Now showing items 1-7 of 7

    • Biological, clinical and population relevance of 95 loci for blood lipids 

      Teslovich TM; Musunuru K; Smith AV; Edmondson AC; Stylianou IM; Koseki M; Pirruccello JP; Ripatti S; Chasman DI; Willer CJ; Johansen CT; Fouchier SW; Isaacs A; Peloso GM; Barbalic M; Ricketts SL; Bis JC; Aulchenko YS; Thorleifsson G; Feitosa MF; Chambers J; Orho-Melander M; Melander O; Johnson T; Li X; Guo X; Li M; Shin Cho Y; Jin Go M; Jin Kim Y; Lee JY; Park T; Kim K; Sim X; Twee-Hee Ong R; Croteau-Chonka DC; Lange LA; Smith JD; Song K; Hua Zhao J; Yuan X; Luan J; Lamina C; Ziegler A; Zhang W; Zee RY; Wright AF; Witteman JC; Wilson JF; Willemsen G; Wichmann HE; Whitfield JB; Waterworth DM; Wareham NJ; Waeber G; Vollenweider P; Voight BF; Vitart V; Uitterlinden AG; Uda M; Tuomilehto J; Thompson JR; Tanaka T; Surakka I; Stringham HM; Spector TD; Soranzo N; Smit JH; Sinisalo J; Silander K; Sijbrands EJ; Scuteri A; Scott J; Schlessinger D; Sanna S; Salomaa V; Saharinen J; Sabatti C; Ruokonen A; Rudan I; Rose LM; Roberts R; Rieder M; Psaty BM; Pramstaller PP; Pichler I; Perola M; Penninx BW; Pedersen NL; Pattaro C; Parker AN; Pare G; Oostra BA; O'Donnell CJ; Nieminen MS; Nickerson DA; Montgomery GW; Meitinger T; McPherson R; McCarthy MI; McArdle W; Masson D; Martin NG; Marroni F; Mangino M; Magnusson PK; Lucas G; Luben R; Loos RJ; Lokki ML; Lettre G; Langenberg C; Launer LJ; Lakatta EG; Laaksonen R; Kyvik KO; Kronenberg F; König IR; Khaw KT; Kaprio J; Kaplan LM; Johansson A; Jarvelin MR; Janssens AC; Ingelsson E; Igl W; Kees Hovingh G; Hottenga JJ; Hofman A; Hicks AA; Hengstenberg C; Heid IM; Hayward C; Havulinna AS; Hastie ND; Harris TB; Haritunians T; Hall AS; Gyllensten U; Guiducci C; Groop LC; Gonzalez E; Gieger C; Freimer NB; Ferrucci L; Erdmann J; Elliott P; Ejebe KG; Döring A; Dominiczak AF; Demissie S; Deloukas P; de Geus EJ; de Faire U; Crawford G; Collins FS; Chen YD; Caulfield MJ; Campbell H; Burtt NP; Bonnycastle LL; Boomsma DI; Boekholdt SM; Bergman RN; Barroso I; Bandinelli S; Ballantyne CM; Assimes TL; Quertermous T; Altshuler D; Seielstad M; Wong TY; Tai ES; Feranil AB; Kuzawa CW; Adair LS; Taylor HA; Borecki IB; Gabriel SB; Wilson JG; Holm H; Thorsteinsdottir U; Gudnason V; Krauss RM; Mohlke KL; Ordovas JM; Munroe PB; Kooner JS; Tall AR; Hegele RA; Kastelein JJ; Schadt EE; Rotter JI; Boerwinkle E; Strachan DP; Mooser V; Stefansson K; Reilly MP; Samani NJ; Schunkert H; Cupples LA; Sandhu MS; Ridker PM; Rader DJ; van Duijn CM; Peltonen L; Abecasis GR; Boehnke M; Kathiresan S (2010)
      Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are ...
    • Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo 

      Ikram MK; Sim X; Xueling S; Jensen RA; Cotch MF; Hewitt AW; Ikram MA; Wang JJ; Klein R; Klein BE; Breteler MM; Cheung N; Liew G; Mitchell P; Uitterlinden AG; Rivadeneira F; Hofman A; de Jong PT; van Duijn CM; Kao L; Cheng CY; Smith AV; Glazer NL; Lumley T; McKnight B; Psaty BM; Jonasson F; Eiriksdottir G; Aspelund T; Global BPgen Consortium; Harris TB; Launer LJ; Taylor KD; Li X; Iyengar SK; Xi Q; Sivakumaran TA; Mackey DA; Macgregor S; Martin NG; Young TL; Bis JC; Wiggins KL; Heckbert SR; Hammond CJ; Andrew T; Fahy S; Attia J; Holliday EG; Scott RJ; Islam FM; Rotter JI; McAuley AK; Boerwinkle E; Tai ES; Gudnason V; Siscovick DS; Vingerling JR; Wong TY (2010)
      There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident ...
    • The genetic architecture of type 2 diabetes 

      Fuchsberger C; Flannick J; Teslovich TM; Mahajan A; Agarwala V; Gaulton KJ; Ma C; Fontanillas P; Moutsianas L; McCarthy DJ; Rivas MA; Perry JR; Sim X; Blackwell TW; Robertson NR; Rayner NW; Cingolani P; Locke AE; Fernandez Tajes J; Highland HM; Dupuis J; Chines PS; Lindgren CM; Hartl C; Jackson AU; Chen H; Huyghe JR; van de Bunt M; Pearson RD; Kumar A; Müller-Nurasyid M; Grarup N; Stringham HM; Gamazon ER; Lee J; Chen Y; Scott RA; Below JE; Chen P; Huang J; Go MJ; Stitzel ML; Pasko D; Parker SC; Varga TV; Green T; Beer NL; Day-Williams AG; Ferreira T; Fingerlin T; Horikoshi M; Hu C; Huh I; Ikram MK; Kim BJ; Kim Y; Kim YJ; Kwon MS; Lee S; Lin KH; Maxwell TJ; Nagai Y; Wang X; Welch RP; Yoon J; Zhang W; Barzilai N; Voight BF; Han BG; Jenkinson CP; Kuulasmaa T; Kuusisto J; Manning A; Ng MC; Palmer ND; Balkau B; Stancáková A; Abboud HE; Boeing H; Giedraitis V; Prabhakaran D; Gottesman O; Scott J; Carey J; Kwan P; Grant G; Smith JD; Neale BM; Purcell S; Butterworth AS; Howson JM; Lee HM; Lu Y; Kwak SH; Zhao W; Danesh J; Lam VK; Park KS; Saleheen D; So WY; Tam CH; Afzal U; Aguilar D; Arya R; Aung T; Chan E; Navarro C; Cheng CY; Palli D; Correa A; Curran JE; Rybin D; Farook VS; Fowler SP; Freedman BI; Griswold M; Hale DE; Hicks PJ; Khor CC; Kumar S; Lehne B; Thuillier D; Lim WY; Liu J; van der Schouw YT; Loh M; Musani SK; Puppala S; Scott WR; Yengo L; Tan ST; Taylor HA Jr; Thameem F; Wilson G Sr; Wong TY; Njølstad PR; Levy JC; Mangino M; Bonnycastle LL; Schwarzmayr T; Fadista J; Surdulescu GL; Herder C; Groves CJ; Wieland T; Bork-Jensen J; Brandslund I; Christensen C; Koistinen HA; Doney AS; Kinnunen L; Esko T; Farmer AJ; Hakaste L; Hodgkiss D; Kravic J; Lyssenko V; Hollensted M; Jørgensen ME; Jørgensen T; Ladenvall C; Justesen JM; Käräjämäki A; Kriebel J; Rathmann W; Lannfelt L; Lauritzen T; Narisu N; Linneberg A; Melander O; Milani L; Neville M; Orho-Melander M; Qi L; Qi Q; Roden M; Rolandsson