Abstract
Key Features
* The Cooperative Health Research In South Tyrol (CHRIS) cohort was established to study genetic and lifestyle determinants of health and healthy aging in a single administrative district of the alpine Bolzano-South Tyrol province of Italy with a stable population, cooperative administration, shared single reference hospital, relatively homogenous customs and environment, and high healthy life expectancy.
* A baseline visit at the district reference hospital was completed by 13 393 adults aged ≥18 years (median 46, range 18-94, 54% female) in 2011-2018, providing socio-demographic, health, lifestyle, and exposure data from self-report questionnaires, interviews, and instrumental examinations, plus urine and blood samples for biobanking, DNA extraction, and molecular characterization (chip genotyping, exome sequencing, metabolomics, proteomics).
* To date, 4500 baseline participants have completed a visit as part of ongoing follow-up, providing most of the same data and samples as at baseline; additional data collection from wearable activity trackers and on prominent themes like COVID-19 have been introduced.
* Longitudinal data and biological samples have been collected in the CHRIS study district for over two decades from 2003, encompassing sociodemographic information, medical history, clinical data and molecular phenotypes.
* Dedicated requests for cohort data and samples for research purposes can be submitted via the CHRIS Portal (https://chrisportal.eurac.edu).