Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

S Kanoni; SE Graham; Y Wang; I Surakka; S Ramdas; X Zhu; SL Clarke; KF Bhatti; S Vedantam; TW Winkler; AE Locke; E Marouli; GJM Zajac; KH Wu; I Ntalla; Q Hui; D Klarin; AT Hilliard; Z Wang; C Xue; G Thorleifsson; A Helgadottir; DF Gudbjartsson; H Holm; I Olafsson; MY Hwang; S Han; M Akiyama; S Sakaue; C Terao; M Kanai; W Zhou; BM Brumpton; H Rasheed; AS Havulinna; Y Veturi; JA Pacheco; EA Rosenthal; T Lingren; Q Feng; IJ Kullo; A Narita; J Takayama; HC Martin; KA Hunt; B Trivedi; J Haessler; F Giulianini; Y Bradford; JE Miller; A Campbell; K Lin; IY Millwood; A Rasheed; G Hindy; JD Faul; W Zhao; DR Weir; C Turman; H Huang; M Graff; A Choudhury; D Sengupta; A Mahajan; MR Brown; W Zhang; K Yu; EM Schmidt; A Pandit; S Gustafsson; X Yin; J Luan; JH Zhao; F Matsuda; HM Jang; K Yoon; C Medina-Gomez; A Pitsillides; JJ Hottenga; AR Wood; Y Ji; Z Gao; S Haworth; NA Yousri; RE Mitchell; JF Chai; M Aadahl; AA Bjerregaard; J Yao; A Manichaikul; CM Hwu; YJ Hung; HR Warren; J Ramirez; J Bork-Jensen; LL Kårhus; A Goel; M Sabater-Lleal; R Noordam; P Mauro; F Matteo; AF McDaid; P Marques-Vidal; M Wielscher; S Trompet; N Sattar; LT Møllehave; M Munz; L Zeng; J Huang; B Yang; A Poveda; A Kurbasic; C Lamina; L Forer; M Scholz; TE Galesloot; JP Bradfield; SE Ruotsalainen; E Daw; JM Zmuda; JS Mitchell; Christian Fuchsberger; H Christensen; JA Brody; M Vazquez-Moreno; MF Feitosa; MK Wojczynski; MH Preuss; M Mangino; P Christofidou; N Verweij; JW Benjamins; J Engmann; NL Tsao; A Verma; RC Slieker; KS Lo; NR Zilhao; P Le; ME Kleber; GE Delgado; S Huo; DD Ikeda; H Iha; J Yang; J Liu; A Demirkan; HL Leonard; J Marten; M Frank; B Schmidt; LJ Smyth; M Cañadas-Garre; C Wang; M Nakatochi; A Wong; N Hutri-Kähönen; X Sim; R Xia; A Huerta-Chagoya; JC Fernandez-Lopez; V Lyssenko; SS Nongmaithem; S Bayyana; HM Stringham; MR Irvin; C Oldmeadow; HN Kim; S Ryu; PRHJ Timmers; L Arbeeva; R Dorajoo; LA Lange; G Prasad; L Lorés-Motta; M Pauper; J Long; X Li; E Theusch; F Takeuchi; CN Spracklen; A Loukola; S Bollepalli; SC Warner; YX Wang; WB Wei; T Nutile; D Ruggiero; YJ Sung; S Chen; F Liu; KA Kentistou; B Banas; GG Nardone; K Meidtner; LF Bielak; JA Smith; P Hebbar; AE Farmaki; E Hofer; M Lin; MP Concas; S Vaccargiu; PJ van der Most; N Pitkänen; BE Cade; SW van der Laan; KN Chitrala; S Weiss; AR Bentley; AP Doumatey; AA Adeyemo; JY Lee; ERB Petersen; AA Nielsen; HS Choi; M Nethander; S Freitag-Wolf; L Southam; NW Rayner; CA Wang; SY Lin; JS Wang; C Couture; LP Lyytikäinen; K Nikus; G Cuellar-Partida; H Vestergaard; B Hidalgo; O Giannakopoulou; Q Cai; MO Obura; J van Setten; J Liang; H Tang; N Terzikhan; JH Shin; RD Jackson; AP Reiner; LW Martin; Z Chen; L Li; T Kawaguchi; J Thiery; JC Bis; LJ Launer; H Li; MA Nalls; OT Raitakari; S Ichihara; SH Wild; CP Nelson; H Campbell; S Jäger; T Nabika; F Al-Mulla; H Niinikoski; PS Braund; I Kolcic; P Kovacs; T Giardoglou; T Katsuya; D de Kleijn; GJ de Borst; EK Kim; HHH Adams; MA Ikram; FW Asselbergs; AO Kraaijeveld; JWJ Beulens; XO Shu; LS Rallidis; O Pedersen; T Hansen; P Mitchell; AW Hewitt; M Kähönen; L Pérusse; C Bouchard; A Tönjes; YI Chen; CE Pennell; TA Mori; W Lieb; A Franke; C Ohlsson; D Mellström; YS Cho; H Lee; JM Yuan; WP