Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study

S Karamohamed; LI Golbe; MH Mark; AM Lazzarini; O Suchowersky; N Labelle; M Guttman; LJ Currie; GF Wooten; M Stacy; M Saint-Hilaire; RG Feldman; J Liu; CM Shoemaker; JB Wilk; AL DeStefano; JC Latourelle; G Xu; R Watts; J Growdon; M Lew; C Waters; P Vieregge; Peter P. Pramstaller; C Klein; BA Racette; JS Perlmutter; A Parsian; C Singer; E Montgomery; K Baker; JF Gusella; A Herbert; RH Myers

doi:10.1002/mds.20515

Back

Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study

Journal article

Peer reviewed

Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study

S Karamohamed, LI Golbe, MH Mark, AM Lazzarini, O Suchowersky, N Labelle, M Guttman, LJ Currie, GF Wooten, M Stacy, …

Movement Disorders, Vol.20(9), pp.1188-1191

2005

DOI: https://doi.org/10.1002/mds.20515

Handle:

https://hdl.handle.net/10863/6430

PMID: 15966003

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder in which relatives of the probands are affected approximately 4 times as frequently as relatives of control subjects. Several genes have been implicated as genetic risk factors for PD. We investigated the presence of six reported genetic variations in the SCNA, NR4A2, and DJ-1 genes in 292 cases of familial Parkinson's disease from the GenePD study. None of the variants were found in the GenePD families. Our results suggest that other variants or genes account for the familial risk of PD within the GenePD study.

Details

Title: Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study
Creators: S Karamohamed
LI Golbe
MH Mark
AM Lazzarini
O Suchowersky
N Labelle
M Guttman
LJ Currie
GF Wooten
M Stacy
M Saint-Hilaire
RG Feldman
J Liu
CM Shoemaker
JB Wilk
AL DeStefano
JC Latourelle
G Xu
R Watts
J Growdon
M Lew
C Waters
P Vieregge
Peter P. Pramstaller
C Klein
BA Racette
JS Perlmutter
A Parsian
C Singer
E Montgomery
K Baker
JF Gusella
A Herbert
RH Myers
Publication Details: Movement Disorders, Vol.20(9), pp.1188-1191
ISSN: 0885-3185
Series / Volume: 20
Publisher: Wiley
Identifiers: (EURAC)10346069
991005772548201241
Web of Science ID: WOS:000231838000014
Academic Unit: Institute for Biomedicine
Language: English
Resource Type: Journal article
Local Fields: Scientific
Author Names String: Karamohamed S, Golbe LI, Mark MH, Lazzarini AM, Suchowersky O, Labelle N, Guttman M, Currie LJ, Wooten GF, Stacy M, Saint-Hilaire M, Feldman RG, Liu J, Shoemaker CM, Wilk JB, DeStefano AL, Latourelle JC, Xu G, Watts R, Growdon J, Lew M, Waters C, Vieregge P, Pramstaller PP, Klein C, Racette BA, Perlmutter JS, Parsian A, Singer C, Montgomery E, Baker K, Gusella JF, Herbert A, Myers RH

Metrics

17 Record Views

Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study

Abstract

Related links

Details

Metrics