O; Swift A; Rosengren AH; Stirrups K; Wood AR; Mihailov E; Blancher C; Carneiro MO; Maguire J; Poplin R; Shakir K; Fennell T; DePristo M; Hrabé de Angelis M; Deloukas P; Gjesing AP; Jun G; Nilsson P; Murphy J; Onofrio R; Thorand B; Hansen T; Meisinger C; Hu FB; Isomaa B; Karpe F; Liang L; Peters A; Huth C; O'Rahilly SP; Palmer CN; Pedersen O; Rauramaa R; Tuomilehto J; Salomaa V; Watanabe RM; Syvänen AC; Bergman RN; Bharadwaj D; Bottinger EP; Cho YS; Chandak GR; Chan JC; Chia KS; Daly MJ; Ebrahim SB; Langenberg C; Elliott P; Jablonski KA; Lehman DM; Jia W; Ma RC; Pollin TI; Sandhu M; Tandon N; Froguel P; Barroso I; Teo YY; Zeggini E; Loos RJ; Small KS; Ried JS; DeFronzo RA; Grallert H; Glaser B; Metspalu A; Wareham NJ; Walker M; Banks E; Gieger C; Ingelsson E; Im HK; Illig T; Franks PW; Buck G; Trakalo J; Buck D; Prokopenko I; Mägi R; Lind L; Farjoun Y; Owen KR; Gloyn AL; Strauch K; Tuomi T; Kooner JS; Lee JY; Park T; Donnelly P; Morris AD; Hattersley AT; Bowden DW; Collins FS; Atzmon G; Chambers JC; Spector TD; Laakso M; Strom TM; Bell GI; Blangero J; Duggirala R; Tai ES; McVean G; Hanis CL; Wilson JG; Seielstad M; Frayling TM; Meigs JB; Cox NJ; Sladek R; Lander ES; Gabriel S; Burtt NP; Mohlke KL; Meitinger T; Groop L; Abecasis G; Florez JC; Scott LJ; Morris AP; Kang HM; Boehnke M; Altshuler D; McCarthy MI (2016)
      The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified ...
    • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk 

      International Consortium for Blood Pressure Genome-Wide Association Studies; Ehret GB; Munroe PB; Rice KM; Bochud M; Johnson AD; Chasman DI; Smith AV; Tobin MD; Verwoert GC; Hwang SJ; Pihur V; Vollenweider P; O'Reilly PF; Amin N; Bragg-Gresham JL; Teumer A; Glazer NL; Launer L; Zhao JH; Aulchenko Y; Heath S; Sõber S; Parsa A; Luan J; Arora P; Dehghan A; Zhang F; Lucas G; Hicks AA; Jackson AU; Peden JF; Tanaka T; Wild SH; Rudan I; Igl W; Milaneschi Y; Parker AN; Fava C; Chambers JC; Fox ER; Kumari M; Go MJ; van der Harst P; Kao WH; Sjögren M; Vinay DG; Alexander M; Tabara Y; Shaw-Hawkins S; Whincup PH; Liu Y; Shi G; Kuusisto J; Tayo B; Seielstad M; Sim X; Nguyen KD; Lehtimäki T; Matullo G; Wu Y; Gaunt TR; Onland-Moret NC; Cooper MN; Platou CG; Org E; Hardy R; Dahgam S; Palmen J; Vitart V; Braund PS; Kuznetsova T; Uiterwaal CS; Adeyemo A; Palmas W; Campbell H; Ludwig B; Tomaszewski M; Tzoulaki I; Palmer ND; CARDIoGRAM Consortium; CKDGen Consortium; KidneyGen Consortium; EchoGen consortium; CHARGE-HF consortium; Aspelund T; Garcia M; Chang YP; O'Connell JR; Steinle NI; Grobbee DE; Arking DE; Kardia SL; Morrison AC; Hernandez D; Najjar S; McArdle WL; Hadley D; Brown MJ; Connell JM; Hingorani AD; Day IN; Lawlor DA; Beilby JP; Lawrence RW; Clarke R; Hopewell JC; Ongen H; Dreisbach AW; Li Y; Young