Koh; SY Rhee; JT Woo; IM Heid; KJ Stark; ME Zimmermann; H Völzke; G Homuth; MK Evans; AB Zonderman; O Polasek; G Pasterkamp; IE Hoefer; S Redline; K Pahkala; AJ Oldehinkel; H Snieder; G Biino; R Schmidt; H Schmidt; S Bandinelli; G Dedoussis; TA Thanaraj; SLR Kardia; PA Peyser; N Kato; MB Schulze; G Girotto; CA Böger; B Jung; PK Joshi; DA Bennett; PL De Jager; X Lu; V Mamakou; M Brown; MJ Caulfield; PB Munroe; X Guo; M Ciullo; JB Jonas; NJ Samani; J Kaprio; P Pajukanta; T Tusié-Luna; CA Aguilar-Salinas; LS Adair; SA Bechayda; HJ de Silva; AR Wickremasinghe; RM Krauss; JY Wu; W Zheng; AI Hollander; D Bharadwaj; A Correa; JG Wilson; L Lind; CK Heng; AE Nelson; YM Golightly; JF Wilson; B Penninx; HL Kim; J Attia; RJ Scott; DC Rao; DK Arnett; SC Hunt; M Walker; HA Koistinen; GR Chandak; JM Mercader; MC Costanzo; D Jang; NP Burtt; CG Villalpando; L Orozco; M Fornage; E Tai; RM van Dam; T Lehtimäki; N Chaturvedi; M Yokota; DF Reilly; AJ McKnight; F Kee; KH Jöckel; MI McCarthy; CNA Palmer; V Vitart; C Hayward; E Simonsick; CM van Duijn; ZB Jin; J Qu; H Hishigaki; X Lin; W März; V Gudnason; JC Tardif; G Lettre; LM' Hart; PJM Elders; SM Damrauer; M Kumari; M Kivimaki; P van der Harst; TD Spector; RJF Loos; MA Province; EJ Parra; M Cruz; BM Psaty; I Brandslund; Peter P. Pramstaller; CN Rotimi; K Christensen; S Ripatti; E Widén; H Hakonarson; SFA Grant; LALM Kiemeney; J de Graaf; M Loeffler; F Kronenberg; D Gu; J Erdmann; H Schunkert; PW Franks; A Linneberg; JW Jukema; AV Khera; M Männikkö; MR Jarvelin; Z Kutalik; C Francesco; DO Mook-Kanamori; KW van Dijk; H Watkins; DP Strachan; N Grarup; P Sever; N Poulter; LM Chuang; JI Rotter; TM Dantoft; F Karpe; MJ Neville; NJ Timpson; CY Cheng; TY Wong; CC Khor; C Sabanayagam; A Peters; C Gieger; AT Hattersley; NL Pedersen; PKE Magnusson; DI Boomsma; AHM Willemsen; L Cupples; JBJ van Meurs; M Ghanbari; P Gordon-Larsen; W Huang; YJ Kim; Y Tabara; NJ Wareham; C Langenberg; E Zeggini; J Kuusisto; M Laakso; E Ingelsson; G Abecasis; JC Chambers; JS Kooner; PS de Vries; AC Morrison; S Hazelhurst; M Ramsay; KE North; M Daviglus; P Kraft; NG Martin; JB Whitfield; S Abbas; D Saleheen; RG Walters; MV Holmes; C Black; BH Smith; A Baras; AE Justice; JE Buring; PM Ridker; DI Chasman; C Kooperberg; G Tamiya; M Yamamoto; DA van Heel; RC Trembath; WQ Wei; GP Jarvik; B Namjou; MG Hayes; MD Ritchie; P Jousilahti; V Salomaa; K Hveem; BO Åsvold; M Kubo; Y Kamatani; Y Okada; Y Murakami; BJ Kim; U Thorsteinsdottir; K Stefansson; J Zhang; Y Chen; YL Ho; JA Lynch; DJ Rader; PS Tsao; KM Chang; K Cho; CJ O'Donnell; JM Gaziano; PWF Wilson; TM Frayling; JN Hirschhorn; S Kathiresan; KL Mohlke; YV Sun; AP Morris; M Boehnke; CD Brown; P Natarajan; P Deloukas; CJ Willer; TL Assimes; GM Peloso

doi:10.1186/s13059-022-02837-1

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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

S Kanoni, SE Graham, Y Wang, I Surakka, S Ramdas, X Zhu, SL Clarke, KF Bhatti, S Vedantam, TW Winkler, …

Genome Biology, Vol.23(1)

27/12/2022

DOI: https://doi.org/10.1186/s13059-022-02837-1

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https://hdl.handle.net/10863/31750

Abstract

CHRIS study

Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.

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Title: Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Creators: S Kanoni - Queen Mary University of London
SE Graham - University of Michigan–Ann Arbor
Y Wang - Boston University
I Surakka - University of Michigan–Ann Arbor
S Ramdas - University of Pennsylvania
X Zhu - Pennsylvania State University
SL Clarke - VA Palo Alto Health Care System
KF Bhatti - Queen Mary University of London
S Vedantam - Boston Children's Hospital
TW Winkler - University of Regensburg
AE Locke - Washington University in St. Louis
E Marouli - Queen Mary University of London
GJM Zajac
KH Wu - University of Michigan–Ann Arbor
I Ntalla - Queen Mary University of London
Q Hui - Emory University
D Klarin - VA Palo Alto Health Care System
AT Hilliard - VA Palo Alto Health Care System
Z Wang - Emory University
C Xue - University of Michigan–Ann Arbor
G Thorleifsson - deCODE Genetics
A Helgadottir - deCODE Genetics
DF Gudbjartsson - deCODE Genetics
H Holm - deCODE Genetics
I Olafsson - National University Hospital of Iceland
MY Hwang - Korea National Institute of Health
S Han - Korea National Institute of Health
M Akiyama - RIKEN Center for Integrative Medical Sciences
S Sakaue - RIKEN Center for Integrative Medical Sciences
C Terao - RIKEN Center for Integrative Medical Sciences
M Kanai - Broad Institute
W Zhou - Broad Institute
BM Brumpton - Norwegian University of Science and Technology
H Rasheed - Norwegian University of Science and Technology
AS Havulinna - Institute for Molecular Medicine Finland
Y Veturi - University of Pennsylvania
JA Pacheco
EA Rosenthal - University of Washington Medical Center
T Lingren
Q Feng - Vanderbilt University Medical Center
IJ Kullo - Mayo Clinic
A Narita - Tohoku Medical Megabank Organization
J Takayama - Tohoku Medical Megabank Organization
HC Martin - Wellcome Sanger Institute
KA Hunt - Queen Mary University of London
B Trivedi - Queen Mary University of London
J Haessler - Fred Hutch Cancer Center
F Giulianini - Brigham and Women's Hospital
Y Bradford - University of Pennsylvania
JE Miller - University of Pennsylvania
A Campbell - Western General Hospital
K Lin - Clinical Trial Service Unit
IY Millwood - University of Oxford
A Rasheed - Center for Non-Communicable Diseases
G Hindy - Qatar University
JD Faul - University of Michigan–Ann Arbor
W Zhao - University of Michigan–Ann Arbor
DR Weir - University of Michigan–Ann Arbor
C Turman - Harvard University
H Huang - Harvard University
M Graff - University of North Carolina at Chapel Hill
A Choudhury - University of the Witwatersrand
D Sengupta - University of the Witwatersrand
A Mahajan - Wellcome Centre for Human Genetics
MR Brown - The University of Texas Health Science Center at Houston
W Zhang - Imperial College London
K Yu - University of Michigan–Ann Arbor
EM Schmidt - University of Michigan–Ann Arbor
A Pandit - University of Michigan–Ann Arbor
S Gustafsson - Science for Life Laboratory
X Yin - University of Michigan–Ann Arbor
J Luan - MRC Epidemiology Unit
JH Zhao - MRC Epidemiology Unit
F Matsuda - Kyoto University
HM Jang - Korea National Institute of Health
K Yoon - Korea National Institute of Health
C Medina-Gomez - Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
A Pitsillides - Boston University
JJ Hottenga - Vrije Universiteit Amsterdam
AR Wood - University of Exeter
Y Ji - University of Exeter
Z Gao - Nanjing University of Chinese Medicine
S Haworth - University of Bristol
NA Yousri - Weill Cornell Medical College in Qatar
RE Mitchell - University of Bristol
JF Chai - National University Health System
M Aadahl - Frederiksberg Hospital
AA Bjerregaard - Frederiksberg Hospital
J Yao - The Lundquist Institute
A Manichaikul - University of Virginia
CM Hwu - Taipei Veterans General Hospital
YJ Hung - National Defense Medical Center
HR Warren - Queen Mary University of London
J Ramirez - Queen Mary University of London
J Bork-Jensen - Novo Nordisk Foundation
LL Kårhus - Frederiksberg Hospital
A Goel - Wellcome Centre for Human Genetics
M Sabater-Lleal - Hospital de Sant Pau
R Noordam - Leiden University Medical Center
P Mauro - Institute of Genetic and Biomedical Research
F Matteo - Institute of Genetic and Biomedical Research
AF McDaid - University of Lausanne
P Marques-Vidal - University of Lausanne
M Wielscher - Imperial College London
S Trompet - Leiden University Medical Center
N Sattar - Faculty
LT Møllehave - Frederiksberg Hospital
M Munz - University of Lübeck
L Zeng - German Centre for Cardiovascular Research
J Huang - Peking Union Medical College Hospital
B Yang - Peking Union Medical College Hospital
A Poveda - Lund University
A Kurbasic - Lund University
C Lamina - Innsbruck Medical University
L Forer - Innsbruck Medical University
M Scholz - Leipzig University
TE Galesloot - Radboud University Nijmegen
JP Bradfield - Praevium Research
SE Ruotsalainen - Institute for Molecular Medicine Finland
E Daw
JM Zmuda - University of Pittsburgh
JS Mitchell - Institute for Biomedicine
Christian Fuchsberger - Institute for Biomedicine
H Christensen - Lillebaelt Hospital
JA Brody - University of Washington
M Vazquez-Moreno - Mexican Social Security Institute
MF Feitosa - Washington University in St. Louis
MK Wojczynski - Washington University in St. Louis
Z Wang - Emory University
MH Preuss - Icahn School of Medicine at Mount Sinai
M Mangino - King's College London
P Christofidou - King's College London
N Verweij - University Medical Center Groningen
JW Benjamins - University Medical Center Groningen
J Engmann - University College London
NL Tsao - University of Pennsylvania
A Verma - University of Pennsylvania
RC Slieker - International Center for Public Health
KS Lo - Montreal Heart Institute
NR Zilhao - Icelandic Heart Association
P Le - University of Toronto
ME Kleber - Synlab
GE Delgado - Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.
S Huo - Shanghai Institute of Nutrition and Health
DD Ikeda - Otsuka
H Iha - Otsuka
J Yang - Westlake University
J Liu - University of Oxford
A Demirkan - Erasmus University Rotterdam
HL Leonard - National Institute on Aging
J Marten - Western General Hospital
M Frank - University of Duisburg-Essen
B Schmidt - University of Duisburg-Essen
LJ Smyth - Queen's University Belfast
M Cañadas-Garre - Queen's University Belfast
C Wang - Huazhong University of Science and Technology
M Nakatochi - Nagoya University
A Wong - MRC Unit for Lifelong Health and Ageing
N Hutri-Kähönen - Tampere University
X Sim - National University Health System
R Xia - Brown Foundation
A Huerta-Chagoya - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
JC Fernandez-Lopez - National Institute of Genomic Medicine
V Lyssenko - Lund University
SS Nongmaithem - Academy of Scientific and Innovative Research
S Bayyana - Centre for Cellular and Molecular Biology
HM Stringham - University of Michigan–Ann Arbor
MR Irvin - University of Alabama at Birmingham
C Oldmeadow - Hunter Medical Research Institute
HN Kim - Kangbuk Samsung Hospital
S Ryu - Kangbuk Samsung Hospital
PRHJ Timmers
L Arbeeva - University of North Carolina at Chapel Hill
R Dorajoo - Agency for Science, Technology and Research
LA Lange - University of Colorado Denver
G Prasad - Institute of Genomics and Integrative Biology
L Lorés-Motta - Radboud University Nijmegen
M Pauper - Radboud University Nijmegen
J Long - Vanderbilt University Medical Center
X Li - Case Western Reserve University
E Theusch - University of California System
F Takeuchi - National Center for Global Health and Medicine
CN Spracklen - University of North Carolina at Chapel Hill
A Loukola - Institute for Molecular Medicine Finland
S Bollepalli - Institute for Molecular Medicine Finland
SC Warner - University of Leicester
YX Wang - Boston University
WB Wei - Beijing Tongren Hospital
T Nutile - Institute of Genetics and Biophysics
D Ruggiero - Institute of Genetics and Biophysics
YJ Sung
S Chen - Peking Union Medical College Hospital
F Liu - Peking Union Medical College Hospital
J Yang - Westlake University
KA Kentistou - Centre for Global Health Research
B Banas - University Hospital Regensburg
GG Nardone - IRCCS Materno Infantile Burlo Garofolo
K Meidtner - German Institute of Human Nutrition
LF Bielak - University of Michigan–Ann Arbor
JA Smith - University of Michigan–Ann Arbor
P Hebbar - Dasman Diabetes Institute
AE Farmaki - Harokopio University of Athens
E Hofer - Medical University of Graz
M Lin - Massachusetts General Hospital
MP Concas - IRCCS Materno Infantile Burlo Garofolo
S Vaccargiu - Institute of Genetic and Biomedical Research
PJ van der Most - University Medical Center Groningen
N Pitkänen - University of Turku
BE Cade - Brigham and Women's Hospital
SW van der Laan - University Medical Center Utrecht
KN Chitrala - National Institute on Aging
S Weiss - University of Greifswald
AR Bentley - National Human Genome Research Institute
AP Doumatey - National Human Genome Research Institute
AA Adeyemo - National Human Genome Research Institute
JY Lee - Swedish Institute
ERB Petersen
AA Nielsen - Lillebaelt Hospital
HS Choi - Hallym University
M Nethander - University of Gothenburg
S Freitag-Wolf - Kiel University
L Southam - Wellcome Sanger Institute
NW Rayner - Wellcome Sanger Institute
CA Wang - Huazhong University of Science and Technology
SY Lin - Taichung Veterans General Hospital
JS Wang - Taichung Veterans General Hospital
C Couture - Université Laval
LP Lyytikäinen - Fimlab
K Nikus - Tampere University
G Cuellar-Partida - Translational Research Institute
H Vestergaard - Novo Nordisk Foundation
B Hidalgo - University of Alabama at Birmingham
O Giannakopoulou - Queen Mary University of London
Q Cai - Vanderbilt University Medical Center
MO Obura
J van Setten - Utrecht University
X Li - Case Western Reserve University
J Liang - Case Western Reserve University
H Tang - Stanford University
N Terzikhan - Erasmus University Rotterdam
JH Shin - Hallym University
RD Jackson - The Ohio State University
AP Reiner - University of Washington
LW Martin - George Washington University
Z Chen - University of Oxford
L Li - Peking University
T Kawaguchi - Kyoto University
J Thiery - Leipzig University
JC Bis - University of Washington
LJ Launer - National Institute on Aging
H Li - Shanghai Institute of Nutrition and Health
MA Nalls - Data Tecnica International
OT Raitakari - University of Turku
S Ichihara - Jichi Medical University
SH Wild - University of Edinburgh
CP Nelson - University of Leicester
H Campbell - Centre for Global Health Research
S Jäger - German Institute of Human Nutrition
T Nabika - Shimane University
F Al-Mulla - Dasman Diabetes Institute
H Niinikoski - Turku University Hospital
PS Braund - University of Leicester
I Kolcic - University of Split
P Kovacs - Leipzig University
T Giardoglou - Harokopio University of Athens
T Katsuya - Osaka University
D de Kleijn
GJ de Borst - Utrecht University
EK Kim - Yonsei University
HHH Adams
MA Ikram - Erasmus University Rotterdam
X Zhu - Pennsylvania State University
FW Asselbergs - Utrecht University
AO Kraaijeveld - Utrecht University
JWJ Beulens
XO Shu - Vanderbilt University Medical Center
LS Rallidis - National and Kapodistrian University of Athens
O Pedersen - Novo Nordisk Foundation
T Hansen - Novo Nordisk Foundation
P Mitchell - University of Sydney
AW Hewitt - Centre for Eye Research Australia
M Kähönen - Tampere University Hospital
L Pérusse - Université Laval
C Bouchard - Pennington Biomedical Research Center
A Tönjes - Leipzig University
YI Chen - University of Michigan–Ann Arbor
CE Pennell - University of Newcastle Australia
TA Mori - University of Western Australia
W Lieb - Kiel University
A Franke - Kiel University
C Ohlsson - University of Gothenburg
D Mellström - University of Gothenburg
YS Cho
H Lee - Ewha Womans University
JM Yuan - University of Pittsburgh
WP Koh - National University of Singapore
SY Rhee - Kyung Hee University
JT Woo - Kyung Hee University
IM Heid - University of Regensburg
KJ Stark - University of Regensburg
ME Zimmermann - University of Regensburg
H Völzke - Greifswald University Hospital
G Homuth - University of Greifswald
MK Evans - National Institute on Aging
AB Zonderman - National Institute on Aging
O Polasek - University of Split
G Pasterkamp - University Medical Center Utrecht
IE Hoefer - University Medical Center Utrecht
S Redline - Brigham and Women's Hospital
K Pahkala - University of Turku
AJ Oldehinkel - University Medical Center Groningen
H Snieder - University Medical Center Groningen
G Biino - National Research Council
R Schmidt - Medical University of Graz
H Schmidt - Medical University of Graz
S Bandinelli - Azienda Usl Toscana Centro
G Dedoussis - Harokopio University of Athens
TA Thanaraj - Dasman Diabetes Institute
SLR Kardia
PA Peyser - University of Michigan–Ann Arbor
N Kato - National Center for Global Health and Medicine
MB Schulze - German Institute of Human Nutrition
G Girotto - IRCCS Materno Infantile Burlo Garofolo
CA Böger - University Hospital Regensburg
B Jung - University Hospital Regensburg
PK Joshi - Centre for Global Health Research
DA Bennett - Rush University Medical Center
PL De Jager - Broad Institute
X Lu - Peking Union Medical College Hospital
V Mamakou - National and Kapodistrian University of Athens
M Brown - The University of Texas Health Science Center at Houston
MJ Caulfield - Queen Mary University of London
PB Munroe - Queen Mary University of London
X Guo - The Lundquist Institute
M Ciullo - Institute of Genetics and Biophysics
JB Jonas - Beijing Tongren Hospital
NJ Samani - University of Leicester
J Kaprio - Institute for Molecular Medicine Finland
P Pajukanta - University of California, Los Angeles
T Tusié-Luna - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
CA Aguilar-Salinas - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
LS Adair - University of North Carolina at Chapel Hill
SA Bechayda - University of San Carlos
HJ de Silva - University of Kelaniya
AR Wickremasinghe - University of Kelaniya
RM Krauss - Children's Hospital Oakland Research Institute
JY Wu - Institute of Biomedical Sciences, Academia Sinica
W Zheng - Vanderbilt University Medical Center
AI Hollander - Radboud University Nijmegen
D Bharadwaj - Academy of Scientific and Innovative Research
A Correa - University of Mississippi Medical Center
JG Wilson - University of Mississippi Medical Center
L Lind - Uppsala University
CK Heng - National University Health System
AE Nelson - University of North Carolina at Chapel Hill
YM Golightly - University of North Carolina at Chapel Hill
JF Wilson - Western General Hospital
B Penninx
HL Kim - Ewha Womans University
J Attia - Hunter Medical Research Institute
RJ Scott - Hunter Medical Research Institute
DC Rao - Washington University in St. Louis
DK Arnett - University of South Carolina
SC Hunt - Weill Cornell Medical College in Qatar
M Walker - Newcastle University
HA Koistinen - Finnish Institute for Health and Welfare
GR Chandak - Academy of Scientific and Innovative Research
JM Mercader - Broad Institute
MC Costanzo - Broad Institute
D Jang - Broad Institute
NP Burtt - Broad Institute
CG Villalpando - Instituto Nacional de Salud Pública
L Orozco - Medicina
M Fornage - Brown Foundation
E Tai
RM van Dam - National University Health System
T Lehtimäki - Fimlab
N Chaturvedi - MRC Unit for Lifelong Health and Ageing
M Yokota - Kurume University
J Liu - University of Oxford
DF Reilly - Genetics, Merck Sharp & Dohme Corp., Kenilworth, NJ, 07033, USA.
AJ McKnight - Queen's University Belfast
F Kee - Queen's University Belfast
KH Jöckel - University of Duisburg-Essen
MI McCarthy - Wellcome Centre for Human Genetics
CNA Palmer
V Vitart - Western General Hospital
C Hayward - Western General Hospital
E Simonsick - National Institute on Aging
CM van Duijn - University of Oxford
ZB Jin - Beijing Tongren Hospital
J Qu - Wenzhou Medical University
H Hishigaki - Otsuka
X Lin - Shanghai Institute of Nutrition and Health
W März - Synlab
V Gudnason - Icelandic Heart Association
JC Tardif - Montreal Heart Institute
G Lettre - Montreal Heart Institute
LM' Hart
PJM Elders
SM Damrauer - University of Pennsylvania
M Kumari - University of Essex
M Kivimaki - University College London
P van der Harst - University Medical Center Groningen
TD Spector - King's College London
RJF Loos
MA Province - Washington University in St. Louis
EJ Parra - University of Toronto
M Cruz - Mexican Social Security Institute
BM Psaty - University of Washington
I Brandslund - Lillebaelt Hospital
Peter P. Pramstaller - Institute for Biomedicine
CN Rotimi - National Human Genome Research Institute
K Christensen - University of Southern Denmark
S Ripatti - Institute for Molecular Medicine Finland
E Widén - Institute for Molecular Medicine Finland
H Hakonarson - University of Pennsylvania
SFA Grant
LALM Kiemeney
J de Graaf - Radboud University Nijmegen
M Loeffler - Leipzig University
F Kronenberg - Innsbruck Medical University
D Gu - Peking Union Medical College Hospital
J Erdmann - University of Lübeck
H Schunkert - German Centre for Cardiovascular Research
PW Franks - Lund University
A Linneberg - Frederiksberg Hospital
JW Jukema - Leiden University Medical Center
AV Khera - Broad Institute
M Männikkö - University of Oulu
MR Jarvelin - Imperial College London
Z Kutalik - University of Lausanne
C Francesco - Institute of Genetic and Biomedical Research
DO Mook-Kanamori - Leiden University Medical Center
KW van Dijk - Leiden University Medical Center
H Watkins - Wellcome Centre for Human Genetics
DP Strachan - St George's, University of London
N Grarup - Novo Nordisk Foundation
P Sever - Imperial College London
N Poulter - Imperial College London
LM Chuang - National Taiwan University Hospital
JI Rotter - The Lundquist Institute
TM Dantoft - Frederiksberg Hospital
F Karpe - Churchill Hospital
MJ Neville - Churchill Hospital
NJ Timpson - University of Bristol
CY Cheng - Singapore Eye Research Institute
TY Wong - Singapore Eye Research Institute
CC Khor - Agency for Science, Technology and Research
H Li - Shanghai Institute of Nutrition and Health
C Sabanayagam - Singapore Eye Research Institute
A Peters - Helmholtz Zentrum München
C Gieger - Helmholtz Zentrum München
AT Hattersley - University of Exeter
NL Pedersen - Karolinska Institutet
PKE Magnusson
DI Boomsma - Vrije Universiteit Amsterdam
AHM Willemsen
L Cupples - Boston University
JBJ van Meurs
M Ghanbari - Erasmus University Rotterdam
P Gordon-Larsen - University of North Carolina at Chapel Hill
W Huang - Chinese National Human Genome Center
YJ Kim
Y Tabara - Kyoto University
NJ Wareham - MRC Epidemiology Unit
C Langenberg - MRC Epidemiology Unit
E Zeggini - Wellcome Sanger Institute
J Kuusisto - University of Eastern Finland
M Laakso - University of Eastern Finland
E Ingelsson - Stanford University
G Abecasis - University of Michigan–Ann Arbor
JC Chambers - Imperial College London
JS Kooner - Ealing Hospital
PS de Vries - The University of Texas Health Science Center at Houston
AC Morrison - The University of Texas Health Science Center at Houston
S Hazelhurst - University of the Witwatersrand
M Ramsay - University of the Witwatersrand
KE North - University of North Carolina at Chapel Hill
M Daviglus - Illinois College
P Kraft - Harvard University
NG Martin - QIMR Berghofer Medical Research Institute
JB Whitfield - QIMR Berghofer Medical Research Institute
S Abbas - Center for Non-Communicable Diseases
D Saleheen - Center for Non-Communicable Diseases
RG Walters - University of Oxford
MV Holmes - National Institute for Health Research
C Black - University of Aberdeen
BH Smith - Ninewells Hospital
A Baras - Regeneron
AE Justice - Geisinger Health System
JE Buring - Brigham and Women's Hospital
PM Ridker - Brigham and Women's Hospital
DI Chasman - Brigham and Women's Hospital
C Kooperberg - Fred Hutch Cancer Center
G Tamiya - Tohoku Medical Megabank Organization
M Yamamoto - Tohoku Medical Megabank Organization
DA van Heel - Queen Mary University of London
RC Trembath - King's College London
WQ Wei - Beijing Tongren Hospital
GP Jarvik - University of Washington
B Namjou - Cincinnati Children's Hospital Medical Center
MG Hayes - Northwestern University
MD Ritchie - University of Pennsylvania
P Jousilahti - Finnish Institute for Health and Welfare
V Salomaa - Finnish Institute for Health and Welfare
K Hveem - Norwegian University of Science and Technology
BO Åsvold - Norwegian University of Science and Technology
M Kubo - RIKEN Center for Integrative Medical Sciences
Y Kamatani - RIKEN Center for Integrative Medical Sciences
Y Okada - Osaka University
Y Murakami - The University of Tokyo
BJ Kim - Korea National Institute of Health
U Thorsteinsdottir - deCODE Genetics
K Stefansson - deCODE Genetics
J Zhang - University of Michigan–Ann Arbor
Y Chen - University of Michigan–Ann Arbor
YL Ho - VA Boston Healthcare System
JA Lynch - VA Salt Lake City Healthcare System
DJ Rader - University of Pennsylvania
PS Tsao - VA Palo Alto Health Care System
KM Chang - Philadelphia VA Medical Center
K Cho - VA Boston Healthcare System
CJ O'Donnell - VA Boston Healthcare System
JM Gaziano - VA Boston Healthcare System
PWF Wilson
TM Frayling - University of Exeter
JN Hirschhorn - Boston Children's Hospital
S Kathiresan - Broad Institute
KL Mohlke - University of North Carolina at Chapel Hill
YV Sun - Emory University
AP Morris - Versus Arthritis
M Boehnke - University of Michigan–Ann Arbor
CD Brown - University of Pennsylvania
P Natarajan - Broad Institute
P Deloukas - Queen Mary University of London
CJ Willer - University of Michigan–Ann Arbor
TL Assimes - VA Palo Alto Health Care System
GM Peloso - Boston University
Publication Details: Genome Biology, Vol.23(1)
ISSN: 1474-760X
EISSN: 1465-6906
Series / Volume: 23
Publisher: BioMed Central
Identifiers: (EURAC)27009991
991006510995301241
Web of Science ID: 8R4QG
Copyright: © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data
Academic Unit: Institute for Biomedicine
Language: English
Resource Type: Journal article
Description coverage: international
Description audience: Scientific
Local Fields: Scientific
Author Names String: Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu KH, Ntalla I, Hui Q, Klarin D, Hilliard AT, Wang Z, Xue C, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Hwang MY, Han S, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Havulinna AS, Veturi Y, Pacheco JA, Rosenthal EA, Lingren T, Feng Q, Kullo IJ, Narita A, Takayama J, Martin HC, Hunt KA, Trivedi B, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Rasheed A, Hindy G, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Choudhury A, Sengupta D, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Wood AR, Ji Y, Gao Z, Haworth S, Yousri NA, Mitchell RE, Chai JF, Aadahl M, Bjerregaard AA, Yao J, Manichaikul A, Hwu CM, Hung YJ, Warren HR, Ramirez J, Bork-Jensen J, Kårhus LL, Goel A, Sabater-Lleal M, Noordam R, Mauro P, Matteo F, McDaid AF, Marques-Vidal P, Wielscher M, Trompet S, Sattar N, Møllehave LT, Munz M, Zeng L, Huang J, Yang B, Poveda A, Kurbasic A, Lamina C, Forer L, Scholz M, Galesloot TE, Bradfield JP, Ruotsalainen SE, Daw E, Zmuda JM, Mitchell JS, Fuchsberger C, Christensen H, Brody JA, Vazquez-Moreno M, Feitosa MF, Wojczynski MK, Wang Z, Preuss MH, Mangino M, Christofidou P, Verweij N, Benjamins JW, Engmann J, Tsao NL, Verma A, Slieker RC, Lo KS, Zilhao NR, Le P, Kleber ME, Delgado GE, Huo S, Ikeda DD, Iha H, Yang J, Liu J, Demirkan A, Leonard HL, Marten J, Frank M, Schmidt B, Smyth LJ, Cañadas-Garre M, Wang C, Nakatochi M, Wong A, Hutri-Kähönen N, Sim X, Xia R, Huerta-Chagoya A, Fernandez-Lopez JC, Lyssenko V, Nongmaithem SS, Bayyana S, Stringham HM, Irvin MR, Oldmeadow C, Kim HN, Ryu S, Timmers PRHJ, Arbeeva L, Dorajoo R, Lange LA, Prasad G, Lorés-Motta L, Pauper M, Long J, Li X, Theusch E, Takeuchi F, Spracklen CN, Loukola A, Bollepalli S, Warner SC, Wang YX, Wei WB, Nutile T, Ruggiero D, Sung YJ, Chen S, Liu F, Yang J, Kentistou KA, Banas B, Nardone GG, Meidtner K, Bielak LF, Smith JA, Hebbar P, Farmaki AE, Hofer E, Lin M, Concas MP, Vaccargiu S, van der Most PJ, Pitkänen N, Cade BE, van der Laan SW, Chitrala KN, Weiss S, Bentley AR, Doumatey AP, Adeyemo AA, Lee JY, Petersen ERB, Nielsen AA, Choi HS, Nethander M, Freitag-Wolf S, Southam L, Rayner NW, Wang CA, Lin SY, Wang JS, Couture C, Lyytikäinen LP, Nikus K, Cuellar-Partida G, Vestergaard H, Hidalgo B, Giannakopoulou O, Cai Q, Obura MO, van Setten J, Li X, Liang J, Tang H, Terzikhan N, Shin JH, Jackson RD, Reiner AP, Martin LW, Chen Z, Li L, Kawaguchi T, Thiery J, Bis JC, Launer LJ, Li H, Nalls MA, Raitakari OT, Ichihara S, Wild SH, Nelson CP, Campbell H, Jäger S, Nabika T, Al-Mulla F, Niinikoski H, Braund PS, Kolcic I, Kovacs P, Giardoglou T, Katsuya T, de Kleijn D, de Borst GJ, Kim EK, Adams HHH, Ikram MA, Zhu X, Asselbergs FW, Kraaijeveld AO, Beulens JWJ, Shu XO, Rallidis LS, Pedersen O, Hansen T, Mitchell P, Hewitt AW, Kähönen M, Pérusse L, Bouchard C, Tönjes A, Chen YI, Pennell CE, Mori TA, Lieb W, Franke A, Ohlsson C, Mellström D, Cho YS, Lee H, Yuan JM, Koh WP, Rhee SY, Woo JT, Heid IM, Stark KJ, Zimmermann ME, Völzke H, Homuth G, Evans MK, Zonderman AB, Polasek O, Pasterkamp G, Hoefer IE, Redline S, Pahkala K, Oldehinkel AJ, Snieder H, Biino G, Schmidt R, Schmidt H, Bandinelli S, Dedoussis G, Thanaraj TA, Kardia SLR, Peyser PA, Kato N, Schulze MB, Girotto G, Böger CA, Jung B, Joshi PK, Bennett DA, De Jager PL, Lu X, Mamakou V, Brown M, Caulfield MJ, Munroe PB, Guo X, Ciullo M, Jonas JB, Samani NJ, Kaprio J, Pajukanta P, Tusié-Luna T, Aguilar-Salinas CA, Adair LS, Bechayda SA, de Silva HJ, Wickremasinghe AR, Krauss RM, Wu JY, Zheng W, Hollander AI, Bharadwaj D, Correa A, Wilson JG, Lind L, Heng CK, Nelson AE, Golightly YM, Wilson JF, Penninx B, Kim HL, Attia J, Scott RJ, Rao DC, Arnett DK, Hunt SC, Walker M, Koistinen HA, Chandak GR, Mercader JM, Costanzo MC, Jang D, Burtt NP, Villalpando CG, Orozco L, Fornage M, Tai E, van Dam RM, Lehtimäki T, Chaturvedi N, Yokota M, Liu J, Reilly DF, McKnight AJ, Kee F, Jöckel KH, McCarthy MI, Palmer CNA, Vitart V, Hayward C, Simonsick E, van Duijn CM, Jin ZB, Qu J, Hishigaki H, Lin X, März W, Gudnason V, Tardif JC, Lettre G, Hart LM', Elders PJM, Damrauer SM, Kumari M, Kivimaki M, van der Harst P, Spector TD, Loos RJF, Province MA, Parra EJ, Cruz M, Psaty BM, Brandslund I, Pramstaller PP, Rotimi CN, Christensen K, Ripatti S, Widén E, Hakonarson H, Grant SFA, Kiemeney LALM, de Graaf J, Loeffler M, Kronenberg F, Gu D, Erdmann J, Schunkert H, Franks PW, Linneberg A, Jukema JW, Khera AV, Männikkö M, Jarvelin MR, Kutalik Z, Francesco C, Mook-Kanamori DO, van Dijk KW, Watkins H, Strachan DP, Grarup N, Sever P, Poulter N, Chuang LM, Rotter JI, Dantoft TM, Karpe F, Neville MJ, Timpson NJ, Cheng CY, Wong TY, Khor CC, Li H, Sabanayagam C, Peters A, Gieger C, Hattersley AT, Pedersen NL, Magnusson PKE, Boomsma DI, Willemsen AHM, Cupples L, van Meurs JBJ, Ghanbari M, Gordon-Larsen P, Huang W, Kim YJ, Tabara Y, Wareham NJ, Langenberg C, Zeggini E, Kuusisto J, Laakso M, Ingelsson E, Abecasis G, Chambers JC, Kooner JS, de Vries PS, Morrison AC, Hazelhurst S, Ramsay M, North KE, Daviglus M, Kraft P, Martin NG, Whitfield JB, Abbas S, Saleheen D, Walters RG, Holmes MV, Black C, Smith BH, Baras A, Justice AE, Buring JE, Ridker PM, Chasman DI, Kooperberg C, Tamiya G, Yamamoto M, van Heel DA, Trembath RC, Wei WQ, Jarvik GP, Namjou B, Hayes MG, Ritchie MD, Jousilahti P, Salomaa V, Hveem K, Åsvold BO, Kubo M, Kamatani Y, Okada Y, Murakami Y, Kim BJ, Thorsteinsdottir U, Stefansson K, Zhang J, Chen Y, Ho YL, Lynch JA, Rader DJ, Tsao PS, Chang KM, Cho K, O'Donnell CJ, Gaziano JM, Wilson PWF, Frayling TM, Hirschhorn JN, Kathiresan S, Mohlke KL, Sun YV, Morris AP, Boehnke M, Brown CD, Natarajan P, Deloukas P, Willer CJ, Assimes TL, Peloso GM

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