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  • A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function 

    Neely GG; Kuba K; Cammarato A; Isobe K; Amann S; Zhang L; Murata M; Elmén L; Gupta V; Arora S; Sarangi R; Dan D; Fujisawa S; Usami T; Xia CP; Keene AC; Alayari NN; Yamakawa H; Elling U; Berger C; Novatchkova M; Koglgruber R; Fukuda K; Nishina H; Isobe M; Pospisilik JA; Imai Y; Pfeufer A; Hicks AA; Pramstaller PP; Subramaniam S; Kimura A; Ocorr K; Bodmer R; Penninger JM (2010)
    Heart diseases are the most common causes of morbidity and death in humans. Using cardiac-specific RNAi-silencing in Drosophila, we knocked down 7061 evolutionarily conserved genes under conditions of stress. We present a ...