Rap: A new wearable/portable device for extracorporeal blood ultrafiltration
De Rossi N
MetadataShow full item record
The interest in the design of portable and wearable medical devices is related to both the relevant clinical and social benefits for patients and the potential economic savings for national health services. The development of such biomedical devices can help people live in a more comfortable way and allow for the execution of therapies, that are usually performed in hospitals, at home. This article presents a new wearable and portable mechatronic device for extracorporeal blood ultrafiltration, named RAP, able to remove excess fluids from overhydrated patients with chronic kidney disease and/or congestive heart failure. An innovative layout paradigm has been introduced for the RAP, involving a box-like design that can fit a backpack or a trolley, ensuring miniaturization and ergonomics, and an original-effective positioning of the components. These have been divided on three independent planar panels: One for disposable devices, one for non-disposable components and one for electronic boards and controllers. This solution guarantees the best trade-off between miniaturization and ergonomics and can drastically simplify and speed up the in-hospital operations needed before and after a therapy with the RAP. The design of an effective, efficient, safe and reliable control architecture, based on two microcontrollers and one microcomputer, has been carried out too, being essential features of the RAP. Currently, the RAP is ready for clinical tests which will include a phase-1 trial in humans after Ethical Committee approval.
Showing items related by title, author, creator and subject.
Description and in-vitro test results of a new Wearable/Portable device for extracorporeal blood ultrafiltration Boscariol P; Boschetti G; Dalla Via A; De Rossi N; Neri M; Palomba I; Richiedei D; Ronco C; Trevisani A (MDPI AG, 2019)This paper presents the design of Rene Artificiale Portatile (RAP), a novel wearable and portable device for extracorporeal blood ultrafiltration, capable of providing remote treatment of fluid overload in patients with ...
Ferric carboxymaltose reduces the number of red blood cell units transfused and allows transfusion independence to be obtained in patients with iron deficiency anemia secondary to gastrointestinal chronic blood loss Salvadori U; Sandri M; Melli C; Polese F; Simeoni M; Capelli S; Al-Khaffaf A (2016)BACKGROUND: The aim of this study was to evaluate the effectiveness of ferric carboxymaltose (FCM) in patients with iron deficiency anemia (IDA) secondary to gastrointestinal chronic blood loss (CBL), who received chronic ...
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney Wain LV; Vaez A; Jansen R; Joehanes R; van der Most PJ; Erzurumluoglu AM; O'Reilly PF; Cabrera CP; Warren HR; Rose LM; Verwoert GC; Hottenga JJ; Strawbridge RJ; Esko T; Arking DE; Hwang SJ; Guo X; Kutalik Z; Trompet S; Shrine N; Teumer A; Ried JS; Bis JC; Smith AV; Amin N; Nolte IM; Lyytikäinen LP; Mahajan A; Wareham NJ; Hofer E; Joshi PK; Kristiansson K; Traglia M; Havulinna AS; Goel A; Nalls MA; Sõber S; Vuckovic D; Luan J; Del Greco M F; Ayers KL; Marrugat J; Ruggiero D; Lopez LM; Niiranen T; Enroth S; Jackson AU; Nelson CP; Huffman JE; Zhang W; Marten J; Gandin I; Harris SE; Zemunik T; Lu Y; Evangelou E; Shah N; de Borst MH; Mangino M; Prins BP; Campbell A; Li-Gao R; Chauhan G; Oldmeadow C; Abecasis G; Abedi M; Barbieri CM; Barnes MR; Batini C; Beilby J; Blake T; Boehnke M; Bottinger EP; Braund PS; Brown M; Brumat M; Campbell H; Chambers JC; Cocca M; Collins F; Connell J; Cordell HJ; Damman JJ; Davies G; de Geus EJ; de Mutsert R; Deelen J; Demirkale Y; Doney ASF; Dörr M; Farrall M; Ferreira T; Frånberg M; Gao H; Giedraitis V; Gieger C; Giulianini F; Gow AJ; Hamsten A; Harris TB; Hofman A; Holliday EG; Hui J; Jarvelin MR; Johansson Å; Johnson AD; Jousilahti P; Jula A; Kähönen M; Kathiresan S; Khaw KT; Kolcic I; Koskinen S; Langenberg C; Larson M; Launer LJ; Lehne B; Liewald DCM; Lin L; Lind L; Mach F; Mamasoula C; Menni C; Mifsud B; Milaneschi Y; Morgan A; Morris AD; Morrison AC; Munson PJ; Nandakumar P; Nguyen QT; Nutile T; Oldehinkel AJ; Oostra BA; Org E; Padmanabhan S; Palotie A; Paré G; Pattie A; Penninx BWJH; Poulter N; Pramstaller PP; Raitakari OT; Ren M; Rice K; Ridker PM; Riese H; Ripatti S; Robino A; Rotter JI; Rudan I; Saba Y; Saint-Pierre A; Sala CF; Sarin AP; Schmidt R; Scott R; Seelen MA; Shields DC; Siscovick D; Sorice R; Stanton A; Stott DJ; Sundström J; Swertz M; Taylor KD; Thom S; Tzoulaki I; Tzourio C; Uitterlinden AG; Völker U; Vollenweider P; Wild S; Willemsen G; Wright AF; Yao J; Thériault S; Conen D; Attia J; Sever P; Debette S; Mook-Kanamori DO; Zeggini E; Spector TD; van der Harst P; Palmer CNA; Vergnaud AC; Loos RJF; Polasek O; Starr JM; Girotto G; Hayward C; Kooner JS; Lindgren CM; Vitart V; Samani NJ; Tuomilehto J; Gyllensten U; Knekt P; Deary IJ; Ciullo M; Elosua R; Keavney BD; Hicks AA; Scott RA; Gasparini P; Laan M; Liu Y; Watkins H; Hartman CA; Salomaa V; Toniolo D; Perola M; Wilson JF; Schmidt H; Zhao JH; Lehtimäki T; van Duijn CM; Gudnason V; Psaty BM; Peters A; Rettig R; James A; Jukema JW; Strachan DP; Palmas W; Metspalu A; Ingelsson E; Boomsma DI; Franco OH; Bochud M; Newton-Cheh C; Munroe PB; Elliott P; Chasman DI; Chakravarti A; Knight J; Morris AP; Levy D; Tobin MD; Snieder H; Caulfield MJ; Ehret GB (2017)Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets ...