked down 7061 evolutionarily conserved genes under conditions of stress. We present a ...