Now showing items 348-367 of 535

    • Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels 

      Kwan JS; Hsu YH; Cheung CL; Dupuis J; Saint-Pierre A; Eriksson J; Handelman SK; Aragaki A; Karasik D; Pramstaller PP; Kooperberg C; Lacroix AZ; Larson MG; Lau KS; Lorentzon M; Pichler I; Sham PC; Taliun D; Vandenput L; Kiel DP; Hicks AA; Jackson RD; Ohlsson C; Benjamin EJ; Kung AW (2014)
      Osteoprotegerin (OPG) is involved in bone homeostasis and tumor cell survival. Circulating OPG levels are also important biomarkers of various clinical traits, such as cancers and atherosclerosis. OPG levels were measured ...
    • Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels 

      Dehghan A; Dupuis J; Barbalic M; Bis JC; Eiriksdottir G; Lu C; Pellikka N; Wallaschofski H; Kettunen J; Henneman P; Baumert J; Strachan DP; Fuchsberger C; Vitart V; Wilson JF; Paré G; Naitza S; Rudock ME; Surakka I; de Geus EJ; Alizadeh BZ; Guralnik J; Shuldiner A; Tanaka T; Zee RY; Schnabel RB; Nambi V; Kavousi M; Ripatti S; Nauck M; Smith NL; Smith AV; Sundvall J; Scheet P; Liu Y; Ruokonen A; Rose LM; Larson MG; Hoogeveen RC; Freimer NB; Teumer A; Tracy RP; Launer LJ; Buring JE; Yamamoto JF; Folsom AR; Sijbrands EJ; Pankow J; Elliott P; Keaney JF; Sun W; Sarin AP; Fontes JD; Badola S; Astor BC; Hofman A; Pouta A; Werdan K; Greiser KH; Kuss O; Meyer Zu Schwabedissen H; Thiery J; Jamshidi Y; Nolte IM; Soranzo N; Spector TD; Völzke H; Parker AN; Aspelund T; Bates D; Young L; Tsui K; Siscovick DS; Guo X; Rotter JI; Uda M; Schlessinger D; Rudan I; Hicks AA; Penninx BW; Thorand B; Gieger C; Coresh J; Willemsen G; Harris TB; Uitterlinden AG; Järvelin MR; Rice K; Radke D; Salomaa V; Willems van Dijk K; Boerwinkle E; Vasan RS; Ferrucci L; Gibson QD; Bandinelli S; Snieder H; Boomsma DI; Xiao X; Campbell H; Hayward C; Pramstaller PP; van Duijn CM; Peltonen L; Psaty BM; Gudnason V; Ridker PM; Homuth G; Koenig W; Ballantyne CM; Witteman JC; Benjamin EJ; Perola M; Chasman DI (2011)
      BACKGROUND: C-reactive protein (CRP) is a heritable marker of chronic inflammation that is strongly associated with cardiovascular disease. We sought to identify genetic variants that are associated with CRP levels. METHODS ...
    • Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes 

      Ng MC; Shriner D; Chen BH; Li J; Chen WM; Guo X; Liu J; Bielinski SJ; Yanek LR; Nalls MA; Comeau ME; Rasmussen-Torvik LJ; Jensen RA; Evans DS; Sun YV; An P; Patel SR; Lu Y; Long J; Armstrong LL; Wagenknecht L; Yang L; Snively BM; Palmer ND; Mudgal P; Langefeld CD; Keene KL; Freedman BI; Mychaleckyj JC; Nayak U; Raffel LJ; Goodarzi MO; Chen YD; Taylor HA; Correa A; Sims M; Couper D (2014)
      Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by ...
    • A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level 

      Pattaro C; De Grandi A; Vitart V; Hayward C; Franke A; Aulchenko YS; Johansson A; Wild SH; Melville SA; Isaacs A; Polasek O; Ellinghaus D; Kolcic I; Nöthlings U; Zgaga L; Zemunik T; Gnewuch C; Schreiber S; Campbell S; Hastie N; Boban M; Meitinger T; Oostra BA; Riegler P; Minelli C; Wright AF; Campbell H; van Duijn CM; Gyllensten U; Wilson JF; Krawczak M; Rudan I; Pramstaller PP; EUROSPAN Consortium (2010)
      BACKGROUND: Serum creatinine (S CR) is the most important biomarker for a quick and non-invasive assessment of kidney function in population-based surveys. A substantial proportion of the inter-individual variability in ...
    • Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2 

      Pankratz N; Beecham GW; DeStefano AL; Dawson TM; Doheny KF; Factor SA; Hamza TH; Hung AY; Hyman BT; Ivinson AJ; Krainc D; Latourelle JC; Clark LN; Marder K; Martin ER; Mayeux R; Ross OA; Scherzer CR; Simon DK; Tanner C; Vance JM; Wszolek ZK; Zabetian CP; Myers RH; Payami H; Scott WK; Foroud T; PD GWAS Consortium (2012)
      OBJECTIVE: Genome-wide association (GWAS) methods have identified genes contributing to Parkinson's disease (PD); we sought to identify additional genes associated with PD susceptibility. METHODS: A 2-stage design was ...
    • A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function 

      Porcu E; Medici M; Pistis G; Volpato CB; Wilson SG; Cappola AR; Bos SD; Deelen J; den Heijer M; Freathy RM; Lahti J; Liu C; Lopez LM; Nolte IM; O'Connell JR; Tanaka T; Trompet S; Arnold A; Bandinelli S; Beekman M; Böhringer S; Brown SJ; Buckley BM; Camaschella C; de Craen AJ; Davies G; de Visser MC; Ford I; Forsen T; Frayling TM; Fugazzola L; Gögele M; Hattersley AT; Hermus AR; Hofman A; Houwing-Duistermaat JJ; Jensen RA; Kajantie E; Kloppenburg M; Lim EM; Masciullo C; Mariotti S; Minelli C; Mitchell BD; Nagaraja R; Netea-Maier RT; Palotie A; Persani L; Piras MG; Psaty BM; Räikkönen K; Richards JB; Rivadeneira F; Sala C; Sabra MM; Sattar N; Shields BM; Soranzo N; Starr JM; Stott DJ; Sweep FC; Usala G; van der Klauw MM; van Heemst D; van Mullem A; Vermeulen SH; Visser WE; Walsh JP; Westendorp RG; Widen E; Zhai G; Cucca F; Deary IJ; Eriksson JG; Ferrucci L; Fox CS; Jukema JW; Kiemeney LA; Pramstaller PP; Schlessinger D; Shuldiner AR; Slagboom EP; Uitterlinden AG; Vaidya B; Visser TJ; Wolffenbuttel BH; Meulenbelt I; Rotter JI; Spector TD; Hicks AA; Toniolo D; Sanna S; Peeters RP; Naitza S (2013)
      Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyroid function lead to common endocrine disorders affecting approximately 10% of individuals over their life span. In addition, ...
    • The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits 

      Voight BF; Kang HM; Ding J; Palmer CD; Sidore C; Chines PS; Burtt NP; Fuchsberger C; Li Y; Erdmann J; Frayling TM; Heid IM; Jackson AU; Johnson T; Kilpeläinen TO; Lindgren CM; Morris AP; Prokopenko I; Randall JC; Saxena R; Soranzo N; Speliotes EK; Teslovich TM; Wheeler E; Maguire J; Parkin M; Potter S; Rayner NW; Robertson N; Stirrups K; Winckler W; Sanna S; Mulas A; Nagaraja R; Cucca F; Barroso I; Deloukas P; Loos RJ; Kathiresan S; Munroe PB; Newton-Cheh C; Pfeufer A; Samani NJ; Schunkert H; Hirschhorn JN; Altshuler D; McCarthy MI; Abecasis GR; Boehnke M (2012)
      Genome-wide association studies have identified hundreds of loci for type 2 diabetes, coronary artery disease and myocardial infarction, as well as for related traits such as body mass index, glucose and insulin levels, ...
    • Metabolic fate of adenine in red blood cells during storage in SAGM solution 

      Paglia G; Sigurjónsson ÓE; Bordbar A; Rolfsson Ó; Magnusdottir M; Palsson S; Wichuk K; Gudmundsson S; Palsson BO (2016)
      BACKGROUND: Red blood cells (RBCs) are routinely stored and transfused worldwide. Recently, metabolomics have shown that RBCs experience a three-phase metabolic decay process during storage, resulting in the definition ...
    • Metabolic Profiling as a Screening Tool for Cytotoxic Compounds: Identification of 3-Alkyl Pyridine Alkaloids from Sponges Collected at a Shallow Water Hydrothermal Vent Site North of Iceland 

      Einarsdottir E; Magnusdottir M; Astarita G; Köck M; Ögmundsdottir HM; Thorsteinsdottir M; Rapp HT; Omarsdottir S; Paglia G (2017)
      Twenty-eight sponge specimens were collected at a shallow water hydrothermal vent site north of Iceland. Extracts were prepared and tested in vitro for cytotoxic activity, and eight of them were shown to be cytotoxic. A ...
    • Metabolic Signature of Dietary Iron Overload in a Mouse Model 

      Volani C; Paglia G; Smarason S; Pramstaller PP; Demetz E; Pfeifhofer-Obermair C; Weiss G (2018)
      Iron is an essential co-factor for several metabolic processes, including the Krebs cycle and mitochondrial oxidative phosphorylation. Therefore, maintaining an appropriate iron balance is essential to ensure sufficient ...
    • Metabolomics 

      Rainer J (2019)
      At: CSAMA 2019: Statistical Data Analysis for Genome Scale Biology ; Bressanone/Brixen ; 21/07/2019 - 26/07/2019
    • Metabolomics 

      Rainer J (2019)
      At: BIDOC PhD-Programme. Graduate Course. Population-based studies in the -omics era ; Bolzano/Bozen ; 28/11/2019 - 29/11/2019
    • Metabolomics and lipidomics using travelling wave ion mobility mass spectrometry 

      Paglia G; Astarita G. (2017)
      Metabolomics and lipidomics aim to profile the wide range of metabolites and lipids that are present in biological samples. Recently, ion mobility spectrometry (IMS) has been used to support metabolomics and lipidomics ...
    • metaRbolomics hackathon plus 

      Rainer J; Schymanski E; Willighagen E; Slenter D (2020)
      At: European RFMF Metabomeeting 2020 (RFMF-MPF-2019) ; Toulouse ; 22/01/2020 - 24/01/2020
    • The metaRbolomics Toolbox in Bioconductor and beyond 

      Stanstrup J; Broeckling CD; Helmus R; Hoffmann N; Mathe E; Naake T; Nicolotti L; Peters K; Rainer J; Salek RM; Schulze T; Schymanski EL; Stravs MA; Thevenot EA; Treutler H; Weber RJM; Willighagen E; Witting M; Neumann S (2019)
      Metabolomics aims to measure and characterise the complex composition of metabolites in a biological system. Metabolomics studies involve sophisticated analytical techniques such as mass spectrometry and nuclear magnetic ...
    • Methods for meta-analyses of genome-wide association studies: critical assessment of empirical evidence 

      Gögele M; Minelli C; Thakkinstian A; Yurkiewich A; Pattaro C; Pramstaller PP; Little J; Attia J; Thompson JR (2012)
      There has been a steep increase in the number of meta-analyses of genome-wide association (GWA) studies aimed at identifying genetic variants with increasingly smaller effects, but pressure to publish findings of new genetic ...
    • The Michigan Imputation Server 

      Unknown author (2019)
      At : American Society of Human Genetics 2019 Annual Meeting ; Houston ; 15/10/2019 - 19/10/2019 ; Genotype imputation is a key component of modern genetic studies. This interactive workshop is intended for anyone interested ...
    • Microbiota, type 2 diabetes and non-alcoholic fatty liver disease: protocol of an observational study 

      Motta BM; Grander C; Gögele M; Foco L; Vukovic V; Melotti R; Fuchsberger C; De Grandi A; Cantaloni C; Picard A; Mascalzoni D; Rossini A; Pattaro C; Tilg H; Pramstaller PP (2019)
      BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is characterized by triglyceride accumulation in the hepatocytes in the absence of alcohol overconsumption, commonly associated with insulin resistance and obesity. ...
    • microRNAs and Cardiac Cell Fate 

      Piubelli C; Meraviglia V; Pompilio G; D'Alessandra Y; Colombo GI; Rossini A (2014)
      The role of small, non-coding microRNAs (miRNAs) has recently emerged as fundamental in the regulation of the physiology of the cardiovascular system. Several specific miRNAs were found to be expressed in embryonic, ...
    • Mining the human phenome using allelic scores that index biological intermediates 

      Evans DM; Brion MJ; Paternoster L; Kemp JP; McMahon G; Munafò M; Whitfield JB; Medland SE; Montgomery GW; GIANT Consortium; CRP Consortium; TAG Consortium; Timpson NJ; St Pourcain B; Lawlor DA; Martin NG; Dehghan A; Hirschhorn J; Davey Smith G (2013)
      It is common practice in genome-wide association studies (GWAS) to focus on the relationship between disease risk and genetic variants one marker at a time. When relevant genes are identified it is often possible to implicate ...