Now showing items 1-4 of 4

    • Genome-wide association analyses identify 18 new loci associated with serum urate concentrations 

      Köttgen A; Albrecht E; Teumer A; Vitart V; Krumsiek J; Hundertmark C; Pistis G; Ruggiero D; O'Seaghdha CM; Haller T; Yang Q; Tanaka T; Johnson AD; Kutalik Z; Smith AV; Shi J; Struchalin M; Middelberg RP; Brown MJ; Gaffo AL; Pirastu N; Li G; Hayward C; Zemunik T; Huffman J; Yengo L; Zhao JH; Demirkan A; Feitosa MF; Liu X; Malerba G; Lopez LM; van der Harst P; Li X; Kleber ME; Hicks AA; Nolte IM; Johansson A; Murgia F; Wild SH; Bakker SJ; Peden JF; Dehghan A; Steri M; Tenesa A; Lagou V; Salo P; Mangino M; Rose LM; Lehtimäki T; Woodward OM; Okada Y; Tin A; Müller C; Oldmeadow C; Putku M; Czamara D; Kraft P; Frogheri L; Thun GA; Grotevendt A; Gislason GK; Harris TB; Launer LJ; McArdle P; Shuldiner AR; Boerwinkle E; Coresh J; Schmidt H; Schallert M; Martin NG; Montgomery GW; Kubo M; Nakamura Y; Munroe PB; Samani NJ; Jacobs DR; Liu K; D'Adamo P; Ulivi S; Rotter JI; Psaty BM; Vollenweider P; Waeber G; Campbell S; Devuyst O; Navarro P; Kolcic I; Hastie N; Balkau B; Froguel P; Esko T; Salumets A; Khaw KT; Langenberg C; Wareham NJ; Isaacs A; Kraja A; Zhang Q; Wild PS; Scott RJ; Holliday EG; Org E; Viigimaa M; Bandinelli S; Metter JE; Lupo A; Trabetti E; Sorice R; Döring A; Lattka E; Strauch K; Theis F; Waldenberger M; Wichmann HE; Davies G; Gow AJ; Bruinenberg M; LifeLines Cohort Study; Stolk RP; Kooner JS; Zhang W; Winkelmann BR; Boehm BO; Lucae S; Penninx BW; Smit JH; Curhan G; Mudgal P; Plenge RM; Portas L; Persico I; Kirin M; Wilson JF; Mateo Leach I; van Gilst WH; Goel A; Ongen H; Hofman A; Rivadeneira F; Uitterlinden AG; Imboden M; von Eckardstein A; Cucca F; Nagaraja R; Piras MG; Nauck M; Schurmann C; Budde K; Ernst F; Farrington SM; Theodoratou E; Prokopenko I; Stumvoll M; Jula A; Perola M; Salomaa V; Shin SY; Spector TD; Sala C; Ridker PM; Kähönen M; Viikari J; Hengstenberg C; Nelson CP; CARDIoGRAM Consortium; DIAGRAM Consortium; ICBP Consortium; MAGIC Consortium; Meschia JF; Nalls MA; Sharma P; Singleton AB; Kamatani N; Zeller T; Burnier M; Attia J; Laan M; Klopp N; Hillege HL; Kloiber S; Choi H; Pirastu M; Tore S; Probst-Hensch NM; Völzke H; Gudnason V; Parsa A; Schmidt R; Whitfield JB; Fornage M; Gasparini P; Siscovick DS; Polašek O; Campbell H; Rudan I; Bouatia-Naji N; Metspalu A; Loos RJ; van Duijn CM; Borecki IB; Ferrucci L; Gambaro G; Deary IJ; Wolffenbuttel BH; Chambers JC; März W; Pramstaller PP; Snieder H; Gyllensten U; Wright AF; Navis G; Watkins H; Witteman JC; Sanna S; Schipf S; Dunlop MG; Tönjes A; Ripatti S; Soranzo N; Toniolo D; Chasman DI; Raitakari O; Kao WH; Ciullo M; Fox CS; Caulfield M; Bochud M; Gieger C (2013)
      Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we ...
