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Localising loci underlying complex trait variation using Regional Genomic Relationship Mapping
(2012)The limited proportion of complex trait variance identified in genome-wide association studies may reflect the limited power of single SNP analyses to detect either rare causative alleles or those of small effect. Motivated ... -
Large-scale replication and heterogeneity in Parkinson disease genetic loci
(2012)OBJECTIVE: Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which ... -
Evidence of inbreeding depression on human height
(2012)Stature is a classical and highly heritable complex trait, with 80%-90% of variation explained by genetic factors. In recent years, genome-wide association studies (GWAS) have successfully identified many common additive ... -
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations
(2012)Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their ... -
Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts
(2012)Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric ...
