Abstract
Dear Colleagues,
Human induced-pluripotent stem cells (hIPSCs) represent a source to produce a virtually unlimited number of cells from patients and healthy controls, which are otherwise difficult to obtain, such as, but not limited to, cardiomyocytes and neurons.
Cells derived from hIPSCs can be subsequently applied in preclinical and, possibly in the future, clinical studies such as target validation, drug screening, and tissue regeneration. However, IPSC-derived somatic cells often present significant differences from their adult counterparts in terms of maturity and gene expression.
This Special Issue of IJMS will cover, but will not be not limited to, the following topics:
* The success and limitations of hIPSC for disease modeling (including cardiac, neurological, liver, skin, blood diseases, and more)
* How to promote and evaluate the maturation of hiPSC-derived somatic cells
* hIPSCs to derive tissue and organ models
* The direct reprogramming of human somatic cells to bypass the generation of iPSC
You are warmly invited to submit original research and review articles related to any of these aspects.
Dr. Alessandra Rossini
Dr. Andrea Barbuti
Guest Editors