    • Genome-wide association and functional follow-up reveals new loci for kidney function 

      Pattaro C; Köttgen A; Teumer A; Garnaas M; Böger CA; Fuchsberger C; Olden M; Chen MH; Tin A; Taliun D; Li M; Gao X; Gorski M; Yang Q; Hundertmark C; Foster MC; O'Seaghdha CM; Glazer N; Isaacs A; Liu CT; Smith AV; O'Connell JR; Struchalin M; Tanaka T; Li G; Johnson AD; Gierman HJ; Feitosa M; Hwang SJ; Atkinson EJ; Lohman K; Cornelis MC; Johansson Å; Tönjes A; Dehghan A; Chouraki V; Holliday EG; Sorice R; Kutalik Z; Lehtimäki T; Esko T; Deshmukh H; Ulivi S; Chu AY; Murgia F; Trompet S; Imboden M; Kollerits B; Pistis G; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium; Wellcome Trust Case Control Consortium 2; Harris TB; Launer LJ; Aspelund T; Eiriksdottir G; Mitchell BD; Boerwinkle E; Schmidt H; Cavalieri M; Rao M; Hu FB; Demirkan A; Oostra BA; de Andrade M; Turner ST; Ding J; Andrews JS; Freedman BI; Koenig W; Illig T; Döring A; Wichmann HE; Kolcic I; Zemunik T; Boban M; Minelli C; Wheeler HE; Igl W; Zaboli G; Wild SH; Wright AF; Campbell H; Ellinghaus D; Nöthlings U; Jacobs G; Biffar R; Endlich K; Ernst F; Homuth G; Kroemer HK; Nauck M; Stracke S; Völker U; Völzke H; Kovacs P; Stumvoll M; Mägi R; Hofman A; Uitterlinden AG; Rivadeneira F; Aulchenko YS; Polasek O; Hastie N; Vitart V; Helmer C; Wang JJ; Ruggiero D; Bergmann S; Kähönen M; Viikari J; Nikopensius T; Province M; Ketkar S; Colhoun H; Doney A; Robino A; Giulianini F; Krämer BK; Portas L; Ford I; Buckley BM; Adam M; Thun GA; Paulweber B; Haun M; Sala C; Metzger M; Mitchell P; Ciullo M; Kim SK; Vollenweider P; Raitakari O; Metspalu A; Palmer C; Gasparini P; Pirastu M; Jukema JW; Probst-Hensch NM; Kronenberg F; Toniolo D; Gudnason V; Shuldiner AR; Coresh J; Schmidt R; Ferrucci L; Siscovick DS; van Duijn CM; Borecki I; Kardia SL; Liu Y; Curhan GC; Rudan I; Gyllensten U; Wilson JF; Franke A; Pramstaller PP; Rettig R; Prokopenko I; Witteman JC; Hayward C; Ridker P; Parsa A; Bochud M; Heid IM; Goessling W; Chasman DI; Kao WH; Fox CS (2012)
      Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD ...
    • The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study 

      Winkler TW; Justice AE; Graff M; Barata L; Feitosa MF; Chu S; Czajkowski J; Esko T; Fall T; Kilpeläinen TO; Lu Y; Mägi R; Mihailov E; Pers TH; Rüeger S; Teumer A; Ehret GB; Ferreira T; Heard-Costa NL; Karjalainen J; Lagou V; Mahajan A; Neinast MD; Prokopenko I; Simino J; Teslovich TM; Jansen R; Westra HJ; White CC; Absher D; Ahluwalia TS; Ahmad S; Albrecht E; Alves AC; Bragg-Gresham JL; de Craen AJ; Bis JC; Bonnefond A; Boucher G; Cadby G; Cheng YC; Chiang CW; Delgado G; Demirkan A; Dueker N; Eklund N; Eiriksdottir G; Eriksson J; Feenstra B; Fischer K; Frau F; Galesloot TE; Geller F; Goel A; Gorski M; Grammer TB; Gustafsson S; Haitjema S; Hottenga JJ; Huffman JE; Jackson AU; Jacobs KB; Johansson Å; Kaakinen M; Kleber ME; Lahti J; Mateo Leach I; Lehne B; Liu Y; Lo KS; Lorentzon M; Luan J; Madden PA; Mangino M; McKnight B; Medina-Gomez C; Monda KL; Montasser ME; Müller G; Müller-Nurasyid M; Nolte IM; Panoutsopoulou K; Pascoe L; Paternoster L; Rayner NW; Renström F; Rizzi