JH; Bis JC; Kähönen M; Viikari J; Adair LS; Lee NR; Chen MH; Olden M; Pattaro C; Bolton JA; Köttgen A; Bergmann S; Mooser V; Chaturvedi N; Frayling TM; Islam M; Jafar TH; Erdmann J; Kulkarni SR; Bornstein SR; Grässler J; Groop L; Voight BF; Kettunen J; Howard P; Taylor A; Guarrera S; Ricceri F; Emilsson V; Plump A; Barroso I; Khaw KT; Weder AB; Hunt SC; Sun YV; Bergman RN; Collins FS; Bonnycastle LL; Scott LJ; Stringham HM; Peltonen L; Perola M; Vartiainen E; Brand SM; Staessen JA; Wang TJ; Burton PR; Soler Artigas M; Dong Y; Snieder H; Wang X; Zhu H; Lohman KK; Rudock ME; Heckbert SR; Smith NL; Wiggins KL; Doumatey A; Shriner D; Veldre G; Viigimaa M; Kinra S; Prabhakaran D; Tripathy V; Langefeld CD; Rosengren A; Thelle DS; Corsi AM; Singleton A; Forrester T; Hilton G; McKenzie CA; Salako T; Iwai N; Kita Y; Ogihara T; Ohkubo T; Okamura T; Ueshima H; Umemura S; Eyheramendy S; Meitinger T; Wichmann HE; Cho YS; Kim HL; Lee JY; Scott J; Sehmi JS; Zhang W; Hedblad B; Nilsson P; Smith GD; Wong A; Narisu N; Stancáková A; Raffel LJ; Yao J; Kathiresan S; O'Donnell CJ; Schwartz SM; Ikram MA; Longstreth WT; Mosley TH; Seshadri S; Shrine NR; Wain LV; Morken MA; Swift AJ; Laitinen J; Prokopenko I; Zitting P; Cooper JA; Humphries SE; Danesh J; Rasheed A; Goel A; Hamsten A; Watkins H; Bakker SJ; van Gilst WH; Janipalli CS; Mani KR; Yajnik CS; Hofman A; Mattace-Raso FU; Oostra BA; Demirkan A; Isaacs A; Rivadeneira F; Lakatta EG; Orru M; Scuteri A; Ala-Korpela M; Kangas AJ; Lyytikäinen LP; Soininen P; Tukiainen T; Würtz P; Ong RT; Dörr M; Kroemer HK; Völker U; Völzke H; Galan P; Hercberg S; Lathrop M; Zelenika D; Deloukas P; Mangino M; Spector TD; Zhai G; Meschia JF; Nalls MA; Sharma P; Terzic J; Kumar MV; Denniff M; Zukowska-Szczechowska E; Wagenknecht LE; Fowkes FG; Charchar FJ; Schwarz PE; Hayward C; Guo X; Rotimi C; Bots ML; Brand E; Samani NJ; Polasek O; Talmud PJ; Nyberg F; Kuh D; Laan M; Hveem K; Palmer LJ; van der Schouw YT; Casas JP; Mohlke KL; Vineis P; Raitakari O; Ganesh SK; Wong TY; Tai ES; Cooper RS; Laakso M; Rao DC; Harris TB; Morris RW; Dominiczak AF; Kivimaki M; Marmot MG; Miki T; Saleheen D; Chandak GR; Coresh J; Navis G; Salomaa V; Han BG; Zhu X; Kooner JS; Melander O; Ridker PM; Bandinelli S; Gyllensten UB; Wright AF; Wilson JF; Ferrucci L; Farrall M; Tuomilehto J; Pramstaller PP; Elosua R; Soranzo N; Sijbrands EJ; Altshuler D; Loos RJ; Shuldiner AR; Gieger C; Meneton P; Uitterlinden AG; Wareham NJ; Gudnason V; Rotter JI; Rettig R; Uda M; Strachan DP; Witteman JC; Hartikainen AL; Beckmann JS; Boerwinkle E; Vasan RS; Boehnke M; Larson MG; Järvelin MR; Psaty BM; Abecasis GR; Chakravarti A; Elliott P; van Duijn CM; Newton-Cheh C; Levy D; Caulfield MJ; Johnson T (2011)
      Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg ...
    • Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India 

      Saxena R; Saleheen D; Been LF; Garavito ML; Braun T; Bjonnes A; Young R; Ho WK; Rasheed A; Frossard P; Sim X; Hassanali N; Radha V; Chidambaram M; Liju S; Rees SD; Ng DP; Wong TY; Yamauchi T; Hara K; Tanaka Y; Hirose H; McCarthy MI; Morris AP; DIAGRAM Consortium; MuTHER Consortium; AGEN; Basit A; Barnett AH; Katulanda P; Matthews D; Mohan V; Wander GS; Singh JR; Mehra NK; Ralhan S; Kamboh MI; Mulvihill JJ; Maegawa H; Tobe K; Maeda S; Cho YS; Tai ES; Kelly MA; Chambers JC; Kooner JS; Kadowaki T; Deloukas P; Rader DJ; Danesh J; Sanghera DK (2013)
      We performed a genome-wide association study (GWAS) and a multistage meta-analysis of type 2 diabetes (T2D) in Punjabi Sikhs from India. Our discovery GWAS in 1,616 individuals (842 case subjects) was followed by in silico ...
    • Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations 

      Okada Y; Sim X; Go MJ; Wu JY; Gu D; Takeuchi F; Takahashi A; Maeda S; Tsunoda T; Chen P; Lim SC; Wong TY; Liu J; Young TL; Aung T; Seielstad M; Teo YY; Kim YJ; Lee JY; Han BG; Kang D; Chen CH; Tsai FJ; Chang LC; Fann SJ; Mei H; Rao DC; Hixson JE; Chen S; Katsuya T; Isono M; Ogihara T; Chambers JC; Zhang W; Kooner JS; KidneyGen Consortium; CKDGen Consortium; Albrecht E; GUGC consortium; Yamamoto K; Kubo M; Nakamura Y; Kamatani N; Kato N; He J; Chen YT; Cho YS; Tai ES; Tanaka T (2012)
      Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a ...
    • Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians 

      Cho YS; Chen CH; Hu C; Long J; Ong RT; Sim X; Takeuchi F; Wu Y; Go MJ; Yamauchi T; Chang YC; Kwak SH; Ma RC; Yamamoto K; Adair LS; Aung T; Cai Q; Chang LC; Chen YT; Gao Y; Hu FB; Kim HL; Kim S; Kim YJ; Lee JJ; Lee NR; Li Y; Liu JJ; Lu W; Nakamura J; Nakashima E; Ng DP; Tay WT; Tsai FJ; Wong TY; Yokota M; Zheng W; Zhang R; Wang C; So WY; Ohnaka K; Ikegami H; Hara K; Cho YM; Cho NH; Chang TJ; Bao Y; Hedman ÅK; Morris AP; McCarthy MI; DIAGRAM Consortium; MuTHER Consortium; Takayanagi R; Park KS; Jia W; Chuang LM; Chan JC; Maeda S; Kadowaki T; Lee JY; Wu JY; Teo YY; Tai ES; Shu XO; Mohlke KL; Kato N; Han BG; Seielstad M (2011)
      We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases ...