Show simple item record

dc.contributor.authorLecca P
dc.contributor.authorSorio C
dc.date.accessioned2020-01-31T11:10:53Z
dc.date.available2020-01-31T11:10:53Z
dc.date.issued2016
dc.identifier.issn1757-9694
dc.identifier.urihttp://dx.doi.org/10.1039/c6ib00127k
dc.identifier.urihttps://academic.oup.com/ib/article-abstract/8/12/1261/5115326?redirectedFrom=fulltext
dc.identifier.urihttps://bia.unibz.it/handle/10863/12012
dc.description.abstractChronic myeloid leukemia (CML) is a malignant clonal disorder whose hallmark is a reciprocal translocation between chromosomes 9 and 22 occurring in 95% of affected patients. This translocation causes the expression of a deregulated BCR/ABL fusion oncogene and, interestingly, is detectable in healthy individuals. Based on this information we assumed that the sole presence of the BCR/ABL transcript represents a necessary but not sufficient event for the clonal expansion of CML precursors. We developed a mathematical model introducing a probability that any normal cell undergoes a first aberration, and a probability that a cell that experienced a first mutation undergoes a second mutation as well. Two variants are proposed and analyzed: in the first the probability of the first mutation is supposed to be age independent and in the second, it depends on the hemopoietic cell turnover and mass. The model parameters have been estimated by regression from the observed CML incidence curves. Our models offer a significantly improved version of existing one-step and two-steps models, as they integrate key clinical and biological data reported in the literature and accurately fit the observed incidence. Our models also estimate the increased radiation-associated mutation rate at a younger age in atomic bomb survivors. Although this work focuses on CML, the modelling approach can be applied to all types of leukemia and lymphoma.en_US
dc.languageEnglish
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation
dc.rights
dc.titleAccurate prediction of the age incidence of chronic myeloid leukemia with an improved two-mutation mathematical modelen_US
dc.typeArticleen_US
dc.date.updated2020-01-30T03:01:26Z
dc.language.isiEN-GB
dc.journal.titleIntegrative Biology
dc.description.fulltextnoneen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record