F; Rose LM; Ryan KA; Salo P; Sanna S; Scharnagl H; Shi J; Smith AV; Southam L; Stančáková A; Steinthorsdottir V; Strawbridge RJ; Sung YJ; Tachmazidou I; Tanaka T; Thorleifsson G; Trompet S; Pervjakova N; Tyrer JP; Vandenput L; van der Laan SW; van der Velde N; van Setten J; van Vliet-Ostaptchouk JV; Verweij N; Vlachopoulou E; Waite LL; Wang SR; Wang Z; Wild SH; Willenborg C; Wilson JF; Wong A; Yang J; Yengo L; Yerges-Armstrong LM; Yu L; Zhang W; Zhao JH; Andersson EA; Bakker SJ; Baldassarre D; Banasik K; Barcella M; Barlassina C; Bellis C; Benaglio P; Blangero J; Blüher M; Bonnet F; Bonnycastle LL; Boyd HA; Bruinenberg M; Buchman AS; Campbell H; Chen YD; Chines PS; Claudi-Boehm S; Cole J; Collins FS; de Geus EJ; de Groot LC; Dimitriou M; Duan J; Enroth S; Eury E; Farmaki AE; Forouhi NG; Friedrich N; Gejman PV; Gigante B; Glorioso N; Go AS; Gottesman O; Gräßler J; Grallert H; Grarup N; Gu YM; Broer L; Ham AC; Hansen T; Harris TB; Hartman CA; Hassinen M; Hastie N; Hattersley AT; Heath AC; Henders AK; Hernandez D; Hillege H; Holmen O; Hovingh KG; Hui J; Husemoen LL; Hutri-Kähönen N; Hysi PG; Illig T; De Jager PL; Jalilzadeh S; Jørgensen T; Jukema JW; Juonala M; Kanoni S; Karaleftheri M; Khaw KT; Kinnunen L; Kittner SJ; Koenig W; Kolcic I; Kovacs P; Krarup NT; Kratzer W; Krüger J; Kuh D; Kumari M; Kyriakou T; Langenberg C; Lannfelt L; Lanzani C; Lotay V; Launer LJ; Leander K; Lindström J; Linneberg A; Liu YP; Lobbens S; Luben R; Lyssenko V; Männistö S; Magnusson PK; McArdle WL; Menni C; Merger S; Milani L; Montgomery GW; Morris AP; Narisu N; Nelis M; Ong KK; Palotie A; Pérusse L; Pichler I; Pilia MG; Pouta A; Rheinberger M; Ribel-Madsen R; Richards M; Rice KM; Rice TK; Rivolta C; Salomaa V; Sanders AR; Sarzynski MA; Scholtens S; Scott RA; Scott WR; Sebert S; Sengupta S; Sennblad B; Seufferlein T; Silveira A; Slagboom PE; Smit JH; Sparsø TH; Stirrups K; Stolk RP; Stringham HM; Swertz MA; Swift AJ; Syvänen AC; Tan ST; Thorand B; Tönjes A; Tremblay A; Tsafantakis E; van der Most PJ; Völker U; Vohl MC; Vonk JM; Waldenberger M; Walker RW; Wennauer R; Widén E; Willemsen G; Wilsgaard T; Wright AF; Zillikens MC; van Dijk SC; van Schoor NM; Asselbergs FW; de Bakker PI; Beckmann JS; Beilby J; Bennett DA; Bergman RN; Bergmann S; Böger CA; Boehm BO; Boerwinkle E; Boomsma DI; Bornstein SR; Bottinger EP; Bouchard C; Chambers JC; Chanock SJ; Chasman DI; Cucca F; Cusi D; Dedoussis G; Erdmann J; Eriksson JG; Evans DA; de Faire U; Farrall M; Ferrucci L; Ford I; Franke L; Franks PW; Froguel P; Gansevoort RT; Gieger C; Grönberg H; Gudnason V; Gyllensten U; Hall P; Hamsten A; van der Harst P; Hayward C; Heliövaara M; Hengstenberg C; Hicks AA; Hingorani A; Hofman A; Hu F; Huikuri HV; Hveem K; James AL; Jordan JM; Jula A; Kähönen M; Kajantie E; Kathiresan S; Kiemeney LA; Kivimaki M; Knekt PB; Koistinen HA; Kooner JS; Koskinen S; Kuusisto J; Maerz W; Martin NG; Laakso M; Lakka TA; Lehtimäki T; Lettre G; Levinson DF; Lind L; Lokki ML; Mäntyselkä P; Melbye M; Metspalu A; Mitchell BD; Moll FL; Murray JC; Musk AW; Nieminen MS; Njølstad I; Ohlsson C; Oldehinkel AJ; Oostra BA; Palmer LJ; Pankow JS; Pasterkamp G; Pedersen NL; Pedersen O; Penninx BW; Perola M; Peters A; Polašek O; Pramstaller PP; Psaty BM; Qi L; Quertermous T; Raitakari OT; Rankinen T; Rauramaa R; Ridker PM; Rioux JD; Rivadeneira F; Rotter JI; Rudan I; den Ruijter HM; Saltevo J; Sattar N; Schunkert H; Schwarz PE; Shuldiner AR; Sinisalo J; Snieder H; Sørensen TI; Spector TD; Staessen JA; Stefania B; Thorsteinsdottir U; Stumvoll M; Tardif JC; Tremoli E; Tuomilehto J; Uitterlinden AG; Uusitupa M; Verbeek AL; Vermeulen SH; Viikari JS; Vitart V; Völzke H; Vollenweider P; Waeber G; Walker M; Wallaschofski H; Wareham NJ; Watkins H; Zeggini E; CHARGE Consortium; DIAGRAM Consortium; GLGC Consortium; Global-BPGen Consortium; ICBP Consortium; MAGIC Consortium; Chakravarti A; Clegg DJ; Cupples LA; Gordon-Larsen P; Jaquish CE; Rao DC; Abecasis GR; Assimes TL; Barroso I; Berndt SI; Boehnke M; Deloukas P; Fox CS; Groop LC; Hunter DJ; Ingelsson E; Kaplan RC; McCarthy MI; Mohlke KL; O'Connell JR; Schlessinger D; Strachan DP; Stefansson K; van Duijn CM; Hirschhorn JN; Lindgren CM; Heid IM; North KE; Borecki IB; Kutalik Z; Loos RJ (2015)
      Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and ...
    • Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function 

      Chasman DI; Fuchsberger C; Pattaro C; Teumer A; Böger CA; Endlich K; Olden M; Chen MH; Tin A; Taliun D; Li M; Gao X; Gorski M; Yang Q; Hundertmark C; Foster MC; O'Seaghdha CM; Glazer N; Isaacs A; Liu CT; Smith AV; O'Connell JR; Struchalin M; Tanaka T; Li G; Johnson AD; Gierman HJ; Feitosa MF; Hwang SJ; Atkinson EJ; Lohman K; Cornelis MC; Johansson A; Tönjes A; Dehghan A; Lambert JC; Holliday EG; Sorice R; Kutalik Z; Lehtimäki T; Esko T; Deshmukh H; Ulivi S; Chu AY; Murgia F; Trompet S; Imboden M; Coassin S; Pistis G; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium; WTCCC2; Harris TB; Launer LJ; Aspelund T; Eiriksdottir G; Mitchell BD; Boerwinkle E; Schmidt H; Cavalieri M; Rao M; Hu F; Demirkan A; Oostra BA; de Andrade M; Turner ST; Ding J; Andrews JS; Freedman BI; Giulianini F; Koenig W; Illig T; Meisinger C; Gieger C; Zgaga L; Zemunik T; Boban M; Minelli C; Wheeler HE; Igl W; Zaboli G; Wild SH; Wright AF; Campbell H; Ellinghaus D; Nöthlings U; Jacobs G; Biffar R; Ernst F; Homuth G; Kroemer HK; Nauck M; Stracke S; Völker U; Völzke H; Kovacs P; Stumvoll M; Mägi R; Hofman A; Uitterlinden AG; Rivadeneira F; Aulchenko YS; Polasek O; Hastie N; Vitart V; Helmer C; Wang JJ; Stengel B; Ruggiero D; Bergmann S; Kähönen M; Viikari J; Nikopensius T; Province M; Ketkar S; Colhoun H; Doney A; Robino A; Krämer BK; Portas L; Ford I; Buckley BM; Adam M; Thun GA; Paulweber B; Haun M; Sala C; Mitchell P; Ciullo M; Kim SK; Vollenweider P; Raitakari O; Metspalu A; Palmer C; Gasparini P; Pirastu M; Jukema JW; Probst-Hensch NM; Kronenberg F; Toniolo D; Gudnason V; Shuldiner AR; Coresh J; Schmidt R; Ferrucci L; Siscovick DS; van Duijn CM; Borecki IB; Kardia SL; Liu Y; Curhan GC; Rudan I; Gyllensten U; Wilson JF; Franke A; Pramstaller PP; Rettig R; Prokopenko I; Witteman J; Hayward C; Ridker PM; Parsa A; Bochud M; Heid IM; Kao WH; Fox CS; Köttgen A (2012)
      In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated ...