A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses

Manuela Ciocca; Serena Marcozzi; Paolo Mariani; Valentina Lacconi; Aldo Di Carlo; L Cinà; Marcelo D. Rosato-Siri; Alessandra Zanon; Giada Cattelan; Enrico Avancini; Paolo Lugli; Shashank Priya; Antonella Camaioni; TM Brown

doi:10.1109/NMDC57951.2023.10344066

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A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses

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A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses

Manuela Ciocca, Serena Marcozzi, Paolo Mariani, Valentina Lacconi, Aldo Di Carlo, L Cinà, Marcelo D. Rosato-Siri, Alessandra Zanon, Giada Cattelan, Enrico Avancini, …

2023 IEEE Nanotechnology Materials and Devices Conference (NMDC), pp.527-528

18th IEEE Nanotechnology Materials and Devices Conference (Paestum, 22/10/2023–25/10/2023)

2023

DOI: https://doi.org/10.1109/NMDC57951.2023.10344066

Handle:

https://hdl.handle.net/10863/48763

Abstract

Semiconductor device measurement

Calcium

Cells (biology)

Organic semiconductors

Ions

Time measurement

Medical Treatment

Organic semiconductors are promising for interfacing with biological systems because they are biocompatible, printable and their optical properties tuned. We developed a bio-photoelectrolytic platform based on semiconducting polymer thin films, onto which neuroblastoma SH-SY5Y cells were cultured immersing both in an aqueous biological medium. It was possible to inhibit cell proliferation by 50% in this cancer cell line by subjecting the platform to a series of light pulses over time. Light stimulation was found to increase the concentration of calcium ions inside the cells by three times. The platform also enabled to measure bio-electrical signals. The bio-photoelectrolytic platform and the effective use of light stimulation may open new avenues for in vitro light control/manipulation of cell behaviour, for the development of future novel non-invasive tools for application in biosensing, regenerative medicine and cell-based therapy, and for cancer progression control and therapy.

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Title: A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses
Creators: Manuela Ciocca - University of Rome Tor Vergata
Serena Marcozzi - University of Rome Tor Vergata
Paolo Mariani - University of Rome Tor Vergata
Valentina Lacconi - University of Rome Tor Vergata
Aldo Di Carlo - Institute of Structure of Matter
L Cinà
Marcelo D. Rosato-Siri - Eurac Research
Alessandra Zanon - Eurac Research
Giada Cattelan
Enrico Avancini - Free University of Bozen-Bolzano
Paolo Lugli - Free University of Bozen-Bolzano
Shashank Priya - Pennsylvania State University
Antonella Camaioni - University of Rome Tor Vergata
TM Brown - University of Rome Tor Vergata
Publication Details: 2023 IEEE Nanotechnology Materials and Devices Conference (NMDC), pp.527-528
ISBN: 9798350335477
EISBN: 9798350335460
Conference: 18th IEEE Nanotechnology Materials and Devices Conference (Paestum, 22/10/2023–25/10/2023)
Publisher: Institute of Electrical and Electronics Engineers Inc.
Number of pages: 2
Identifiers: 979-8-3503-3547-7
(UNIBZ)86588480
991006956756801241
Scopus ID: 2-s2.0-85182017124
Academic Unit: Faculty of Engineering
Language: English
Resource Type: Conference proceeding
Author Names String: Ciocca M, Marcozzi S, Mariani P, Lacconi V, Di Carlo A, Cinà L, Rosato-Siri MD, Zanon A, Cattelan G, Avancini E, Lugli P, Priya S, Camaioni A, Brown TM

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